Los Programas De Educacion Para La Maternidad Como Medio De Empoderamiento Social. Un Ejemplo

La salud de las personas se inicia en la gestaci n Los programas de educaci n prenatal y postnatal son una poderosa herramienta para que las mujeres tomen el control de su salud y se empoderen Los programas han demostrado su eficacia para producir cambios en los h bitos los conocimientos las t cnicas de autocontrol la seguridad la autoeficacia y la vinculaci n con sus beb s Este trabajo aporta un ejemplo de c mo los programas prenatales y postnatales no s lo cambian a los individuos que asisten a ellos sino que favorecen la formaci n de grupos de iguales que establecen relaciones de colaboraci n lo cual facilita un cambio social que a su vez incide en la salud de los individuos de la comunidad generando una espiral de desarrollo individuo-grupo-comunidad Este ejemplo puede promover investigaciones sobre los cambios sociales que facilitan los programas de educaci n para la salud impartidos desde la concepci n de empoderar a la poblac

Emerging concepts in drug discovery for cancer therapy.

These are exciting times to be involved in biomedical research. The transition from a scientific hypothesis to a testable therapy is now faster than ever, and new technologies that facilitate drug development are constantly emerging. The rapid development of COVID-19 vaccines provides a clear example of the current pace of drug discovery and its clinical implementation. Importantly, the wide availability of technologies that speed up drug development has also reached oncology, and investigators can now consider several independent strategies when looking to develop a new therapy. This thematic issue provides an overview of recent advances in cancer drug discovery, in areas such as fragment-based drug development, targeting the DNA damage response or the MYC oncogene, senolytic therapies and computational tools that facilitate drug discovery and the selection of treatments in personalized medicine. We are confident that reading these reviews will help those interested in the development of cancer therapies get a broader and updated view of available opportunities and challenges.Research in OF laboratory is funded by grants from the Spanish Ministry of Science, Innovation and Universities (PID2021-128722OB-I00, co-financed with European FEDER funds), the Spanish Association Against Cancer (AECC; PROYE20101FERN), Cancerfonden (180640) and the Swedish Research Council (538-2014-31).S

Value-at-risk portfolio optimization: a not on multiobgective genetic algoritnm

n this paper we develop a general framework for market risk optimization. The model is valid for any given risk measure. Our em- pirical procedure is focused on VaR. We solve the problem using a multiobjective genetic algorithm (GA). The algorithm is very efficient and it can handle hundreds of assets in reasonable computer time. One of the advantages of this approach is that it is easily extendable. = Рассматривается дальнейшее развитие общего подхода оптимизации риска в условиях рынка. Предлагается модель, ориентированная на различные меры риска, и эмпирическая методика расчета на основе многоцелевого генетического алгоритма

Design and Analysis of Conformal Antenna for Future Public Safety Communications: Enabling Future Public Safety Communication Infrastructure

Future 4G wireless communication systems include, in their capabilities portfolio, emergency-specific needs, such as data support, broadband communication, and extremely high reliability. An emergency situation can be addressed with undoubtedly more chances of success if augmented information is enabled within the public safety communication novel capabilities. In this article, for a fully augmented information provision based on broadband transmission, a user-end (UE) communication-capabilities enhancement is addressed by deploying multiple antennas without compromising the portability and light weight of first-responder equipment. With this aim, we propose the design of a 4.9-GHz conformal antenna array at the rescuer side (integrated in a helmet) and evaluate its performance in terms of relative data rate gain. The conformal array design is based on traditional patch antennas that consider the need for deployment over an ellipsoidal surface. The antenna array is simulated and then built, and several parameter characterizations (bandwidth, radiation pattern, reflection coefficient, and MC) and measurements are undertaken to ensure the suitability of the design. Furthermore, an analysis of the specific absorption rate (SAR) is performed to guarantee that the exposure to electromagnetic fields is below the standardized levels.The authors would like to thank Prof. Eva Rajo-Iglesias from Universidad Carlos III de Madrid. This work has been partly funded by the Spanish Government through projects CIES (RTC-2015-4213-7), MIMOTEX (TEC2014-61776-EXP) and TERESAADA (TEC2017-90093-C3-2-R) (MINECO/AEI/FEDER, UE

