Permutation entropy and irreversibility in gait kinematic time series from patients with mild cognitive decline and early alzheimer’s dementia

Gait is a basic cognitive purposeful action that has been shown to be altered in late stages of neurodegenerative dementias. Nevertheless, alterations are less clear in mild forms of dementia, and the potential use of gait analysis as a biomarker of initial cognitive decline has hitherto mostly been neglected. Herein, we report the results of a study of gait kinematic time series for two groups of patients (mild cognitive impairment and mild Alzheimer’s disease) and a group of matched control subjects. Two metrics based on permutation patterns are considered, respectively measuring the complexity and irreversibility of the time series. Results indicate that kinematic disorganisation is present in early phases of cognitive impairment; in addition, they depict a rich scenario, in which some joint movements display an increased complexity and irreversibility, while others a marked decrease. Beyond their potential use as biomarkers, complexity and irreversibility metrics can open a new door to the understanding of the role of the nervous system in gait, as well as its adaptation and compensatory mechanismsThis research was funded through the Premio del Ilustre Colegio Profesional de Fisioterapeutas de la Comunidad De Madrid, prize number ICPFM-IX-201

¿Quién se ha sentido así? Fomentando la vulnerabilidad y la esperanza transformadora en el conocimiento activista del Grado de Estudios Ingleses

Memoria ID2022-112. Ayudas de la Universidad de Salamanca para la innovación docente, curso 2022-2023

Hacia una práctica de aprendizaje-servicio a través de la literatura y el cine en el Grado de Estudios Ingleses: herramientas pedagógicas y educativas para desmantelar discursos colectivos de miedo

Memoria ID-096. Ayudas de la Universidad de Salamanca para la innovación docente, curso 2019-2020.[ES]El objetivo del proyecto es fomentar el aprendizaje-servicio en el Grado de Estudios Ingleses, en temáticas consideradas no canónicas (literaturas y cines postcoloniales de diversidad racial, de género y sexual) para estudiar y promover análisis e intervenciones sobre cómo constructos culturales y performativos vertebran discursos de miedo, y establecer dinámicas de intervención, ordenación y, en la mayoría de los casos, subalternida

Prácticas de Aprendizaje-servicio a través de la literatura y el cine en el Grado de Estudios Ingleses: Creación de un archivo virtual de pedagogías y acciones disidentes contra los discursos de miedo

Memoria ID-067 Ayudas de la Universidad de Salamanca para la innovación docente, curso 2020-2021

Morbilidad obstétrica en la Unidad de Cuidados Intensivos del Hospital General Docente “Aleida Fernández Chardiet”

Introduction: Pregnancy, berthing and puerperium are processes not free of risks and complications that can put in danger patient’s life which require their hospitalization in an intensive care unit. Objective: To characterize the obstetric morbidity in the Intensive Care Unit (ICU) at General Hospital "Aleida Fernández Chardiet". Material and Methods: A descriptive, retrospective and transversal study was performed in obstetric patients hospitalized at the ICU from 2012 to 2014. With a number of hospitalized patients equal to 117. Results: The highest number of hospitalized patients corresponded to puerperal. The mean age was 25.9 years old and a gestational age of 25.45 weeks as an average value. 38.6% presented obstetric hemorrhages followed by a 35.1% with hypertensive disorders of pregnancy; sepsis was in third place with a 26.3%. The most frequent non obstetric affections were acute bronchial asthma attack, with a 40% followed by bronchopneumonia with 30% of the patients. Caesarean represented 57.6% of surgeries and sepsis; 13.7% most of them in puerperal women.  APACHE II was higher in surgical patients. Conclusions: The most frequent obstetric affections leading to admission in the intensive care unit were obstetric hemorrhages and hypertensive disorders in puerperal women.Keywords: Morbidity, obstetric, intensive cares, maternal, preeclampsia, hemorrhages, sepsis, APACHE II.Introducción: La gestación, parto y puerperio son un proceso que no está exento de riesgos y complicaciones que pueden poner en grave peligro la vida de la paciente y requerir ingreso una Unidad de Cuidados Intensivos. Objetivo: Caracterizar la morbilidad obstétrica en la Unidad de Cuidados Intensivos del Hospital General Docente “Aleida Fernández Chardiet”. Material y Métodos: Se realizó un estudio descriptivo, retrospectivo y transversal en pacientes obstétricas ingresadas en la Unidad de Cuidados Intensivos de este hospital entre 2012 a 2014. Con un total de 117 pacientes ingresadas Resultados: El mayor número de ingresos correspondió a pacientes puérperas. La edad media fue de 25.9 años; una edad gestacional de 25.45 semanas como valor de media. El 38.6% presentó hemorragias obstétricas seguido de los trastornos hipertensivos del embarazo con 35.1%; la sepsis ocupo un tercer lugar con 26.3%. Las afecciones no obstétricas más frecuentes fueron la crisis aguda de asma bronquial con 40% seguido por la bronconeumonía con 30% de pacientes. La cesárea representó 57.6% de las cirugías y la sepsis 13.7% en su gran mayoría puérperas. El APACHE II fue más elevado en las pacientes quirúrgicas. Conclusiones: Las hemorragias obstétricas y los trastornos hipertensivos del embarazo fueron las principales causas de morbilidad materna en las puérperas por las que ingresaron las pacientes en la unidad de cuidados intensivo

