The radio talk as a means of learning history and tourism of Madrid: an innovative experience

El Espacio Europeo de Educación Superior (EEES) ha supuesto la implantación de nuevas metodologías docentes en el aula para fomentar la interacción entre docentes y discentes. La innovación y mejora de la docencia, entendida como un proceso de intervención, reflexión y evaluación para la mejora de la instrucción, constituye, sin duda, una de las modalidades relevantes para la mejora de la calidad de la enseñanza. En esta investigación se pretende desarrollar el hábito de lectura entre los alumnos a través de la técnica del "Role Playing" mediante la simulación de una tertulia radiofónica. Este estudio de caso se ha realizado con 135 alumnos del Grado en Turismo de la Universidad Rey Juan Carlos mediante la escenificación, a través de una práctica de radio simulada en el aula, de dos libros de Historia y Turismo de Madrid. Los resultados confirman, por un lado, la idoneidad de esta metodología dada la alta participación de los alumnos y el alto grado de interacción e intercambio de experiencias. Además, por otro lado, se constata la práctica del trabajo en grupo y el aumento del nivel cultural, así como el desarrollo de la competencia oral y las técnicas discursivas por parte del alumnado.The European Higher Education Area (EHEA) has supposed the implementation of new educational methodologies in the classroom to promote the interaction between teachers and students. The innovation and improvement of the teaching, understood as a process of intervention, reflection and evaluation for the improvement of the teaching, constitutes, undoubtedly, one of the relevant modalities for the improvement of the quality of the education. In this research is intended to develop the habit of reading between the students across the technology of "Role Playing" by means of the simulation of radio talk. This study of this case has been carried out with 135 students of the Degree in Tourism of the Rey Juan Carlos University, by means of the staging, across a practice of radio simulated in the classroom concerning two books of History and Tourism of Madrid. The results confirm, on the one hand, the suitability of this methodology, the high participation of the students and the high degree of interaction and exchange of experiences. Furthermore, on the other hand, finds the practice of group work and cultural level rise, as well as the development of the oral competence and the discursive technologies by the students

Mechanical thrombectomy during ischaemic stroke due to a calcified cerebral embolism

Carta al editor de Neurología, en la que los autores hacen el estudio de un caso al que han aplicado oclusión de la arteria cerebral media (ACM) por un émbolo cálcico tras cirugía de válvula aórtica, mediante neurointervencionismo.Letter to the editor of Neurology, in which the authors make the study of a case to which they have applied occlusion of the cerebral artery media (ACM) by a calcium embolus after aortic valve surgery, by neurointervention.peerReviewe

The cuarto real de Santo Domingo. Sustainable tourism as a chance for social and cultural Granada

El turismo cultural, especialmente el recuperado y puesto en valor desde una perspectiva de gestión y conservación sostenible, es, hoy en día, una oportunidad única en la búsqueda de soluciones específicas a problemas concretos que demandan muchas ciudades con un alto potencial patrimonial. El turismo cultural sostenible se convierte así en el mejor medio para amortizar el desarrollo socioeconómico de éstas con un manejo adecuado de los recursos naturales y el medio ambiente. En Granada, el proceso de musealización del Cuarto Real de Santo Domingo, un conjunto arquitectónico único de la edificación árabe residencial del siglo XIII, declarado Bien de Interés Cultural, podría contribuir al desarrollo social, cultural y económico del eje Realejo-Salón, recuperando y revitalizando tanto el entorno natural y urbanístico como el tejido comercial, cultural y social. La sostenibilidad ha sido el eje vertebrador de los objetivos de las últimas propuestas y proyectos seleccionados para su ejecución, así como queda recogida en el marco estratégico del actual Plan de Turismo para Granada, que valora, principalmente, los criterios de historia, conservación y difusión del patrimonio en su estrecha vinculación con el entorno natural.Cultural tourism, especially the recovered and valued from the perspective of sustainable management and conservation, is today, an extraordinary opportunity in finding specific solutions to particular problems that require many cities with a high historical artistic heritage. Sustainable cultural tourism, it becomes, like this, in the best means to redeem the socioeconomic development of these with proper management of natural resources and environment. In Granada, the process of converting into a museum "Cuarto Real de Santo Domingo", a unique architectural residential building of the thirteenth century Arab, declared of monument of cultural interest, will promote to social, cultural and economic development of "Realejo-Salón" artistic axis, restoring and revitalizing both the natural environment as the business, cultural and social area. All it, thanks, to cultural and social sustainability proposal has been submitted as a priority objective the projects selected for implementation and strategic framework reflected in the current Tourism Plan for Granada, that values, mainly, the approaches of history, heritage conservation and promotion in its close link with the natural environment

