349 research outputs found
An Investigation of Three Approaches to Vocabulary Learning in High School Spanish Classes
Three vocabulary learning approaches -- rote memorization; Cover, Copy, Compare (CCC); and Cover, Copy, Compare Adapted with picture (CCCA) – were examined for effectiveness in promoting long-term memory retention for productive vocabulary in foreign language learning. Pretest, posttest, and delayed posttest data were collected using Conjuguemos, an on-line Spanish program. Results indicated a significant increase in mean scores with each assessment for all treatments; however, there was no significant difference in recall among the three learning approaches. Students were also surveyed about their preferences in approaches. Although survey responses indicated a preference for CCC, most students reported abandoning use of this method after six months
Leveraging food-based recommendations for women and children in Nairobi slums with animal source foods
Correlation Between Caregiver Reports of Physical Function and Performance-based Measures in a Cohort of Older Adults With Alzheimer Disease
The objectives of this report are to determine the association between performance-based measures of physical function with caregiver reports of physical function in older adults with Alzheimer disease (AD) and to examine whether those associations vary by the level of patients' cognitive functioning. Subjects included 180 patient-caregiver dyads who are enrolled in a clinical trial testing the impact of an occupational therapy intervention plus guideline-level care to delay functional decline among older adults with AD. The primary caregiver-reported measure is the Alzheimer's Disease Cooperative Study Group Activities of Daily Living Inventory (ADCS-ADL). Performance-based measures include the Short Physical Performance Battery and the Short Portable Sarcopenia Measure. Analysis of covariance (ANCOVA) models were used to determine the associations of each physical performance measure with ADCS-ADL, adjusting for cognition function and other covariates. We found significant correlations between caregiver reports and observed performance-based measures across all levels of cognitive function, with patients in the lowest cognitive group showing the highest correlation. These findings support the use of proxy reports to assess physical function among older adults with AD
Targeting Functional Decline: Results from the Alzheimer’s Disease Multiple Intervention Trial
Background
Alzheimer’s disease (AD) results in progressive functional decline leading to loss of independence
Objective
To determine whether collaborative care plus two years of home-based occupational therapy delays functional decline
Design
Randomized controlled clinical trial
Setting
Urban public health system
Patients
180 community-dwelling subjects who were diagnosed with AD and their informal caregivers
Interventions
All subjects received collaborative care for dementia. Intervention patients also received in-home occupational therapy delivered in 24 sessions over 2 years.
Measurements
The primary outcome measures was the Alzheimer’s Disease Cooperative Studies Group Activities of Daily Living Scale (ADCS ADL); performance based measures included the Short Physical Performance Battery (SPPB) and Short Portable Sarcopenia Measure (SPSM)
Results
At baseline, there were no significant between group differences in clinical characteristics; the mean MMSE for both groups was 19 (SD=7). The intervention group received a median of 18 home visits from the study occupational therapists. Both groups declined in ADCS ADL scores over 24 months. At the primary endpoint of 24 months, there were no between group differences in ADCS ADL scores (mean difference 2.34, 95% CI −5.27, 9.96). We were also unable to definitively demonstrate between-group differences in the mean SPPB or SPSM.
Limitations
The results of this trial are indeterminate and do not rule out potentially clinically important effects of the intervention.