Recent GRBs observed with the 1.23m CAHA telescope and the status of its upgrade

We report on optical observations of Gamma-Ray Bursts (GRBs) followed up by our collaboration with the 1.23m telescope located at the Calar Alto observatory. The 1.23m telescope is an old facility, currently undergoing upgrades to enable fully autonomous response to GRB alerts. We discuss the current status of the control system upgrade of the 1.23m telescope. The upgrade is being done by the ARAE our group, based on members of IAA (Instituto de Astrofiisica de Andalucia). Currently the ARAE group is responsible to develop the BOOTES network of robotic telescopes based on the Remote Telescope System, 2nd Version (RTS2), which controls the available instruments and interacts with the EPICS database of Calar Alto. Currently the telescope can run fully autonomously or under observer supervision using RTS2. The fast reaction response mode for GRB reaction (typically with response times below 3 minutes from the GRB onset) still needs some development and testing. The telescope is usually operated in legacy interactive mode, with periods of supervised autonomous runs under RTS2. We show the preliminary results of several GRBs followed up with observer intervention during the testing phase of the 1.23m control software upgrade.Comment: 15 pages, 7 figures. Accepted for publication in the Special issue "Robotic Astronomy" of Advances in Astronomy. It includes two iterations with the referee

ATM regulates ATR chromatin loading in response to DNA double-strand breaks

DNA double-strand breaks (DSBs) are among the most deleterious lesions that can challenge genomic integrity. Concomitant to the repair of the breaks, a rapid signaling cascade must be coordinated at the lesion site that leads to the activation of cell cycle checkpoints and/or apoptosis. In this context, ataxia telangiectasia mutated (ATM) and ATM and Rad-3–related (ATR) protein kinases are the earliest signaling molecules that are known to initiate the transduction cascade at damage sites. The current model places ATM and ATR in separate molecular routes that orchestrate distinct pathways of the checkpoint responses. Whereas ATM signals DSBs arising from ionizing radiation (IR) through a Chk2-dependent pathway, ATR is activated in a variety of replication-linked DSBs and leads to activation of the checkpoints in a Chk1 kinase–dependent manner. However, activation of the G2/M checkpoint in response to IR escapes this accepted paradigm because it is dependent on both ATM and ATR but independent of Chk2. Our data provides an explanation for this observation and places ATM activity upstream of ATR recruitment to IR-damaged chromatin. These data provide experimental evidence of an active cross talk between ATM and ATR signaling pathways in response to DNA damage

A Genome-wide CRISPR Screen Identifies CDC25A as a Determinant of Sensitivity to ATR Inhibitors

One recurring theme in drug development is to exploit synthetic lethal properties as means to preferentially damage the DNA of cancer cells. We and others have previously developed inhibitors of the ATR kinase, shown to be particularly genotoxic for cells expressing certain oncogenes. In contrast, the mechanisms of resistance to ATR inhibitors remain unexplored. We report here on a genome-wide CRISPR-Cas9 screen that identified CDC25A as a major determinant of sensitivity to ATR inhibition. CDC25A-deficient cells resist high doses of ATR inhibitors, which we show is due to their failure to prematurely enter mitosis in response to the drugs. Forcing mitotic entry with WEE1 inhibitors restores the toxicity of ATR inhibitors in CDC25A-deficient cells. With ATR inhibitors now entering the clinic, our work provides a better understanding of the mechanisms by which these compounds kill cells and reveals genetic interactions that could be used for their rational use.We thank the laboratories of Feng Zhang and Kosuke Yusa for sharing all CRISPR-related plasmids used here through Addgene (plasmids 42230, 50946, and 50947) and Edna Fonseca for her comments on the manuscript. Research was funded by Fundacion Botin, Banco Santander, through its Santander Universities Global Division and by grants from the Spanish Ministry of Economy and Competitiveness (MINECO) (SAF2011-23753 and SAF2014-57791-REDC), Fundacio La Marato de TV3, the Howard Hughes Medical Institute, and the European Research Council (ERC-617840) to O.F.-C.; by a PhD fellowship from La Caixa Foundation to C.M.-R.; by grants from MINECO to S.R. (RYC2011-09242 and SAF2013-49147P, this last project co-financed with European FEDER funds); and by a grant from MINECO (SAF2013-44866-R) to S.O.S

