Self-esteem in physically active middle school students

The present research examined the effect of physical fitness on self-esteem of pre-adolescent children. Students performed the MOTORFIT tests and filled IPAQ-C and Self-Esteem questionnaires. According to the level of the physical fitness we evaluated the self-esteem. Results showed no gender differences, while differences for the level of physical fitness was found. In particular, participants who performed better the MOTORFIT test reported a higher self-esteem compared to less physical fit participants. However, a discrepancy emerged when the self-esteem was analysed as a function of the physical activity reported where no differences emerged between the groups. In conclusion, our results provided an effect of physical activity on self-esteem through objective measures. Key words: physical activity, pre-adolescent, psychosocial characteristics

Risk based, multi objective vehicle routing problem for hazardous materials: a test case in downstream fuel logistics

Abstract The paper analyses a practical case of study related to the distribution of fuels for the Total Erg Oil Company to the service stations located in the Province of Rome (Italy). The problem is formulated as a capacitated vehicle routing problem with time windows, where several heuristic procedures have been tested, considering both static and dynamic travel times. With respect to the standard operational costs used typically, a multivariable objective function has been proposed which takes into account also a new risk index. The risk index proposed is function of the population density of the zones covered by each path and of the estimated number of road accidents on each road link. In such a way, we take into account the population's exposure to the risk associated with an incidental event involving a fuel tank. The obtained output is the set of planned routes with minimum service cost and minimum risk. Results demonstrate how an accurate planning of the service saves up to 3 hours and 30 km on a daily basis compared to a benchmark. Moreover, the distribution company can parameterize the configuration of the service, by varying the weight adopted in order to include the risk index. Including the risk index may bring to a higher safety route planning, with an increase of the operating costs of only 2%

Nuovi scavi a Cartagine. Rapporto preliminare sulla seconda campagna di scavi (2022) dell'institute National du Patrimoine e dell'Università di Roma «La Sapienza»

Within the framework of the scientific cooperation agreement between the Institut National du Patrimoine and the University of Rome «La Sapienza», the second archaeological season of excavation took place from 31st May to 15th June 2022. In the area of the archaeological park of Antonin’s thermal Baths beside the Borj-Jedid hill, under the remains of a domestic building (Building A), an important Punic industrial installation of the late 5th century BC was discovered south of the area of the Phoenician and Punic necropolis of Dermech. In the meantime, north of the Antonin’s thermal Baths, in the area of the Roman villas on the Odeon Hill, eleven tombs of the 5th - 2nd centuries BC have been unearthed by the Tunisian-Italian team of the Archaeological Mission to Carthage (MAC).Dans le cadre de la coopération scientifique entre l’Institut National du Patrimoine et l’Université de Rome « La Sapienza », la deuxième campagne de fouille a eu lieu à Carthage, au parc des thermes d’Antonin, du 31 mai au 15 juin 2022. Aux abords de la colline de Borj-Jedid, sous les vestiges d’un bâtiment à caractère domestique (Building A), une importante installation artisanale punique de la fin du V siècle av. J.-C. a été mise au jour, au sud du secteur de la nécropole phénicienne et punique de Dermech. Parallèlement, au nord des thermes d’Antonin, dans le parc des villas romaines sur la Colline de l’Odéon, ont été dégagées onze tombes du Vème – IIème siècles av. J.-C. par l’équipe tuniso-italienne de la Mission Archéologique à Carthage (MAC)

The role of the extra physical activity on memory storage and psychosocial features

The present research investigated the role of the physical activity on cognitive functions and psychosocial characteristics. Pre-adolescent children of a middle School of Rimini participated to extra physical activities (EPA) organised by the school. They performed a Free Recall memory Test (Nielson, Radtke & Jensen, 1996) and filled the self-esteem questionnaire (Rosenberg, 1965) and their results were compared with a group of students that did not performed the activity proposed (non-EPA). Moreover, to control the level of physical activity of the sample, participants filled the International activity questionnaire. The results showed that the students who participated to the extra physical activities had high self-esteem compared to the non-EPA group, while no differences between the groups emerged from the Free Recall Memory test

