325 research outputs found
Direct formulation of the supersonic acoustic intensity in space domain
International audienceThis paper proposes and examines a direct formulation in space domain of the so-called supersonic acoustic intensity. This quantity differs from the usual (active) intensity by excluding the circulating energy in the near-field of the source, providing a map of the acoustic energy that is radiated into the far field. To date, its calculation has been formulated in the wave number domain, filtering out the evanescent waves outside the radiation circle and reconstructing the acoustic field with only the propagating waves. In this study, the supersonic intensity is calculated directly in space domain by means of a two-dimensional convolution between the acoustic field and a spatial filter mask that corresponds to the space domain representation of the radiation circle. Therefore, the acoustic field that propagates effectively to the far field is calculated via direct filtering in space domain. This paper presents the theory, as well as a numerical example to illustrate some fundamental principles. An experimental study on planar radiators was conducted to verify the validity of the technique. The experimental results are presented, and serve to illustrate the usefulness of the analysis, its strengths and limitations
Magnetic properties of ZnO nanoparticles
We experimentally show that it is possible to induce room-temperature ferromagnetic-like behavior in ZnO nanoparticles without doping with magnetic impurities but simply inducing an alteration of their electronic configuration. Capping ZnO nanoparticles (similar to 10 nm size) with different organic molecules produces an alteration of their electronic configuration that depends on the particular molecule, as evidenced by photoluminescence and X-ray absorption spectroscopies and altering their magnetic properties that varies from diamagnetic to ferromagnetic-like behavior
Prevalence and risk factors of gestational diabetes mellitus: findings from a universal screening feasibility program in Lima, Peru.
BACKGROUND: Gestational diabetes mellitus (GDM) is a global public health concern with potential implications for the health of a mother and her offspring. However, data on the prevalence and risk factors of GDM in Latin America are scarce. The study was designed to estimate the prevalence of GDM and identify maternal risk factors among Peruvian women. METHODS: A cross-sectional study was conducted among 1300 pregnant women attending a prenatal clinic in Lima, Peru. GDM was diagnosed using an Oral Glucose Tolerance Test (OGTT) performed between 24 and 28 gestational weeks using the International Association of Diabetes and Pregnancy Study Groups (IADPSG) criteria. Depression status was assessed using the Patient Health Questionnaire-9. Multivariate logistic regression models were used to identify risk factors of GDM. RESULTS: Approximately 16% of pregnant women were diagnosed with GDM. The prevalence of obesity and depression were 24.4 and 10.6%, respectively. After adjusting for confounders, mid-pregnancy obesity was associated with a 1.64-fold increased odds of GDM (OR: 1.64; 95% CI: 1.03-2.61). Participants with a family history of diabetes had a 1.5-fold increased odds of developing GDM (OR: 1.51, 95% CI: 1.10-2.07) as compared to women without this family history. Depression was associated with a 1.54-fold increased odds of GDM (OR: 1.54; 95% CI:1.09-2.17). CONCLUSIONS: GDM is highly prevalent and was associated with maternal obesity, family history of diabetes and antepartum depression among Peruvian women. Intervention programs aimed at early diagnoses and management of GDM need to take maternal obesity, family history of diabetes and antepartum depression into account
Fully human agonist antibodies to TrkB using autocrine cell-based selection from a combinatorial antibody library
The diverse physiological roles of the neurotrophin family have long prompted exploration of their potential as therapeutic agents for nerve injury and neurodegenerative diseases. To date, clinical trials of one family member, brain-derived neurotrophic factor (BDNF), have disappointingly failed to meet desired endpoints. Contributing to these failures is the fact that BDNF is pharmaceutically a nonideal biologic drug candidate. It is a highly charged, yet is a net hydrophobic molecule with a low molecular weight that confers a short t1/2 in man. To circumvent these shortcomings of BDNF as a drug candidate, we have employed a function-based cellular screening assay to select activating antibodies of the BDNF receptor TrkB from a combinatorial human short-chain variable fragment antibody library. We report here the successful selection of several potent TrkB agonist antibodies and detailed biochemical and physiological characterization of one such antibody, ZEB85. By using a human TrkB reporter cell line and BDNF-responsive GABAergic neurons derived from human ES cells, we demonstrate that ZEB85 is a full agonist of TrkB, comparable in potency to BDNF toward human neurons in activation of TrkB phosphorylation, canonical signal transduction, and mRNA transcriptional regulation
Height and timing of growth spurt during puberty in young people living with vertically acquired HIV in Europe and Thailand.
