Low-level laser (light) therapy (LLLT) on muscle tissue: performance, fatigue and repair benefited by the power of light

The use of low level laser (light) therapy (LLLT) has recently expanded to cover areas of medicine that were not previously thought of as the usual applications such as wound healing and inflammatory orthopedic conditions. One of these novel application areas is LLLT for muscle fatigue and muscle injury. Since it is becoming agreed that mitochondria are the principal photoacceptors present inside cells, and it is known that muscle cells are exceptionally rich in mitochondria, this suggests that LLLT should be highly beneficial in muscle injuries. The ability of LLLT to stimulate stem cells and progenitor cells means that muscle satellite cells may respond well to LLLT and help muscle repair. Furthermore the ability of LLLT to reduce inflammation and lessen oxidative stress is also beneficial in cases of muscle fatigue and injury. This review covers the literature relating to LLLT and muscles in both preclinical animal experiments and human clinical studies. Athletes, people with injured muscles, and patients with Duchenne muscular dystrophy may all benefit

Intravitreal injection of Ozurdex(®) implant in patients with persistent diabetic macular edema, with six-month follow-up

AIM: To evaluate the efficacy of intravitreal dexamethasone injections in diabetic macular edema (DME). METHODS: A 700 μg slow-release intravitreal dexamethasone implant (Ozurdex®) was placed in the vitreal cavity of 17 patients (19 eyes) affected with persistent DME. Best corrected visual acuity (BCVA) was assessed through Early Treatment Diabetic Retinopathy Study (ETDRS). Central macular thickness (CMT) was measured by spectral-domain optical coherence tomography. BCVA and CMT examinations were carried out at baseline (T0) and repeated after three days, one month (T1), three months (T3), four months (T4), and six months (T6) post injection. RESULTS: Dexamethasone implant induced an improvement in ETDRS at T1, T3, T4, and T6 post injection. CMT was reduced at T1, T3, and T4, while at T6, CMT values were not statistically different from baseline. No complications were observed during the follow-up. CONCLUSION: Our data suggest that dexamethasone implant is effective in reducing DME symptoms within a six-month frame

A Portable Device for the Measurement of Venous Pulse Wave Velocity

Pulse wave velocity in veins (vPWV) has recently been reconsidered as a potential index of vascular filling, which may be valuable in the clinic for fluid therapy. The measurement requires that an exogenous pressure pulse is generated in the venous blood stream by external pneumatic compression. To obtain optimal measure repeatability, the compression is delivered synchronously with the heart and respiratory activity. We present a portable prototype for the assessment of vPWV based on the PC board Raspberry Pi and equipped with an A/D board. It acquires respiratory and ECG signals, and the Doppler shift from the ultrasound monitoring of blood velocity from the relevant vein, drives the pneumatic cuff inflation, and returns multiple measurements of vPWV. The device was tested on four healthy volunteers (2 males, 2 females, age 33 & PLUSMN;13 years), subjected to the passive leg raising (PLR) manoeuvre simulating a transient increase in blood volume. Measurement of vPWV in the basilic vein exhibited a low coefficient of variation (3.6 & PLUSMN;1.1%), a significant increase during PLR in all subjects, which is consistent with previous findings. This device allows for carrying out investigations in hospital wards on different patient populations as necessary to assess the actual clinical potential of vPWV

Surgical site infections in treatment of musculoskeletal tumors: experience from a single oncologic orthopedic institution

Objective: Limb-sparing surgery is the mainstay treatment for musculoskeletal tumors thanks to advances in surgical techniques, imaging modalities and multimodal therapies. As patients survive longer, plastic reconstructive procedures and revision surgery are increasingly required after tumor excision. Infection rate is reported to be up to 20% after prosthetic replacement and 30-44% after pelvic resection. The purpose of this study was to investigate the incidence of surgical site infections (SSIs), identifying the causative microrganisms related to specific surgical procedures and significant risk factors for SSIs. Methods: We retrospectively reviewed 723 interventions performed between 2009 and 2015 for oncological conditions. Non neoplastic lesions, aseptic wound complications, non-skeletally mature patients were excluded. Standardised antibiotic prophylaxis was used for different surgical procedures and maintained until removal of surgical drains. Results: Without considering tumor types and surgical sites, the overall infection rate was 8.7% (63/724). Infection occurred in prosthetic reconstruction with an incidence rate of 7.8%, whereas almost half of patients having undergone pelvic surgery got infected and about 20% of patients with spinal surgery and amputations were infected. Pelvic location, malignancy and radiotherapy were related to a major risk of SSI. The causative pathogens were detected in all examined cases. The most frequent pathogens detected by culture included Staphylococcus aureus (27 cases, 47.4%) and S. epidermidis (10 cases, 17.5%). Among the S. aureus cases, 10/27 cases (37%) were methicillin-resistant S. aureus (MRSA). Sixty-three out of 130 microbial isolations (47.7%) were nosocomial ALERT organisms. Conclusion: Oncologic orthopedic surgery is burdened by frequent and challenging SSIs because of extensive soft tissues dissection, long operative times and poor skin conditions. Patients are immunosuppressed and often have concomitant comorbidities predisposing to SSIs. Monitoring of local bacterial aetiology of SSIs could help orthopedic oncologic specialized centres in achieving the optimisation of antibiotic prophylactic regimens