Conclusions
We were unable to definitively demonstrate whether the addition of two years of in-home occupational therapy to a collaborative care management model slows the rate of functional decline among persons with AD. This trial underscores the burden undertaken by family caregivers as they provide care for persons with AD and the difficulty in slowing functional decline
Beluga whales in the western Beaufort Sea : current state of knowledge on timing, distribution, habitat use and environmental drivers
ECG was supported by a National Research Council-National Academy of Sciences Postdoctoral Fellowship.The seasonal and geographic patterns in the distribution, residency, and density of two populations (Chukchi and Beaufort) of beluga whales (Delphinapterus leucas) were examined using data from aerial surveys, passive acoustic recordings, and satellite telemetry to better understand this arctic species in the oceanographically complex and changing western Beaufort Sea. An aerial survey data-based model of beluga density highlights the Beaufort Sea slope as important habitat for belugas, with westerly regions becoming more important as summer progresses into fall. The Barrow Canyon region always had the highest relative densities of belugas from July-October. Passive acoustic data showed that beluga whales occupied the Beaufort slope and Beaufort Sea from early April until early November and passed each hydrophone location in three broad pulses during this time. These pulses likely represent the migrations of the two beluga populations: the first pulse in spring being from Beaufort animals, the second spring pulse Chukchi belugas, with the third, fall pulse a combination of both populations. Core-use and home range analyses of satellite-tagged belugas showed similar use of habitats as the aerial survey data, but also showed that it is predominantly the Chukchi population of belugas that uses the western Beaufort, with the exception of September when both populations overlap. Finally, an examination of these beluga datasets in the context of wind-driven changes in the local currents and water masses suggests that belugas are highly capable of adapting to oceanographic changes that may drive the distribution of their prey.PostprintPeer reviewe
Cultivated Vaginal Microbiomes Alter HIV-1 Infection and Antiretroviral Efficacy in Colonized Epithelial Multilayer Cultures
There is a pressing need for modeling of the symbiotic and at times dysbiotic relationship established between bacterial microbiomes and human mucosal surfaces. In particular clinical studies have indicated that the complex vaginal microbiome (VMB) contributes to the protection against sexually-transmitted pathogens including the life-threatening human immunodeficiency virus (HIV-1). The human microbiome project has substantially increased our understanding of the complex bacterial communities in the vagina however, as is the case for most microbiomes, very few of the community member species have been successfully cultivated in the laboratory limiting the types of studies that can be completed. A genetically controlled ex vivo model system is critically needed to study the complex interactions and associated molecular dialog. We present the first vaginal mucosal culture model that supports colonization by both healthy and dysbiotic VMB from vaginal swabs collected from routine gynecological patients. The immortalized vaginal epithelial cells used in the model and VMB cryopreservation methods provide the opportunity to reproducibly create replicates for lab-based evaluations of this important mucosal/bacterial community interface. The culture system also contains HIV-1 susceptible cells allowing us to study the impact of representative microbiomes on replication. Our results show that our culture system supports stable and reproducible colonization by VMB representing distinct community state types and that the selected representatives have significantly different effects on the replication of HIV-1. Further, we show the utility of the system to predict unwanted alterations in efficacy or bacterial community profiles following topical application of a front line antiretroviral
Public Response to Community Mitigation Measures for Pandemic Influenza
Results from a national survey indicated that most persons would follow public health officials’ guidelines
Prevalence of sleep disordered breathing in a population of Canadian grainworkers
