System dynamics modelling in systems biology and applications in pharmacology

El modelado matemático de sistemas biológicos complejos es uno de los temas clave en la Biología de Sistemas y varios métodos computacionales basados ​​en la simulación computarizada han sido aplicados hasta ahora para determinar el comportamiento de los sistemas no lineales. La Dinamica de Sistemas es una metodología de modelado intuitivo basada en el razonamiento cualitativo por el cual un modelo conceptual se puede describir como un conjunto de relaciones de causa y efecto entre las variables de un sistema. A partir de esta estructura, es posible obtener un conjunto de ecuaciones dinámicas que describan cuantitativamente el comportamiento del sistema. Centrándose en los sistemas farmacológicos, el modelado compartimental a menudo se utiliza para resolver un amplio espectro de problemas relacionados con la distribución de materiales en los sistemas vivos en la investigación, el diagnóstico y la terapia en todo el cuerpo, los órganos y los niveles celulares. En este artículo presentamos la metodología de modelado de Dinámica del Sistema y su aplicación al modelado de un modelo compartimental farmacocinético-farmacodinámico del efecto de profundidad anestésica en pacientes sometidos a intervenciones quirúrgicas, derivando un modelo de simulación en el entorno de simulación orientada a objetos OpenModelica. La Dinamica de Sistemas se puede ver como una herramienta educativa poderosa y fácil de usar y en la enseñanza de Biología de Sistemas.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Temporal projection of an input-output tables series for the region of Asturias

The interest on regional economics has strongly developed in the lastest decades; however, and in spite of the great extension of the information that statistical sources of data offer to economic researchers, one of the major problems arising with these kind of studies still keep being the lack of data. Regional studies can be focused from several points of view, one of these is the input-output framework. This method allows the economic researcher to analyze the intersectorial relationship underlying on a economy in a joint way, as well as the aggregate demand, so it makes feasible to get a integrated knowledge of economic activity. This technique is a key part on the konwledge of a region, because supplies the necesary information to study the economic situation of the mentioned region. However, its use now at days is quite restricted because the discontinuity in the publications of the input-output (IO) tables by statistical agencies, as well as the long time is necessary to wait between each published table. Specifically, focusing the problem on the region of Asturias (north of Spain), the last available input-output table was made for 1995, having been published in 1999. Having account this situation, we believe that for an effective and rigorous application of this kind of analysis a previous step we must take is the input-output tables series estimation. The input-output table elaboration is a work that implies a great effort to get statistical information, as well as a very high cost on every kind of resources. So, the IO tables obtaining by the use of indirect (semidirect) methods of estimation would reduce the needs for information and material and human resources. The information theory is being applied in the latest decades as a very flexible tool that allows to estimate the IO tables coeficients when the available data are not perfectly consistent. Our aim in this work is to make a comparison between the cross entropy method, an information theory derivated thecnique, and the biproportional RAS method, with a long tradition on applied works (Robinson et al. 1998, Mc Dougall, 1999). On a second stage, and basing on the conclusions for the previous comparison and our information availabilities, we will estimate the the input-output tables series corresponding to the region of Asturias for the years 1995-2000. For this estimation, we will apply a cross-time analysis taking as starting point the IOT for Asturias in 1995.

How triathletes mount their bikes after first transition (T1). A proposal of classification

A proposal is submit for the classification referring to the different ways in which triathletes mount their bikes to start pedalling. This action happens at the end of the transition area (T1) after having gone across on foot, with the bikes at their side, or, led across by hand, in a specific way (Fernández, Romero, Merino and April, 2015). These are unique aspects of this sport, compared to other sports in which a bike is also used. The purpose of this research was concentrates in describing and classifying the motor behaviours that occur at the end of the transition area, in front of the “judge’s line”. This study was bassed on participants of 3 Spanish Elite Championships of different distances (407 triathletes). It was filmed in the moment when they picked up their bikes, passed through the transition area and mounted their bikes. Eleven different ways were discovered on how to mount a bike when passing the judge’s line.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tec

Smart-Cities urban mobility management architecture for electric vehicles

Improving efficiency is one of the most important objectives of the Smart Cities standards, and Electric Vehicles (EVs). TICS can help to soften one of their main limitations –autonomy– planning efficient driving strategies. This paper evaluates the physical variables that have an impact on the EV consumption and presents an electronic architecture to monitor them in an Experimental Ultralight Electric Vehicle. This system includes a set of very low cost sensors integrated with a data logger and a GPRS transmission system that can connect, in real time, with a control center where a route-finding reinforcement-learning algorithm that helps to find the most-effective route and reduce the time spent on urban environment tips.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

“Hay que aceptar que existen otras realidades, hay que probar otras terapias y maneras de curar”, Experiencias y narrativas de usuarios de salud que recurren a un modelo de atención a la salud alternativo

Treballs Finals de Grau Antropologia Social i Cultural, Facultat de Geografia i Història, Universitat de Barcelona, Curs: 2014-2015, Tutor: Mariona Rosés TubauEste artículo consiste en una aproximación etnográfica a usuarios de salud que recurren a las terapias alternativas. Mediante sus experiencias y narrativas intentaremos abordar los principales motivos por los cuales los itinerarios terapéuticos de algunos pacientes pasan por un modelo de atención a la salud alternativo. Querremos poner de relieve el auge de las terapias alternativas y su uso cada vez mayor por parte de unos usurarios de salud que, sobretodo, para determinados padecimientos o enfermedades muestran descontento con el modelo médico convencional, el de la biomedicina

El acceso a la información en el Proyecto de Ley de Transparencia, Acceso a la Información Pública y Buen Gobierno

En este trabajo se realiza un estudio de urgencia del Proyecto de Ley de Transparencia, Acceso a la Información Pública y Buen Gobierno, aprobado por el Consejo de Ministros el 27 de julio de 2012, tras someterlo previamente, en una decisión sin precedentes, a consulta pública. Fundamentalmente, se analiza si el Anteproyecto responde a los estándares mínimos contenidos en el Convenio sobre acceso a los documentos públicos, adoptado por el Comité de Ministros del Consejo de Europa el 27 de noviembre de 2008, y que presumiblemente habrá de ratificar nuestro país