There's plenty of light at the bottom: Statistics of photon penetration depth in random media

We propose a comprehensive statistical approach describing the penetration depth of light in random media. The presented theory exploits the concept of probability density function f(z|ρ, t) for the maximum depth reached by the photons that are eventually re-emitted from the surface of the medium at distance ρ and time t. Analytical formulas for f, for the mean maximum depth 〈zmax〉 and for the mean average depth 〈z〉 reached by the detected photons at the surface of a diffusive slab are derived within the framework of the diffusion approximation to the radiative transfer equation, both in the time domain and the continuous wave domain. Validation of the theory by means of comparisons with Monte Carlo simulations is also presented. The results are of interest for many research fields such as biomedical optics, advanced microscopy and disordered photonics

Mapping the Lyman-Alpha Emission Around a z~6.6 QSO with MUSE: Extended Emission and a Companion at Close Separation

We utilize the Multi Unit Spectroscopic Explorer (MUSE) on the Very Large Telescope (VLT) to search for extended Lyman-Alpha emission around the z~6.6 QSO J0305-3150. After carefully subtracting the point-spread-function, we reach a nominal 5-sigma surface brightness limit of SB = 1.9x10$^{-18}$ erg/s/cm$^2$/arcsec$^2$ over a 1 arcsec$^2$ aperture, collapsing 5 wavelength slices centered at the expected location of the redshifted Lyman-Alpha emission (i.e. at 9256 Ang.). Current data suggest the presence (5-sigma, accounting for systematics) of a Lyman-Alpha nebula that extends for 9 kpc around the QSO. This emission is displaced and redshifted by 155 km/s with respect to the location of the QSO host galaxy traced by the [CII] emission line. The total luminosity is L = 3.0x10$^{42}$ erg/s. Our analysis suggests that this emission is unlikely to rise from optically thick clouds illuminated by the ionizing radiation of the QSO. It is more plausible that the Lyman-Alpha emission is due to fluorescence of the highly ionized optically thin gas. This scenario implies a high hydrogen volume density of n$_H$ ~ 6 cm$^{-3}$. In addition, we detect a Lyman-Alpha emitter (LAE) in the immediate vicinity of the QSO: i.e., with a projected separation of 12.5 kpc and a line-of-sight velocity difference of 560 km/s. The luminosity of the LAE is L = 2.1x10$^{42}$ erg/s and its inferred star-formation-rate is SFR ~ 1.3 M$_\odot$/yr. The probability of finding such a close LAE is one order of magnitude above the expectations based on the QSO-galaxy cross-correlation function. This discovery is in agreement with a scenario where dissipative interactions favour the rapid build-up of super-massive black holes at early Cosmic times.Comment: 17 pages, 15 figures. Accepted for publication in Ap

Mapping the Lyman-Alpha Emission Around a z~6.6 QSO with MUSE: Extended Emission and a Companion at Close Separation

We utilize the Multi Unit Spectroscopic Explorer (MUSE) on the Very Large Telescope (VLT) to search for extended Lyman-Alpha emission around the z~6.6 QSO J0305-3150. After carefully subtracting the point-spread-function, we reach a nominal 5-sigma surface brightness limit of SB = 1.9x10$^{-18}$ erg/s/cm$^2$/arcsec$^2$ over a 1 arcsec$^2$ aperture, collapsing 5 wavelength slices centered at the expected location of the redshifted Lyman-Alpha emission (i.e. at 9256 Ang.). Current data suggest the presence (5-sigma, accounting for systematics) of a Lyman-Alpha nebula that extends for 9 kpc around the QSO. This emission is displaced and redshifted by 155 km/s with respect to the location of the QSO host galaxy traced by the [CII] emission line. The total luminosity is L = 3.0x10$^{42}$ erg/s. Our analysis suggests that this emission is unlikely to rise from optically thick clouds illuminated by the ionizing radiation of the QSO. It is more plausible that the Lyman-Alpha emission is due to fluorescence of the highly ionized optically thin gas. This scenario implies a high hydrogen volume density of n$_H$ ~ 6 cm$^{-3}$. In addition, we detect a Lyman-Alpha emitter (LAE) in the immediate vicinity of the QSO: i.e., with a projected separation of 12.5 kpc and a line-of-sight velocity difference of 560 km/s. The luminosity of the LAE is L = 2.1x10$^{42}$ erg/s and its inferred star-formation-rate is SFR ~ 1.3 M$_\odot$/yr. The probability of finding such a close LAE is one order of magnitude above the expectations based on the QSO-galaxy cross-correlation function. This discovery is in agreement with a scenario where dissipative interactions favour the rapid build-up of super-massive black holes at early Cosmic times.Comment: 17 pages, 15 figures. Accepted for publication in Ap

Time-domain Raman analytical forward solvers

A set of time-domain analytical forward solvers for Raman signals detected from homogeneous diffusive media is presented. The time-domain solvers have been developed for two geometries: the parallelepiped and the finite cylinder. The potential presence of a background fluorescence emission, contaminating the Raman signal, has also been taken into account. All the solvers have been obtained as solutions of the time dependent diffusion equation. The validation of the solvers has been performed by means of comparisons with the results of "gold standard" Monte Carlo simulations. These forward solvers provide an accurate tool to explore the information content encoded in the time-resolved Raman measurements

DNA Damage Triggers a New Phase in Neurodegeneration.

