Analysis of Research Topics and Scientific Collaborations in Energy Saving Using Bibliometric Techniques and Community Detection

Concern about everything related to energy is increasingly latent in the world and therefore the use of energy saving concepts has been increasing over the past several years. The interest in the subject has allowed a conceptual evolution in the scientific community regarding the understanding of the adequate use of energy. The objective of this work is to determine the contribution made by international institutions to the specialized publications in the area of energy-saving from 1939 to 2018, using Scopus Database API Interface. The methodology followed in this research was to perform a bibliometric analysis of the whole scientific production indexed in Scopus. The world’s scientific production has been analysed in the following domains: First the trend over time, types of publications and countries, second, the main subjects and keywords, third, main institutions and their main topics, and fourth, the main journals and proceedings that publish on this topic. Then, these data are presented using community detection algorithms and graph visualization software. With these techniques, it is possible to determine the main areas of research activity as well as to identify the structures of the collaboration network in the field of renewable energy. The results of the work show that the literature in this field have substantially increased during the last 10 years

A Careful Design for a Tool to Detect Child Pornography in P2P Networks

This paper addresses the social problem of child pornography on peer-to-peer (P2P) networks on the Internet and presents an automated system with effective computer and telematic tools for seeking out and identifying data exchanges with pedophilic content on the Internet. The paper analyzes the social and legal context in which the system must operate and describes the processes by which the system respects the rights of the persons investigated and prevents these tools from being used to establish processes of surveillance and attacks on the privacy of Internet users

Early Ordovician Magmatism in the northern Central Iberian Zone (Iberian Massif): New U-Pb (SHRIMP) ages and isotopic Sr-Nd data

Depto. de Mineralogía y PetrologíaFac. de Ciencias GeológicasTRUEpu

Processing of preribosomal RNA in Saccharomyces cerevisiae

Most, if not all RNAs, are transcribed as precursors that require processing to gain functionality. Ribosomal RNAs (rRNA) from all organisms undergo both exo- and endonucleolytic processing. Also, in all organisms, rRNA processing occurs inside large preribosomal particles and is coupled to nucleotide modification, folding of the precursor rRNA (pre-rRNA), and assembly of the ribosomal proteins (r-proteins). In this review, we focus on the processing pathway of pre-rRNAs of cytoplasmic ribosomes in the yeast Saccharomyces cerevisiae, without doubt, the organism where this pathway is best characterized. We summarize the current understanding of the rRNA maturation process, particularly focusing on the pre-rRNA processing sites, the enzymes responsible for the cleavage or trimming reactions and the different mechanisms that monitor and regulate the pathway. Strikingly, the overall order of the various processing steps is reasonably well conserved in eukaryotes, perhaps reflecting common principles for orchestrating the concomitant events of pre-rRNA processing and ribosome assembly

El magmatismo (Ortoneises y volcanismo del Ordovícico Superior) del Paleozoico de los Catalánides.

En el presente trabajo se caracterizan petrológica y geoquímicamente las rocas metavolcánicas del Ordovícico Superior de los Catalánides (Gavarres y Guilleries) y los ortoneises de las Guilleries. Estos últimos se encuentran en disposición estratiforme en materiales metasedimentarios cuya edad supuesta es Proterozoico Superior o Cámbrico Inferior. Las rocas metavolcánicas están constituidas por metarriolitas masivas y tobas dacítico-riolíticas con abundante mezcla de material fragmentario. Corresponden a un volcanismo explosivo subaéreo y de carácter freatomagmático. Sus caracteres geoquímicos lo definen como los términos ácidos de una secuencia calcoalcalina de procedencia cortical emplazada postcolisionalmente dentro de un contexto extensivo. El modelo de REE indica que se trata de fundidos poco fraccionados procedentes de la fusión de una corteza reciclada. Los "Ortoneises de las Guilleries" corresponden a leuconeises biotíticos con granate. Sus caracteres geoquímicos los caracterizan como metagranilos alumínicos de procedencia cortical. Sus espectros geoquímicos (elementos incompatibles y REE) presentan pautas análogas a los de las rocas metavolcánicas e indican que se trata de fundidos de procedencia cortical de baja alcalinidad emplazados en un contexto anorogénico. La ausencia de correlación geoquímica y de pautas de fraccionación entre metavolcanitas y ortoneises descarta la idea de una fuente común para ambos

Los espacios marinos protegidos en España: ¿Nuevas formas institucionales para las estrategias de apropiación?

