De la metáfora del mercado a la sinécdoque del emprendedor: la reconfiguración política del modelo referencial de trabajador

De la metáfora del mercado a la sinécdoque del emprendedor: la reconfiguración política del modelo referencial de trabajador

Efectos adversos de la vacunación contra el virus del papiloma humano

ResumenObjetivoDescribir las reacciones adversas más frecuentes producidas por la vacunación contra el virus del papiloma humano (VPH).DiseñoEstudio descriptivo transversal mediante encuesta telefónica.EmplazamientoSistema Sanitario Público de Andalucía.ParticipantesMujeres vacunadas frente al VPH en Andalucía, seleccionadas por muestreo aleatorio simple con representatividad provincial.MedicionesSe realizaron 3.135 llamadas telefónicas por el servicio público “Salud Responde” dependiente de teleoperadores con supervisión de personal sanitario.Resultados principalesDe las 2.880 llamadas que cumplían criterio de inclusión, se consiguió encuestar a 1.207 personas (41,9% de respuesta). De las 2.124 encuestas realizadas tuvieron algún tipo de reacción adversa (fiebre, inflamación, dolor o enrojecimiento) en 467 dosis (22%): el 6,6% fue fiebre, el 49,5% inflamación, el 72,4% dolor, y el 6% enrojecimiento.ConclusionesSe puede decir que es una vacuna segura, lo que concuerda con lo recogido en su ficha técnica y en la literatura.AbstractObjectiveTo describe the most frequent adverse reactions produced by the human papillomavirus (HPV) vaccine.DesignCross-sectional descriptive study using a telephone survey.SettingA province in the Andalusian Public Health System.ParticipantsFemales vaccinated against HPV in Andalusia, selected by simple random sampling representative of the province.Main measurementsA total of 3,135 telephone calls were made by the public service “Health Answers” using telephone operators supervised by health personnel.ResultsOf the 2,880 calls that fulfilled the inclusion criteria, 1,207 people (41.9% response) took part in the survey. Of the 2,124 surveys made there was some type of adverse reaction (fever, inflammation, pain or rash) in 467 doses (22%): 6.6% was fever, 49.5% inflammation, 72.4% pain, and 6% a rash.ConclusionsIt can be said that HPV vaccine is safe, which is in agreement with that published in the summary of the product characteristics and in the literature

Semisupervised Speech Data Extraction from Basque Parliament Sessions and Validation on Fully Bilingual Basque–Spanish ASR

In this paper, a semisupervised speech data extraction method is presented and applied to create a new dataset designed for the development of fully bilingual Automatic Speech Recognition (ASR) systems for Basque and Spanish. The dataset is drawn from an extensive collection of Basque Parliament plenary sessions containing frequent code switchings. Since session minutes are not exact, only the most reliable speech segments are kept for training. To that end, we use phonetic similarity scores between nominal and recognized phone sequences. The process starts with baseline acoustic models trained on generic out-of-domain data, then iteratively updates the models with the extracted data and applies the updated models to refine the training dataset until the observed improvement between two iterations becomes small enough. A development dataset, involving five plenary sessions not used for training, has been manually audited for tuning and evaluation purposes. Cross-validation experiments (with 20 random partitions) have been carried out on the development dataset, using the baseline and the iteratively updated models. On average, Word Error Rate (WER) reduces from 16.57% (baseline) to 4.41% (first iteration) and further to 4.02% (second iteration), which corresponds to relative WER reductions of 73.4% and 8.8%, respectively. When considering only Basque segments, WER reduces on average from 16.57% (baseline) to 5.51% (first iteration) and further to 5.13% (second iteration), which corresponds to relative WER reductions of 66.7% and 6.9%, respectively. As a result of this work, a new bilingual Basque–Spanish resource has been produced based on Basque Parliament sessions, including 998 h of training data (audio segments + transcriptions), a development set (17 h long) designed for tuning and evaluation under a cross-validation scheme and a fully bilingual trigram language model.This work was partially funded by the Spanish Ministry of Science and Innovation (OPEN-SPEECH project, PID2019-106424RB-I00) and by the Basque Government under the general support program to research groups (IT-1704-22)

Adherence and long-term outcomes of growth hormone therapy with easypod™ in pediatric subjects: Spanish ECOS study