The role of the extra physical activity on memory storage and psychosocial features

The present research investigated the role of the physical activity on cognitive functions and psychosocial characteristics. Pre-adolescent children of a middle School of Rimini participated to extra physical activities (EPA) organised by the school. They performed a Free Recall memory Test (Nielson, Radtke & Jensen, 1996) and filled the self-esteem questionnaire (Rosenberg, 1965) and their results were compared with a group of students that did not performed the activity proposed (non-EPA). Moreover, to control the level of physical activity of the sample, participants filled the International activity questionnaire. The results showed that the students who participated to the extra physical activities had high self-esteem compared to the non-EPA group, while no differences between the groups emerged from the Free Recall Memory test

Fissurectomy versus lateral internal sphincterotomy in the treatment of chronic anal fissures: no advantages in terms of post-operative incontinence

PurposeThe standard treatment for chronic anal fissures that have failed non-operative management is lateral internal sphincterotomy. Surgery can cause de novo incontinence. Fissurectomy has been proposed as a sphincter/saving procedure, especially in the presence of a deep posterior pouch with or without a crypt infection. This study investigated whether fissurectomy offers a benefit in terms of de novo post-operative incontinence.MethodsPatients surgically managed with fissurectomy or lateral internal sphincterotomy for chronic anal fissures from 2013 to 2019 have been included. Healing rate, changes in continence and patient satisfaction were investigated at long-term follow-up.ResultsOne hundred twenty patients (55 females, 65 males) were analysed: 29 patients underwent fissurectomy and 91 lateral internal sphincterotomy. Mean follow-up was 55 months [confidence interval (CI) 5-116 months]. Both techniques showed some rate of de novo post-operative incontinence (> +3 Vaizey score points): 8.9% lateral internal sphincterotomy, 17.8% fissurectomy (p = 0.338). The mean Vaizey score in these patients was 10.37 [standard deviation (sd) 6.3] after lateral internal sphincterotomy (LIS) and 5.4 (sd 2.3) after fissurectomy Healing rate was 97.8% in the lateral internal sphincterotomy group and 75.8% in the fissurectomy group (p = 0.001). In the lateral internal sphincterotomy group, patients with de novo post-op incontinence showed a statistically significant lower satisfaction rate (9.2 +/- 1.57 versus 6.13 +/- 3; p = 0.023) while no differences were present in the fissurectomy group (8.87 +/- 1.69 versus 7.4 +/- 1.14; p = 0.077).ConclusionsLateral internal sphincterotomy is confirmed as the preferred technique in term of healing rate. Fissurectomy did not offer a lower rate of de novo post-operative incontinence, but resulted in lower Vaizey scores in patients in whom this occurred. Satisfaction was lower in patients suffering a de novo post-operative incontinence after lateral internal sphincterotomy

Cyclophilin A modulates bone marrow-derived CD117+ cells and enhances ischemia-induced angiogenesis via the SDF-1/CXCR4 axis

Abstract Background Critical limb ischemia (CLI) is a major health problem with no adequate treatment. Since CLI is characterized by insufficient tissue vascularization, efforts have focused on the discovery of novel angiogenic factors. Cyclophilin A (CyPA) is an immunophilin that has been shown to promote angiogenesis in vitro and to enhance bone marrow (BM) cell mobilization in vivo . However, its potential as an angiogenic factor in CLI is still unknown. Thus, this study aimed to evaluate whether CyPA might induce neo-angiogenesis in ischemic tissues. Methods and results Wild-type C57Bl/6j mice underwent acute hind-limb ischemia (HLI) and received a single intramuscular administration of recombinant CyPA or saline. Limb perfusion, capillary density and arteriole number in adductor muscles were significantly increased after CyPA treatment. Interestingly, BM-derived CD117 + cell recruitment was significantly higher in ischemic adductor tissue of mice treated with CyPA versus saline. Therefore, the effect of CyPA on isolated BM-derived CD117 + cells in vitro was evaluated. Low concentrations of CyPA stimulated CD117 + cell proliferation while high concentrations promoted cell death. Moreover, CyPA enhanced CD117 + cell adhesion and migration in a dose-dependent manner. Mechanistic studies revealed that CyPA up-regulated CXCR4 in CD117 + cells and in adductor muscles after ischemia. Additionally, SDF-1/CXCR4 axis inhibition by the CXCR4 antagonist AMD3100 decreased CyPA-mediated CD117 + cell recruitment in the ischemic limb. Conclusion CyPA induces neo-angiogenesis by recruiting BM-derived CD117 + cell into ischemic tissues, at least in part, through SDF-1/CXCR4 axis

