Estakhr Project - Third preliminary report of the joint Mission of the Iranian center for archaeological research, the Parsa-Pasargadae research foundation and the Sapienza University of Rome, Italy

This report presents the preliminary results of the study of the pottery collected during the excavation campaign carried out in 2012 in the framework of the joint Iranian-Italian Archaeological Mission in Estakhr. The ceramic finds relate to a time span ranging from the 9th to the 12th century, corresponding to the occupation phases identified within the stratigraphy. Moreover, the use of archaeometry made it possible to identify both imported and locally manufactured wares

A deep learning experiment for semantic segmentation of overlapping characters in palimpsests

Palimpsests refer to historical manuscripts where erased writings have been partially covered by the superimposition of a second writing. By employing imaging techniques, e.g., multispectral imaging, it becomes possible to identify features that are imperceptible to the naked eye, including faded and erased inks. When dealing with overlapping inks, Artificial Intelligence techniques can be utilized to disentangle complex nodes of overlapping letters. In this work, we propose deep learning-based semantic segmentation as a method for identifying and segmenting individual letters in overlapping characters. The experiment was conceived as a proof of concept, focusing on the palimpsests of the Ars Grammatica by Prisciano as a case study. Furthermore, caveats and prospects of our approach combined with multispectral imaging are also discussed

Vascular-confined multi-passage discoidal nanoconstructs for the low-dose docetaxel inhibition of triple-negative breast cancer growth

AbstractTaxane efficacy in triple negative breast cancer (TNBC) is limited by insufficient tumor accumulation and severe off-target effects. Nanomedicines offer a unique opportunity to enhance the anti-cancer potency of this drug. Here, 1,000 nm × 400 nm discoidal polymeric nanoconstructs (DPN) encapsulating docetaxel (DTXL) and the near infrared compound lipid-Cy5 were engineered. DPN were obtained by filling multiple times cylindrical wells in a poly(vinyl alcohol) template with a polymer mixture comprising poly(lactic-co-glycolic acid) (PLGA) and poly(ethylene glycol) diacrylate (PEG-DA) chains together with therapeutic and imaging agents. The resulting "multi-passage" DPN exhibited higher DTXL loading, lipid-Cy5 stability, and stiffness as compared to the conventional "single-passage" approach. Confocal microscopy confirmed that DTXL-DPN were not taken up by MDA-MB-231 cells but would rather sit next to the cell membrane and slowly release DTXL thereof. Empty DPN had no toxicity on TNBC cells, whereas DTXL-DPN presented a cytotoxic potential comparable to free DTXL (IC50 = 2.6 nM ± 1.0 nM vs. 7.0 nM ± 1.09 nM at 72 h). In orthotopic murine models, DPN accumulated in TNBC more efficiently than free-DTXL. With only 2 mg/kg DTXL, intravenously administered every 2 days for a total of 13 treatments, DTXL-DPN induced tumor regression and were associated to an overall 80% survival rate as opposed to a 30% survival rate for free-DTXL, at 120 days. All untreated mice succumbed before 90 days. Collectively, this data demonstrates that vascular confined multi-passage DPN, biomimicking the behavior of circulating platelets, can efficiently deliver chemotherapeutic molecules to malignant tissues and effectively treat orthotopic TNBC at minimal taxane doses

Current ramps optimization study with the RAPTOR code

Optimization of the plasma discharge is related to determination of the optimal time evolution of the plasma parameters to reach a specific plasma state taken into account certain physical and technical constraints. The set of plasma parameters which should be optimized consists of the parameters significantly changing the plasma state and can be defined from the different tokamak actuator inputs: plasma current, EC, NBI heating or current drive power, density, etc. In this work we carry out the optimization study of the current ramp down. Numerical optimization of this phase can prescribe evolution of the plasma parameters to terminate plasma as fast as possible and in the same time to avoid disruptions in the real experiments. The simulation is performed with the RAPTOR code. It is a light and fast transport code with a simplified transport model which includes transport equations for electron temperature and poloidal flux. However, this code was constructed assuming a fixed plasma equilibrium, whereas plasma geometry might change during ramp-down phase. Therefore RAPTOR has been extended to include time varying terms. In this way, time varying plasma geometry can be used in the optimization procedure and for example plasma elongation can be an additional parameter for the trajectory optimization. The results of the simulation with the extended transport model and optimization procedure of ramp-down phase of AUG-like plasma parameters are presented

