280 research outputs found
Fatigue survival and damage modes of lithium disilicate and resin nanoceramic crowns
Polymer-based composite materials have been proposed as an alternative for single unit restorations, due to their resilient and shock absorbing behavior, in contrast to the brittleness of ceramic materials that could result in failure by fracture. Objective: To evaluate the fatigue strength and damage modes of monolithic posterior resin nanoceramic and lithium disilicate glass ceramic crowns. Methodology: Twenty-six resin nanoceramic (RNC) and lithium disilicate glass ceramic (LD) 2 mm monolithic crowns (n=13) were cemented on composite resin replicas of a prepared tooth and subjected to cyclic load with lithium disilicate indenters for 2 million cycles. Specimens and indenters were inspected every 500,000 cycles and suspended when presenting fractures or debonding. Surviving specimens were embedded in epoxy resin, polished and subsurface damage was analyzed. Specimens presenting fractures or severe subsurface damage were considered as failures. Survival data was subjected to Fisher's exact test; damage modes were subjected to Mann-Whitney test (p<0.05). Results: There were no debonding, cohesive or catastrophic failures. Considering subsurface damage, 53.8% of RNC and 46.2% of LD crowns survived the fatigue test, presenting no statistical difference. Chief damage modes were radial cracks for RNC and inner cone cracks for LD, presenting no statistical difference. Conclusions: The results suggest that if debonding issues can be resolved, resin nanoceramic figures can be an alternative to posterior crowns. Although distinct, damage modes revealed potential to cause bulk fracture in both glass ceramic and resin nanoceramic crowns
Pro-oxidant effects of Verbascoside, a bioactive compound from olive oil mill wastewater, on in vitro developmental potential of ovine prepubertal oocytes and bioenergetic/oxidative stress parameters of fresh and vitrified oocytes
Verbascoside (VB) is a bioactive polyphenol from olive oil mill wastewater with known antioxidant activity. Oxidative stress is an emerging problem in assisted reproductive technology (ART). Juvenile ART is a promising topic because, in farm animals, it reduces the generation gap and, in human reproductive medicine, it helps to overcome premature ovarian failure. The aim of this study was to test the effects of VB on the developmental competence of ovine prepubertal oocytes and the bioenergetic/oxidative stress status of fresh and vitrified oocytes. In fresh oocytes, VB exerted prooxidant short-term effects, that is, catalase activity increase and uncoupled increases of mitochondria and reactive oxygen species (ROS) fluorescence signals, and long-term effects, that is, reduced blastocyst formation rate. In vitrified oocytes, VB increased ROS levels. Prooxidant VB effects in ovine prepubertal oocytes could be related to higher VB accumulation, which was found as almost one thousand times higher than that reported in other cell systems in previous studies. Also, long exposure times of oocytes to VB, throughout the duration of in vitro maturation culture, may have contributed to significant increase of oocyte oxidation. Further studies are needed to identify lower concentrations and/or shorter exposure times to figure out VB antioxidant effects in juvenile ARTs
Hemidesmus indicus induces apoptosis via proteasome inhibition and generation of reactive oxygen species.