E-health; Easypod; Electronic deviceE-salut; Easypod; Dispositiu electrònicE-salud; Easypod; Dispositivo electrónicoBackground: Non-adherence to r-hGH treatments occurs in a variable percentage of subjects. One problem found when evaluating adherence is the great variability in methods of detection and definitions utilized in studies. This study assessed the level of adherence in subjects receiving r-hGH with the easypod™ electronic device. Methods: National, multicenter, prospective and observational study involving 238 subjects (144 with GH deficiency (GHD), and 86 with small for gestational age (SGA), 8 with Turner Syndrome), who received r-hGH with easypod™ for at least 3 months before inclusion. The follow-up period was 4 years. Results: Overall adherence was 94.5%; 97.5% after 6 months, 95.3% after 1 year, 93.7% after 2, 94.4% after 3 and 95.5% after 4 years of treatment. No differences in adherence were observed between prepubertal and pubertal groups and GHD and SGA groups. Change in height after 1 and 2 years, change in height SDS after 1 and 2 years, HV after 1 year, HV SDS after at 1 and 4 years, change in BMI after 1 year and change in BMI SDS at 1 and 2 years showed significant correlation with adherence. No significant differences in adherence according to IGF-I levels were found in follow-up visits or between groups. Conclusions: The easypod™ electronic device, apart from being a precise and objective measure of adherence to r-hGH treatment, allows high compliance rates to be achieved over long periods of time. Adherence significantly impacts growth outcomes associated with r-hGH treatmentThis study was funded by Merck, S.L., Madrid, Spain

A Flexible Approach to the Multidimensional Model: The Fuzzy Datacube

As a result of the use of OLAP technology in new fields of knowledge and the merge of data from different sources, it has become necessary for models to support this technology. In this paper, we propose a new multidimensional model that can manage imprecision both in dimensions and facts. Consequently, the multidimensional structure is able to model data imprecision resulting from the integration of data from different sources or even information from experts, which it does by means of fuzzy logic

Pointing Out Some Issues Regarding Reproduction Management in Murciano-Granadina Goats

[EN] The hypothesis of this experiment proposes that it could be possible to identify pregnant goats through maximum progesterone milk levels at any time in the pregnancy, and that there is an optimal moment to apply a lactation inhibitor to dry off lactating goats. The maximum progesterone concentration in milk varied depending on the season of the year, and those concentrations were similar for pregnant and non-pregnant goats, but significantly higher in the case of gestating goats with four foetuses, for which it would be possible to distinguish the pregnancy. The milk yield of goats at mating does not affect fertility until a value of at least 3250 mL/day. If using lactation inhibitors, their application up to the 10th week post-mating would be optimal for drying off lactating goats. Two of the most important problems in high-yielding dairy goat farms are early and accurate pregnancy diagnosis and the appropriate dry off of lactating does before the next kidding. The hypothesis posits that it could be possible to identify pregnant does through maximum progesterone milk levels at any time during the pregnancy, and that there is an optimal time to apply a lactation inhibitor to help dry off lactating does. Therefore, 114 Murciano-Granadina breed goats were used, from which 74 goats were inseminated at week 20 of lactation and samples of milk from pregnant and non-pregnant goats were taken at two-week intervals. The average maximum progesterone milk levels were higher outside the natural breeding season (40 degrees latitude) than in the breeding season (11.6 +/- 1.13 vs. 8.6 +/- 1.02 ng/mL), although the levels from pregnant and non-pregnant goats were similar (10.85 +/- 1.3 vs. 9.74 +/- 1.6 ng/mL), except in the case of pregnancy with four foetuses (12.5 +/- 1.3 ng/mL). Milk yield at mating does not affect fertility until a value of at least 3250 mL/day. Pregnancy started to affect milk yield up to the +7th week and was 59.9% lower in the +10th week after mating, so the use of lactation inhibitors could be more effective from this latter week. In conclusion, the results show that it is not possible to detect gestation in goats reliably through the maximum concentration of progesterone in milk at any time during lactation, except in the case of goats gestating four foetuses, that the milk yield of goats at mating does not affect fertility until a value of at least 3250 mL/day, and that from the 10th week post-mating, the application of lactation inhibitors would be optimal.This research was funded by the project RTA2017-00049-C02-02 (Agencia Estatal de Investigación) with ERDF funds.Fernández Martínez, N.; Beltrán Martínez, MC.; Romero, G.; Roca, MA.; Rodríguez Garcia, M.; Balasch Parisi, S. (2021). Pointing Out Some Issues Regarding Reproduction Management in Murciano-Granadina Goats. Animals. 11(6):1-13. https://doi.org/10.3390/ani11061781S11311