Triticale for Bioenergy Production

Abstract The promotion of renewable energy represents a target of the European 2020 strategy for growth. Plant biomass and organic wastes from agriculture represent an effective resource to be exploited for a sustainable rural development, optimizing the land use, diversifying rural entrepreneurship. Cereals are considered a promising biomass producing crop in temperate regions of Europe to be used for both fuel alcohol and biogas production. In particular, triticale shows a number of advantages such as high grain yield even in marginal environments, tolerance to drought, tolerance to more acid soils, low susceptibility to biotic stresses and is known to have reduced production costs. The characteristics of triticale were reviewed, focusing on bio-energy applications. Furthermore, data from a two-year experiment carried out in Italy using nine triticale lines grown in marginal areas close to Bracciano, Italy, were reported. A bread wheat variety selected for bio-energy application, EW9, were also included for a more complete analysis. Traits such as day-to-heading, plant height, number of plants, number of spikes, grain yields were analysed. Preliminary results concerning biogas potential of biomass consisting of triticale hay harvested at milky-dough phase were also measured and results are reported

Depuration Capacity of Mussels (Mytilus galloprovincialis) in Presence of Marteilia Spp. Parasites

Bivalve molluscs are filter-feeding organisms present in the water column: during their activity, they could retain micro-organisms that are potentially dangerous to human health. For this reason, EU Regulations may require that a purification treatment be performed prior to bivalve trade. The length of the purification process could be affected by stress factors, such as parasitic infections. The purpose of this study was to determine if the presence of Marteilia spp. parasite in shellfish could modify time and efficacy of their microbiological purification treatment, in order to set up specific protocols. Lysosomal membrane stability, phagocytosis capacity, granulocyte/hyalinocyte rate and neutral lipid accumulation are biomarkers used to evaluate shellfish physiological state. These biomarkers were used to exclude any differences caused by stressor factors that could affect the purification results. Mussels were sampled from two different production areas. The presence or absence of parasites was confirmed by cytological test. Both groups of parasitized and non-parasitized mussels were contaminated with E.coli: they were then sampled for microbiological analyses and tested for biomarkers for up to 70 hours of purification. Parasitized and non-parasitized molluscs did not show any differences in levels of E. coli after 12, 24, 36, 48 and 70 hours of depuration. In relation to biomarkers, mussels seem to react to Lysosomal membrane stability in presence of Marteilia. The present study shows that the presence of Marteilia spp. does not affect the purification rate of mussels

Numerical optimization of ramp-down phases for TCV and AUG plasmas

Optimization of the plasma discharge can be defined as determination of an optimal time evolution of the plasma parameters to lead a plasma to a desired state keeping it within the specific limits: physical ones (like the Greenwald density limit, low normalized beta and internal inductance values) and technical ones (like the vertical stability limit). The parameters, time-trajectories of which have to be optimized, are the ones significantly changing the plasma state, and, depending on the optimization goal, can be chosen from a wide range of plasma parameters: plasma current, plasma elongation, EC, NBI heating or current drive power, electron density, etc. Developing non-disruptive termination scenarios is important for safe operation of future tokamaks and especially for ITER since significant heat fluxes to the wall are expected during disruptions because of large amount of energy stored in burning plasmas. Therefore, the main goal of ramp-down optimization is to ramp down a plasma current as fast as possible while avoiding any disruptions. The results of the optimization problem study with the physical and technical limits is presented for TCV and AUG plasmas. The present work was done mainly with the RAPTOR code. The transport model has been extended to include a time-varying plasma equilibrium geometry, increasing the accuracy of full discharge simulations. Due to the design, the RAPTOR code is also an efficient tool for an optimization problem solving. A new ad-hoc transport model has been implemented to the RAPTOR code and tested during this work. Verification of the thermal transport model with simulation of the AUG and TCV full plasma discharges using RAPTOR will be presented

