Massimo Donà, Misterio grande. Filosofia di Giacomo Leopardi

Massimo Donà, Misterio grande. Filosofia di Giacomo Leopardi. Milà: Bompiani, 2013, 316 pp

"La Querelle des anciens et des moderns": Leopardi i la via perduda del romanticisme alemany

El marc interpretatiu d’aquest article parteix de l’establiment de dos bàndols filosòfics: per una banda, Goethe i Leopardi, en tant que respectuosos amb el límit de la natura, i per l’altra, els romàntics i l’idealisme absolut de Hegel, en tant que irrespectuosos amb els límits de la natura. El salt teòric a partir del qual gira aquest article, consisteix a estendre l’enfrontament explícit que Giacomo Leopardi va mantenir contra el romanticisme vers l’idealisme absolut de Hegel. I és que hom es planteja el fet que ambdós moviments van en contra de la veritat en tant que revelació. La veritat leopardiana es revela mitjançant la imaginació o les il•lusions, la qual cosa el porta a depassar el conflicte entre els anciens i els modernes en tant que models. I és que no hi pot haver models perquè la veritat no és pas un objecte

Identification of candidate Parkinson disease genes by integrating genome-wide association study, expression, and epigenetic data sets

Importance Substantial genome-wide association study (GWAS) work in Parkinson disease (PD) has led to the discovery of an increasing number of loci shown reliably to be associated with increased risk of disease. Improved understanding of the underlying genes and mechanisms at these loci will be key to understanding the pathogenesis of PD. Objective To investigate what genes and genomic processes underlie the risk of sporadic PD. Design and Setting This genetic association study used the bioinformatic tools Coloc and transcriptome-wide association study (TWAS) to integrate PD case-control GWAS data published in 2017 with expression data (from Braineac, the Genotype-Tissue Expression [GTEx], and CommonMind) and methylation data (derived from UK Parkinson brain samples) to uncover putative gene expression and splicing mechanisms associated with PD GWAS signals. Candidate genes were further characterized using cell-type specificity, weighted gene coexpression networks, and weighted protein-protein interaction networks. Main Outcomes and Measures It was hypothesized a priori that some genes underlying PD loci would alter PD risk through changes to expression, splicing, or methylation. Candidate genes are presented whose change in expression, splicing, or methylation are associated with risk of PD as well as the functional pathways and cell types in which these genes have an important role. Results Gene-level analysis of expression revealed 5 genes (WDR6 [OMIM 606031], CD38 [OMIM 107270], GPNMB [OMIM 604368], RAB29 [OMIM 603949], and TMEM163 [OMIM 618978]) that replicated using both Coloc and TWAS analyses in both the GTEx and Braineac expression data sets. A further 6 genes (ZRANB3 [OMIM 615655], PCGF3 [OMIM 617543], NEK1 [OMIM 604588], NUPL2 [NCBI 11097], GALC [OMIM 606890], and CTSB [OMIM 116810]) showed evidence of disease-associated splicing effects. Cell-type specificity analysis revealed that gene expression was overall more prevalent in glial cell types compared with neurons. The weighted gene coexpression performed on the GTEx data set showed that NUPL2 is a key gene in 3 modules implicated in catabolic processes associated with protein ubiquitination and in the ubiquitin-dependent protein catabolic process in the nucleus accumbens, caudate, and putamen. TMEM163 and ZRANB3 were both important in modules in the frontal cortex and caudate, respectively, indicating regulation of signaling and cell communication. Protein interactor analysis and simulations using random networks demonstrated that the candidate genes interact significantly more with known mendelian PD and parkinsonism proteins than would be expected by chance. Conclusions and Relevance Together, these results suggest that several candidate genes and pathways are associated with the findings observed in PD GWAS studies

Sobre Emilio Russo, Ridere del mondo. La lezione di Leopardi.

Ressenya del llibre de Emilio Russo, Ridere del mondo. La lezione di Leopardi. Bolonya: Il Mulino, 2017

Enhancing Mixing During Groundwater Remediation via Engineered Injection‐Extraction: The Issue of Connectivity

International audienceIn the context of in-situ groundwater remediation, mixing is vital for a successful outcome. A slow mixing rate between the contaminated groundwater and the injected treatment solution can severely weaken the effective degradation rate. Engineered Injection-Extraction (EIE) has been proposed as a means to accelerate dilution within the porous medium. However, existing studies on the subject have not considered the potential impact of connectivity and preferential flow-paths. Neglecting connectivity can lead to an overestimation of EIE’s capabilities, since the fluid may in reality be carried mainly through a few high-permeability channels, thus hampering mixing and reaction. Due to the fact that channeling can be found in many actual sites, in this work we aim to evaluate EIE methods in both poorly-connected (represented as Multigaussian fields) and well-connected fields (represented as non-Multigaussians). The approach is to identify, for each given medium, a stirring protocol – defined by a specific combination of rotation angle and rotation rate – which maximizes mixing. To that end, metrics are proposed in order to (1) quantify both the mixing and the containment of the treatment solution within a given remediation volume, and (2) characterize the particle trajectories to explicitly evaluate if preferential paths are broken. The results obtained from these metrics are quite similar for both types of fields, proving that the enhancing of mixing by means of EIE is effective regardless of the presence of preferential flow paths. This study demonstrates that EIE via rotating dipoles diminishes the remediation outcome uncertainty induced by medium heterogeneity

Mobilitat activa en entorns metropolitans : Bases per al planejament i gestió de la mobilitat activa a la Ribera Baixa

Projecte troncal del curs 2023/24 del Màster Universitari en Estudis Territorials i Planejament, METiPEl document s'estructura en quatre capítols més un apèndix. El primer capítol comprèn la Memòria on s'hi pot trobar el Reconeixement Territorial i socioeconòmic i la Diagnosi. El segon capítol comprèn les Debilitats, Fortaleses, Amenaces i Oportunitats de cada dimensió de la política integral de la mobilitat en l'àmbit d'estudi. El tercer capítol es dedica a l'establiment dels Criteris que hauran de guiar les polítiques de mobilitat activa. En el quart i darrer capítol es presenten les Propostes i Projectes de cada dimensió per al territori de la Ribera Baixa. Finalment a l'apèndix hi trobareu el quadernet de treball de camp amb la planificació detallada de l'exercici troncal i els pòsters amb el recull dels principals resultats de l'exercici