218 research outputs found
THE JOYCE-KATEB LITERARY CONNECTION AND ELIOTâS MYTHIC METHOD
This research seeks to read James Joyceâs Ulysses through Algerian eyes, with focus on its comparison with Yacine Katebâs Nedjma (1956). Taking its theoretical bearings from postcolonial historicism and dialogism, it makes the case that reading Joyceâs Ulysses from the comparative perspective of the Algerian francophone writerâs Nedjma helps shed light on the manner the Irish author deploys Irish vernacular culture, most particularly carnival or folklore, to undermine the presumably âmythic methodâ associated with his name since Eliot has employed this famous catchy phrase in 1923.Keywords: Kateb, Joyce, Eliot, postcolonialism, literary myth, history, Carnival
Gestion pĂ©ri opĂ©ratoire dâun paragangliome rĂ©tro-pĂ©ritonĂ©al
Nous rapportons l'observation d'un patient ùgé de 62 ans qui présente des douleurs abdominales avec une masse du flanc droit. Les explorations morphologiques ainsi que les données biologiques ont permis de faire le diagnostic d'un paragangliome secrétant. Les particularités diagnostiques ainsi que la gestion périopératoire sont envisagées
Thirteen-Year Disease-Free Survival after Surgery for Cystic Duct Carcinoma: A Case Report
Cystic duct carcinoma is known to have a better prognosis compared to its location in other biliary ducts. Only one case with a survival over ten years has been previously published. The authors report a case of survival over 13 years without recurrence or metastasis. Preoperative diagnosis of cystic duct tumor was carried in a 66-year-old male. Under the diagnosis of carcinoma of the cystic duct, the patient underwent en bloc resection of the gallbladder, cystic duct, hepaticocholedochus and lymph node dissection. A Roux-en-Y hepaticojejunostomy was performed. Histological examination revealed a moderately differentiated adenocarcinoma of the cystic duct. Five months later the patient underwent second look surgery for benign obstruction of the hepaticojejunal anastomosis. The patient is still doing well 13 years later without any local recurrence or metastasis. To our knowledge, this is the longest disease-free survival ever published in the literature. This case sustains that better and longer survival is possible with a real chance of potential cure if radical surgery is performed
Basin tectonic history and paleo-physiography of the pelagian platform, northern Tunisia, using vitrinite reflectance data
Constraining the thermal, burial and uplift/exhumation history of sedimentary basins is crucial in the understanding of upper crustal strain evolution and also has implications for understanding the nature and timing of hydrocarbon maturation and migration. In this study, we use Vitrinite Reflectance (VR) data to elucidate the paleoâphysiography and thermal history of an inverted basin in the foreland of the Atlasic orogeny in Northern Tunisia. In doing so, it is the primary aim of this study to demonstrate how VR techniques may be applied to unravel basin subsidence/uplift history of structural domains and provide valuable insights into the kinematic evolution of sedimentary basins. VR measurements of both the onshore Pelagian Platform and the Tunisian Furrow in Northern Tunisia are used to impose constraints on the deformation history of a longâlived structural feature in the studied region, namely the Zaghouan Fault. Previous work has shown that this fault was active as an extensional structure in Lower Jurassic to Aptian times, before subsequently being inverted during the Late Cretaceous Eocene Atlas I tectonic event and Upper Miocene Atlas II tectonic event. Quantifying and constraining this latter inversion stage, and shedding light on the roles of structural inheritance and the basin thermal history, are secondary aims of this study. The results of this study show that the Atlas II WNWâESE compressive event deformed both the Pelagian Platform and the Tunisian Furrow during TortonianâMessinian times. Maximum burial depth for the Pelagian Platform was reached during the Middle to Upper Miocene, i.e. prior to the Atlas II folding event. VR measurements indicate that the Cretaceous to Ypresian section of the Pelagian Platform was buried to a maximum burial depth of ~3 km, using a geothermal gradient of 30°C/km. Cretaceous rock samples VR values show that the hanging wall of the Zaghouan Fault was buried to a maximum depth of <2 km. This suggests that a vertical kmâscale throw along the Zaghouan Fault preâdated the Atlas II shortening, and also proves that the fault controlled the subsidence of the Pelagian Platform during the OligoâMiocene. Mean exhumation rates of the Pelagian Platform throughout the Messinian to Quaternary were in the order of 0.3 mm/year. However, when the additional effect of TortonianâMessinian folding is accounted for, exhumation rates could have reached 0.6-0.7 mm/year
Characterisation of the biflavonoid hinokiflavone as a premRNA splicing modulator that inhibits SENP
We have identified the plant biflavonoid hinokiflavone as an inhibitor of splicing in vitro and modulator of alternative splicing in cells. Chemical synthesis confirms hinokiflavone is the active molecule. Hinokiflavone inhibits splicing in vitro by blocking spliceosome assembly, leading to accumulation of the A complex. Cells treated with hinokiflavone show altered subnuclear organization specifically of splicing factors required for A complex formation, which relocalize together with SUMO1 and SUMO2 into enlarged nuclear speckles. Hinokiflavone increases protein SUMOylation levels, both in in vitro splicing reactions and in cells. Hinokiflavone also inhibited a purified, E. coli expressed SUMO protease, SENP1, in vitro, indicating the increase in SUMOylated proteins results primarily from inhibition of de-SUMOylation. Using a quantitative proteomics assay we identified many SUMO2 sites whose levels increased in cells following hinokiflavone treatment, with the major targets including 6 proteins that are components of the U2 snRNP and required for A complex formation
RĂ©sultats prĂ©liminaires de la valvulation pulmonaire par bioprothĂšse. ExpĂ©rience de lâHEGP, Paris : Ă propos de 20 cas
Le Remplacement valvulaire pulmonaire (RVP) est frĂ©quent dans le suivi de nombreuses cardiopathies congĂ©nitales Ă lâĂąge adulte. Lâindication et le moment de cette intervention ont suscitĂ© un intĂ©rĂȘt particulier mais font toujours lâobjet de controverses.