Antibacterial effect of zinc oxide-based nanomaterials on environmental biodeteriogens affecting historical buildings

The colonization of microorganisms and their subsequent interaction with stone substrates under different environmental conditions encourage deterioration of materials by multiple mechanisms resulting in changes in the original color, appearance and durability. One of the emerging alternatives to remedy biodeterioration is nanotechnology, thanks to nanoparticle properties such as small size, no-toxicity, high photo-reactivity, and low impact on the environment. This study highlighted the effects of ZnO-based nanomaterials of two bacteria genera isolated from the Temple of Concordia (Agrigento’s Valley of the Temples in Sicily, Italy) that are involved in biodeterioration processes. The antimicrobial activities of ZnO-nanorods (Zn-NRs) and graphene nanoplatelets decorated with Zn-NRs (ZNGs) were evaluated against the Gram positive Arthrobacter aurescens and two isolates of the Gram negative Achromobacter spanius. ZNGs demonstrated high antibacterial and antibiofilm activities on several substrates such as stones with different porosity. In the case of ZNGs, a marked time- and dose-dependent bactericidal effect was highlighted against all bacterial species. Therefore, these nanomaterials represent a promising tool for developing biocompatible materials that can be exploited for the conservation of cultural heritage. These nanostructures can be successfully applied without releasing toxic compounds, thus spreading their usability

Broadband enhancement of light-matter interaction in photonic crystal cavities integrating site-controlled quantum dots

The fabrication of integrated quantum dot (QD)-optical microcavity systems is a requisite step for the realization of a wide range of nanophotonic experiments (and applications) that exploit the ability of QDs to emit nonclassical light, e.g., single photons. Thanks to their similar to 20-nm positioning accuracy and to their proven potential for single-photon operation, the QDs obtained by spatially selective hydrogen irradiation of dilute-nitride semiconductors-such as Ga(AsN) and Ga(PN)-are uniquely suited for integration with photonic nanodevices. In the present work, we demonstrate the ability to deterministically integrate single, site-controlled Ga(AsN)/Ga(AsN):H QDs within a photonic crystal (PhC) cavity. The properties of the fabricated QD-PhC cavity systems are then probed by photon correlation-providing clear evidence of single-photon emission-and time-resolved microphotoluminescence spectroscopy. Detailed information on the dynamics of our integrated nanodevices can be inferred by comparing these experiments to the solutions of a rate-equations system, developed by taking into account all the main processes leading to the capture, relaxation, and recombination of carriers in and out of the QD. This allows us to follow the evolution of the relevant recombination rates in our system for varying energy detuning, Delta E, between the QD and the PhC cavity. When the QD exciton transition is nearly resonant with the cavity mode, a large (>tenfold) enhancement of the spontaneous emission rate is observed, in substantial agreement with Jaynes-Cummings (JC) theory. For intermediate detunings (Delta E similar to 1.5-3.5 meV), on the other hand, the observed enhancement is significantly larger than that predicted by JC theory, due to the important role played by acoustic phonons in mediating the QD-PhC cavity coupling in a solid-state environment. Apart from its fundamental interest, the observation of such phonon-mediated, broadband enhancement of light-matter interaction significantly relaxes the requirements for the realization of a large variety of cavity QED-based experiments and applications. These include many photonic devices for which the use of site-controlled Ga(AsN)/Ga(AsN):H QDs would be inherently advantageous, such as those based on the coupling between more than one QD and a single cavity mode (e.g., few-QD nanolasers and QD solids)