Dark chocolate intake positively modulates gut permeability in elite football athletes. A randomized controlled study

: Gut barrier disruption can lead to enhanced intestinal permeability, which allows endotoxins, pathogens, and other proinflammatory substances to move through the intestinal barrier into circulation. Intense exercise over a prolonged period increases intestinal permeability, which can be further worsened by the increased production of reactive oxygen species (ROS) and pro-inflammatory cytokines. The aim of this study was to assess the degree of intestinal permeability in elite football players and to exploit the effect of cocoa polyphenols on intestinal permeability induced by intensive physical exercise. Biomarkers of intestinal permeability, such as circulating levels of zonulin, a modulator of tight junctions, occludin, a tight junction protein, and LPS translocation, were evaluated in 24 elite football players and 23 amateur athletes. Moreover, 24 elite football players were randomly assigned to either a dark chocolate (>85% cocoa) intake (n = 12) or a control group (n = 12) for 30 days in a randomized controlled trial. Biochemical analyses were performed at baseline and after 30 days of chocolate intake. Compared to amateur athletes, elite football players showed increased intestinal permeability as indicated by higher levels of zonulin, occludin, and LPS. After 30 days of dark chocolate intake, decreased intestinal permeability was found in elite athletes consuming dark chocolate. In the control group, no changes were observed. In vitro, polyphenol extracts significantly improved intestinal damage in the human intestinal mucosa cell line Caco-2. These results indicate that chronic supplementation with dark chocolate as a rich source of polyphenols positively modulates exercise-induced intestinal damage in elite football athletes

Acute shock efficacy of the subcutaneous implantable cardioverter-defibrillator according to the implantation technique

Background: The traditional technique for subcutaneous implantable cardioverter defibrillator (S-ICD) implantation involves three incisions and a subcutaneous (SC) pocket. An intermuscular (IM) 2-incision technique has been recently adopted. Aims: We assessed acute defibrillation efficacy (DE) of S-ICD (DE ≤65 J) according to the implantation technique. Methods: We analyzed consecutive patients who underwent S-ICD implantation and DE testing at 53 Italian centers. Regression analysis was used to determine the association between DFT and implantation technique. Results: A total of 805 patients were enrolled. Four groups were assessed: IM + 2 incisions (n = 546), SC + 2 incisions (n = 133), SC + 3 incisions (n = 111), and IM + 3 incisions (n = 15). DE was ≤65 J in 782 (97.1%) patients. Patients with DE ≤65 J showed a trend towards lower body mass index (25.1 vs. 26.5; p = .12), were less frequently on antiarrhythmic drugs (13% vs. 26%; p = .06) and more commonly underwent implantation with the 2-incision technique (85% vs. 70%; p = .04). The IM + 2-incision technique showed the lowest defibrillation failure rate (2.2%) and shock impedance (66 Ohm, interquartile range: 57-77). On multivariate analysis, the 2-incision technique was associated with a lower incidence of shock failure (hazard ratio: 0.305; 95% confidence interval: 0.102-0.907; p = .033). Shock impedance was lower with the IM than with the SC approach (66 vs. 70 Ohm p = .002) and with the 2-incision than the 3-incision technique (67 vs. 72 Ohm; p = .006). Conclusions: In a large population of S-ICD patients, we observed a high defibrillation success rate. The IM + 2-incision technique provides lower shock impedance and a higher likelihood of successful defibrillation