Properties of Cosmological Filaments extracted from Eulerian Simulations

Using a new parallel algorithm implemented within the VisIt framework, we analysed large cosmological grid simulations to study the properties of baryons in filaments. The procedure allows us to build large catalogues with up to $\sim 3 \cdot 10^4$ filaments per simulated volume and to investigate the properties of cosmic filaments for very large volumes at high resolution (up to $300^3 ~\rm Mpc^3$ simulated with $2048^3$ cells). We determined scaling relations for the mass, volume, length and temperature of filaments and compared them to those of galaxy clusters. The longest filaments have a total length of about $200 ~\rm Mpc$ with a mass of several $10^{15} M_{\odot}$. We also investigated the effects of different gas physics. Radiative cooling significantly modifies the thermal properties of the warm-hot-intergalactic medium of filaments, mainly by lowering their mean temperature via line cooling. On the other hand, powerful feedback from active galactic nuclei in surrounding halos can heat up the gas in filaments. The impact of shock-accelerated cosmic rays from diffusive shock acceleration on filaments is small and the ratio of between cosmic ray and gas pressure within filaments is of the order of $\sim 10-20$ percent.Comment: 27 pages, 24 figures, accepted for publication in Monthly Notices of the Royal Astronomical Society Main Journa

Anatomía de las crisis económicas de la Región Rosario

El presente trabajo tiene por objetivo identificar y caracterizar los diferentes shocks económicos por los cuales atravesó la Región Rosario en los últimos 30 años. Se pretende conocer si el área ha sido más resistente que la nación ante los shocks y si fue más fuerte en su recuperación. Uno de los principales hallazgos fue que la Región Rosario tendió a ser débil ante cada perturbación pero fuerte en su recuperación. No obstante, durante la última crisis de 2017/20 que incluye el período de pandemia por COVID, dicha configuración cambió, influenciada posiblemente por la estructura económica del área.The objective of this paper is to identify and characterize the different economic shocks that the Rosario Region has experienced in the last 30 years. The aim is to find out if the area has been more resistant than the nation in the face of shocks and if it was stronger in its recovery. One of the main findings was that the Rosario Region tended to be weak in the face of each shock but strong in its recovery. However, during the last crisis of 2017/20, which includes the period of the COVID pandemic, this configuration changed, possibly influenced by the economic structure of the area.Favre, Pablo. Universidad Nacional de Rosario. Facultad de Ciencias Económicas y Estadística. Rosario, ArgentinaLapelle, Hernán Claudio. Universidad Nacional de Rosario. Facultad de Ciencias Económicas y Estadística. Rosario, Argentin

ALMA observations of polarized emission toward the CW Tau and DG Tau protoplanetary disks: constraints on dust grain growth and settling

We present polarimetric data of CW Tau and DG Tau, two well-known Class II disk/jet systems, obtained with the Atacama Large Millimeter/submillimeter Array at 870 $\mu$m and 0."2 average resolution. In CW Tau, the total and polarized emission are both smooth and symmetric, with polarization angles almost parallel to the minor axis of the projected disk. In contrast, DG Tau displays a structured polarized emission, with an elongated brighter region in the disk's near side and a belt-like feature beyond about 0."3 from the source. At the same time the total intensity is spatially smooth, with no features. The polarization pattern, almost parallel to the minor axis in the inner region, becomes azimuthal in the outer belt, possibly because of a drop in optical depth. The polarization fraction has average values of 1.2% in CW Tau and 0.4% in DG Tau. Our results are consistent with polarization from self-scattering of the dust thermal emission. Under this hypothesis, the maximum size of the grains contributing to polarization is in the range 100 - 150 $\mu$m for CW Tau and 50 - 70 $\mu$m for DG Tau. The polarization maps combined with dust opacity estimates indicate that these grains are distributed in a geometrically thin layer in CW Tau, representing a settling in the disk midplane. Meanwhile, such settling is not yet apparent for DG Tau. These results advocate polarization studies as a fundamental complement to total emission observations, in investigations of the structure and the evolution of protoplanetary disks.Comment: 8 pages, 5 figures. Accepted for publication in ApJ Letter