Stability of Ampicillin plus Ceftriaxone Combined in Elastomeric Infusion Devices for Outpatient Parenteral Antimicrobial Therapy

Ampicillin; Infective endocarditis; Outpatient parenteral antimicrobial therapyAmpicil·lina; Endocarditis infecciosa; Teràpia antimicrobiana parenteral ambulatòriaAmpicilina; Endocarditis infecciosa; Terapia antimicrobiana parenteral ambulatoriaCurrently, ampicillin plus ceftriaxone (AC) is one of the preferred treatments for Enterococcus faecalis infective endocarditis. However, there is a lack of stability data for the combination of both drugs in elastomeric devices, so the inclusion of AC in Outpatient Parenteral Antimicrobial Therapy (OPAT) programs is challenging. The objective of the study was to determine the stability of AC in elastomeric pumps when stored at 8 ± 2 °C, 25 ± 2 °C, 30 ± 2 °C and 37 ± 2 °C using LC-MS/MS. The combination was diluted in 0.9% sodium chloride and the final concentrations were ampicillin 24 g/L plus ceftriaxone 8 g/L. Physical and chemical stability were evaluated at 12, 20, 24, 36 and 48 h after preparation. Stability was met at each time point if the percentage of intact drug was ≥90% of its respective baseline concentration and color and clearness remained unchanged. The drug combination was stable for 48 h when it was kept at 8 ± 2 °C. At 25 ± 2 °C and 30 ± 2 °C, they were stable for 24 h of storage. At 37 ± 2 °C, the stability criterion was not met at any time point. These results prove that AC could be included in OPAT programs using elastomeric infusion devices for the treatment of E. faecalis infections.This work was supported by the Sociedad Española de Farmacia Hospitalaria and the AFinf Working Group for the project “Stability study of antimicrobials under conditions analogous to the outpatient parenteral antibiotic therapy program (OPAT)”. A.G.-V. was supported by the Instituto de Salud Carlos III, co-financed by the European Development Regional Fund (“A way to achieve Europe”), Subprograma Miguel Servet (grant CP19/00159). L.H.-H. was supported by the Instituto de Salud Carlos III, co-financed by the European Development Regional Fund (“A way to achieve Europe”), Subprograma Juan Rodés (grant JR22/00049)

La Alta Velocidad Española : un viaje en el tiempo a través del turismo cultural, la tecnología y el progreso

La Alta Velocidad Española (AVE) se ha configurado, desde la inauguración, en 1992, de la línea Madrid-Sevilla, como el medio de transporte puntero de la última década del siglo XX y de los albores del XXI. El tren de alta velocidad ha revolucionado el turismo cultural y de negocios de los destinos como atractivo de su proyección turística. Este medio de transporte ha transformado las infraestructuras de las estaciones ferroviarias y, por ende, el trazado urbano de las ciudades. Así, Andalucía cuenta con más de 2.000 bienes inmuebles (monumentos, jardines, conjuntos y sitios históricos, zonas arqueológicas y museos) de interés cultural integrados en el Patrimonio Histórico Español. El AVE ha supuesto un instrumento de cohesión territorial, fundamentalmente, para la zona sur de España, pero también para la Costa Mediterránea y Galicia con la apertura de las líneas Madrid-Valencia, Madrid-Barcelona, Madrid-Málaga y La Coruña-Orense. La rapidez, el aumento de viajeros, el acercamiento de culturas, la descongestión de la red viaria y la escasa nocividad con el medio ambiente son las principales ventajas de la alta velocidad, aunque no está exenta de inconvenientes como el precio y el retraso en la apertura de las nuevas líneas programadas por su alto coste.The Spanish high speed train has been formed, from the opening, in 1992, of the railway route Madrid-Sevilla, as the way of top transport of last decade of the 20th century and at dawn of the XXIst. The high-speed train has revolutionized the cultural and business tourism of the destinations as attraction of his tourist projection. This way of transport has transformed the infrastructures of the railway stations and, therefore, the urban design of the cities. So Andalucía has more than 2.000 real estate (monuments, gardens, sets and historical sites, archaeological zones and museums) of cultural interest joined the Historical Spanish Heritage. The AVE has supposed an instrument of territorial cohesion, fundamentally, for the south zone of Spain, but also for the Mediterranean coast and Galicia with the opening of the railway routes Madrid- Valencia, Madrid-Barcelona, Madrid-Malaga and La Coruña-Orense. The speed, the travelers' increase, the rapprochement of cultures, the relieving of roads and the little noxiousness with the environment are the principal advantages of the high speed, though it is not exempt from disadvantages as the price and the delay in the opening of the new lines programmed by his high cost

