Pseudo-Probabilistic Design for High-Resolution Tsunami Simulations in the Southwestern Spanish Coast

The application of simulation software has proven to be a crucial tool for tsunami hazard assessment studies. Understanding the potentially devastating effects of tsunamis leads to the development of safety and resilience measures, such as the design of evacuation plans or the planning of the economic investment necessary to quickly mitigate their consequences. This article introduces a pseudo-probabilistic seismic-triggered tsunami simulation approach to investigate the potential impact of tsunamis in the southwestern coast of Spain, in the provinces of Huelva and Cádiz. Selected faults, probabilistic distributions and sampling methods are presented as well as some results for the nearly 900 Atlantic-origin tsunamis computed along the 250 km-long coast.This work has being carried out under a project funded by a public mutual agreement of understanding between the CN-IGME (CSIC) and the CCS (Law reference: BOE 103, 30/04/2019). This project is supported by an agreement of understanding between CN-IGME and UMA, creating a cooperative entity INGEA (Law reference: BOE 332, 22/12/2020). The numerical results presented in this work have been performed with the computational resources allocated by the Spanish Network for Supercomputing (RES) grants AECT-2020-3-0023 and AECT-2021-2-0018. Further support has also been received from the Spanish Government research project MEGAFLOW (RTI2018-096064-B-C21) and ChEESE project (EU Horizon 2020, grant agreement No. 823844, https://cheese-coe.eu/) due to the synergies found between the projects. Partial funding for open access charge: Universidad de Málag

USP7 and VCP define the SUMO/Ubiquitin landscape at the DNA replication fork

The AAA+ ATPase VCP regulates the extraction of SUMO and ubiquitin-modified DNA replication factors from chromatin. We have previously described that active DNA synthesis is associated with a SUMO-high/ubiquitin-low environment governed by the deubiquitylase USP7. Here, we unveil a functional cooperation between USP7 and VCP in DNA replication, which is conserved from Caenorhabditis elegans to mammals. The role of VCP in chromatin is defined by its cofactor FAF1, which facilitates the extraction of SUMOylated and ubiquitylated proteins that accumulate after the block of DNA replication in the absence of USP7. The inactivation of USP7 and FAF1 is synthetically lethal both in C. elegans and mammalian cells. In addition, USP7 and VCP inhibitors display synergistic toxicity supporting a functional link between deubiquitylation and extraction of chromatin-bound proteins. Our results suggest that USP7 and VCPFAF1 facilitate DNA replication by controlling the balance of SUMO/Ubiquitin-modified DNA replication factors on chromatinMINECO (BFU2014-55168-JIN; RTI2018-093485-B-I00) and a Ramo´ n y Cajal Fellowship from MINECO (RYC-2016-20705), co-funded by European Regional Development Funds (FEDER) to E.L.; by grants from the Spanish Ministry of Science, Innovation and Universities (RTI2018-102204-B-I00, co-financed with European FEDER funds) and the European Research Council (ERC-617840) to O.F.-C.; fellowships from Fundacion Ramón Areces-UAM and La Caixa Foundation to P.V. (LCF/BQ/ES18/11670008

マスメディアおよびソーシャルメディアの利用が震災復興に与える効果 -理論的枠組み-

Peer reviewe

Alternativas de comercialización de mora de Castilla en el Valle del Cauca

Ilustraciones (principalmente a color), diagramas, figuras, fotografíasComo resultado del proyecto de regalías Incremento de la competitividad sostenible en la agricultura de ladera en todo el departamento del Valle del Cauca, Occidente, en el cual participaron la Universidad Nacional, la Universidad del Valle y el Centro Internacional de Agricultura Tropical (ciat), en esta cartilla se presentan dos alternativas de conservación de mora de Castilla: mora congelada y mora en polvo. Se espera que la información aquí consignada sirva de guía a productores, comercializadores y procesadores para agregar valor al producto, tanto a la fruta congelada como a la procesada (mora en polvo), reduciendo, de esta manera, las altas pérdidas postcosecha de la mora. (Texto tomado de la fuente)1° ed

External quality assessment of Rift Valley fever diagnosis in 17 veterinary laboratories of the Mediterranean and Black Sea regions

Rift Valley fever (RVF) is an arboviral zoonosis that primarily affects ruminants but can also cause illness in humans. The increasing impact of RVF in Africa and Middle East and the risk of expansion to other areas such as Europe, where competent mosquitos are already established, require the implementation of efficient surveillance programs in animal populations. For that, it is pivotal to regularly assess the performance of existing diagnostic tests and to evaluate the capacity of veterinary labs of endemic and non-endemic countries to detect the infection in an accurate and timely manner. In this context, the animal virology network of the MediLabSecure project organized between October 2016 and March 2017 an external quality assessment (EQA) to evaluate the RVF diagnostic capacities of beneficiary veterinary labs. This EQA was conceived as the last step of a training curriculum that included 2 diagnostic workshops that were organized by INIA-CISA (Spain) in 2015 and 2016. Seventeen veterinary diagnostic labs from 17 countries in the Mediterranean and Black Sea regions participated in this EQA. The exercise consisted of two panels of samples for molecular and serological detection of the virus. The laboratories were also provided with positive controls and all the kits and reagents necessary to perform the recommended diagnostic techniques. All the labs were able to apply the different protocols and to provide the results on time. The performance was good in the molecular panel with 70.6% of participants reporting 100% correct results, and excellent in the serological panel with 100% correct results reported by 94.1% of the labs. This EQA provided a good overview of the RVFV diagnostic capacities of the involved labs and demonstrated that most of them were able to correctly identify the virus genome and antibodies in different animal samples

