5,919 research outputs found
Bis(7-methÂoxy-1-methyl-4,9-dihydro-3H-ÎČ-carbolinium) tetraÂchloridozincate
In the title compound, (C13H15N2O)2[ZnCl4], also known as di(harmalinium) tetraÂchloridozincate, the ZnII atom is in a distorted tetrahedral coordination of the chlorido ligands. In the cation, the methÂoxy and methyl groups are both coplanar with with rings to which they are attached [maximum deviations of 0.232â
(4) and 0.259â
(4)â
Ă
, respectively]. In the crystal, the alkaloid cations and metal complex anions interÂact by way of NâHâŻCl hydrogen bonds involving each Cl atom, resulting in a network structure
Price discovery in dualâclass shares across multiple markets
This paper proposes a new measure of price discovery that uses the spectral decomposition. The methodology is especially important in the context of large price systems, such as interest rate parities with spot and futures contracts or dual-class shares in multiple markets. We employ high frequency data to study price discovery in dual-class Brazilian stocks and their ADRs. We find that the foreign market is at least as informative as the home market and that shocks in the dual-class premium entail a permanent effect in normal times, but transitory in periods of financial distress
Bis(6-methÂoxy-1-methyl-2,3,4,9-tetraÂhydro-1H-ÎČ-carbolin-2-ium) tetraÂchloridozincate(II) dihydrate
The asymmetric unit of the title compound, (C13H17N2O)2[ZnCl4]·2H2O, contains two tetraÂhydroÂharmine cations, one tetraÂchloroÂzincate(II) anion and two water molÂecules. In the cations, the two 1H-indole ring systems are essentially planar, with maximum deviations of 0.016â
(2) and 0.018â
(2)â
Ă
, and both tetraÂhydroÂpyridinium rings show a half-chair conformation. The ZnII complex anion has a distorted tetraÂhedral geometry. In the crystal, interÂmolecular NâHâŻO, NâHâŻCl, OâHâŻO, OâHâŻCl and CâHâŻO hydrogen bonds link the components into a three-dimensional network. A ÏâÏ interÂaction with a centroidâcentroid distance of 3.542â
(14)â
Ă
is also observed
Group Theory of Non-Abelian Vortices
We investigate the structure of the moduli space of multiple BPS non-Abelian
vortices in U(N) gauge theory with N fundamental Higgs fields, focusing our
attention on the action of the exact global (color-flavor diagonal) SU(N)
symmetry on it. The moduli space of a single non-Abelian vortex, CP(N-1), is
spanned by a vector in the fundamental representation of the global SU(N)
symmetry. The moduli space of winding-number k vortices is instead spanned by
vectors in the direct-product representation: they decompose into the sum of
irreducible representations each of which is associated with a Young tableau
made of k boxes, in a way somewhat similar to the standard group composition
rule of SU(N) multiplets. The K\"ahler potential is exactly determined in each
moduli subspace, corresponding to an irreducible SU(N) orbit of the
highest-weight configuration.Comment: LaTeX 46 pages, 4 figure
Out-of-equilibrium physics in driven dissipative coupled resonator arrays
Coupled resonator arrays have been shown to exhibit interesting many- body
physics including Mott and Fractional Hall states of photons. One of the main
differences between these photonic quantum simulators and their cold atoms
coun- terparts is in the dissipative nature of their photonic excitations. The
natural equi- librium state is where there are no photons left in the cavity.
Pumping the system with external drives is therefore necessary to compensate
for the losses and realise non-trivial states. The external driving here can
easily be tuned to be incoherent, coherent or fully quantum, opening the road
for exploration of many body regimes beyond the reach of other approaches. In
this chapter, we review some of the physics arising in driven dissipative
coupled resonator arrays including photon fermionisa- tion, crystallisation, as
well as photonic quantum Hall physics out of equilibrium. We start by briefly
describing possible experimental candidates to realise coupled resonator arrays
along with the two theoretical models that capture their physics, the
Jaynes-Cummings-Hubbard and Bose-Hubbard Hamiltonians. A brief review of the
analytical and sophisticated numerical methods required to tackle these systems
is included.Comment: Chapter that appeared in "Quantum Simulations with Photons and
Polaritons: Merging Quantum Optics with Condensed Matter Physics" edited by
D.G.Angelakis, Quantum Science and Technology Series, Springer 201
CBX7 and miR-9 are part of an autoregulatory loop controlling p16(INK) (4a).