OBJECTIF : Etude des résultats préliminaires à court et à moyen terme du RVP par bioprothÚse péricardique.
MATERIEL ET METHODES : Il sâagit dâune Ă©tude rĂ©trospective menĂ©e dans le service de chirurgie cardiovasculaire Ă lâHEGP (Paris) entre Juillet 2005 et Juillet 2009, ayant inclus 20 patients de 35 ± 13 ans dâĂąge moyen, sans prĂ©dominance de sexe, tous opĂ©rĂ©s dâun RVP au cours du suivi de leur cardiopathie congĂ©nitale.
RESULTATS :
LâĂąge moyen au moment de la cure complĂšte Ă©tait de 11 ans. Le dĂ©lai moyen entre celle-ci et le RVP est de 32 ± 9 ans. 15 patients avaient une TĂ©tralogie de Fallot, dont 12 ont bĂ©nĂ©ficiĂ© dâune cure complĂšte dans lâenfance. 7 patients Ă©taient au stade I, 10 au stade II, et 3 au stade III ou IV de la NYHA. A lâECG, 19 patients Ă©taient en rythme sinusal, 1 patient en ACFA. 16 patients avaient un BBD, complet chez 10 patients. A lâETT prĂ©opĂ©ratoire, la moyenne des paramĂštres Ă©tait comme suit : FEVD=43 ± 8 %, gradient max VD-AP=43 mmHg, FEVG=58 ± 7 %. En outre, le VD Ă©tait dilatĂ© chez 18 patients, il y avait une IT modĂ©rĂ©e chez 4 patients, une IAo minime Ă modĂ©rĂ©e chez 9 patients, une IM minime Ă modĂ©rĂ©e chez 3 patients et une CIV rĂ©siduelle chez 2 patients. A lâIRM, le VTDVDi=194 ± 51 ml/mÂČ, le VTSVDi=107 ± 48 ml/mÂČ, la Fraction de rĂ©gurgitation(FR) = 52 ± 27 %, la FEVD=36 ± 13 %, la FEVG=54 ± 19 %. La TDM rĂ©alisĂ©e chez 3 patients a trouvĂ© un DTD VD moyen Ă 123 ml. La VO2 max Ă©tait en moyenne de 25 ± 6 ml/kg/min. Le BNP dosĂ© chez 6 patients et a Ă©tĂ© en moyenne de 38 ± 14 pg/ml. 5 patients ont Ă©tĂ© opĂ©rĂ©s sous CEC Ă cĆur battant et 15 avec cardioplĂ©gie. Le substitut valvulaire Ă©tait une bioprothĂšse pĂ©ricardique bovine. Les gestes associĂ©s comprenaient,13 patchs dâĂ©largissement pĂ©ricardiques, 8 tubes VD-AP, 3 cures complĂštes de T4F, 1 RVAo, 3 RVT et 1 cas de cryothĂ©rapie.
La mortalité opératoire est de 10%(2 patientes) ; A 3 mois en moyenne (n=15), 14 étaient asymptomatiques. 7 patients sont passés du stade II, III ou IV au stade I de la NYHA
A 10 mois en moyenne (n=10), 8 patients Ă©taient asymptomatiques et 2 au stade III de la NYHA et lâETT a montrĂ© une amĂ©lioration des dimensions du VD chez 6 patients. Par ailleurs, le gradient maximal VD-AP est passĂ© Ă 30 ± 11 mmHg.
LâIRM a montrĂ©, Ă 8 mois en moyenne, un VTDVDi Ă 126 ± 54 ml/m2, un VTSVDi de 107 ± 48 ml/mÂČ, une fraction de rĂ©gurgitation au niveau de lâAP Ă 16 ± 11% et une FEVD Ă 34 ± 9%.
CONCLUSION : Les résultats du RVP sur la symptomatologie et la fonction ventriculaire droite sont bons, à court et à moyen terme, à conditions que les indications et le timing opératoire soient respectés
Les Trara (ouest algérien), espace d'émigration
Ferhi Salah. Les Trara (ouest algérien), espace d'émigration. In: Méditerranée, tome 76, 3-4-1992. pp. 63-66
- âŠ