Vegetation changes during the Holocene in the North Iberá, Corrientes, Argentina

Los humedales son sitios de gran importancia para los estudios palinológicos, ya que representan uno de los ambientes más idóneos para la preservación del polen fósil. El objetivo del trabajo es determinar, mediante del análisis palinológico de sedimentos lacustres, las comunidades vegetales y el ambiente predominante durante el Holoceno en el NO del Iberá, ya que los humedales representan uno de los ambientes más aptos para la preservación del polen fósil. Las lagunas estudiadas son: San Sebastián y San Juan Poriahú, cuyos sedimentos fueron obtenidos con un sacatestigo ?Levingstone square-rod sampler?, las muestras fueron procesadas con las técnicas de Faegri e Iversen y datadas con C14. Los diagramas palinológicos se dividieron en zonas utilizando el programa Tilia. El análisis palinológico permite distinguir diversos cambios vegetacionales: desde los 6 140±50 hasta 5 170±100 A.P.; el NO del Iberá se caracterizó por una vegetación palustre-herbácea y una vegetación arbórea característica de ambientes secos. Desde los 5 170±100 hasta 3 460±60 A.P., se produce la disminución en la frecuencia de especies características de ambientes húmedos y la colmatación del cuerpo de agua. Desde los 3 460±60 A.P. en adelante, si bien continúa el predominio de la vegetación herbácea característica de ambientes palustres, el polen arbóreo, indica el comienzo del desarrollo de un bosque higrófilo.Wetlands are very important sites for palynological studies, since they represent one of the most suitable environments for fossil pollen preservation. The aim of this work was to determine, by palynological analysis of lacustrine sediments, the vegetal communities and the predominant environment during the Holocene in NW of Iberá. Two lagoons were studied: San Sebastián and San Juan Poriahú. Sediment samples were obtained with witness using a “Levingstone square-rod sampler”, processed with Faegri e Iversen techniques and dated with C14. The palynological graphs were divided in zones using the Tilia program. The palynological analysis allowed visualizing diverse changes in the vegetation: from 6 140±50 to 5 170±100 a. C., the NW of Iberá was characterized by marsh-herbaceous vegetation and arboreal vegetation typical of dry vegetation. From 5 170±100 to 3 460±60 a. C., a decrease in the species frequency, typical of wet environments, is produced, and the clogging of the waterbody, from 3460±60 a. C. onwards, while continuing the dominance of herbaceous vegetation typical of these environments, the arboreal pollen, indicates the beginning of a hygrophilous forest development.Fil: Fernandez Pacella, Lionel Edgar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Centro de Ecología Aplicada del Litoral. Universidad Nacional del Nordeste. Centro de Ecología Aplicada del Litoral; ArgentinaFil: Garralla, Silvina Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Centro de Ecología Aplicada del Litoral. Universidad Nacional del Nordeste. Centro de Ecología Aplicada del Litoral; ArgentinaFil: Anzótegui, Luisa Matilde. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Centro de Ecología Aplicada del Litoral. Universidad Nacional del Nordeste. Centro de Ecología Aplicada del Litoral; Argentin

A Chemical Screen Identifies Compounds Capable of Selecting for Haploidy in Mammalian Cells

The recent availability of somatic haploid cell lines has provided a unique tool for genetic studies in mammals. However, the percentage of haploid cells rapidly decreases in these cell lines, which we recently showed is due to their overgrowth by diploid cells present in the cultures. Based on this property, we have now performed a phenotypic chemical screen in human haploid HAP1 cells aiming to identify compounds that facilitate the maintenance of haploid cells. Our top hit was 10-Deacetyl-baccatin-III (DAB), a chemical precursor in the synthesis of Taxol, which selects for haploid cells in HAP1 and mouse haploid embryonic stem cultures. Interestingly, DAB also enriches for diploid cells in mixed cultures of diploid and tetraploid cells, including in the colon cancer cell line DLD-1, revealing a general strategy for selecting cells with lower ploidy in mixed populations of mammalian cells.We would like to thank the members of the O.F.-C. laboratory and MonicaAlvarez-Fernandez for insightful comments and the Transgenic Mice, FlowCytometry, and Confocal Microscopy Units from the CNIO for their technicalhelp. T.O. was funded by a PhD fellowship from Boehringer IngelheimFonds. Research was funded by Fundacion Botı n, Banco Santander throughits Santander Universities Global Division, and by grants from MINECO(SAF2014-57791-REDC and SAF2014-59498-R to O.F.-C., SAF-2013-44866-R to S.O., and SAF2013-49147-P and SAF2016-80874-P to S.R.; pro-jects that were co-financed with ERDF-EU funds) and the EuropeanResearch Council (ERC-617840). Research at the G.d.C. laboratory is fundedby the AECC Scientific Foundation (LABAE16017DECA).S