Ivermectin Treatment of a Traveler Who Returned from Peru with Cutaneous Gnathostomiasis

We describe a 21-year-old patient who experienced a relapse of cutaneous gnathostomiasis after receiving initial treatment with albendazole and who had a successful outcome after receiving a short course of ivermectin for the relapse. This is the first reported case of gnathostomiasis acquired by a human in Per

Scalable Safe Policy Improvement via Monte Carlo Tree Search

Algorithms for safely improving policies are important to deploy reinforcement learning approaches in real-world scenarios. In this work, we propose an algorithm, called MCTS-SPIBB, that computes safe policy improvement online using a Monte Carlo Tree Search based strategy. We theoretically prove that the policy generated by MCTS-SPIBB converges, as the number of simulations grows, to the optimal safely improved policy generated by Safe Policy Improvement with Baseline Bootstrapping (SPIBB), a popular algorithm based on policy iteration. Moreover, our empirical analysis performed on three standard benchmark domains shows that MCTS-SPIBB scales to significantly larger problems than SPIBB because it computes the policy online and locally, i.e., only in the states actually visited by the agent

Spectral states evolution of 4U 1728-34 observed by INTEGRAL and RXTE: non-thermal component detection

We report results of a one-year monitoring of the low mass X-ray binary (LMXB) source (atoll type) 4U 1728-34 with INTEGRAL and RXTE. Three time intervals were covered by INTEGRAL, during which the source showed strong spectral evolution. We studied the broad-band X-ray spectra in detail by fitting several models in the different sections of the hardness-intensity diagram. The soft states are characterised by prominent blackbody emission plus a contribution from a Comptonized emission. The hard states are characterised by the presence of an excess flux with respect to the Comptonization model above 50 keV while the soft component is fainter. To obtain an acceptable fit to the data this excess is modeled either with a power law with photon index Gamma ~ 2 or a Comptonization (CompPS) spectrum implying the presence of hybrid thermal and non-thermal electrons in a corona. This makes 4U 1728-34 one of the few LMXBs of atoll type showing non-thermal emission at high energy. From our analysis, it is also apparent that the presence of the hard tail is more prominent as the overall spectrum becames harder. We discuss also alternative models which can discribe these hard states.Comment: Accepted for publication in MNRAS (accepted 2011 April 20. Received 2011 April 20; in original form 2010 December 07); 9 pages, 7 figure

Scalable Safe Policy Improvement for Factored Multi-Agent MDPs

In this work, we focus on safe policy improvement in multi-agent domains where current state-of-the-art methods cannot be effectively applied because of large state and action spaces. We consider recent results using Monte Carlo Tree Search for Safe Policy Improvement with Baseline Bootstrapping and propose a novel algorithm that scales this approach to multi-agent domains, exploiting the factorization of the transition model and value function. Given a centralized behavior policy and a dataset of trajectories, our algorithm generates an improved policy by selecting joint actions using a novel extension of Max-Plus (or Variable Elimination) that constrains local actions to guarantee safety criteria. An empirical evaluation on multi-agent SysAdmin and multi-UAV Delivery shows that the approach scales to very large domains where state-of-the-art methods cannot work

A Hard X-ray View on Scorpius X-1 with INTEGRAL: non-Thermal Emission ?

We present here simultaneous INTEGRAL/RXTE observations of Sco X-1, and in particular a study of the hard X-ray emission of the source and its correlation with the position in the Z-track of the X-ray color-color diagram. We find that the hard X-ray (above about 30 keV) emission of Sco X-1 is dominated by a power-law component with a photon index of ~3. The flux in the power-law component slightly decreases when the source moves in the color-color diagram in the sense of increasing inferred mass accretion rate from the horizontal branch to the normal branch/flaring branch vertex. It becomes not significantly detectable in the flaring branch, where its flux has decreased by about an order of magnitude. These results present close analogies to the behavior of GX 17+2, one of so-called Sco-like Z sources. Finally, the hard power law in the spectrum of Sco X-1 does not show any evidence of a high energy cutoff up to 100 - 200 keV, strongly suggesting a non-thermal origin of this component.Comment: 5 pages including 3 figures. Accepted for publication by ApJ Letter