Subcellular compartmentalization contributes to the organization of a plethora of molecular events occurring within cells. This can be achieved in membraneless organelles generated through liquid-liquid phase separation (LLPS), a demixing process that separates and concentrates cellular reactions. RNA is often a critical factor in mediating LLPS. Recent evidence indicates that DNA damage response foci are membraneless structures formed via LLPS and modulated by noncoding transcripts synthesized at DNA damage sites. Neurodegeneration is often associated with DNA damage, and dysfunctional LLPS events can lead to the formation of toxic aggregates. In this review, we discuss those gene products involved in neurodegeneration that undergo LLPS and their involvement in the DNA damage response

Depth sensitivity of frequency domain optical measurements in diffusive media

The depth sensitivity functions for AC amplitude, phase (PH) and DC intensity signals have been obtained in the frequency domain (where the source amplitude is modulated at radio-frequencies) by making use of analytical solutions of the photon diffusion equation in an infinite slab geometry. Furthermore, solutions for the relative contrast of AC, PH and DC signals when a totally absorbing plane is placed at a fixed depth of the slab have also been obtained. The solutions have been validated by comparisons with gold standard Monte Carlo simulations. The obtained results show that the AC signal, for modulation frequencies < 200 MHz, has a depth sensitivity with similar characteristics to that of the continuous-wave (CW) domain (source modulation frequency of zero). Thus, the depth probed by such a signal can be estimated by using the formula of penetration depth for the CW domain (Sci. Rep. 6, 27057 (2016)). However, the PH signal has a different behavior compared to the CW domain, showing a larger depth sensitivity at shallow depths and a less steep relative contrast as a function of depth. These results mark a clear difference in term of depth sensitivity between AC and PH signals, and highlight the complexity of the estimation of the actual depth probed in tissue spectroscopy.Postprint (published version

Frequency offset Raman spectroscopy (FORS) for depth probing of diffusive media

We present a new technique, frequency offset Raman spectroscopy (FORS), to probe Raman spectra of diffusive media in depth. The proposed methodology obtains depth sensitivity exploiting changes in optical properties (absorption and scattering) with excitation wavelengths. The approach was demonstrated experimentally on a two-layer tissue phantom and compared with the already consolidated spatially offset Raman spectroscopy (SORS) technique. FORS attains a similar enhancement of signal from deep layers as SORS, namely 2.81 against 2.62, while the combined hybrid FORS-SORS approach leads to a markedly higher 6.0 enhancement. Differences and analogies between FORS and SORS are discussed, suggesting FORS as an additional or complementary approach for probing heterogeneous media such as biological tissues in depth

Identification of Soft Tissue-Mimicking Materials and Application in the Characterization of Sensors for Lung Sounds

Early diagnosis of pulmonary implications is fundamental for the treatment of several diseases, such as idiopathic pulmonary fibrosis, rheumatoid arthritis, connective tissue diseases and interstitial pneumonia secondary to COVID-19 among the many. Recent studies prove that a wide class of pulmonary diseases can be early detected by auscultation and suitably developed algorithms for the analysis of lung sounds. Indeed, the technical characteristics of sensors have an impact on the quality of the acquired lung sounds. The availability of a fair and quantitative approach to sensors’ comparison is a prerequisite for the development of new diagnostic tools. In this work the problem of a fair comparison between sensors for lung sounds is decoupled into two steps. The first part of this study is devoted to the identification of a synthetic material capable of mimicking the acoustic behavior of human soft tissues; this material is then adopted as a reference. In the second part, the standard skin is exploited to quantitatively compare several types of sensors in terms of noise floor and sensitivity. The proposed methodology leads to reproducible results and allows to consider sensors of different nature, e.g. laryngophone, electret microphone, digital MEMS microphone, mechanical phonendoscope and electronic phonendoscope. Finally, the experimental results are interpreted under the new perspective of equivalent sensitivity and some important guidelines for the design of new sensors are provided. These guidelines could represent the starting point for improving the devices for acquisition of lung sounds

Role of the ENPP1 K121Q Polymorphism in Glucose Homeostasis

OBJECTIVE— To study the role of the ENPP1 Q121 variant on glucose homeostasis in whites from Italy

Time-domain functional diffuse optical tomography system based on fiber-free silicon photomultipliers

Based on recent developments in both single-photon detectors and timing electronic circuits, we designed a compact and cost effective time-domain diffuse optical tomography system operated at 1 Hz acquisition rate, based on eight silicon photomultipliers and an 8-channel time-to-digital converter. The compact detectors are directly hosted on the probe in a circular arrangement around a single light injection fiber, so to maximize light harvesting. Tomography is achieved exploiting the depth sensitivity that is encoded in the arrival time of detected photons. The system performances were evaluated on simulations to assess possible the limitations arising from the use of a single injection point, and then on phantoms and in vivo to prove the eligibility of these technologies for diffuse optical tomography