Se analiza la forma de patrimonialización de los espacios protegidos marinos en España destacando la verticalidad de estas decisiones y llamando la atención sobre la inportancia que puede tener implicar a los pescadores (usuarios tradicionales de estos espacios) en estos procesos de protección del medio

¿Áreas marinas protegidas para mejorar la gobernabilidad local? El caso de la reserva marina de La Restinga

La gobernabilidad (Kooiman, 2008) de los espacios marinos protegidos constituye un reto para las políticas actuales de protección de los ecosistemas. Los conflictos en torno a la creación y funcionamiento de estos modelos institucionales son mucho más frecuentes de lo deseable, llevando a cuestionar en ocasiones su viabilidad. En este trabajo analizamos el proceso de creación de la Reserva Marina Punta de La Restinga—Mar de las Calmas, considerando especialmente la implicación de los usuarios locales en su gestación. Ponemos el énfasis en una serie de factores que entendemos esenciales para su éxito, destacando las características de un proceso que permitió que el diseño institucional y las imágenes que definían en la mente de los locales a esta figura de protección, se fueran gestando lentamente con la implicación tanto de los usuarios como de científicos y autoridades. Los procesos de creación de estas figuras con frecuencia divergen claramente de lo que hemos hallado en este caso, y asumimos que esto conduce a muchas de las dificultades para su implementación y gestión. Por ello, enfatizar los esfuerzos necesarios en las fases iniciales de la gestación de los espacios protegidos suele ser esencial para su viabilidad futura.The governability (Kooiman, 2008) of marine protected areas represents a challenge for ecosystem conservation policies. Conflicts related to the creation and management of these institutional models are much more frequent than desirable, bringing into question its viability. This paper analyzes the creation process of the Marine Reserve Punta de La Restinga—Mar de las Calmas considering the involvement of local users from its early steps. Furthermore, it emphasizes a number of factors that we consider essential to understand the success of this marine reserve, highlighting how the institutional design and the formation of images took shape in the minds of the locals, helping to accept and support this model of protection. Locals got the support from scientist and administration in this development. The creation processes of Marine Protected Areas may diverge frequently from the case of La Restinga, and this may be related with sources of conflict. For this reason, we underline that the efforts to be placed during the inception of MPAs may be essential for their viability.Ministerio de Economía y Competitividad CSO2009-0980

miR-200c-3p, miR-222-5p, and miR-512-3p Constitute a Biomarker Signature of Sorafenib Effectiveness in Advanced Hepatocellular Carcinoma

Background: Sorafenib constitutes a suitable treatment alternative for patients with advanced hepatocellular carcinoma (HCC) in whom atezolizumab + bevacizumab therapy is contraindicated. The aim of the study was the identification of a miRNA signature in liquid biopsy related to sorafenib response. Methods: miRNAs were profiled in hepatoblastoma HepG2 cells and tested in animal models, extracellular vesicles (EVs), and plasma from HCC patients. Results: Sorafenib altered the expression of 11 miRNAs in HepG2 cells. miR-200c-3p and miR-27a-3p exerted an anti-tumoral activity by decreasing cell migration and invasion, whereas miR-122-5p, miR-148b-3p, miR-194-5p, miR-222-5p, and miR-512-3p exerted pro-tumoral properties by increasing cell proliferation, migration, or invasion, or decreasing apoptosis. Sorafenib induced a change in EVs population with an increased number of larger EVs, and promoted an accumulation of miR-27a-3p, miR-122-5p, miR-148b-3p, miR-193b-3p, miR-194-5p, miR-200c-3p, and miR-375 into exosomes. In HCC patients, circulating miR-200c-3p baseline levels were associated with increased survival, whereas high levels of miR-222-5p and miR-512-3p after 1 month of sorafenib treatment were related to poor prognosis. The RNA sequencing revealed that miR-200c-3p was related to the regulation of cell growth and death, whereas miR-222-5p and miR-512-3p were related to metabolic control. Conclusions: The study showed that Sorafenib regulates a specific miRNA signature in which miR-200c-3p, miR-222-5p, and miR-512-3p bear prognostic value and contribute to treatment response.Instituto de Salud Carlos IIIEuropean Commission PI16/00090 PI19/01266Consejeria de Igualdad, Salud y Politicas Sociales PI-0198-2016Spanish Government FPU17/00026GEIVEX Mobility Fellowships 2020German Research Foundation (DFG)National Health and Medical Research Council (NHMRC) of Australia EST19/01091European CommissionInstituto de Salud Carlos IIIEuropean Commission PI15/00145 PI18/0358 PI18/00768AECC PI044031Instituto de Salud Carlos II