Severe ocular involvement in a newborn with Langerhans Cell Histiocytosis

Abstract Langerhans Cell Histiocytosis (LCH) is a rare proliferative disease of the mononuclear phagocyte system, characterised by tissue infiltration of CD1a + CD207+ histiocytes. The clinical presentation is variable, ranging from unifocal asymptomatic bone involvement to life-threatening multisystem disease, requiring aggressive therapeutic approaches. Intraocular involvement is uncommon and associated to poor visual and general prognosis. We report a case of LCH in a newborn with severe ocular and multisystem risk-organ involvement, unresponsive to several lines of chemotherapy. Off-label administration of vemurafenib led to dramatic improvement at systemic level; however, chronic sequelae of ocular involvement resulted in poor visual prognosis. Intraocular LCH involvement may be asymptomatic and clinical signs delayed, leading to severe complications, especially in newborns and young children. Screening for ocular involvement is essential for early treatment initiation, which can possibly improve the visual outcome. Vemurafenib is effective on systemic involvement, and its role in ocular LCH needs to be evaluated

Phenotypic and functional characterisation of CCR7(+ )and CCR7(- )CD4(+ )memory T cells homing to the joints in juvenile idiopathic arthritis

The aim of the study was to characterise CCR7(+ )and CCR7(- )memory T cells infiltrating the inflamed joints of patients with juvenile idiopathic arthritis (JIA) and to investigate the functional and anatomical heterogeneity of these cell subsets in relation to the expression of the inflammatory chemokine receptors CXCR3 and CCR5. Memory T cells freshly isolated from the peripheral blood and synovial fluid (SF) of 25 patients with JIA were tested for the expression of CCR7, CCR5, CXCR3 and interferon-γ by flow cytometry. The chemotactic activity of CD4 SF memory T cells from eight patients with JIA to inflammatory (CXCL11 and CCL3) and homeostatic (CCL19, CCL21) chemokines was also evaluated. Paired serum and SF samples from 28 patients with JIA were tested for CCL21 concentrations. CCR7, CXCR3, CCR5 and CCL21 expression in synovial tissue from six patients with JIA was investigated by immunohistochemistry. Enrichment of CD4(+), CCR7(- )memory T cells was demonstrated in SF in comparison with paired blood from patients with JIA. SF CD4(+)CCR7(- )memory T cells were enriched for CCR5(+ )and interferon-γ(+ )cells, whereas CD4(+)CCR7(+ )memory T cells showed higher coexpression of CXCR3. Expression of CCL21 was detected in both SF and synovial membranes. SF CD4(+ )memory T cells displayed significant migration to both inflammatory and homeostatic chemokines. CCR7(+ )T cells were detected in the synovial tissue in either diffuse perivascular lymphocytic infiltrates or organised lymphoid aggregates. In synovial tissue, a large fraction of CCR7(+ )cells co-localised with CXCR3, especially inside lymphoid aggregates, whereas CCR5(+ )cells were enriched in the sublining of the superficial subintima. In conclusion, CCR7 may have a role in the synovial recruitment of memory T cells in JIA, irrespective of the pattern of lymphoid organisation. Moreover, discrete patterns of chemokine receptor expression are detected in the synovial tissue

Implementación de un modelo de validación para la definición y mantenimiento de procesos de desarrollo de software

Las empresas de desarrollo de software, en búsqueda de mejorar su rendimiento y la calidad de sus productos, implementan modelos y normas como CMMI e ISO. Para sostener la mejora en el tiempo, es necesario modificar los procesos continuamente para adaptarlos al contexto cambiante. Los cambios en el proceso pueden incurrir en el incumplimiento de una norma o modelo en los que el proceso fue basado. Por ello es importante crear, mantener y evaluar mapeos entre el proceso y los modelos. Estos mapeos son útiles al momento de la validación de los procesos respecto de los modelos. Una dificultad que se presenta al momento de la validación es que los requerimientos de los modelos están descriptos en lenguaje natural quedando librados a la interpretación de un experto. Este trabajo presenta un metamodelo que permite definir en forma más precisa los requerimientos de los modelos y las normas y un mecanismo de mapeo y validación de procesos.Sociedad Argentina de Informática e Investigación Operativ