Оптимизация преподавания нормальной физиологии студентам-стоматологам

ВУЗЫВЫСШИЕ УЧЕБНЫЕ ЗАВЕДЕНИЯОБРАЗОВАНИЕ МЕДИЦИНСКОЕОБРАЗОВАНИЕ СТОМАТОЛОГИЧЕСКОЕСТУДЕНТЫ МЕДИЦИНСКИХ УЧЕБНЫХ ЗАВЕДЕНИЙФИЗИОЛОГИЯ /ОБУЧНОРМАЛЬНАЯ ФИЗИОЛОГИЯ (ДИСЦИПЛИНА)МЕТОДИКА ПРЕПОДАВАНИ

Diseño y elaboración de un portal virtual interactivo para alumnos del máster interuniversitario en Lógica y Filosofía de la ciencia

Memoria ID11-113. Ayudas de la Universidad de Salamanca para la innovación docente, curso 2011-2012

Prevalence of familial hypercholesterolemia phenotype and ten-year risk of cardiovascular events in a working population in primary prevention: The ICARIA study

[Background and aims] We aimed to assess the prevalence of familial hypercholesterolaemia (FH) and to determine the incidence of cardiovascular events during a 10-year follow up in individuals with FH, compared to unaffected individuals in a working, middle-aged/young population.[Methods and results] 576,724 active workers (36 ± 10 years-old, 70% men) without cardiovascular disease were given regular health check-ups and followed for a median of 8.5 years (i.e., 4,123,927 person-years). The FH phenotype was defined according to validated low-density lipoprotein-cholesterol thresholds, adjusted for age and sex. The primary outcome was a first cardiovascular event, whether fatal or non-fatal. We found that 707 workers (0.12% or 1 in 816 individuals) met the criteria for a heterozygous FH phenotype. During the follow-up, cardiovascular events occurred in 23 of 707 (3.25%) subjects with the FH phenotype and in 3297 of 576,017 (0.57%) subjects without the FH phenotype (p<0.001). The hazard ratio (HR, assessed with a Cox regression model) for the primary outcome was 5.7 (99% CI 3.33–9.78), before adjustments, and 4.7 (99% CI 2.62–8.58) after adjusting for sex, age, smoking, blood pressure, and diabetes. The HRs were significant for both men and women, but the magnitude of the effect was greater for men than for women.[Conclusions] Our findings confirmed the high incidence of cardiovascular disease in individuals with untreated FH. We showed that regular health check-ups in an active, and mostly young, working population could contribute to the early identification of FH. Therefore, this approach may provide an opportunity for early treatment.This work was supported by the Instituto de Salud Carlos III and Fondo Europeo de Desarrollo Regional-FEDER (grant number PI12/02812), in 2012; by the Instituto de Salud Carlos III (grant number PI18/01809), in 2018; and by a grant awarded to the CTS-159 group of Plan Andaluz de Investigación, Desarrollo e Innovación (PAIDI).Peer reviewe