Detection of Intergalactic Red-Giant-Branch Stars in the Virgo Cluster

It has been suspected for nearly 50 years that clusters of galaxies contain a population of intergalactic stars, ripped from galaxies during cluster formation or when the galaxies’ orbits take them through the cluster center. Support for the existence of such a population of free-floating stars comes from measurements of the diffuse light in clusters and from recent detections of planetary nebulae with positions and/or velocities far removed from any observed cluster galaxy. 10 , 11 But estimates for the mass of the diffuse population and its distribution relative to the galaxies are still highly uncertain. Here we report the direct detection of intergalactic stars in deep images of a blank field in the Virgo Cluster. The data suggest that approximately 10% of the stellar mass of the cluster is in intergalactic stars. We observe a relatively homogeneous distribution of stars, with evidence of a slight gradient toward M87

Intergalactic Globular Clusters

We confirm and extend our previous detection of a population of intergalactic globular clusters in Abell 1185, and report the first discovery of an intergalactic globular cluster in the nearby Virgo cluster of galaxies. The numbers, colors and luminosities of these objects can place constraints on their origin, which in turn may yield new insights to the evolution of galaxies in dense environments.Comment: 2 pages, no figures. Talk presented at JD6, IAU General Assembly XXV, Sydney, Australia, July 2003, to appear in Highlights of Astronomy, Vol. 1

The Pine Needle, vol 5, no 3 (aka Scare)

Libraries and archives collect materials from different cultures and time periods to preserve and make available the historical record. As a result, materials such as those presented here may reflect sexist, misogynistic, abusive, racist, or discriminatory attitudes or actions that some may find disturbing, harmful, or difficult to view. Both a humor and literary magazine, The Pine Needle was a University of Maine student periodical that began publication in the fall of 1946, the first post-World War II semester that saw GIs returning to campus. Unlike past UMaine student publications, The Needle celebrated the sexualization of co-eds and the use of drugs, tobacco, and alcohol by students. Outrage expressed by older alumni resulted stricter oversight of the magazine beginning in 1947. By 1949, the first wave of World War II GI\u27s were graduating and the restless, rebellious tone of The Needle began to shift as the threat of the Korean War loomed. The The Pine Needle for spring 1951 is a parody issue titled Scare. Mrs. Fleur Cowles, editor of the short-lived but celebrated magazine Flair, is acknowledged as an inspiration. The cover illustration is a pen-and-ink drawing of a magnifying glass, the center of which is a die-cut hole. A glimpse of the page-two illustration appears to be the shapely outline of a nude woman\u27s torso. Opening the magazine reveals the distorted drawing of a basset hound by Len Keenan

Dynamic Health Policies for Controlling the Spread of Emerging Infections: Influenza as an Example

The recent appearance and spread of novel infectious pathogens provide motivation for using models as tools to guide public health decision-making. Here we describe a modeling approach for developing dynamic health policies that allow for adaptive decision-making as new data become available during an epidemic. In contrast to static health policies which have generally been selected by comparing the performance of a limited number of pre-determined sequences of interventions within simulation or mathematical models, dynamic health policies produce “real-time” recommendations for the choice of the best current intervention based on the observable state of the epidemic. Using cumulative real-time data for disease spread coupled with current information about resource availability, these policies provide recommendations for interventions that optimally utilize available resources to preserve the overall health of the population. We illustrate the design and implementation of a dynamic health policy for the control of a novel strain of influenza, where we assume that two types of intervention may be available during the epidemic: (1) vaccines and antiviral drugs, and (2) transmission reducing measures, such as social distancing or mask use, that may be turned “on” or “off” repeatedly during the course of epidemic. In this example, the optimal dynamic health policy maximizes the overall population's health during the epidemic by specifying at any point of time, based on observable conditions, (1) the number of individuals to vaccinate if vaccines are available, and (2) whether the transmission-reducing intervention should be either employed or removed

Chronologically dating the early assembly of the Milky Way

The standard cosmological model predicts that galaxies are built through hierarchical assembly on cosmological timescales1,2. The Milky Way, like other disk galaxies, underwent violent mergers and accretion of small satellite galaxies in its early history. Owing to Gaia Data Release 23 and spectroscopic surveys4, the stellar remnants of such mergers have been identified5,6,7. The chronological dating of such events is crucial to uncover the formation and evolution of the Galaxy at high redshift, but it has so far been challenging due to difficulties in obtaining precise ages for these oldest stars. Here we combine asteroseismology—the study of stellar oscillations—with kinematics and chemical abundances to estimate precise stellar ages (~11%) for a sample of stars observed by the Kepler space mission8. Crucially, this sample includes not only some of the oldest stars that were formed inside the Galaxy but also stars formed externally and subsequently accreted onto the Milky Way. Leveraging this resolution in age, we provide compelling evidence in favour of models in which the Galaxy had already formed a substantial population of its stars (which now reside mainly in its thick disk) before the infall of the satellite galaxy Gaia-Enceladus/Sausage5,6 around 10 billion years ago

Virgo's Intracluster Globular Clusters as Seen by the Advanced Camera for Surveys

