Progetto di nuova viabilita' per il comune di Forte dei Marmi

Il presente lavoro ha come oggetto lo studio progettuale di una nuova viabilità nel comune di Forte dei Marmi ed in particolare la realizzazione di un nuovo tracciato stradale a partire dal termine della S.P. 70 Emilia posto in località Vittoria Apuana fino al raggiungimento del viale litoraneo denominato nel punto di intersezione “Viale Italico”. Questo tipo di intervento costituisce una variante al progetto preliminare di collegamento fra i comuni di Forte dei Marmi, Montignoso e Massa attraverso una viabilità alternativa rispetto al viale litoraneo e alla S.S. 1 Aurelia, intervento di difficile attuazione visto la recente espansione urbanistica della zona coinvolta. Lo studio elaborato prevede la realizzazione di un nuovo tracciato stradale ubicato per la quasi totalità nel comune di Forte dei Marmi salvo per un piccolo tratto, posto a ridosso del fiume Versilia e per la precisione in prossimità del fosso Colatore sinistro, posizionato nel territorio del comune di Montignoso. Gli obbiettivi centrali dello studio sono: 1. Alleggerire il traffico sulla S.P. 45 “del polverificio” denominata via Padre Ignazio da Carrara , arteria principale della frazione Vittoria Apuana, ormai congestionata soprattutto durante la stagione estiva. 2. Consentire un facile accesso ad una zona con una recente e notevole espansione urbanistica. 3. Realizzare un nuovo e più agevole accesso al palasport di Forte dei Marmi, attualmente raggiungibile mediante strette strade residenziali. 4. Creare un nuovo percorso ciclabile di collegamento fra la S.P. 70 Emilia e il viale litorane

Combining EEG signal processing with supervised methods for Alzheimer’s patients classification

Background Alzheimer’s Disease (AD) is a neurodegenaritive disorder characterized by a progressive dementia, for which actually no cure is known. An early detection of patients affected by AD can be obtained by analyzing their electroencephalography (EEG) signals, which show a reduction of the complexity, a perturbation of the synchrony, and a slowing down of the rhythms. Methods In this work, we apply a procedure that exploits feature extraction and classification techniques to EEG signals, whose aim is to distinguish patient affected by AD from the ones affected by Mild Cognitive Impairment (MCI) and healthy control (HC) samples. Specifically, we perform a time-frequency analysis by applying both the Fourier and Wavelet Transforms on 109 samples belonging to AD, MCI, and HC classes. The classification procedure is designed with the following steps: (i) preprocessing of EEG signals; (ii) feature extraction by means of the Discrete Fourier and Wavelet Transforms; and (iii) classification with tree-based supervised methods. Results By applying our procedure, we are able to extract reliable human-interpretable classification models that allow to automatically assign the patients into their belonging class. In particular, by exploiting a Wavelet feature extraction we achieve 83%, 92%, and 79% of accuracy when dealing with HC vs AD, HC vs MCI, and MCI vs AD classification problems, respectively. Conclusions Finally, by comparing the classification performances with both feature extraction methods, we find out that Wavelets analysis outperforms Fourier. Hence, we suggest it in combination with supervised methods for automatic patients classification based on their EEG signals for aiding the medical diagnosis of dementia

Complications of extraperitoneal robot-assisted radical prostatectomy in high-risk prostate cancer: A single high-volume center experience