Heavy metals and their impact on surface waters of the Mantaro river basin, Junin, Peru

In the Mantaro river basin, located in Central Peru, an agricultural activity developed, even supplying the capital of Peru. An intense mining activity took place in the headwaters of this basin, and the La Oroya Metallurgical Complex was built a century ago. Mining activity has left mining environmental liabilities, which directly impact the quality of the water and the soil. In this sense, it is very important to investigate the presence of heavy metals and identify the geochemical associations present in surface waters to assess the real impact on the environment. For this purpose, 30 water samples were analyzed, collected from the Mantaro River and the channels that derive water for irrigation and animal consumption. The samples were analyzed by ICP-MS techniques, inductively coupled plasma-mass spectrometry, and ICP-AES, inductively coupled plasma-optical emission spectrometry. For the evaluation of the main physicochemical parameters, the ECA has been used, as the environmental quality standard of Peru, according to the Ministry of the Environment (2017); while for the chemical quality of surface water, the quality standards of the WHO, World Health Organization, were taken as a reference, according to the WHO guide (2017), being the elements considered: Al, As, Mn, Pb, and Zn. Investigations results show that the waters of some sectors have concentrations of As and Pb, which exceed the standards established by WHO, and there are also some specific cases (Muqui canal) in which Al and Mn exceed the WHO standard. In the case of Zn, its concentrations are much lower than the WHO standard

