The Nia Project: Baseline report

The onset of puberty and menarche is a particularly vulnerable time for girls, when external pressures are exacerbated by their lack of knowledge of their bodies, their rights, and the implications of their decisions, and by their inability to manage puberty and adolescence safely and comfortably with appropriate menstrual health and hygiene management (MHM) products. Although several programs have previously been developed to address girls’ MHM needs globally, few have been evaluated, and where evidence does exist the results have been mixed. In collaboration with ZanaAfrica, the Population Council is evaluating the Nia Project, a set of interventions for adolescent girls in Kilifi County, Kenya. This evaluation analyzes the effect of distribution of Nia brand disposable sanitary pads and provision of reproductive health education (i.e., facilitated sessions and the Nia Teen magazine) on girls’ education and reproductive health outcomes. This report presents data from the baseline survey of the Nia Project, providing a multidimensional description of a sample of the girls who will be participating in the Nia Project and the schools they attend

The Nia Project—Brief

This brief provides highlights from the Nia Project conducted in Kenya. The study found that while gaps exist in girls’ capabilities, particularly knowledge and attitudes related to menstruation and reproductive health, the Nia Project has the potential to bridge those gaps. The Project is one of the first randomized controlled trials to explore the role of sanitary pad distribution and reproductive health education—individually and in combination—to improve girls’ educational and sexual and reproductive health outcomes. The findings of this study will make a critical contribution to filling an evidence gap in the field of menstrual health and hygiene management, and in doing so will guide education and health policy in this area in Kenya and in the region

Lower limb biomechanics and muscle function

This is the author accepted manuscript. The final version is available from Elsevier via the DOI in this recor

Binary Black-Hole Mergers in Magnetized Disks: Simulations in Full General Relativity

We present results from the first fully general relativistic, magnetohydrodynamic (GRMHD) simulations of an equal-mass black hole binary (BHBH) in a magnetized, circumbinary accretion disk. We simulate both the pre and post-decoupling phases of a BHBH-disk system and both "cooling" and "no-cooling" gas flows. Prior to decoupling, the competition between the binary tidal torques and the effective viscous torques due to MHD turbulence depletes the disk interior to the binary orbit. However, it also induces a two-stream accretion flow and mildly relativistic polar outflows from the BHs. Following decoupling, but before gas fills the low-density "hollow" surrounding the remnant, the accretion rate is reduced, while there is a prompt electromagnetic (EM) luminosity enhancement following merger due to shock heating and accretion onto the spinning BH remnant. This investigation, though preliminary, previews more detailed GRMHD simulations we plan to perform in anticipation of future, simultaneous detections of gravitational and EM radiation from a merging BHBH-disk system.Comment: 5 pages, 5 figure

Histone Hypervariants H2A.Z.1 and H2A.Z.2 Play Independent and Context-Specific Roles in Neuronal Activity-Induced Transcription of Arc/Arg3.1 and Other Immediate Early Genes.

The histone variant H2A.Z is an essential and conserved regulator of eukaryotic gene transcription. However, the exact role of this histone in the transcriptional process remains perplexing. In vertebrates, H2A.Z has two hypervariants, H2A.Z.1 and H2A.Z.2, that have almost identical sequences except for three amino acid residues. Due to such similarity, functional specificity of these hypervariants in neurobiological processes, if any, remain largely unknown. In this study with dissociated rat cortical neurons, we asked if H2A.Z hypervariants have distinct functions in regulating basal and activity-induced gene transcription. Hypervariant-specific RNAi and microarray analyses revealed that H2A.Z.1 and H2A.Z.2 regulate basal expression of largely nonoverlapping gene sets, including genes that code for several synaptic proteins. In response to neuronal activity, rapid transcription of our model gene Arc is impaired by depletion of H2A.Z.2, but not H2A.Z.1. This impairment is partially rescued by codepletion of the H2A.Z chaperone, ANP32E. In contrast, under a different context (after 48 h of tetrodotoxin, TTX), rapid transcription of Arc is impaired by depletion of either hypervariant. Such context-dependent roles of H2A.Z hypervariants, as revealed by our multiplexed gene expression assays, are also evident with several other immediate early genes, where regulatory roles of these hypervariants vary from gene to gene under different conditions. Together, our data suggest that H2A.Z hypervariants have context-specific roles that complement each other to mediate activity-induced neuronal gene transcription

Does increasing biodiversity in an urban woodland setting promote positive emotional responses in humans? A stress recovery experiment using 360-degree videos of an urban woodland