OBJECTIVES: To determine the prevalence of sleep disordered breathing (SDB) in a Canadian population of industrial workers (grainworkers). To determine the clinical features that are predictive of SDB and the validity of self-reported snoring. DESIGN: Cross-sectional, interviewer-administered questionnaire with selective recruitment of subjects for home sleep monitoring. SETTING: Community setting, Vancouver, British Columbia. PARTICIPANTS: All male grainworkers at grain elevators in Vancouver were approached for completion of a questionnaire. Eighty-three per cent of 524 subjects completed the questionnaire and were divided by presumed risk for SDB into four groups. All subjects in the highest risk group (group 1-frequent snoring and witnessed apneas) and a random sample of 40 subjects in the other three groups (group 2 -frequent snoring without witnessed apneas; group 3 -infrequent snoring rare; group 4 -nonsnoring) were approached for home sleep monitoring and 42% consented. INTERVENTIONS: Interviewer-administered questionnaire and home sleep monitoring. RESULTS: The overall prevalence of SDB in this relatively overweight group was estimated to be 25%, with a stepwise increase from group 4 to group 1 (7%, 29%, 40%, 60%). Presence of snoring and witnessed apneas, a greater body-mass index and a larger neck circumference were associated with SDB. Self-reported snoring was not found to be predictive. CONCLUSIONS: This first study of the prevalence of SDB in Canada suggests that SDB is at least as prevalent in Canada as in other industrialized nations and may actually be more common than previously thought. Further studies are required to determine the morbidity, mortality and economic loss associated with SDB in industrial workers. Key Words: Home monitoring, Obstructive sleep apnea, Screening, Self-reported snoring, Sleep disordered breathing Prévalence des troubles respiratoires du sommeil dans une population de travailleurs du grain OBJECTIFS : Déterminer la prévalence des troubles respiratoires du sommeil dans une population canadienne de travailleurs de l'industrie du grain. Déterminer les caractéristiques cliniques prédictives des troubles respiratoires du sommeil et la validité du ronflement signalé par les sujets eux-mêmes. MODÈLE : Questionnaire transversal rempli par un intervieweur et recrutement sélectif de sujets pour mener des études du sommeil à domicile. CONTEXTE : Dans la communauté de Vancouver en Colombie-Britannique. PARTICIPANTS : On a demandé à tous les sujets de sexe masculin travaillant dans les silos à grains de répondre à un questionnaire. Quatre-vingt-trois pour cent des 524 sujets ont complété le questionnaire ; ils étaient divisés en quatre groupes selon le risque présumé de troubles respiratoires du sommeil. On a demandé à tous les sujets du groupe à risque le plus élevé (groupe 1 -ronflement fréquent et apnées observées) et un échantillon aléatoire de 40 sujets dans les trois autres groupes (groupe 2 -ronflement fréquent sans apnées observées ; groupe 3 -rare ronflement occasionnel ; groupe 4 -aucun ronflement) de subir des études de sommeil à domicile. Quarante-deux pour cent des sujets ont consenti à subir de telles études. INTERVENTIONS : Questionnaire rempli par un intervieweur et études du sommeil à domicile. RÉSULTATS : La prévalence globale des troubles respiratoires du sommeil dans cette population relativement obèse a été estimée à 25 %, avec une augmentation par paliers du groupe 4 jusqu'au groupe 1 (7 %, 29 %, 40 %, 60 %). Le ronflement et les apnées observées, un index de masse corporelle plus élevé et un tour du cou plus grand étaient associés à des troubles respiratoires du sommeil. voir page suivante S leep disordered breathing (SDB), including obstructive sleep apnea and obstructive sleep hypopnea, is associated with significant mortality (1,2) and morbidity (3). SDB is most common in middle-aged men, but its true prevalence in this group is still being determined. While early studies estimated the prevalence of SDB to be 0.9% and 1.3%, (4,5) more recent studies from the United States and Australia (6-8) have reported prevalence rates of SDB in middle-aged men to be in the range of 10% to 15%. To date there have been no published studies of the prevalence of SDB in Canada. The main objective of this study was to obtain an estimate of the prevalence of SDB in industrial workers, using a population of men working at grain elevators in Vancouver, British Columbia as a model. To achieve this objective we studied subjects with all levels of risk for SDB. A secondary objective was to determine which clinical features and anthropometric data were predictive of SDB. We also examined the relationship between self-reported snoring and recorded snoring. PATIENTS AND METHODS Subjects: The target population was men working in grain terminals. The sample frame, for the purpose of this study, consisted of men working at the grain terminals in the Vancouver area. Questionnaire administration: Subjects completed a questionnaire administered by trained