We report the discovery of 4 candidate intracluster globular clusters (IGCs) in a single deep HST ACS field of the Virgo Cluster. We show that each cluster is roughly spherical, has a magnitude near the peak of the Virgo globular cluster luminosity function, has a radial profile that is best-fit by a King model, and is surrounded by an excess of point sources which have the colors and magnitudes of cluster red giant stars. Despite the fact that two of our IGC candidates have integrated colors redder than the mean of the M87 globular cluster system, we propose that all of the objects are metal-poor with [M/H] < -1. We show that the tidal radii of our intracluster globulars are all larger than the mean for Milky Way clusters, and suggest that the clusters have undergone less tidal stress than their Galactic counterparts. Finally, we normalize our globular cluster observations to the luminosity of intracluster stars, and derive a value of S_N ~ 6 for the specific frequency of Virgo intracluster globular clusters. We use these data to constrain the origins of Virgo's intracluster population, and suggest that globular clusters in our intracluster field have a different origin than globular clusters in the vicinity of M87. In particular, we argue that dwarf elliptical galaxies may be an important source of intracluster stars.Comment: 24 pages, 1 table, 5 figures, accepted for publication in Ap

Changes in Mouse Thymus and Spleen after Return from the STS-135 Mission in Space

Our previous results with flight (FLT) mice showed abnormalities in thymuses and spleens that have potential to compromise immune defense mechanisms. In this study, the organs were further evaluated in C57BL/6 mice after Space Shuttle Atlantis returned from a 13-day mission. Thymuses and spleens were harvested from FLT mice and ground controls housed in similar animal enclosure modules (AEM). Organ and body mass, DNA fragmentation and expression of genes related to T cells and cancer were determined. Although significance was not obtained for thymus mass, DNA fragmentation was greater in the FLT group (P<0.01). Spleen mass alone and relative to body mass was significantly decreased in FLT mice (P<0.05). In FLT thymuses, 6/84 T cell-related genes were affected versus the AEM control group (P<0.05; up: IL10, Il18bp, Il18r1, Spp1; down: Ccl7, IL6); 15/84 cancer-related genes had altered expression (P<0.05; up: Casp8, FGFR2, Figf, Hgf, IGF1, Itga4, Ncam1, Pdgfa, Pik3r1, Serpinb2, Sykb; down: Cdc25a, E2F1, Mmp9, Myc). In the spleen, 8/84 cancer-related genes were affected in FLT mice compared to AEM controls (P<0.05; up: Cdkn2a; down: Birc5, Casp8, Ctnnb1, Map2k1, Mdm2, NFkB1, Pdgfa). Pathway analysis (apoptosis signaling and checkpoint regulation) was used to map relationships among the cancer–related genes. The results showed that a relatively short mission in space had a significant impact on both organs. The findings also indicate that immune system aberrations due to stressors associated with space travel should be included when estimating risk for pathologies such as cancer and infection and in designing appropriate countermeasures. Although this was the historic last flight of NASA’s Space Shuttle Program, exploration of space will undoubtedly continue

Detection of intergalactic red-giant-branch stars in the Virgo cluster

It has been suspected for nearly 50 years that clusters of galaxies contain a population of intergalactic stars, ripped from galaxies during cluster formation or when the galaxies' orbits take them through the cluster center. Support for the existence of such a population of free-floating stars comes from measurements of the diffuse light in clusters, and from recent detections of planetary nebulae with positions and/or velocities far removed from any observed cluster galaxy. But estimates for the mass of the diffuse population and its distribution relative to the galaxies are still highly uncertain. Here we report the direct detection of intergalactic stars in deep images of a blank field in the Virgo Cluster. The data suggest that approximately 10% of the stellar mass of the cluster is in intergalactic stars. We observe a relatively homogeneous distribution of stars, with evidence of a slight gradient toward M87.Comment: Accepted for publication in Nature. 10 pages, 2 postscript figures included. Uses nature.sty and astrobib.sty. (Astrobib is available from http://www.stsci.edu/software/TeX.html.

Spaceflight Activates Lipotoxic Pathways in Mouse Liver

Spaceflight affects numerous organ systems in the body, leading to metabolic dysfunction that may have long-term consequences. Microgravity-induced alterations in liver metabolism, particularly with respect to lipids, remain largely unexplored. Here we utilize a novel systems biology approach, combining metabolomics and transcriptomics with advanced Raman microscopy, to investigate altered hepatic lipid metabolism in mice following short duration spaceflight. Mice flown aboard Space Transportation System -135, the last Shuttle mission, lose weight but redistribute lipids, particularly to the liver. Intriguingly, spaceflight mice lose retinol from lipid droplets. Both mRNA and metabolite changes suggest the retinol loss is linked to activation of PPARα-mediated pathways and potentially to hepatic stellate cell activation, both of which may be coincident with increased bile acids and early signs of liver injury. Although the 13-day flight duration is too short for frank fibrosis to develop, the retinol loss plus changes in markers of extracellular matrix remodeling raise the concern that longer duration exposure to the space environment may result in progressive liver damage, increasing the risk for nonalcoholic fatty liver disease