Proteasome inhibition represents an important anticancer strategy. Here, we studied the mechanisms at the basis of the pro-apoptotic activity of the standardized decoction of Hemidesmus indicus, a plant evoking a complex anticancer activity, and explored its inhibition of proteasome activity in human leukemia cells. Additionally, we preliminary tested the cytotoxicity of some H. indicus's phytochemicals on leukemia cells and their intestinal absorption on a human intestinal epithelium model consisting of a monolayer of differentiated Caco2 cells. We observed a potent antileukemic effect for H. indicus, imputable to the modulation of different critical targets at protein and mRNA levels and the reduction of the 26S proteasome expression. We found that some phytomarkers of H. indicus decoction passed through the enterocyte monolayer. Overall, our study supports the pharmacological potential of H. indicus, which can represent an interesting botanical drug in the oncological area
Concept and optical design of the cross-disperser module for CRIRES
This is the peer reviewed version of the following article: Oliva, Ernesto, A. Tozzi, D. Ferruzzi, L. Origlia, A. Hatzes, R. Follert, T. Loewinger et al. "Concept and optical design of the cross-disperser module for CRIRES+." In SPIE Astronomical Telescopes+ Instrumentation, pp. 91477R-91477R. International Society for Optics and Photonics, 2014, which has been published in final form at 10.1117/12.2054381
Updated optical design and trade-off study for MOONS, the Multi-Object Optical and Near Infrared spectrometer for the VLT
This paper presents the latest optical design for the MOONS triple-arm
spectrographs. MOONS will be a Multi-Object Optical and Near-infrared
Spectrograph and will be installed on one of the European Southern Observatory
(ESO) Very Large Telescopes (VLT). Included in this paper is a trade-off
analysis of different types of collimators, cameras, dichroics and filters.Comment: 10 pages, 8 figures, 5 tables. Presented at SPIE Astronomical
Telescope + Instrumentation 2014 (Ground-based and Airbone Instrumentation
for Astronomy 5, 9147-84). To be published in Proceeding of SPIE Volume 914
Direct constraint on the distance of y2 Velorum from AMBER/VLTI observations
In this work, we present the first AMBER observations, of the Wolf-Rayet and
O (WR+O) star binary system y2 Velorum. The AMBER instrument was used with the
telescopes UT2, UT3, and UT4 on baselines ranging from 46m to 85m. It delivered
spectrally dispersed visibilities, as well as differential and closure phases,
with a resolution R = 1500 in the spectral band 1.95-2.17 micron. We interpret
these data in the context of a binary system with unresolved components,
neglecting in a first approximation the wind-wind collision zone flux
contribution. We show that the AMBER observables result primarily from the
contribution of the individual components of the WR+O binary system. We discuss
several interpretations of the residuals, and speculate on the detection of an
additional continuum component, originating from the free-free emission
associated with the wind-wind collision zone (WWCZ), and contributing at most
to the observed K-band flux at the 5% level. The expected absolute separation
and position angle at the time of observations were 5.1±0.9mas and
66±15° respectively. However, we infer a separation of
3.62+0.11-0.30 mas and a position angle of 73+9-11°. Our analysis thus
implies that the binary system lies at a distance of 368+38-13 pc, in agreement
with recent spectrophotometric estimates, but significantly larger than the
Hipparcos value of 258+41-31 pc
Near-Infrared interferometry of Eta Carinae with high spatial and spectral resolution using the VLTI and the AMBER instrument
We present the first NIR spectro-interferometry of the LBV Eta Carinae. The K
band observations were performed with the AMBER instrument of the ESO Very
Large Telescope Interferometer using three 8.2m Unit Telescopes with baselines
from 42 to 89m. The aim of this work is to study the wavelength dependence of
Eta Car's optically thick wind region with a high spatial resolution of 5 mas
(11 AU) and high spectral resolution. The medium spectral resolution
observations (R=1,500) were performed in the wavelength range around both the
HeI 2.059 micron and the Br gamma 2.166 micron emission lines, the high
spectral resolution observations (R=12,000) only in the Br gamma line region.
In the K-band continuum, a diameter of 4.0 +/-0.2 mas (Gaussian FWHM, fit range
28-89m) was measured for Eta Car's optically thick wind region. If we fit
Hillier et al. (2001) model visibilities to the observed AMBER visibilities, we
obtain 50 % encircled-energy diameters of 4.2, 6.5 and 9.6mas in the 2.17
micron continuum, the HeI, and the Br gamma emission lines, respectively. In
the continuum near the Br gamma line, an elongation along a position angle of
120+/-15 degrees was found, consistent with previous VLTI/VINCI measurements by
van Boekel et al. (2003). We compare the measured visibilities with predictions
of the radiative transfer model of Hillier et al. (2001), finding good
agreement. Furthermore, we discuss the detectability of the hypothetical hot
binary companion. For the interpretation of the non-zero differential and
closure phases measured within the Br gamma line, we present a simple geometric
model of an inclined, latitude-dependent wind zone. Our observations support
theoretical models of anisotropic winds from fast-rotating, luminous hot stars
with enhanced high-velocity mass loss near the polar regions.Comment: 22 pages, 14 figures, 2 tables; A&A in pres
Preliminary analysis of ground-to-flight mechanical tolerances of the Ariel mission telescope
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