Modelling temperature dependence in the Arabidopsis thaliana circadian clock

The circadian clock is the mechanism responsible for generating and controlling the biological rhythms that occur with 24 h periodicity in most living organisms. This clock allows organisms to anticipate the environmental variation caused by the rotation of the Earth such as the daily light and temperature cycles, providing them adaptive advantages. The circadian clock is a complex network of genes interacting with each other in regulatory processes which have been represented by mathematical models. In the plant Arabidopsis thaliana, the mechanisms by which light regulates the circadian clock have been widely modelled mathematically and implemented computationally permitting to explain experimental observations and to generate hypotheses, which have led experimental investigation. However, the role of temperature and the mechanisms of adaptation to temperature variation are poorly understood, and especially in the scenario of global climate change, modelling a temperature responsive plant clock is of increasing importance. Here we present a framework of temperature dependence for the Arabidopsis circadian clock by applying Arrhenius equations to the most predominant models for the plant system and we additionally propose three minimal models via random parameterisations to explore design principles underlying temperature compensation. By numerical investigation, we conclude that temperature compensation is especially sensitive to degradation processes, and that the combined effect of light and temperature favors the robustness of the clock. We also propose to analyse the plant clock as a whole system and under that perspective we suggest that context graph-theoretic approaches could be a powerful tool to uncover the design principles for temperature mechanisms

Turning teachers into entrepreneurship role models: development of a measurement scale of useful characteristics

The circumstances under which students consider their teachers of entrepreneurship as role models have not received in-depth exploration in the literature. This paper focuses on determining the main personal, professional and pedagogical characteristics that would turn teachers of entrepreneurship into role models and thereby improve the entrepreneurial intentions of students. A three-step empirical research process combining documentary, qualitative and quantitative methods is developed in order to propose and test a measurement scale of teacher characteristics that is reliable, valid and useful for causal modelling. A total of 26 characteristics are identified and classified into personal, professional and pedagogical categories

Monitoring and analyzing exoplanetary transits from Argentina

Photometric observations of transits can be used to derive physical and orbital parameters of the system, like the planetary and stellar radius, orbital inclination and mean density of the star. Furthermore, monitoring possible periodic variations in transit timing of planets is important, since small changes can be caused by the presence of other planets or moons in the system. On the other hand, long term changes in the transit length can be due to the orbital precession of the planets. For these reasons we started an observational program dedicated to observe transits of known exoplanets with the aim of contributing to a better understanding of these planetary systems. In this work we present our first results obtained using the observational facilities in Argentina including the 2.15 telescope at CASLEO.Instituto de Astrofísica de La PlataFacultad de Ciencias Astronómicas y Geofísica

Aplicación de un sistema de información basado en la gestión de los costos aplicados al retail

El siguiente trabajo de investigación propone un medio para que la empresa retail “Susana", la cual no cuenta con ningún tipo de sistema de información costeo, pueda llevar a cabo la gestión de sus costos y obtener una mayor rentabilidad. El objetivo es proponer herramientas que sirvan como sistema de información que le permita a la empresa tener un control de sus costos y ventas, y conocer en qué situación se encuentra actualmente mediante un análisis estratégico. Las empresas retail son aquellas que se dedican a la comercialización y venta minorista en forma directa al consumidor final. Generalmente este tipo de empresas no llevan a cabo una adecuada gestión de sus costos e ingresos, ya que básicamente realizan anotaciones simples o utilizan planillas de Excel almacenando la información en su computadora. El trabajo consiste principalmente en el conocimiento de la empresa retail “Susana", en sus aspectos internos y externos, para poder realizar un análisis estratégico de la misma y diseñar un sistema que se adapte favorablemente a sus características. De esta manera se demostrará que, a través de la aplicación de herramientas, la empresa podrá obtener información que le permita tomar decisiones eficientes y así aumentar su rentabilidad, y mejorar su posición en el mercado.Fil: Fernández, Andrea. Universidad Nacional de Cuyo. Facultad de Ciencias Económicas.Fil: Pisi, Paula. Universidad Nacional de Cuyo. Facultad de Ciencias Económicas.Fil: Turco, Macarena. Universidad Nacional de Cuyo. Facultad de Ciencias Económicas

La diversidad cultural y la formación del pensamiento social en niños y niñas de grado tercero de primaria