Polycomb repressive complexes (PRC1 and PRC2) are epigenetic regulators that act in coordination to influence multiple cellular processes including pluripotency, differentiation, cancer and senescence. The role of PRCs in senescence can be mostly explained by their ability to repress the INK4/ARF locus. CBX7 is one of five mammalian orthologues of Drosophila Polycomb that forms part of PRC1. Despite the relevance of CBX7 for regulating senescence and pluripotency, we have a limited understanding of how the expression of CBX7 is regulated. Here we report that the miR-9 family of microRNAs (miRNAS) downregulates the expression of CBX7. In turn, CBX7 represses miR-9-1 and miR-9-2 as part of a regulatory negative feedback loop. The miR-9/CBX7 feedback loop is a regulatory module contributing to induction of the cyclin-dependent kinase inhibitor (CDKI) p16(INK4a) during senescence. The ability of the miR-9 family to regulate senescence could have implications for understanding the role of miR-9 in cancer and aging
The Endogenous Th17 Response in NO<inf>2</inf>-Promoted Allergic Airway Disease Is Dispensable for Airway Hyperresponsiveness and Distinct from Th17 Adoptive Transfer
Severe, glucocorticoid-resistant asthma comprises 5-7% of patients with asthma. IL-17 is a biomarker of severe asthma, and the adoptive transfer of Th17 cells in mice is sufficient to induce glucocorticoid-resistant allergic airway disease. Nitrogen dioxide (NO2) is an environmental toxin that correlates with asthma severity, exacerbation, and risk of adverse outcomes. Mice that are allergically sensitized to the antigen ovalbumin by exposure to NO2 exhibit a mixed Th2/Th17 adaptive immune response and eosinophil and neutrophil recruitment to the airway following antigen challenge, a phenotype reminiscent of severe clinical asthma. Because IL-1 receptor (IL-1R) signaling is critical in the generation of the Th17 response in vivo, we hypothesized that the IL-1R/Th17 axis contributes to pulmonary inflammation and airway hyperresponsiveness (AHR) in NO2-promoted allergic airway disease and manifests in glucocorticoid-resistant cytokine production. IL-17A neutralization at the time of antigen challenge or genetic deficiency in IL-1R resulted in decreased neutrophil recruitment to the airway following antigen challenge but did not protect against the development of AHR. Instead, IL-1R-/- mice developed exacerbated AHR compared to WT mice. Lung cells from NO2-allergically inflamed mice that were treated in vitro with dexamethasone (Dex) during antigen restimulation exhibited reduced Th17 cytokine production, whereas Th17 cytokine production by lung cells from recipient mice of in vitro Th17-polarized OTII T-cells was resistant to Dex. These results demonstrate that the IL-1R/Th17 axis does not contribute to AHR development in NO2-promoted allergic airway disease, that Th17 adoptive transfer does not necessarily reflect an endogenously-generated Th17 response, and that functions of Th17 responses are contingent on the experimental conditions in which they are generated. © 2013 Martin et al
Rethinking feasibility analysis for urban development: a multidimensional decision support tool
Large-scale urban development projects featured over the past thirty years have shown some critical issues related to the implementation phase. Con-sequently, the current practice seems oriented toward minimal and wide-spread interventions meant as urban catalyst. This planning practice might solve the problem of limited reliability of large developmentsâ feasibility studies, but it rises an evaluation demand related to the selection of coali-tion of projects within a multidimensional and multi-stakeholders deci-sion-making context. This study aims to propose a framework for the generation of coalitions of elementary actions in the context of urban regeneration processes and for their evaluation using a Multi Criteria Decision Analysis approach. The proposed evaluation framework supports decision makers in exploring dif-ferent combinations of actions in the context of urban interventions taking into account synergies, i.e. positive or negative effects on the overall per-formance of an alternative linked to the joint realization of specific pairs of actions. The proposed evaluation framework has been tested on a pilot case study dealing with urban regeneration processes in the city of Milan (Italy)
The ethics of digital well-being: a multidisciplinary perspective
This chapter serves as an introduction to the edited collection of the same name, which includes chapters that explore digital well-being from a range of disciplinary perspectives, including philosophy, psychology, economics, health care, and education. The purpose of this introductory chapter is to provide a short primer on the different disciplinary approaches to the study of well-being. To supplement this primer, we also invited key experts from several disciplinesâphilosophy, psychology, public policy, and health careâto share their thoughts on what they believe are the most important open questions and ethical issues for the multi-disciplinary study of digital well-being. We also introduce and discuss several themes that we believe will be fundamental to the ongoing study of digital well-being: digital gratitude, automated interventions, and sustainable co-well-being
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