Cerebral hemodynamics and vasoconstriction in preeclampsia: From diagnosis to resolution

Objectives: To evaluate maternal cerebral hemodynamics in patients with preeclampsia (PE) from diagnosis to clinical resolution using transcranial Doppler (TCD) and compare these findings with those of healthy pregnant women. Furthermore, we sought to describe the prevalence of vasoconstriction (VC) and related clinical parameters in PE. Study design: Case-control study including consecutive patients with PE at diagnosis and healthy pregnant women at week 36 of pregnancy. We prospectively collected clinical and neuroimaging data. TCD was repeated at inclusion and on days 1, 7, and 30 postpartum. Main outcome measures: Evolution of intracranial arteries hemodynamics (mean velocities (MV), resistance index). VC diagnosis and related features are described. Results: A total of 165 patients (80 with PE) underwent 467 TCD procedures. Patients with PE presented higher MAP. Intracranial arteries MV were significantly higher in patients with PE (at diagnosis and days 1 and 7 postpartum) but were normalized by day 30, without correlation with MAP evolution or treatment. VC was present in 32.5% of patients with PE (p < 0.001) and was mainly mild according to the Lindegaard index. Severe PE was associated with VC (50.0% vs. 22.6%; odds ratio 3.484; 95% confidence interval 1.425-8.520; p = 0.014). No other independent risk factors for reversible VC were identified. Conclusions: Patients with PE presented significantly higher MV in the anterior circulation compared to healthy controls, which worsened by day 7 and reverted by day 30 after delivery. VC was present in one-third of PE but was mainly mild and asymptomatic. Severe PE was associated with VC development.Sin financiación2.899 JCR (2020) Q2, 37/83 Obstetrics & Gynecology0.95 SJR (2021) Q1, 33/192 Obstetrics and GynecologyNo data IDR 2020UE

Treatment with statins and ischemic stroke severity Does the dose matter?

Objective: To examine the effects of pretreatment with statins at high doses (40 mg of rosuvastatin or 80 mg of any other statin) and low to moderate doses (<40 mg of rosuvastatin or <80 mg of any other statin) on ischemic stroke (IS) severity in clinical practice. Methods: Observational study of IS admissions to our stroke unit over a 3-year period (2008-2010). Mild stroke severity was defined as NIH Stroke Scale score ≤5 on admission. Multivariable regression models and matched propensity score analyses were used to quantify the association of statin pretreatment at high and low to moderate doses with mild stroke severity. Results: Of the 969 IS patients, 23% were taking low to moderate doses and 4.1% were taking high doses of statins prior to the stroke. Statins were associated with lower NIHSS scores on admission (median [interquartile range] 4 [9] for nonstatin patients, 4 [9] for low to moderate doses of statins, and 2 [4] for high doses of statins; p = 0.010). After multivariable adjustment, pretreatment with statins was associated with a higher probability of mild stroke severity in the unmatched analysis (odds ratio [OR] = 1.637, 95% confidence interval [CI] 1.156-2.319 for the low to moderate doses and OR = 3.297, 95% CI 1.480-7.345 for the high doses of statins) as well as in the propensity score matched analysis (OR = 2.023, 95% CI 1.248-3.281 for the low to moderate doses and OR = 3.502, 95% CI 1.477-8.300 for the high doses of statins). Conclusion: Pretreatment with statins is associated with lower stroke severity, at high as well as at low to moderate doses

Automatic learning for improvement in joint mobility in the elderly

In Europe, the elderly are the majority group, an issue that implies specific attention. On many occasions, they need to be taken care of by other people. It is essential to talk about the gait, this plays an important role and it is necessary to maintain a joint width of movement adequate in the hip, knee and ankle so that the standing and walking are functional. Among the physical factors that limit mobility in the elderly are the articular and capsular, which can produce an immobility of the person and the appearance of pain, causing a significant deterioration in the quality of life of the elderly, a question that will give rise in most cases to the appearance of depressive symptoms. It is an obvious fact that public coverage must offer health activities to promote the health of this group. The purpose of this work is to document in a bibliographic and visual way a table of physical exercises and psychological techniques for its future implantation within the Primary Health Care (PHC) and the Machine Learning tools to develop a virtual gerontology nurse to assist in deploying the exercises at home. After an adequate automatic learning and health education, with greater implication of the nursing specialist in geriatrics and gerontology (GS) and once exercised, allow the elderly to develop with a maximum of autonomy and independence at home, as well as reduce the doses of drugs, an issue that will benefit health expenditure. We are proposing a Virtual Agent based in Computer Vision, Artificial Intelligence and Natural Interfaces that can perform unattended sessions for joint mobility improvement