200 research outputs found
UMA REFLEXÃO NECESSÁRIA PARA A UNIVERSIDADE DO SÉCULO XXI
Por meio de uma discussão teórica com um estudo bibliográfico, aborda-se os conceitos de Universidade, do agir educacional proposto por Paulo Freire, do agir comunicativo de Habermas entre outros conceitos pertinentes à reflexão de como está a Universidade na atualidade e como ela pode sair desta inércia e alcançar novos rumos e conquistas no século XXI. Alguns afirmam que a Universidade vai acabar, será substituída, mas é necessário pensar não do papel somente de ensino. A universidade tem que ser o núcleo transformador da sociedade, baseada em conhecimento e cooperação, sendo aberta e lidando com a complexidade inerente a sua natureza. Não se deve tentar simplificá-la, sua alma é complexa e é isso que a difere, que a torna importante e admirável. Assim, a Universidade no século XXI precisa mudar. É necessário uma busca da integração entre o agir educacional e o agir comunicativo. Preparar as pessoas para essa dinâmica, com práticas para desenvolver a autoridade do argumento. E enfim, contribuir para uma sociedade mais cooperativa e voltada ao entendimento
Polyamines, peroxidase and proteins involved in the senescence process
Senescence is the natural aging process at the cellular level or range of phenomena associated with this process. The objective of this review was to show the involvement of substances that may be related to senescence in plants, such as polyamines, peroxidase and proteins. These substances were related with the terminal stages of development of various plant organs (leaves, flowers, roots).Keywords: Flowers, putrescine, spermidine, spermine, reactive oxygen speciesAfrican Journal of Biotechnology, Vol. 12(14), pp. 1571-157
Monitoramento de eleições municipais no estado do Espírito Santo - amostragem clássica e bayesiana
Neste trabalho apresentamos a utilização de dois procedimentos para monitorização de uma pesquisa eleitoral: a abordagem clássica de amostragem comumente adotada e o modelo bayesiano para previsão de resultados eleitorais introduzido por Bernardo (1984), juntamente com a metodologia para seleção do número de locais descrita em Brasil & Pego e Silva (1994); nestes uma amostra de mesmo tamanho é selecionada nos locais de comportamento mais similar a toda região sendo pesquisada, no caso, o município. No período de um ano antecedendo as eleições municipais de 03/10/92, realizarmos cinco pesquisas no município de Guarapari-ES, incluindo a pesquisa de "boca-de-urna", das quais, quatro via metodologia clássica e três, via metodologia bayesiana. Em duas ocasiões, agosto e setembro de 92, as duas metodologias foram aplicadas simultaneamente sendo que algumas conclusões extraidas dessa comparação são aqui discutidas
Influence of low-level laser on bone remodeling during induced tooth movement in rats
Objective: To analyze the effect of low-level laser on bone remodeling during induced tooth movement in rats. Materials and Methods: A diode laser (808 nm, 100 mW, 54 J on an area of 0.0028 cm2) was used. The application was continuous, punctual, and with contact. Forty-two 70-day-old Wistar rats had the maxillary left first molar moved using a force level of 25 g. In two experimental subgroups the movement was performed over 7 days and in three subgroups the movement occurred over 14 days. In the 7-day movement subgroups, one subgroup received laser irradiation on day 1 only; the other subgroup received laser irradiation on days 1, 3, and 5. In the 14-day movement subgroups, one subgroup received laser irradiation on day 1 only; the second on days 1, 3, and 5; and the third on days 1, 3, 5, 7, 9, 11, and 13. The control group was also divided into two subgroups, and movement occurred over two different periods of treatment (7 days and 14 days) without laser application; these were used as controls for the respective experimental subgroups. Inter-subgroup comparison was performed with Kruskal-Wallis, followed by Mann-Whitney and analysis of variance, followed by Tukey tests within the 7- and 14-day subgroups. Results: The subgroup with three laser applications showed significantly greater osteoclastic activity and bone resorption than the other subgroups in the 7-day movement subgroups. Conclusions: Low-level laser application significantly increased the osteoclastic but not the osteoblastic activity during the initial phases of tooth movement. In addition, the osteoclastic activity was dose-dependen
The Multiscenario Multienvironment BioSecure Multimodal Database (BMDB)
A new multimodal biometric database designed and acquired within the
framework of the European BioSecure Network of Excellence is presented. It is
comprised of more than 600 individuals acquired simultaneously in three
scenarios: 1) over the Internet, 2) in an office environment with desktop PC,
and 3) in indoor/outdoor environments with mobile portable hardware. The three
scenarios include a common part of audio/video data. Also, signature and
fingerprint data have been acquired both with desktop PC and mobile portable
hardware. Additionally, hand and iris data were acquired in the second scenario
using desktop PC. Acquisition has been conducted by 11 European institutions.