interviewers that included questions concerning demographic data, sleep disturbance (snoring, witnessed apneas, daytime sleepiness), smoking history and included the American Thoracic Society Respiratory Disease Questionnaire (9). All subjects had their height, weight, blood pressure and neck circumference measured. The subjects were divided into four groups based on the reported presence of snoring and witnessed apneas: group 1, frequent snoring and witnessed apneas; group 2, frequent snoring without witnessed apneas; group 3, infrequent snoring or rare; group 4, nonsnoring. All subjects in group 1 and a random sample of 40 subjects in groups 2 to 4 were approached about overnight home sleep monitoring. Subjects who consented formed the sample population for determining SDB prevalence. Home sleep monitoring: Home sleep was monitored using the Mesam 4 (Madaus Medizin Elektronik, Freiburg, Germany) (10). The Mesam 4 is a four-channel digital recording device. The Mesam system has been validated in two previous studies (10,11). A polysomnographic technologist, trained in the use of the Mesam 4, set up the device at the subject's home on the study night and retrieved it the next morning. Heart rate was monitored through a single-lead electrocardiogram (modified V2) and R-R intervals were measured in milliseconds. Snoring sounds were monitored through an electric subminiature microphone, type MCE 2,000 (frequency range, 30 to 20,000 cycles/s ± 2dB, sensitivity 0.6 mV/microbar at 1000 cycles/s ± 4 dB; Conrad Electronics, Hirschau, Germany), taped above the larynx. Arterial oxygen saturation was measured continuously with a finger probe. The body position sensor, a flat cylinder 18 mm high with a diameter of 50 mm, was placed on the lower part of the sternum. Automated scoring software is available with the Mesam that provides a respiratory disturbance index. However, previous research has shown that hand scoring provides results that are more closely related to the results of simultaneous polysomnography than the automated analysis results (11). The Mesam recordings were therefore hand scored in 5 min epochs. This was done independently and in a blinded fashion by two physicians trained in SDB and familiar with the Mesam 4. Interobserver variability was determined using the Kappa statistic (12). Snoring was scored as absent, present during less than 50% of the recording, or present during 50% or more of the recording. A respiratory event was scored if at least two of the following three parameters were present: pauses in snoring of at least 10 s; heart rate deceleration and acceleration of at least 10 beats/min; and an associated arterial oxygen desaturation of at least 2%. If recurrent episodes were present during the majority of a 5 min epoch, the epoch was defined as positive for SDB. The subjects' records were then classified based on the following criteria: normalevents less than 10% of the recording; possible SDB -events 10% to 30% of the recording; definite SDB -events greater than 30% of the recording. The Mesam 4 does not record sleep; therefore, the total study time is not equivalent to a total sleep time. Using a total study time rather than a total sleep time tends to underestimate the degree of SDB. This approach was adopted to avoid concerns that the prevalence of SDB would be overestimated in this population. Calculation of prevalence: The prevalence of both suspected and definite SDB was calculated but the conservative latter definition was used for the primary analysis. The prevalence of SDB was calculated in each sample group by the equation: Prevalence = (number of subjects with definite SDB × 100%)/ total number of subjects To estimate the overall prevalence of definite SDB in the entire group of grainworkers the prevalence obtained from each sample groups was projected to their respective total groups. Overall prevalence = [(sample group 1)(number of subjects in total group 1) + (sample group 2)(number of subjects in total group 2) + (sample group 3)(number of subjects in total group 3) + (sample group 4)(number of subjects in total group 4)] × 100%/total number of grainworkers Can Respir J Vol 5 No 3 May/June 1998 185 Prevalence of SDB in grainworkers Le ronflement signalé par les sujets eux-mêmes ne représentait pas un facteur prédictif. CONCLUSIONS : Cette première étude sur la prévalence des troubles respiratoires du sommeil au Canada permet de croire qu'ils sont aussi fréquents dans ce pays que dans les autres pays industrialisés mais aussi que leur incidence serait en fait plus importante que celle présumée antérieurement. D'autres études sont nécessaires pour déterminer la morbidité, la mortalité et la perte économique associées aux troubles respiratoires du sommeil chez