12 research outputs found
Acid-base balance and oxygen tension during dialysis in uremic patients with chronic obstructive pulmonary disease
Recent reports on the effects of dialysis on acid-base balance and metabolic
acidosis correction in end-stage renal disease (ESRD) patients with chronic
obstructive pulmonary disease (COPD) are lacking. Here, we compared acid-base
balance and blood gasses among 14 patients with established COPD (group A) and
eight patients with normal respiratory function (group B). The two groups were
homogeneous for age, time on dialysis, and male/female ratio. At the beginning of
dialysis, acid-base balance and blood gasses were comparable between patients of
groups A and B. A significant difference between groups was observed only in
pCO(2) at 20 min, together with a delay in pH increase. Effective correction of
acidosis was reported at the end of dialysis and is not significantly affected by
COPD. Nevertheless, weight loss must be carefully monitored in these patients in
order to prevent hyperhydration and worsening of respiratory function
Medial artery calcification of uremic patients: a histological, histochemical and ultrastructural study
Recent findings suggest that vascular
calcification (VC) is an active process similar to bone
mineralization, the vascular smooth muscle cells
(VSMCs) undergoing phenotypic differentiation into
osteoblastic cells and synthesizing calcificationregulating
proteins found in bone. This study has
investigated the VC process of uremic patients, with a
morphologic approach. Epigastric artery samples from
49 uremic, non-diabetic patients were taken during
kidney transplantation. Sections from paraffin-embedded
samples were stained with hematoxylin/eosin and von
Kossa. CD68 was immunohistochemically detected, and
sections from frozen samples were stained with Oil Red
O. Deeply calcified samples were stained with
Picrosirius Red, PAS, and Alcian blue. Specimens from
one patient with moderate and one with severe VC were
examined under the electron microscope. None of the
samples had atherosclerosis. Calcifications were found
in the media of 38 patients. In 23, dot-like calcifications
were irregularly scattered near the adventitia (light VC);
in 11, granular calcifications formed concentric rings
near the adventitia (moderate-advanced VC); in 4, zones
of consolidated calcifications were found (severe VC).
These zones were poor in collagen, glycoproteins and
proteoglycans. In cases with moderate or severe VC,
VSCMs showed necrotic changes. Matrix vesicles could
be recognized in the extracellular spaces. In cases with
severe VC, uncalcified or partially calcified
membranous bodies were found, together with
Liesegang rings. Patches of fibrin were also found.
These findings point to a mainly degenerative
mechanism of VC, which proceeds from the outer
portion of the media. An active mechanism, however,
cannot be excluded. A unifying hypothesis is suggested