Cellular and humoral functional responses after BNT162b2 mRNA vaccination differ longitudinally between naive and subjects recovered from COVID-19

We have analyzed BNT162b2 vaccine-induced immune responses in naive subjects and individuals recovered from coronavirus disease 2019 (COVID-19), both soon after (14 days) and later after (almost 8 months) vaccination. Plasma spike (S)-specific immunoglobulins peak after one vaccine shot in individuals recovered from COVID-19, while a second dose is needed in naive subjects, although the latter group shows reduced levels all along the analyzed period. Despite how the neutralization capacity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mirrors this behavior early after vaccination, both groups show comparable neutralizing antibodies and S-specific B cell levels late post-vaccination. When studying cellular responses, naive individuals exhibit higher SARS-CoV-2-specific cytokine production, CD4+ T cell activation, and proliferation than do individuals recovered from COVID-19, with patent inverse correlations between humoral and cellular variables early post-vaccination. However, almost 8 months post-vaccination, SARS-CoV-2-specific responses are comparable between both groups. Our data indicate that a previous history of COVID-19 differentially determines the functional T and B cell-mediated responses to BNT162b2 vaccination over time.C.d.F., J.G.-P., and J.A. are supported by Instituto de Salud Carlos III (ISCII). We thank JM Ligos and Cytek Biosciences for their technical support. Research in E.L.-C.’s lab was supported by Fundación Familia Alonso, Santander Bank, Real Seguros, Fundación Mutua Madrileña, Fundación Uria, Fundación La Caixa, and Ayuntamiento de Madrid.S

Healthcare workers hospitalized due to COVID-19 have no higher risk of death than general population. Data from the Spanish SEMI-COVID-19 Registry

Aim To determine whether healthcare workers (HCW) hospitalized in Spain due to COVID-19 have a worse prognosis than non-healthcare workers (NHCW). Methods Observational cohort study based on the SEMI-COVID-19 Registry, a nationwide registry that collects sociodemographic, clinical, laboratory, and treatment data on patients hospitalised with COVID-19 in Spain. Patients aged 20-65 years were selected. A multivariate logistic regression model was performed to identify factors associated with mortality. Results As of 22 May 2020, 4393 patients were included, of whom 419 (9.5%) were HCW. Median (interquartile range) age of HCW was 52 (15) years and 62.4% were women. Prevalence of comorbidities and severe radiological findings upon admission were less frequent in HCW. There were no difference in need of respiratory support and admission to intensive care unit, but occurrence of sepsis and in-hospital mortality was lower in HCW (1.7% vs. 3.9%; p = 0.024 and 0.7% vs. 4.8%; p<0.001 respectively). Age, male sex and comorbidity, were independently associated with higher in-hospital mortality and healthcare working with lower mortality (OR 0.211, 95%CI 0.067-0.667, p = 0.008). 30-days survival was higher in HCW (0.968 vs. 0.851 p<0.001). Conclusions Hospitalized COVID-19 HCW had fewer comorbidities and a better prognosis than NHCW. Our results suggest that professional exposure to COVID-19 in HCW does not carry more clinical severity nor mortality

Manuel Sacristán at the Onset of Ecological Marxism after Stalinism

Thirty-one years ago, in 1985, Manuel Sacristán died in Barcelona at the age of 59. After the publication in 2014 of a volume with some of his writings translated into English (Llorente 2014), it is time to help non-Spanish-speaking readers to know more about him. Yet it is not easy to explain to generations born after the fall of the Berlin Wall in 1989 that Manuel Sacristán was a most important Marxist philosopher and at the same time one of the few pioneers introducing political ecology and antinuclear peace movement during the last quarter of the 20th century in Spain. Many people believe that Marxism, environmentalism and pacifism are views that exclude each other. Most of what has been said and done on behalf of Marxism since Stalin took over the leadership of the Communist Party of the USSR in the 1930s, up to its dissolution in 1991, contributes to sustaining this belief. The fast industrialization of the Old Russian Empire undertaken by the Soviet State was nowhere near taking into account ecological sustainability. Its socio-environmental impact turned out to be comparable or even worse than the ones caused by capitalist industrialization

Procesos agroindustriales en piña md2

Ilustraciones (principalmente a color), diagramas, figuras, fotografías,En este documento se incluyen los resultados de los productos y los procesos seleccionados de acuerdo con las brechas identificadas para piña md2, tanto en fresco como procesada, y se realiza un análisis comparativo de dichos resultados. La vigilancia tecnológica se llevó a cabo incluyendo 4 tipos de vigilancias (competitiva, comercial, científico-tecnológica y estratégica). Con base en estas, se seleccionaron los productos y procesos correspondientes a la fruta que fue objeto de este estudio. (Texto tomado de la fuente)1° ed

Procesos agroindustriales en aguacate cv. Hass

Ilustraciones (principalmente a color), diagramas, figuras, fotografías, mapasEste documento se presenta en el marco del proyecto “Incremento de la competitividad sostenible en la agricultura de ladera en todo el departamento del Valle del Cauca, Occidente”, ejecutado por la Universidad Nacional de Colombia, sede Palmira, la Universidad del Valle y el Centro Internacional de Agricultura Tropical (Ciat), con el apoyo económico del Sistema General de Regalías de Colombia (sgr). Este estudio se desarrolló mediante la metodología de vigilancia tecnológica e inteligencia competitiva con el fin de establecer una herramienta que brinde información estratégica para la toma de decisiones de los actores involucrados en el proyecto. Su objetivo principal es identificar a través de la información recopilada, procesada y analizada los productos para desarrollar, tanto frescos como procesados, y la selección de procesos para el aguacate Hass. (Texto tomado de la fuente)1° ed