Use of CR100 scale for session-RPE in soccer and interchangeability with CR10

©2016 Human Kinetics,Inc. Purpose: To examine the construct validity of the session rating perceived exertion (s-RPE) assessed with the Borg CR100® scale to measure training loads in elite soccer and to examine if the CR100® is interchangeable and can provide more accurate ratings compared to the CR10® scale. Methods: Two studies were conducted. The validity of the CR100® was determined in 19-elite soccer players (age 28 ± 6 y, height 180 ± 7 cm, body mass 77 ± 6 kg) during training sessions through correlations with Edwards heart rate method (study one). The interchangeability with CR10® was assessed in 78 soccer players (age 19.3 ± 4.1 y, height 178 ± 5.9 cm, body mass 71.4 ± 6.1 kg) through Bland?Altman method and correlations between change scores in different sessions. To examine whether the CR100® is more fine graded than the CR10®, the proportion of responses corresponding to the verbal expressions were calculated (study two). Results: Individual correlations between Edwards' and s-RPE were large to very large (0.52 to 0.85). The mean difference between the two scales was -0.3 ± 0.33 AU (90% CI -0.41 to -0.29 AU) with 95% limits of agreements 0.31 to -0.96 AU. Correlations between scales and between changes scores were nearly perfect (0.95 and 0.91 to 0.98). Ratings corresponding to the verbal anchors were 49% in CR10® and 26% in CR100®. Conclusions: The CR100® is valid for assessing the training load in elite soccer players. It can be used interchangeably with the CR10® and may provide more precise measures of exercise intensity

Control of the urban pigeon Columba livia population and the preservation of common swift Apus apus and bats Chiroptera during the restoration of the Ghirlandina tower in the city of Modena (Italy)

Ferri, M., Ferraresi, M., Gelati, A., Zannetti, G., Domenichini, A., Ravizza, L., Cadignani, R

Multilingual Word Sense Induction to Improve Web Search Result Clustering

In [12] a novel approach to Web search result clustering based on Word Sense Induction, i.e. the automatic discovery of word senses from raw text was presented; key to the proposed approach is the idea of, first, automatically in- ducing senses for the target query and, second, clustering the search results based on their semantic similarity to the word senses induced. In [1] we proposed an innovative Word Sense Induction method based on multilingual data; key to our approach was the idea that a multilingual context representation, where the context of the words is expanded by considering its translations in different languages, may im- prove the WSI results; the experiments showed a clear per- formance gain. In this paper we give some preliminary ideas to exploit our multilingual Word Sense Induction method to Web search result clustering

The ‘Great Lockdown’ and its Determinants

This is the author accepted manuscript. The final version is available from Elsevier via the DOI in this recordSince COVID-19 was declared a pandemic, countries on the same pandemic trajectory have adopted very different lockdown strategies. Using data for over 132 countries, and employing an event-study design, this paper identifies the role of political, economic and institutional factors in explaining the differential timing and intensity of stringency measures undertaken.Economic and Social Research Council (ESRC

Adattamento di opentrack v2.0 per piattaforma embedded

OpenPTrack è un progetto open source lanciato nel 2013 da UCLA REMAP e Open Perception, in collaborazione con l’Università degli Studi di Padova. Il progetto aveva come obiettivo la creazione di un sistema di tracking real-time per applicazioni di teatro e arte, ed è stato migliorato ed espanso negli anni fino alla più recente versione datata 2017. Il sistema si basa sull’utilizzo di ROS (Robot Operative System, piattaforma Linux) e di una serie di applicazioni realizzate in C++ per svolgere determinati compiti, come il tracking della persona (human detection), il tracking di un determinato oggetto (object detection) o il rilevamento dello skeleton della persona nella scena, così da riconoscerne la posa (pose detection). Il team di sviluppo originale ha con successo sviluppato una versione embedded della prima release del progetto su schede NVIDIA Jetson TX1 e TK1, mentre l’ultima versione non è ancora stata adattata per piattaforma embedded. L’obiettivo del lavoro qui presentato è quello di compiere questa trasposizione anche per l’ultima e più completa versione su scheda NVIDIA Jetson TX2, ed effettuare una caratterizzazione del sistema in configurazione multicamera embedded

Can biowarfare agents be defeated with light?

Biological warfare and bioterrorism is an unpleasant fact of 21st century life. Highly infectious and profoundly virulent diseases may be caused in combat personnel or in civilian populations by the appropriate dissemination of viruses, bacteria, spores, fungi, or toxins. Dissemination may be airborne, waterborne, or by contamination of food or surfaces. Countermeasures may be directed toward destroying or neutralizing the agents outside the body before infection has taken place, by destroying the agents once they have entered the body before the disease has fully developed, or by immunizing susceptible populations against the effects. A range of light-based technologies may have a role to play in biodefense countermeasures. Germicidal UV (UVC) is exceptionally active in destroying a wide range of viruses and microbial cells, and recent data suggests that UVC has high selectivity over host mammalian cells and tissues. Two UVA mediated approaches may also have roles to play; one where UVA is combined with titanium dioxide nanoparticles in a process called photocatalysis, and a second where UVA is combined with psoralens (PUVA) to produce “killed but metabolically active” microbial cells that may be particularly suitable for vaccines. Many microbial cells are surprisingly sensitive to blue light alone, and blue light can effectively destroy bacteria, fungi, and Bacillus spores and can treat wound infections. The combination of photosensitizing dyes such as porphyrins or phenothiaziniums and red light is called photodynamic therapy (PDT) or photoinactivation, and this approach cannot only kill bacteria, spores, and fungi, but also inactivate viruses and toxins. Many reports have highlighted the ability of PDT to treat infections and stimulate the host immune system. Finally pulsed (femtosecond) high power lasers have been used to inactivate pathogens with some degree of selectivity. We have pointed to some of the ways light-based technology may be used to defeat biological warfare in the future