Green spaces can support human stress reduction and foster positive emotional well-being. Previous research has suggested that biodiversity (i.e. the variety of species of plants and animals in a given location) can enhance recovery from stress even further. However, there is limited experimental evidence testing this hypothesis and results, to date, have been mixed. This study aimed to provide further understanding of the role of biodiversity (actual or perceived) on human well-being by experimentally manipulating species richness and stress. Participants (372 in total) took part in an online experiment, where they received an episode of mild stress before watching a 360-degree video to recover. The video showed the same location, an urban woodland, but at one of four artificially manipulated levels of biodiversity. The participants reported their Positive and Negative Affect before and after the stress induction and after watching the video, providing a measure of their stress and well-being throughout the experiment. Participants also reported their perceptions of biodiversity (i.e. how diverse they thought the location was) and elaborated on their responses with brief comments. Repeated Measure Analysis of Variance revealed that exposure to all levels of biodiversity reduced the participants’ Negative Affect, but with no significant difference between the conditions. However, the analysis showed higher Positive Affect in those participants who perceived the environment as more biodiverse. Comments from participants indicated that those who reported noticing flowers and trees in the environment also showed higher Positive Affect. This suggests that perceiving biodiversity promotes more positive emotions, but critically one needs to actually notice (engage with) the components of biodiversity to elicit these extra benefits

Mussel Inventory and Population Status of the Federally Endangered Potamilus capax (Green 1832) in the Tyronza River, Arkansas

Currently, few data exist for the mussel assemblages of the Tyronza River, Arkansas. The goal of this project was to inventory the freshwater mussel assemblages of the Tyronza River and determine the status of the federally endangered Potamilus capax. We qualitatively and quantitatively sampled mussel assemblages and documented the occurrence of S1 (extremely rare), S2 (very rare), and S3 (rare to uncommon) species. A total of 70.4 river kilometers were sampled in 2006 and 2007 resulting in 363 sampling sites, 4030 live individuals, and 25 species. We observed a total of 1 S1, 2 S2, and 9 S3 species. Mean catch-per-unit-of-effort was 0.9 (1.2 SD) individuals / min. and mean species richness and individual abundance were 3.4 (2.7 SD) species / site and 11.1 (15.1 SD) individuals / site, respectively. Thirteen Potamilus capax were collected during this survey, with only 1 gravid female and 2 juveniles. Quantitative survey mean densities per site ranged from 1.0 to 1.9 mussels / m2 with an overall mean of 1.4 individuals / m2 (0.3 SD). A total of 7 Potamilus capax were observed during quantitative sampling. Community Numerical Standing Crop estimates ranged from 70 ± 30 to 22,986 ± 7,905 individuals. The data collected from this survey provide a valuable baseline on the mussel assemblages of an altered-alluvial river and the location and status of all S1, S2 and S3 species. This information is essential to the management of this imperiled fauna in the Tyronza River

Deconstructing the power resistance relationship for squats: a joint-level analysis

Generating high leg power outputs is important for executing rapid movements. Squats are commonly used to increase leg strength and power. Therefore, it is useful to understand factors affecting power output in squatting. We aimed to deconstruct the mechanisms behind why power is maximized at certain resistances in squatting. Ten male rowers (age = 20 ± 2.2 years; height = 1.82 ± 0.03 m; mass = 86 ± 11 kg) performed maximal power squats with resistances ranging from body weight to 80% of their one repetition maximum (1RM). Three-dimensional kinematics was combined with ground reaction force (GRF) data in an inverse dynamics analysis to calculate leg joint moments and powers. System center of mass (COM) velocity and power were computed from GRF data. COM power was maximized across a range of resistances from 40% to 60% 1RM. This range was identified because a trade-off in hip and knee joint powers existed across this range, with maximal knee joint power occurring at 40% 1RM and maximal hip joint power at 60% 1RM. A non-linear system force-velocity relationship was observed that dictated large reductions in COM power below 20% 1RM and above 60% 1RM. These reductions were due to constraints on the control of the movement

Neuroendocrine tumour arising inside a retro-rectal tailgut cyst: report of two cases and a review of the literature

Tailgut cysts (or retro-rectal cyst-hamartomas (RCHs)) are developmental abnormalities consisting of multiloculated cysts lined by squamous, transitional or glandular epithelium which, albeit rarely, may give rise to malignant transformations. Carcinoid tumours arising in the presacral region are extremely rare and usually benign, and only a few are described in the literature. Case 1: A 63-year-old female diagnosed as having bilateral ovarian cysts underwent surgery to remove a right adnexial mass that was histopathologically diagnosed as a well-differentiated carcinoid tumour. She is currently disease free after 18 months of follow-up. Case 2: A 41-year-old-female diagnosed with hepatic metastases and a solid pelvic mass arising from a moderately differentiated neuroendocrine carcinoma is currently alive with disease after having undergone surgical removal of the mass and several medical treatments. We here describe two different clinical histories of well- and moderately differentiated neuroendocrine tumours (NETs) arising from tailgut cysts in the prerectal space together with a review of the relevant literature