On the Spectral Evolution of Cygnus X-2 along its Color-Color Diagram

We report on the results of a broad band (0.1-200 keV) spectral study of Cyg X-2 using two BeppoSAX observations taken in 1996 and 1997, respectively, for a total effective on-source time of ~100 ks. The color-color (CD) and hardness-intensity (HID) diagrams show that the source was in the horizontal branch (HB) and normal branch (NB) during the 1996 and 1997 observation, respectively. Five spectra were selected around different positions of the source in the CD/HID, two in the HB and three in the NB. These spectra are fit to a model consisting of a disk blackbody, a Comptonization component, and two Gaussian emission lines at ~1 keV and ~6.6 keV, respectively. The addition of a hard power-law tail with photon index ~2, contributing ~1.5% of the source luminosity, improves the fit of the spectra in the HB. We interpret the soft component as the emission from the inner accretion disk, with inner temperature, k T_in, varying between 0.8 and 1.7 keV and inner radius, R_in, varying between 26 and 11 km (assuming an inclination angle of the system of 60 degrees). The Comptonization component is probably emitted by hot plasma (electron temperature k T_e varying between 3 and ~20 keV, optical depth \tau ~ 11-0.4, seed-photon temperature k T_W ~ 1-2.4 keV) surrounding the NS. The changes in the parameters of the blackbody component indicate that the inner rim of the disk approaches the NS surface when the source moves from the HB to the NB, i.e. as the (inferred) mass accretion rate increases. The parameters of the Comptonized component also change significantly when the source moves from the HB to the NB. We discuss possible scenarios which can explain these changes

Coordination of Mobile Mules via Facility Location Strategies

In this paper, we study the problem of wireless sensor network (WSN) maintenance using mobile entities called mules. The mules are deployed in the area of the WSN in such a way that would minimize the time it takes them to reach a failed sensor and fix it. The mules must constantly optimize their collective deployment to account for occupied mules. The objective is to define the optimal deployment and task allocation strategy for the mules, so that the sensors' downtime and the mules' traveling distance are minimized. Our solutions are inspired by research in the field of computational geometry and the design of our algorithms is based on state of the art approximation algorithms for the classical problem of facility location. Our empirical results demonstrate how cooperation enhances the team's performance, and indicate that a combination of k-Median based deployment with closest-available task allocation provides the best results in terms of minimizing the sensors' downtime but is inefficient in terms of the mules' travel distance. A k-Centroid based deployment produces good results in both criteria.Comment: 12 pages, 6 figures, conferenc

Changing emotional engagement with running through communal self-tracking: The implications of ‘teleoaffective shaping’ for public health,

Emerging research explores the role of self-tracking in supporting healthy behaviour. Self-tracking comprises a number of interrelated practices; some individual some communal. In this paper we focus on practices that enable interaction between self-trackers through data sharing and communication around personal data. For public health, communal self-tracking has been explored for the additional benefits it provides in addition to self-knowledge. However, under-explored is the emotional entanglement of self-tracking and tracked activities, or the role of practitioners in the dynamic evolution of tracked practices. Qualitative, mixed methods data was collected from leisure-time runners in the SW England who self-track using social fitness app ‘Strava’, and was interpreted through the lens of practice theory. We find that communal self-tracking affords the active shaping of the emotion and purpose of running. This ‘teleoaffective shaping’ allows practitioners to negotiate and reconstitute appealing meanings associated with running to protect their practice loyalty. We identify three mechanisms for teleoaffective shaping afforded by Strava: labelling, reward and materialising effort. Findings advance our understanding of how social fitness apps work to retain practitioners of physically active leisure practices. Future research should further explore the multiple ways that associations with tracked physical activity evolve through entanglement with self-tracking practices

Rapid adaptation drives invasion of airway donor microbiota by Pseudomonas after lung transplantation.

In cystic fibrosis (CF) patients, chronic airway infection by Pseudomonas leads to progressive lung destruction ultimately requiring lung transplantation (LT). Following LT, CF-adapted Pseudomonas strains, potentially originating from the sinuses, may seed the allograft leading to infections and reduced allograft survival. We investigated whether CF-adapted Pseudomonas populations invade the donor microbiota and adapt to the non-CF allograft. We collected sequential Pseudomonas isolates and airway samples from a CF-lung transplant recipient during two years, and followed the dynamics of the microbiota and Pseudomonas populations. We show that Pseudomonas invaded the host microbiota within three days post-LT, in association with a reduction in richness and diversity. A dominant mucoid and hypermutator mutL lineage was replaced after 11 days by non-mucoid strains. Despite antibiotic therapy, Pseudomonas dominated the allograft microbiota until day 95. We observed positive selection of pre-LT variants and the appearance of novel mutations. Phenotypic adaptation resulted in increased biofilm formation and swimming motility capacities. Pseudomonas was replaced after 95 days by a microbiota dominated by Actinobacillus. In conclusion, mucoid Pseudomonas adapted to the CF-lung remained able to invade the allograft. Selection of both pre-existing non-mucoid subpopulations and of novel phenotypic traits suggests rapid adaptation of Pseudomonas to the non-CF allograft