Transició energètica i indústria

L’objectiu d’aquest estudi és donar resposta a les demandes plantejades pel Pacte Nacional per a la Indústria, les quals es fonamenten en definir les implicacions que pugui tenir la transició energètica (TE) a la indústria catalana. L’enfocament que s’ha pres es caracteritza per analitzar, en primer lloc, les raons que justifiquen realitzar una TE a Catalunya. D’acord amb això, es presenta la situació en què es troba actualment i els elements clau que hauria de complir per fer-la efectiva (infraestructura de renovables, electrificació i descarbonització ). A més, en el transcurs de l’anàlisi, es fa valdre el caràcter transversal de la TE explorant els seus efectes i relacions, no només entre sectors industrials, sinó també els que involucren altres esferes del teixit productiu com l’ocupació i la formació.Objectius de Desenvolupament Sostenible::7 - Energia Assequible i No Contaminant::7.1 - Per a 2030, garantir l’accés universal a serveis d’energia assequibles, confiables i modernsObjectius de Desenvolupament Sostenible::7 - Energia Assequible i No Contaminant::7.2 - Per a 2030, augmentar substancialment el percentatge d’energia renovable en el con­junt de fonts d’energiaObjectius de Desenvolupament Sostenible::7 - Energia Assequible i No ContaminantObjectius de Desenvolupament Sostenible::7 - Energia Assequible i No Contaminant::7.3 - Per a 2030, duplicar la taxa mundial de millora de l’eficiència energèticaObjectius de Desenvolupament Sostenible::7 - Energia Assequible i No Contaminant::7.a - Per a 2030, augmentar la cooperació internacional per tal de facilitar l’accés a la investigació i a les tecnolo­gies energètiques no contaminants, incloses les fonts d’energia renovables, l’eficiència energètica i les tecnologies de combustibles fòssils avançades i menys contaminants, i promoure la inversió en infraestructures energètiques i tecnologies d’energia no contaminantObjectius de Desenvolupament Sostenible::7 - Energia Assequible i No Contaminant::7.b - Per a 2030, ampliar la infraestructura i millorar la tecnologia per tal d’oferir serveis d’energia moderns i sos­tenibles per a tots els països en desenvolupament, en particular els països menys avançats, els petits estats insulars en desenvolupament i els països en desenvolupament sense litoral, d’acord amb els programes de suport respectiusObjectius de Desenvolupament Sostenible::9 - Indústria, Innovació i InfraestructuraObjectius de Desenvolupament Sostenible::9 - Indústria, Innovació i Infraestructura::9.2 - Promoure una industrialització inclusiva i sostenible i, a tot tardar el 2030, augmentar de manera significativa la contribució de la indústria a l’ocupació i al producte interior brut, d’acord amb les circumstàncies nacionals, i duplicar aquesta contribució als països menys avançatsObjectius de Desenvolupament Sostenible::9 - Indústria, Innovació i Infraestructura::9.4 - Per a 2030, modernitzar les infraestructures i reconvertir les indústries perquè siguin sostenibles, usant els recursos amb més eficàcia i promovent l’adopció de tecnologies i processos industrials nets i racionals ambiental­ment, i aconseguint que tots els països adoptin mesures d’acord amb les capacitats respectivesObjectius de Desenvolupament Sostenible::9 - Indústria, Innovació i Infraestructura::9.5 - Augmentar la investigació científica i millorar la capacitat tecnològica dels sectors industrials de tots els països, en particular els països en desenvolupament, entre d’altres maneres fomentant la innovació i augmentant substancialment, d’aquí al 2030, el nombre de persones que treballen en el camp de la investigació i el desenvolupa­ment per cada milió d’habitants, així com la despesa en investigació i desenvolupament dels sectors públic i privatObjectius de Desenvolupament Sostenible::13 - Acció per al ClimaObjectius de Desenvolupament Sostenible::12 - Producció i Consum ResponsablesObjectius de Desenvolupament Sostenible::12 - Producció i Consum Responsables::12.2 - Per a 2030, assolir la gestió sostenible i l’ús eficient dels recursos naturalsObjectius de Desenvolupament Sostenible::12 - Producció i Consum Responsables::12.4 - Per a 2020, aconseguir la gestió ecològicament racional dels productes químics i de tots els residus al llarg del seu cicle de vida, de conformitat amb els marcs internacionals convinguts, i reduir-ne de manera significativa l’alliberament a l’atmosfera, a l’aigua i al sòl a fi de minimitzar-ne els efectes adversos sobre la salut humana i el medi ambientObjectius de Desenvolupament Sostenible::12 - Producció i Consum Responsables::12.5 - Per a 2030, disminuir de manera substancial la generació de residus mitjançant polítiques de prevenció, reducció, reciclatge i reutilitzacióObjectius de Desenvolupament Sostenible::12 - Producció i Consum Responsables::12.6 - Encoratjar les empreses, en especial les grans empreses i les empreses transnacionals, a adoptar pràctiques sostenibles i a incorporar informació sobre la sostenibilitat en el seu cicle de presentació d’informesObjectius de Desenvolupament Sostenible::13 - Acció per al Clima::13.3 - Millorar l’educació, la conscienciació i la capacitat humana i institucional en relació amb la mitigació del canvi climàtic, l’adaptació a aquest, la reducció dels efectes i l’alerta primerencaObjectius de Desenvolupament Sostenible::13 - Acció per al Clima::13.2 - Incorporar mesures relatives al canvi climàtic en les polítiques, les estratègies i els plans nacionalsPostprint (published version

Quality of life with palbociclib plus fulvestrant versus placebo plus fulvestrant in postmenopausal women with endocrine-sensitive hormone receptor-positive and HER2-negative advanced breast cancer : patient-reported outcomes from the FLIPPER trial

