Factors associated with the appearance of gingival papillae

Chow YC, Eber RM, Tsao Y-P, Shotwell JL, Wang H-L. Factors associated with the appearance of gingival papillae. J Clin Periodontol 2010; 37: 719-727 doi: . The purpose of this study was to evaluate factors associated with the fill of inter-dental spaces by gingival papillae.Ninety-six adult subjects were evaluated. Papilla score (PS), tooth form/shape, interproximal contact length and gingival thickness were recorded for 672 maxillary anterior and first pre-molar interproximal sites. Statistical analyses included a non-parametric χ 2 test, anova , the Mixed Procedure for SAS and Pearson's correlation coefficient ( r ).Papilla deficiency was more frequent in older subjects ( p <0.05), as papilla height decreased 0.012 mm with each year of increasing age ( p <0.05). Competent papillae (complete fill inter-dentally) were associated with: (1) crown width: length ges;0.87; (2) proximal contact length ges;2.8 mm; (3) bone crest-contact point ≤5 mm; and (4) interproximal gingival tissue thickness ges;1.5 mm. Gingival thickness correlated negatively with PS ( r =−0.37 to −0.54) and positively with tissue height ( r =0.23–0.43). Tooth form (i.e. crown width to length ratio) correlated negatively with PS ( r =−0.37 to −0.61). Other parameters failed to show any significant effects.Gingival papilla appearance was associated significantly with subject age, tooth form/shape, proximal contact length, crestal bone height and interproximal gingival thickness.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/79213/1/j.1600-051X.2010.01594.x.pd

Comprehensive lung injury pathology induced by mTOR inhibitors

Molecular Targets in Oncology[Abstract] Interstitial lung disease is a rare side effect of temsirolimus treatment in renal cancer patients. Pulmonary fibrosis is characterised by the accumulation of extracellular matrix collagen, fibroblast proliferation and migration, and loss of alveolar gas exchange units. Previous studies of pulmonary fibrosis have mainly focused on the fibro-proliferative process in the lungs. However, the molecular mechanism by which sirolimus promotes lung fibrosis remains elusive. Here, we propose an overall cascade hypothesis of interstitial lung diseases that represents a common, partly underlying synergism among them as well as the lung pathogenesis side effects of mammalian target of rapamycin inhibitors

Isolation and characterization of coliphage Omega18A specific for Escherichia coli O18ac strains

The bactedophage Q18A, specific for Escherichia coli 018ac srrains, was isolated frorn sewage. The results of host range and conjugation experiments showed that the sensitivity of bacteria to the phage is associated with rhe presence of 018ac antigens. With sorne of rhe 018 strains rhe phage Q18A produces clear Iysis on bacterial lawns only when applied at a high multiplicity and moreover the phage does not multiply. With rhe help of the phage Ql8A, E. coli 0 18ac strains could be divided inro rwo serologically clistinct subgroups called 018A and 018A1• E. coli strains belanging to the sugroup 0 ISAare sensitive to phage Q t8A wheteas bacteria of subgroup A1 are resistanr.Der Bakteriophage Q18A, der spezifisch Escherichia coli 018ac Bakterien lysierr, wurde aus Abwasser isoliert. Die Untersuchungen des Wirtsbereichs und Konjugationsversuche zeigten, daß die Sensitivität der Bakterien gegenüber dem Phagen mit dem Vorhandensein des 0 '18ac Antigens assoziiert ist. Bei eir1igen 0 18 Stämmen wird nur bei Anwendung hoher Phagenkonzentrationen eine klare Lysis auf dem Bakterienrasen erzeugt. Darüber hinaus läßt sich der Phage auf diesen Stämmen nicht vermehren. Mit Hilfe des Phagen Q l8A konnten E, wli 0 18ac Stämme in zwei serologische Subgruppen unteneilt werden, die als 0 lHA und 0 l8A 1 bezeichnet werden. E. coli Bakterien der Subgruppe 0 ISA sind gegenüber dem Phagen Ql8A sensitiv und diejenigen der Subgruppe 0 18A 1 sind resistent