In2CoP 2020 - International Conference on Co-Creation Processes in Higher Education 2020: book of abstracts

A Cocriação e a Inovação no Ensino Superior representam um dos principais compromissos do Instituto Politécnico de Bragança (IPB), cuja atividade formativa e de investigação se orienta, de forma sinérgica, para a cooperação com as empresas e instituições da região. O IPB pretende contribuir, de forma ativa, para uma economia regional baseada no conhecimento e com uma forte articulação internacional. Nesta esteira, teve lugar, na cidade de Bragança, nos dias 29 a 30 de janeiro de 2020, a Conferência Internacional em Processos de Cocriação no Ensino Superior (In2CoP). Privilegiamos um espaço de reflexão de processos e de partilha de resultados de ecossistemas de cocriação, visando o desenvolvimento de uma comunidade de aprendizagem integradora, interdisciplinar e multicultural. Ao longo dos três dias da conferência, mais de 150 conferencistas, nacionais e estrangeiros, participaram, ativamente, nas diversas atividades propostas: uma sessão plenária com seis intervenções, quatro workshops e uma sessão pitch com a apresentação de trinta e seis projetos de inovação e cocriação. Com um espírito inovador, as atividades decorreram no campus do IPB e em espaços emblemáticos da cidade de Bragança, designadamente: Centro de Arte Contemporânea Graças Morais, Centro de Fotografia Georges Dussaud e Centro de Ciência Viva. Foi ainda realizada uma visita social ao Museu do Côa em Vila Nova de Foz Côa.Co-creation and Innovation in Higher Education represents one of the main commitments of the Polytechnic Institute of Bragança (IPB), whose training and research activity is synergistically oriented towards cooperation with companies and institutions in the region. The IPB intends to contribute actively to a regional economy based on knowledge and with a strong international articulation. In this context, the International Conference on Co-Creation Processes in Higher Education (In2CoP) took place in the city of Bragança, on January 29-30, 2020. We privilege a space for reflection of processes and sharing of results from co-creation ecosystems, aiming at the development of an integrative, interdisciplinary, and multicultural learning community. Over the three days of the conference, more than 150 national and foreign conferencists actively participated in the various activities proposed: a plenary session with six interventions, four workshops, and a pitch session with the presentation of thirty-six innovation and co-creation projects. With an innovative spirit, the activities took place in IPB's campus and in emblematic spaces in the city of Bragança, namely: Centro de Arte Contemporânea Graças Morais, Centro de Fotografia Georges Dussaud and Centro de Ciência Viva. A social visit was also made to the Côa Museum in Vila Nova de Foz Côa.info:eu-repo/semantics/publishedVersio

Global prevalence and genotype distribution of hepatitis C virus infection in 2015 : A modelling study

Publisher Copyright: © 2017 Elsevier LtdBackground The 69th World Health Assembly approved the Global Health Sector Strategy to eliminate hepatitis C virus (HCV) infection by 2030, which can become a reality with the recent launch of direct acting antiviral therapies. Reliable disease burden estimates are required for national strategies. This analysis estimates the global prevalence of viraemic HCV at the end of 2015, an update of—and expansion on—the 2014 analysis, which reported 80 million (95% CI 64–103) viraemic infections in 2013. Methods We developed country-level disease burden models following a systematic review of HCV prevalence (number of studies, n=6754) and genotype (n=11 342) studies published after 2013. A Delphi process was used to gain country expert consensus and validate inputs. Published estimates alone were used for countries where expert panel meetings could not be scheduled. Global prevalence was estimated using regional averages for countries without data. Findings Models were built for 100 countries, 59 of which were approved by country experts, with the remaining 41 estimated using published data alone. The remaining countries had insufficient data to create a model. The global prevalence of viraemic HCV is estimated to be 1·0% (95% uncertainty interval 0·8–1·1) in 2015, corresponding to 71·1 million (62·5–79·4) viraemic infections. Genotypes 1 and 3 were the most common cause of infections (44% and 25%, respectively). Interpretation The global estimate of viraemic infections is lower than previous estimates, largely due to more recent (lower) prevalence estimates in Africa. Additionally, increased mortality due to liver-related causes and an ageing population may have contributed to a reduction in infections. Funding John C Martin Foundation.publishersversionPeer reviewe

Iron Behaving Badly: Inappropriate Iron Chelation as a Major Contributor to the Aetiology of Vascular and Other Progressive Inflammatory and Degenerative Diseases

The production of peroxide and superoxide is an inevitable consequence of aerobic metabolism, and while these particular "reactive oxygen species" (ROSs) can exhibit a number of biological effects, they are not of themselves excessively reactive and thus they are not especially damaging at physiological concentrations. However, their reactions with poorly liganded iron species can lead to the catalytic production of the very reactive and dangerous hydroxyl radical, which is exceptionally damaging, and a major cause of chronic inflammation. We review the considerable and wide-ranging evidence for the involvement of this combination of (su)peroxide and poorly liganded iron in a large number of physiological and indeed pathological processes and inflammatory disorders, especially those involving the progressive degradation of cellular and organismal performance. These diseases share a great many similarities and thus might be considered to have a common cause (i.e. iron-catalysed free radical and especially hydroxyl radical generation). The studies reviewed include those focused on a series of cardiovascular, metabolic and neurological diseases, where iron can be found at the sites of plaques and lesions, as well as studies showing the significance of iron to aging and longevity. The effective chelation of iron by natural or synthetic ligands is thus of major physiological (and potentially therapeutic) importance. As systems properties, we need to recognise that physiological observables have multiple molecular causes, and studying them in isolation leads to inconsistent patterns of apparent causality when it is the simultaneous combination of multiple factors that is responsible. This explains, for instance, the decidedly mixed effects of antioxidants that have been observed, etc...Comment: 159 pages, including 9 Figs and 2184 reference

The James Webb Space Telescope Mission

Twenty-six years ago a small committee report, building on earlier studies, expounded a compelling and poetic vision for the future of astronomy, calling for an infrared-optimized space telescope with an aperture of at least $4m$. With the support of their governments in the US, Europe, and Canada, 20,000 people realized that vision as the $6.5m$ James Webb Space Telescope. A generation of astronomers will celebrate their accomplishments for the life of the mission, potentially as long as 20 years, and beyond. This report and the scientific discoveries that follow are extended thank-you notes to the 20,000 team members. The telescope is working perfectly, with much better image quality than expected. In this and accompanying papers, we give a brief history, describe the observatory, outline its objectives and current observing program, and discuss the inventions and people who made it possible. We cite detailed reports on the design and the measured performance on orbit.Comment: Accepted by PASP for the special issue on The James Webb Space Telescope Overview, 29 pages, 4 figure