In the FLIPPER trial, palbociclib/fulvestrant significantly improved progression-free survival (PFS) compared with placebo/fulvestrant in postmenopausal women with HR+/HER2− advanced breast cancer (ABC). We assessed health-related quality of life (QoL) using patient-reported outcomes (PROs). In this phase II double-blinded study, PROs were assessed at baseline after every three cycles and at the end of the treatment using the European Organisation for Research and Treatment of Cancer QLQ-C30 and QLQ-BR23. Time to deterioration (TTD) in global health status (GHS)/QoL was defined as a decrease of ⩾10 points. Changes from baseline (CFB) and TTD were analysed using linear mixed-effect and Cox regression models, respectively. Of the 189 randomised (1:1) patients, 178 (94%) completed ⩾1 post-baseline assessment; 50% received ⩾22 cycles of study treatment, with a questionnaire compliance >90%. Mean baseline scores were comparable between arms. GHS/QoL scores were maintained throughout the palbociclib/fulvestrant treatment. CFB showed significant differences for GHS/QoL, appetite loss, constipation and systemic therapy side effect scores favouring placebo/fulvestrant. TTD in GHS/QoL was delayed in placebo/fulvestrant versus palbociclib/fulvestrant [30.3 versus 11.1 months; adjusted hazard ratio (aHR): 1.57, 95% CI: 1.03-2.39, p = 0.036]; this difference was not significant in patients with progressive disease (aHR: 1.2, 95% CI: 0.6-2.2, p = 0.658). No statistically significant differences in TTD were found for the other QLQ-C30 and QLQ-BR23 scales. Although TTD in GHS/QoL was prolonged with placebo/fulvestrant, no differences were observed on other functional or symptom scales. This finding and the improvement in PFS support the combination of palbociclib/fulvestrant as a beneficial therapeutic option for HR+/HER2− ABC. Sponsor Study Code: GEICAM/2014-12 EudraCT Number: 2015-002437-21 ClinTrials.gov reference: NCT0269048

Clinical features and outcomes of Streptococcus anginosus group infective Endocarditis: a multicenter matched cohort study

[EN] Background. Although Streptococcus anginosus group (SAG) endocarditis is considered a severe disease associated with abscess formation and embolic events, there is limited evidence to support this assumption. Methods. We performed a retrospective analysis of prospectively collected data from consecutive patients with definite SAG endocarditis in 28 centers in Spain and Italy. A comparison between cases due to SAG endocarditis and viridans group streptococci (VGS) or Streptococcus gallolyticus group (SGG) was performed in a 1:2 matched analysis. Results. Of 5336 consecutive cases of definite endocarditis, 72 (1.4%) were due to SAG and matched with 144 cases due to VGS/ SGG. SAG endocarditis was community acquired in 64 (88.9%) cases and affected aortic native valve in 29 (40.3%). When comparing SAG and VGS/SGG endocarditis, no significant differences were found in septic shock (8.3% vs 3.5%, P = .116); valve disorder, including perforation (22.2% vs 18.1%, P = .584), pseudoaneurysm (16.7% vs 8.3%, P = .108), or prosthesis dehiscence (1.4% vs 6.3%, P = .170); paravalvular complications, including abscess (25% vs 18.8%, P = .264) and intracardiac fistula (5.6% vs 3.5%, P = .485); heart failure (34.7% vs 38.9%, P = .655); or embolic events (41.7% vs 32.6%, P = .248). Indications for surgery (70.8% vs 70.8%; P = 1) and mortality (13.9% vs 16.7%; P = .741) were similar between groups. Conclusions. SAG endocarditis is an infrequent but serious condition that presents a prognosis similar to that of VGS/SGG.This work was supported by Plan Nacional de I+D+i 2013‐2016 and Instituto de Salud Carlos III, Subdirección General de Redes y Centros de Investigación Cooperativa, Ministerio de Ciencia, Innovación y Universidades, Spanish Network for Research in Infectious Diseases (REIPI RD16/0016/0005), co‐financed by the European Development Regional Fund “A way to achieve Europe,” Operative Program Intelligent Growth 2014–2020. We thank CERCA Programme/Generalitat de Catalunya for institutional support. J. M. M. received a personal 80:20 research grant from Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain, during 2017–2021