En este trabajo se presenta una investigación de carácter educativo que tiene como objetivo interpretar las habilidades del pensamiento social que se desarrollan en una propuesta didáctica de enseñanza y aprendizaje del tema de la diversidad cultural; con el apoyo de videos educativos, a partir de esto surge la siguiente pregunta de investigación: ¿Qué habilidades de pensamiento social se identifican en los procesos de enseñanza y aprendizaje del concepto de diversidad cultural, apoyada por los videos educativos en los estudiantes de grado tercero de la institución educativa Jaime Salazar Robledo?. La investigación está basada en el enfoque interpretativo donde se pretende develar la realidad social y educativa de la enseñanza y aprendizaje de las ciencias sociales, apoyado desde un modelo socio- constructivista, el cual entiende que desde la interacción de los sujetos en los contextos sociales y culturales de la enseñanza y aprendizaje; donde busca ayudar a los estudiantes a transformar la información nueva, esta transformación ocurre a través de la creación de nuevos aprendizajes y esto resulta del surgimiento de nuevas estructuras cognitivas que permiten enfrentarse a situaciones iguales o parecidas en la realidad. El objetivo de la investigación pretende interpretar las habilidades del pensamiento social identificadas en la propuesta didáctica de enseñanza y aprendizaje desde el concepto de diversidad cultural. La estructura metodológica que se emplea es el estudio de caso simple donde se tiene un claro límite físico, social y temporal que confiere la entidad (Yin 2004). Con esto se pretende interpretar las habilidades del pensamiento social que se ejecutan en la planificación de la unidad didáctica y la práctica educativa, ayudado por el video educativo.Según Los resultados obtenidos, el video educativo se convierte en una herramienta tecnológica, para apoyar las problemáticas que explicita el tema de la diversidad cultural y los subtemas que de allí de desprenden como el racismo, el cual es protagonista en la sociedad; donde son incluidas las habilidades del pensamiento social planeadas por el docente. Fueron las habilidades de descripción, explicación, interpretación y argumentación, las cuales tienen particularidades como: la descripción y la explicación son las habilidades más destacadas en el proceso ejecutado, y la interpretación y argumentación son las habilidades que tiene el tercero y cuarto puesto de aparición, siendo estas dos las habilidades menos destacadas en el desempeño de la ejecución.In this work one presents an investigation (research) of educational character that has as aim(lens) interpret the skills of the social thought that develop in a didactic offer of education and learning of the topic of the cultural diversity; with the support of educational videoes, from this the following question of investigation(research) arises: what skills of social thought are identified in the processes of education and learning of the concept of cultural diversity, supported by the educational videoes in the students of third degree of the educational institution Jaime Salazar Robledo?. The investigation(research) is based on the interpretive approach where partner claims develop the social and educational reality of the education and learning of the social sciences, supported from a model - constructivist, who understands that from the interaction of the subjects in the social and cultural contexts of the education and learning; where it(he, she) seeks to help the students to transform the new information, this transformation happens across the creation of new learning’s and this ensues from the emergence of new cognitive structures that allow to face equal or similar situations in the reality. The aim (lens) of the investigation (research) tries to interpret the skills of the social thought identified in the didactic offer of education and learning from the concept of cultural diversity. The methodological structure that is used is the study of simple case where there is had a clear physical, social and temporary limit that awards the entity (yin 2004). With this one tries to interpret the skills of the social thought that are executed in the planning of the didactic unit and the educational practice, helped by the educational video. According to The obtained results, the educational video turns into a technological tool, to support the problematic ones that explicit the topic of the cultural diversity and the sub subjects that of there of detach as the racism, which is a protagonist in the company(society); where there are included the skills of the social thought planned by the teacher. They were the skills of description, explanation, interpretation and argumentation, which have particularities as (like): the description and the explanation are the skills most emphasized in the executed process, and the interpretation and argumentation are the skills that there has the third and fourth position (place) of appearance, being these two the skills least emphasized in the performance(discharge) of the execution

MemoMarote: a working memory training game

Mate Marote is a flexible framework for large-scale educational interventions that include games developed, based on aspects from cognitive sciences as an effective way of learning. MemoMarote is a computer game designed for training working memory. The pilot study of this platform was an intervention in La Rioja province (Argentina). In this article we analyze the registered statistics of use of the unsupervised version of the game. We found that playing activity had a peak when recently installed, decreasing during the first year and observing an increase when starting school classes in 2013. Analyzing the usage statistics we observed that players have a poor performance, with more incorrect answers than correct ones. These results suggest that children did not read instructions or they were not understood, and so they played the game incorrectly. We plan the creation of an interactive tutorial to increase the understanding of the game.Sociedad Argentina de Informática e Investigación Operativ

MemoMarote: a working memory training game

Mate Marote is a flexible framework for large-scale educational interventions that include games developed, based on aspects from cognitive sciences as an effective way of learning. MemoMarote is a computer game designed for training working memory. The pilot study of this platform was an intervention in La Rioja province (Argentina). In this article we analyze the registered statistics of use of the unsupervised version of the game. We found that playing activity had a peak when recently installed, decreasing during the first year and observing an increase when starting school classes in 2013. Analyzing the usage statistics we observed that players have a poor performance, with more incorrect answers than correct ones. These results suggest that children did not read instructions or they were not understood, and so they played the game incorrectly. We plan the creation of an interactive tutorial to increase the understanding of the game.Sociedad Argentina de Informática e Investigación Operativ