les travailleurs industriels. where sample group refers to the prevalance of SDB in the sample group specificed. Before this calculation, subjects approached for home sleep monitoring who did not participate (refused or could not be contacted) were compared with their respective total groups in terms of age, body mass index (BMI) and neck circumference. If no significant difference was found between the sample group and total group, then the previously described formula was used to calculate prevalence. If a significant difference was found between a sample group and either those who did not participate or the group as a whole then the above formula was modified such that the respective group prevalence was multiplied by only the number of subjects in the sample group and not by the entire total group. Statistics: One-way ANOVA was used to to compare the anthropometric data and a c 2 test was used to compare the questionnaire data (categorical) among the four total groups and among the three home sleep monitoring derived diagnostic groups (normal, possible SDB, definite SDB). The sample groups and the total groups were compared by an unpaired Student's t test. Prevalence was calculated as described above, and the interobserver variability was calculated using the Kappa statistic (a Kappa score greater than 0.7 is indicative of minimal interobserver variability). RESULTS Questionnaire data: Four hundred and thirty-seven men of the 524 men approached completed the questionnaire and had a limited physical examination (83% response rate). Nineteen (4.3%) admitted to snoring often and had a history of witnessed apneas (group 1), 98 (22.3%) snored often without witnessed apneas (group 2), 185 (42.3%) snored sometimes or rarely (group 3) and 135 (31.1%) were nonsnorers (group 4). These groups differed significantly in the distribution of neck circumference (P<0.0001), BMI (P<0.0001) and age (P<0.05) ( The distribution of diagnoses from home sleep monitoring differed among the four groups By projecting the prevalence of definite SDB found in the four sample groups to their respective total group the overall prevalence of SDB was estimated to be 25% in this group of grainworkers: In group 1 the prevalence of the sample group was multiplied by the number of subjects in the sample group rather than the total group. There was a significant difference in BMI between those studied (heavier) and those who were not studied (P<0.02, Table 2), although those who were studied were similar to the total group. There were no significant differences between those subjects studied and those that did not participate in sample groups 2 to 4 (P>0.05, Figure 1) Prevalence of definite sleep disordered breathing in the sample groups and the total population There were no differences among the total groups and their respective sample groups in age, BMI or neck circumference. The two physicians scoring the Mesam studies agreed on categorization of the studies 85% of the time. In the studies in which there was not complete agreement, the two physicians were never more than one category removed. The interobserver variability, as calculated by the Kappa statistic, was 0.7. Factors associated with SDB: Among grainworkers who underwent home sleep monitoring, the presence of snoring (P<0.005) and witnessed apneas (P<0.04), a greater BMI (P<0.040) and a larger neck circumference (P<0.02) were found to be predictive of definite SDB. However, the presence of daytime sleepiness, history of hypertension (patient reported) and smoking history were not associated with the presence of SDB. There was no difference in measured blood pressure between the patients with and those without SDB. The relatively small sample size in each group may limit the power to detect true differences among the groups. Validity of self-reported snoring: Fifty-eight subjects underwent home sleep monitoring. Fourteen of these subjects denied snoring but home sleep monitoring revealed that five did not snore, five snored for less than 50% of the night and four snored for more than 50% of the night DISCUSSION In this first study of the prevalence of SDB in Canada, we found that 25% of a population of male grainworkers had SDB. The known risk factors of male sex and higher than average BMI in the study population are probably responsible for a higher prevalence of SDB than previously reported. A history of snoring and witnessed apneas as well as greater BMI and larger neck circumference were found to be useful predictors of SDB, a finding consistent with previous studies (6,13-15). Smoking was more common in subjects who re- ported snoring (with or without witnessed apneas) but we did not find a previously reported association between smoking history and SDB (7). Furthermore, self-reported snoring was not found to be a reliable guide to the presence of recorded snoring. A number of factors could have contributed to our finding of a greater prevalence of SDB in our study than that reported by others. Certain assumptions were made in previous prevalence studies, the most common of which is that self-reported snoring and daytime sleepiness were reliable symptoms of SDB The recognition of obstructive breathing associated with neurological arousal without accompanying arterial oxygen desaturation has expanded the definition of SDB. It is now apparent that there is a continuum of SDB associated with progressively more clinical consequences, from chronic snoring to obstructive sleep hypopnea to severe obstructive sleep apnea. The diagnostic threshold to define SDB within this continuum directly affects the measured prevalence. For example, the initial study by Lavie (4) used a diagnostic threshold of an apnea index greater than 10/h; however, if one uses an apnea index more than five/h the prevalence moves from 1% to nearly 16% in a group of male industrial workers. The use of home oximetry to define cases of SDB, a less sensitive monitoring system than conventional overnight, in-hospital polysomnography, has also contributed to the underestimation of prevalence rates. Stradling and Crosby (17) studied 893 men with overnight oximetry and found that 45 (5%) had more than five desaturations of 4% per hour. Thirty-one of these men had overnight polysomnography, and three had severe, nonpositional SDB (0.3%) and 18 had mild to moderate, positional apnea (2.4%). Men with clinically significant SDB with apneas and hypopneas without associated desaturations of 4% would have been missed using this methodology. More recent studies conducted in the United States and Australia using expanded definitions of SDB have found prevalence rates similar to our study (10% to 20%). In a recent study from the United States, 40% of middle-aged men and 30% of middle-aged women were found to be habitual snorers (6). Significant SDB was defined as the presence of an apnea-hypopnea index (AHI) greater than five/h (from polysomnography) and symptoms of excessive daytime sleepiness. About 4% of middle-aged men and 2% of middle-aged women met these criteria. When they defined SDB based only on AHI, 24% of middle-aged men had an AHI greater than five/h, 15% had an AHI greater than 10 per hour, and 9% had an AHI greater than 15/h. These prevalence rates are similar to those found in our study. Bearpark and colleagues Obesity is a significant risk factor for SDB. We examined a relatively healthy, nonhypertensive population of middleaged, working men who had a higher average BMI (29±5 kg/m
Monoamine Oxidase is a Major Determinant of Redox Balance in Human Atrial Myocardium and is Associated With Postoperative Atrial Fibrillation
BACKGROUND:
Onset of postoperative atrial fibrillation (POAF) is a common and costly complication of heart surgery despite major improvements in surgical technique and quality of patient care. The etiology of POAF, and the ability of clinicians to identify and therapeutically target high-risk patients, remains elusive.
METHODS AND RESULTS:
Myocardial tissue dissected from right atrial appendage (RAA) was obtained from 244 patients undergoing cardiac surgery. Reactive oxygen species (ROS) generation from multiple sources was assessed in this tissue, along with total glutathione (GSHt) and its related enzymes GSH-peroxidase (GPx) and GSH-reductase (GR). Monoamine oxidase (MAO) and NADPH oxidase were observed to generate ROS at rates 10-fold greater than intact, coupled mitochondria. POAF risk was significantly associated with MAO activity (Quartile 1 [Q1]: adjusted relative risk [ARR]=1.0; Q2: ARR=1.8, 95% confidence interval [CI]=0.84 to 4.0; Q3: ARR=2.1, 95% CI=0.99 to 4.3; Q4: ARR=3.8, 95% CI=1.9 to 7.5; adjusted Ptrend=0.009). In contrast, myocardial GSHt was inversely associated with POAF (Quartile 1 [Q1]: adjusted relative risk [ARR]=1.0; Q2: ARR=0.93, 95% confidence interval [CI]=0.60 to 1.4; Q3: ARR=0.62, 95% CI=0.36 to 1.1; Q4: ARR=0.56, 95% CI=0.34 to 0.93; adjusted Ptrend=0.014). GPx also was significantly associated with POAF; however, a linear trend for risk was not observed across increasing levels of the enzyme. GR was not associated with POAF risk.
CONCLUSIONS:
Our results show that MAO is an important determinant of redox balance in human atrial myocardium, and that this enzyme, in addition to GSHt and GPx, is associated with an increased risk for POAF. Further investigation is needed to validate MAO as a predictive biomarker for POAF, and to explore this enzyme's potential role in arrhythmogenesis
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