Surface Plasmon Resonance Biosensor Method for Palytoxin Detection Based on Na+,K+-ATPase Affinity

Palytoxin (PLTX), produced by dinoflagellates from the genus Ostreopsis was first discovered, isolated, and purified from zoanthids belonging to the genus Palythoa. The detection of this toxin in contaminated shellfish is essential for human health preservation. A broad range of studies indicate that mammalian Na+,K+-ATPase is a high affinity cellular receptor for PLTX. The toxin converts the pump into an open channel that stimulates sodium influx and potassium efflux. In this work we develop a detection method for PLTX based on its binding to the Na+,K+-ATPase. The method was developed by using the phenomenon of surface plasmon resonance (SPR) to monitor biomolecular reactions. This technique does not require any labeling of components. The interaction of PLTX over immobilized Na+,K+-ATPase is quantified by injecting different concentrations of toxin in the biosensor and checking the binding rate constant (kobs). From the representation of kobs versus PLTX concentration, the kinetic equilibrium dissociation constant (KD) for the PLTX-Na+,K+-ATPase association can be calculated. The value of this constant is KD = 6.38 × 10−7 ± 6.67 × 10−8 M PLTX. In this way the PLTX-Na+,K+-ATPase association was used as a suitable method for determination of the toxin concentration in a sample. This method represents a new and useful approach to easily detect the presence of PLTX-like compounds in marine products using the mechanism of action of these toxins and in this way reduce the use of other more expensive and animal based methods.The research leading to these results has received funding from the following FEDER cofunded-grants: From Ministerio de Ciencia y Tecnología, Spain: AGL2009-13581-CO2-01, AGL2012-40485-CO2-01. From Xunta de Galicia, Spain: 10PXIB261254 PR. From the European Union’s Seventh Framework Programme managed by REA—Research Executive Agency http://ec.europa.eu/research/rea (FP7/2007–2013) under grant agreement Nos. 211326-CP (CONffIDENCE), 265896 BAMMBO, 265409 µAQUA, and 262649 BEADS, 315285 Ciguatools and 312184 PharmaSea. From the Atlantic Area Programme (Interreg IVB Trans-national): 2008-1/003 (Atlantox) and 2009-1/117 (Pharmatlantic)S

Cultural audit as a tool to increase employee involvement in small firms: A case study

Employee involvement is a common goal for most companies. This research started when managers of a familyrun horticultural firm decided to increase employee commitment and improve organizational climate. To help them, we considered the possibility of developing a cultural audit, adapting the tool to the fact that it was a small family business. Therefore, this paper will firstly review the existing literature concerning organizational culture, specially which cultural characteristics should be more valuable to achieve employee commitment and involvement and how to run a cultural audit. Secondly, it will expose the design and implementation of a cultural audit at this company, through an explicative case study that aims to compare the existing culture with the characteristics described theoretically. The study discusses the lack of trust, of a creative atmosphere, and of a shared vission, and suggests some recommendations to develop these characteristics, in order to gain the desired level of employee involvement. Key words: Employee involvement, organizationalO envolvimento dos empregados é um objectivo frequente nas organizações. A presente investigação surgiu de uma oportunidade criada no seio de uma empresa familiar no sector da horticultura, quando se decidiu aumentar o envolvimento dos empregados e melhorar o clima organizacional. Os investigadores desenvolveram um instrumento de auditoria cultural, adaptado a pequenas empresas familiares. Este artigo revê a literatura sobre cultura organizacional, com particular destaque para os trabalhos em que se relaciona a cultura e o envolvimento dos empregados, e auditoria cultural. Em segundo lugar, é exposto o desenho e a implementação da auditoria cultural na empresa, para o que se recorre a um estudo de caso. Por fim, são discutidos sucessivamente a falta de confiança, a atmosfera criativa, e a visão partilhada, e sugeridas algumas recomendações sobre como desenvolver estes atributos