Additional features of the BioSecure Multimodal Database (BMDB) are: two
acquisition sessions, several sensors in certain modalities, balanced gender
and age distributions, multimodal realistic scenarios with simple and quick
tasks per modality, cross-European diversity, availability of demographic data,
and compatibility with other multimodal databases. The novel acquisition
conditions of the BMDB allow us to perform new challenging research and
evaluation of either monomodal or multimodal biometric systems, as in the
recent BioSecure Multimodal Evaluation campaign. A description of this campaign
including baseline results of individual modalities from the new database is
also given. The database is expected to be available for research purposes
through the BioSecure Association during 2008Comment: Published at IEEE Transactions on Pattern Analysis and Machine
Intelligence journa
Energy Estimation of Cosmic Rays with the Engineering Radio Array of the Pierre Auger Observatory
The Auger Engineering Radio Array (AERA) is part of the Pierre Auger
Observatory and is used to detect the radio emission of cosmic-ray air showers.
These observations are compared to the data of the surface detector stations of
the Observatory, which provide well-calibrated information on the cosmic-ray
energies and arrival directions. The response of the radio stations in the 30
to 80 MHz regime has been thoroughly calibrated to enable the reconstruction of
the incoming electric field. For the latter, the energy deposit per area is
determined from the radio pulses at each observer position and is interpolated
using a two-dimensional function that takes into account signal asymmetries due
to interference between the geomagnetic and charge-excess emission components.
The spatial integral over the signal distribution gives a direct measurement of
the energy transferred from the primary cosmic ray into radio emission in the
AERA frequency range. We measure 15.8 MeV of radiation energy for a 1 EeV air
shower arriving perpendicularly to the geomagnetic field. This radiation energy
-- corrected for geometrical effects -- is used as a cosmic-ray energy
estimator. Performing an absolute energy calibration against the
surface-detector information, we observe that this radio-energy estimator
scales quadratically with the cosmic-ray energy as expected for coherent
emission. We find an energy resolution of the radio reconstruction of 22% for
the data set and 17% for a high-quality subset containing only events with at
least five radio stations with signal.Comment: Replaced with published version. Added journal reference and DO
Measurement of the Radiation Energy in the Radio Signal of Extensive Air Showers as a Universal Estimator of Cosmic-Ray Energy
We measure the energy emitted by extensive air showers in the form of radio
emission in the frequency range from 30 to 80 MHz. Exploiting the accurate
energy scale of the Pierre Auger Observatory, we obtain a radiation energy of
15.8 \pm 0.7 (stat) \pm 6.7 (sys) MeV for cosmic rays with an energy of 1 EeV
arriving perpendicularly to a geomagnetic field of 0.24 G, scaling
quadratically with the cosmic-ray energy. A comparison with predictions from
state-of-the-art first-principle calculations shows agreement with our
measurement. The radiation energy provides direct access to the calorimetric
energy in the electromagnetic cascade of extensive air showers. Comparison with
our result thus allows the direct calibration of any cosmic-ray radio detector
against the well-established energy scale of the Pierre Auger Observatory.Comment: Replaced with published version. Added journal reference and DOI.
Supplemental material in the ancillary file
Measurement of the cosmic ray spectrum above eV using inclined events detected with the Pierre Auger Observatory
A measurement of the cosmic-ray spectrum for energies exceeding
eV is presented, which is based on the analysis of showers
with zenith angles greater than detected with the Pierre Auger
Observatory between 1 January 2004 and 31 December 2013. The measured spectrum
confirms a flux suppression at the highest energies. Above
eV, the "ankle", the flux can be described by a power law with
index followed by
a smooth suppression region. For the energy () at which the
spectral flux has fallen to one-half of its extrapolated value in the absence
of suppression, we find
eV.Comment: Replaced with published version. Added journal reference and DO
Predictores de riesgo en una cohorte española con cardiolaminopatías. Registro REDLAMINA
[Abstract]
Introduction and objectives.