OBJECTIVE: The aim of this study was to describe growth during puberty in young people with vertically acquired HIV. DESIGN: Pooled data from 12 paediatric HIV cohorts in Europe and Thailand. METHODS: One thousand and ninety-four children initiating a nonnucleoside reverse transcriptase inhibitor or boosted protease inhibitor based regimen aged 1-10 years were included. Super Imposition by Translation And Rotation (SITAR) models described growth from age 8 years using three parameters (average height, timing and shape of the growth spurt), dependent on age and height-for-age z-score (HAZ) (WHO references) at antiretroviral therapy (ART) initiation. Multivariate regression explored characteristics associated with these three parameters. RESULTS: At ART initiation, median age and HAZ was 6.4 [interquartile range (IQR): 2.8, 9.0] years and -1.2 (IQR: -2.3 to -0.2), respectively. Median follow-up was 9.1 (IQR: 6.9, 11.4) years. In girls, older age and lower HAZ at ART initiation were independently associated with a growth spurt which occurred 0.41 (95% confidence interval 0.20-0.62) years later in children starting ART age 6 to 10 years compared with 1 to 2 years and 1.50 (1.21-1.78) years later in those starting with HAZ less than -3 compared with HAZ at least -1. Later growth spurts in girls resulted in continued height growth into later adolescence. In boys starting ART with HAZ less than -1, growth spurts were later in children starting ART in the oldest age group, but for HAZ at least -1, there was no association with age. Girls and boys who initiated ART with HAZ at least -1 maintained a similar height to the WHO reference mean. CONCLUSION: Stunting at ART initiation was associated with later growth spurts in girls. Children with HAZ at least -1 at ART initiation grew in height at the level expected in HIV negative children of a comparable age
ODZ1 allows glioblastoma to sustain invasiveness through a Myc-dependent transcriptional upregulation of RhoA
Long-term survival remains low for most patients with glioblastoma (GBM), which reveals the need for markers of disease outcome and novel therapeutic targets. We describe that ODZ1 (also known as TENM1), a type II transmembrane protein involved in fetal brain development, plays a crucial role in the invasion of GBM cells. Differentiation of glioblastoma stem-like cells drives the nuclear translocation of an intracellular fragment of ODZ1 through proteolytic cleavage by signal peptide peptidase-like 2a. The intracellular fragment of ODZ1 promotes cytoskeletal remodelling of GBM cells and invasion of the surrounding environment both in vitro and in vivo. Absence of ODZ1 by gene deletion or downregulation of ODZ1 by small interfering RNAs drastically reduces the invasive capacity of GBM cells. This activity is mediated by an ODZ1-triggered transcriptional pathway, through the E-box binding Myc protein, that promotes the expression and activation of Ras homolog family member A (RhoA) and subsequent activation of Rho-associated, coiled-coil containing protein kinase (ROCK). Overexpression of ODZ1 in GBM cells reduced survival of xenografted mice. Consistently, analysis of 122 GBM tumour samples revealed that the number of ODZ1-positive cells inversely correlated with overall and progression-free survival. Our findings establish a novel marker of invading GBM cells and consequently a potential marker of disease progression and a therapeutic target in GBM
Intensity contrast of solar network and faculae close to the solar limb, observed from two vantage points
The brightness of faculae and network depends on the angle at which they are
observed and the magnetic flux density. Close to the limb, assessment of this
relationship has until now been hindered by the increasingly lower signal in
magnetograms. This preliminary study aims at highlighting the potential of
using simultaneous observations from different vantage points to better
determine the properties of faculae close to the limb. We use data from the
Solar Orbiter/Polarimetric and Helioseismic Imager (SO/PHI), and the Solar
Dynamics Observatory/Helioseismic and Magnetic Imager (SDO/HMI), recorded at
angular separation of their lines of sight at the Sun. We use
continuum intensity observed close to the limb by SO/PHI and complement it with
the co-observed from SDO/HMI, originating closer to disc centre
(as seen by SDO/HMI), thus avoiding the degradation of the magnetic field
signal near the limb. We derived the dependence of facular brightness in the
continuum on disc position and magnetic flux density from the combined
observations of SO/PHI and SDO/HMI. Compared with a single point of view, we
were able to obtain contrast values reaching closer to the limb and to lower
field strengths. We find the general dependence of the limb distance at which
the contrast is maximum on the flux density to be at large in line with single
viewpoint observations, in that the higher the flux density is, the closer the
turning point lies to the limb. There is a tendency, however, for the maximum
to be reached closer to the limb when determined from two vantage points. We
note that due to the preliminary nature of this study, these results must be
taken with caution. Our analysis shows that studies involving two viewpoints
can significantly improve the detection of faculae near the solar limb and the
determination of their brightness contrast relative to the quiet Sun
The ratio of horizontal to vertical displacement in solar oscillations estimated from combined SO/PHI and SDO/HMI observations
In order to make accurate inferences about the solar interior using
helioseismology, it is essential to understand all the relevant physical
effects on the observations. One effect to understand is the (complex-valued)
ratio of the horizontal to vertical displacement of the p- and f-modes at the
height at which they are observed. Unfortunately, it is impossible to measure
this ratio directly from a single vantage point, and it has been difficult to
disentangle observationally from other effects. In this paper we attempt to
measure the ratio directly using 7.5 hours of simultaneous observations from
the Polarimetric and Helioseismic Imager on board Solar Orbiter and the
Helioseismic and Magnetic Imager on board the Solar Dynamics Observatory. While
image geometry problems make it difficult to determine the exact ratio, it
appears to agree well with that expected from adiabatic oscillations in a
standard solar model. On the other hand it does not agree with a commonly used
approximation, indicating that this approximation should not be used in
helioseismic analyses. In addition, the ratio appears to be real-valued.Comment: Accepted for publication in Astronomy & Astrophysics. 8 pages, 8
figure
- …