MemoMarote: a working memory training game

Mate Marote is a flexible framework for large-scale educational interventions that include games developed, based on aspects from cognitive sciences as an effective way of learning. MemoMarote is a computer game designed for training working memory. The pilot study of this platform was an intervention in La Rioja province (Argentina). In this article we analyze the registered statistics of use of the unsupervised version of the game. We found that playing activity had a peak when recently installed, decreasing during the first year and observing an increase when starting school classes in 2013. Analyzing the usage statistics we observed that players have a poor performance, with more incorrect answers than correct ones. These results suggest that children did not read instructions or they were not understood, and so they played the game incorrectly. We plan the creation of an interactive tutorial to increase the understanding of the game.Sociedad Argentina de Informática e Investigación Operativ

Intra-host dynamics and co-receptor usage of HIV-1 quasi-species in vertically infected patients with phenotypic switch

HIV-1 infection through vertical transmission provides a good model to evaluate intra-host viral evolution and allows to gain insight into the dynamics of viral populations. Our aim was to assess the diversity and dynamics of X4- and R5-using HIV-1 variants in vertically infected children who presented a switch in SI/ NSI phenotype in MT-2 cell assays during chronic infection. Through molecular cloning and next generation sequencing of the C2-V5 env fragment, we investigated HIV-1 evolution and co-receptor usage based on V3 loop prediction bioinformatic tools of longitudinal samples obtained from 4 children. In all cases, the phylogenetic relationships were assessed by Maximum-Likelihood trees constructed with MEGA 6.0. In two cases, V3 loop sequences predicted exclusively R5-using and or X4-using strains, while in another two a higher degree of concordance was observed between the phenotypic and genotypic characteristics. In 3 of the 4 cases, C2-V5 env sequences from different time points were intermingled in phylogenetic trees, with no segregation neither by time or tropism. In only one case monophyletic clustering defined groups of sequences with different co-receptor usage. Comparison of amino acid frequency between isolates with SI and NSI phenotype allowed the identification of 9 possible genetic determinants in subtype F C2-V5 region of env associated to SI/ NSI phenotype in these patients, one of which had previously been reported for subtype B. Overall, we found a low degree of correlation between phenotypic and genotypic properties of HIV-1 quasispecies in patients under chronic infection. Whether HIV-1 subtype or other factors influence the evolution of HIV-1 in vivo will require further research.Fil: Fernández, María Florencia. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Distefano, Maximiliano Ezequiel. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; ArgentinaFil: Mangano, Andrea María Mercedes. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Sen, Luisa. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Aulicino, Paula. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin

Tecnologia e Extensão Universitária: os Sistemas de Alerta Precoce Colaborativos na gestão do risco de inundação

En la cuenca del arroyo Sauce Corto la ocurrencia de eventos hidrometeorológicos extremos genera crecidas que provocan inundaciones. Los Sistemas de Alerta Temprana Colaborativos son herramientas que contribuyen a la prevención de desastres y a la preparación ante peligros. Se exponen las experiencias y resultados de la interacción entre tecnología y extensión en el marco del proyecto: Inundaciones: ¿qué podemos hacer? Las tecnologías colaborativas en la gestión del riesgo. Se desarrolló e implementó la aplicación móvil InundApp que permite a los ciudadanos informar un evento hidrometeorológico y los elementos afectados en su entorno inmediato. Se contribuyó con la instauración y difusión efectiva de una herramienta de gestión reactiva que incorpora la cultura de la prevención en la vida cotidiana de la cuenca del arroyo Sauce Corto.In the Sauce Corto basin extreme hydro–meteorological events causes flooding. Early Alert Collaborative Systems contributes to disasters dangers and threats prevention and preparedness. The experiences and results of the interaction between technology and extension whithin the university extension project: Inundaciones: ¿qué podemos hacer? Las tecnologías colaborativas en la gestión del riesgo. The development and implementation of the InundApp mobile application allows citizens to report a hydrometeorological event as well as the the affected elements in their immediate environment. As a result, a reactive management tool was established which helps to incorporate prevention culture in daily life of the Sauce Corto river basin.Na bacia do arroio Sauce Corto a ocorrência de eventos hidrometeorológicos extremos gera crescidas que provocam inundações. Os Sistemas de Alerta Precoce Colaborativos (SATC, em espanhol) são ferramentas que contribuem para a prevenção de desastres e para a organização em face de perigos. As experiências e os resultados da interação entre tecnologia e extensão se expõem no marco do projeto: Inundaciones: ¿qué podemos hacer? Las tecnologías colaborativas en la gestión del riesgo. Para isso, foi desenvolvido e implementado o aplicativo móvel InundApp que permite os cidadãos informarem um evento hidrometeorológico e os elementos afetados no seu ambiente imediato. Assim se contribuiu com a instituição e difusão efetiva de uma ferramenta de administração reativa que incorpora a cultura da prevenção no cotidiano da bacia do arroio Sauce Corto.Fil: Gentili, Jorge Osvaldo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca; Argentina. Universidad Nacional del Sur; ArgentinaFil: Fernández, María Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca; Argentina. Universidad Nacional del Sur; ArgentinaFil: Zapperi, Paula Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca; Argentina. Universidad Nacional del Sur; ArgentinaFil: Silva, Andrea Marcela. Universidad Nacional del Sur; Argentin