According to sudden cardiac death guidelines, an implantable cardioverter-defibrillator (ICD) should be considered in patients with LMNA-related dilated cardiomyopathy (DCM) and ≥ 2 risk factors: male sex, left ventricular ejection fraction (LVEF) < 45%, nonsustained ventricular tachycardia (NSVT), and nonmissense genetic variants. In this study we aimed to describe the clinical characteristics of carriers of LMNA genetic variants among individuals from a Spanish cardiac-laminopathies cohort (REDLAMINA registry) and to assess previously reported risk criteria.
Methods.
The relationship between risk factors and cardiovascular events was evaluated in a cohort of 140 carriers (age ≥ 16 years) of pathogenic LMNA variants (54 probands, 86 relatives). We considered: a) major arrhythmic events (MAE) if there was appropriate ICD discharge or sudden cardiac death; b) heart failure death if there was heart transplant or death due to heart failure.
Results.
We identified 11 novel and 21 previously reported LMNA-related DCM variants. LVEF < 45% (P = .001) and NSVT (P < .001) were related to MAE, but not sex or type of genetic variant. The only factor independently related to heart failure death was LVEF < 45% (P < .001).
Conclusions.
In the REDLAMINA registry cohort, the only predictors independently associated with MAE were NSVT and LVEF < 45%. Therefore, female carriers of missense variants with either NSVT or LVEF < 45% should not be considered a low-risk group. It is important to individualize risk stratification in carriers of LMNA missense variants, because not all have the same prognosis.[Resumen]
Introducción y objetivos.
Según las guías de muerte súbita, se debe considerar un desfibrilador automático implantable (DAI) para los pacientes con miocardiopatía dilatada debida a variantes en el gen de la lamina (LMNA) con al menos 2 factores: varones, fracción de eyección del ventrículo izquierdo (FEVI) < 45%, taquicardia ventricular no sostenida (TVNS) y variantes no missense. Nuestro objetivo es describir las características clínicas de una cohorte española de pacientes con cardiolaminopatías (registro REDLAMINA) y evaluar los criterios de riesgo vigentes.
Métodos.
Se evaluó la relación entre factores de riesgo y eventos cardiovasculares en una cohorte de 140 portadores de variantes en LMNA (54 probandos, 86 familiares, edad ≥ 16 años). Se consideró: a) evento arrítmico mayor (EAM) si hubo descarga apropiada del DAI o muerte súbita, y b) muerte por insuficiencia cardiaca, incluidos los trasplantes.
Resultados.
Se identificaron 11 variantes nuevas y 21 previamente publicadas. La FEVI < 45% (p = 0,001) y la TVNS (p < 0,001) se relacionaron con los EAM, pero no el sexo o el tipo de variante (missense frente a no missense). La FEVI < 45% (p < 0,001) fue el único factor relacionado con la muerte por insuficiencia cardiaca.
Conclusiones.
En el registro REDLAMINA, los únicos 2 predictores asociados con EAM fueron la TVNS y la FEVI < 45%. No se debería considerar grupo de bajo riesgo a las portadoras de variantes missense con TVNS o FEVI < 45%. Es importante individualizar la estratificación del riesgo de los portadores de variantes missense en LMNA, porque no todas tienen el mismo pronóstico.This study received a grant from the Proyecto de investigación de la Sección de Insuficiencia Cardiaca 2017 from the Spanish Society of Cardiology and grants from the Instituto de Salud Carlos III (ISCIII) [PI14/0967, PI15/01551, AC16/0014] and ERA-CVD Joint Transnational Call 2016 (Genprovic). Grants from the ISCIII and the Ministerio de Economía y Competitividad de España (Spanish Department of Economy and Competitiveness) are supported by the Plan Estatal de I+D+i 2013-2016: Fondo Europeo de Desarrollo Regional (FEDER) “Una forma de hacer Europa”
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