IntroductionThe role of robot-assisted radical prostatectomy (RARP) in high-risk prostate cancer (PCa) has been debated over the years, but it appears safe and effective in selected patients. While the outcomes of transperitoneal RARP for high-risk PCa have been already widely investigated, data on the extraperitoneal approach are scarcely available. The primary aim of this study is to evaluate intra- and postoperative complications in a series of patients with high-risk PCa treated by extraperitoneal RARP (eRARP) and pelvic lymph node dissection. The secondary aim is to report oncological and functional outcomes.MethodsData of patients who underwent eRARP for high-risk PCa were prospectively collected from January 2013 to September 2021. Intraoperative and postoperative complications were recorded, as also perioperative, functional, and oncological outcomes. Intraoperative and postoperative complications were classified by employing Intraoperative Adverse Incident Classification by the European Association of Urology and the Clavien–Dindo classification, respectively. Univariate and multivariate analyses were performed to evaluate a potential association between clinical and pathological features and the risk of complications.ResultsA total of 108 patients were included. The mean operative time and estimated blood loss were 183.5 ± 44 min and 115.2 ± 72.4 mL, respectively. Only two intraoperative complications were recorded, both grade 3. Early complications were recorded in 15 patients, of which 14 were of minor grade, and 1 was grade IIIa. Late complications were diagnosed in four patients, all of grade III. Body mass index (BMI) > 30 kg/m2, Prostate-Specific Antigen (PSA) > 20 ng/mL, PSA density >0.15 ng/mL2, and pN1 significantly correlated with a higher rate of overall postoperative complications. Moreover, BMI >30 kg/m2, PSA >20 ng/mL, and pN1 significantly correlated with a higher rate of early complications, while PSA >20 ng/mL, prostate volume <30 mL, and pT3 were significantly associated with a higher risk of late complications. In multivariate regression analysis, PSA >20 ng/mL significantly correlated with overall postoperative complications, while PSA > 20 and pN1 correlated with early complications. Urinary continence and sexual potency were restored in 49.1%, 66.7%, and 79.6% of patients and in 19.1%, 29.9%, and 36.2% of patients at 3, 6, and 12 months, respectively.ConclusionseRARP with pelvic lymph node dissection in patients with high-risk PCa is a feasible and safe technique, resulting in only a few intra- and postoperative complications, mostly of low grade

Prompt K_short production in pp collisions at sqrt(s)=0.9 TeV

The production of K_short mesons in pp collisions at a centre-of-mass energy of 0.9 TeV is studied with the LHCb detector at the Large Hadron Collider. The luminosity of the analysed sample is determined using a novel technique, involving measurements of the beam currents, sizes and positions, and is found to be 6.8 +/- 1.0 microbarn^-1. The differential prompt K_short production cross-section is measured as a function of the K_short transverse momentum and rapidity in the region 0 < pT < 1.6 GeV/c and 2.5 < y < 4.0. The data are found to be in reasonable agreement with previous measurements and generator expectations.Comment: 6+18 pages, 6 figures, updated author lis

Possibile coinvolgimento degli aplogruppi e di varianti del DNA mitocondriale come modificatori del fenotipo della Malattia di Fabry

La malattia di Fabry (FD) è una malattia da deposito lisosomiale molto eterogenea e che può presentarsi con due fenotipi: classico, con sintomatologia grave e ad esordio precoce, oppure late-onset, con sintomatologia lieve e ad esordio tardivo. Alla base della sintomatologia è presente l'accumulo di Gb3, il quale porta allo sviluppo di uno stato infiammatorio e di stress ossidativo. I mitocondri sono i principali responsabili della produzione di specie reattive dell'ossigeno, mediante la fosforilazione ossidativa, proprietà che dipende anche dal tipo di aplogruppo mitocondriale del suo genoma. Considerato quanto detto, nonché i numerosi studi in letteratura, si ipotizza un ruolo degli aplogruppi e delle varianti mitocondriali come modulatori della penetranza della FD. In questo studio è stato suggerito un ruolo dell'aplogruppo H e del cluster HV come modulatori negativi della penetranza della FD

Long or short? Telomere length and pancreatic cancer and its precursor lesions, a narrative review

Pancreatic ductal adenocarcinoma (PDAC) is the most common and lethal form of pancreatic cancer, with a survival approaching only 11% at 5 years after diagnosis. In the last 15 years, telomere length (TL) measured in leukocyte (LTL) has been studied in relation to PDAC risk. The majority of the studies reported an association between short LTL and increased PDAC risk, but the results are heterogeneous. Genome-wide association studies have identified several single-nucleotide polymorphisms (SNPs) in the telomerase reverse transcriptase (TERT) gene as susceptibility loci for PDAC. Polygenic risk scores computed using SNPs associated with LTL have been tested in relation to PDAC susceptibility with various methods and giving contrasting results. The aim of this review is to analyze all publications carried out specifically on LTL, considering LTL measured with qPCR and with genetic proxies, and PDAC risk. Additionally, we will give an overview of the most relevant associations between SNPs in telomere-associated genes and PDAC, to answer the question shorter or longer? Which one of the two is associated with PDAC risk

Concorso di idée per la progettazione del nuovo complesso scolastico del cintolese, comune di Monsumanno Terme

progettazione del nuovo complesso scolastico del cintolese, comune di Monsumanno Term