ANÁLISE TÉCNICA E ECONÔMICA DO DIMENSIONAMENTO DE RESERVATÓRIOS DE ÁGUAS PLUVIAIS PARA FINS NÃO POTÁVEIS EM CONDOMÍNIO VERTICAL E HORIZONTAL

Rainwater harvesting systems are sustainable alternatives that collaborate with the rational use of water in the urban environment. Thus, the objective of this study was to evaluate technically and economically the hydraulic structure's implementation for the use of rainwater in two types of apartment complexes in Lavras - MG, Brazil, one vertical and the other horizontal, comparing the technical differences between them. The precipitation historical series of the municipality was prepared, and with that, itwas possible to estimate the monthly volume of usable rainwater. Then, the pipelinessystem and the water intake and conduction structures were designed, using thestandards NBR 10844 (ABNT, 1989) and NBR 5626 (ABNT, 1998). Still, the demandfor non-potable water was calculated and thus, the volume of the lower and upperreservoirs was determined. Lower reservoir volumes were calculated by the Rippl,Brazilian Practical and Simulation Methods, all presented by NBR 15527 (ABNT,2007). Finally, the budget composition was performed, and the technical and economicanalysis was performed using the Discounted Payback Method. It was identified thatfor the vertical condominium, the Brazilian Practical Method is the most appropriate,while for the horizontal condominium, the most convenient calculation model is theSimulation Method. In addition, it was found that the systems implemented areconsidered long-term investments, however, enable better management of waterresources.Os sistemas de captação e uso de água pluvial são alternativas sustentáveis que colaboram com o uso racional da água no meio urbano, assim, o objetivou-se com este estudo avaliar de forma técnica e econômica a implantação de estruturas hidráulicas para o aproveitamento de águas pluviais em dois tipos de condomínios de múltiplas unidades habitacionais, em Lavras - MG, sendo um dotipo vertical e outro horizontal, comparando assim as diferenças técnicas existentes entre eles. Então, preparou-se a série histórica de precipitações do município, e, com isso, pôde-se estimar o volume mensal de água de chuva aproveitável. Depois, elaborou-se o traçado dos sistemas e dimensionou-se as estruturas de captação e condução de água, utilizando as normas NBR 10844 (ABNT, 1989) e NBR 5626 (ABNT, 1998). Ainda foi calculada a demanda de água não potável e assim, determinou-se o volume dos reservatórios inferiores e superiores. Os volumes dos reservatórios inferiores foram calculados pelos Métodos de Rippl, Prático Brasileiro e Simulações, todos apresentados pela NBR 15527 (ABNT, 2007). Por fim, realizou-se a composição orçamentária e efetuou-se a análise técnica e econômica, por meio do Método de Payback Descontado. Identificou-se que para o condomínio vertical, o Método Prático Brasileiro é o mais adequado, enquanto para o horizontal, o modelo de cálculo mais conveniente é o Método das Simulações. Além disso, constatou-se que os sistemas implantados são considerados investimentos a longo prazo, entretanto, possibilitam uma melhor gestão dos recursos hídricos

SARS-CoV-2 introductions and early dynamics of the epidemic in Portugal

Genomic surveillance of SARS-CoV-2 in Portugal was rapidly implemented by the National Institute of Health in the early stages of the COVID-19 epidemic, in collaboration with more than 50 laboratories distributed nationwide. Methods By applying recent phylodynamic models that allow integration of individual-based travel history, we reconstructed and characterized the spatio-temporal dynamics of SARSCoV-2 introductions and early dissemination in Portugal. Results We detected at least 277 independent SARS-CoV-2 introductions, mostly from European countries (namely the United Kingdom, Spain, France, Italy, and Switzerland), which were consistent with the countries with the highest connectivity with Portugal. Although most introductions were estimated to have occurred during early March 2020, it is likely that SARS-CoV-2 was silently circulating in Portugal throughout February, before the first cases were confirmed. Conclusions Here we conclude that the earlier implementation of measures could have minimized the number of introductions and subsequent virus expansion in Portugal. This study lays the foundation for genomic epidemiology of SARS-CoV-2 in Portugal, and highlights the need for systematic and geographically-representative genomic surveillance.We gratefully acknowledge to Sara Hill and Nuno Faria (University of Oxford) and Joshua Quick and Nick Loman (University of Birmingham) for kindly providing us with the initial sets of Artic Network primers for NGS; Rafael Mamede (MRamirez team, IMM, Lisbon) for developing and sharing a bioinformatics script for sequence curation (https://github.com/rfm-targa/BioinfUtils); Philippe Lemey (KU Leuven) for providing guidance on the implementation of the phylodynamic models; Joshua L. Cherry (National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health) for providing guidance with the subsampling strategies; and all authors, originating and submitting laboratories who have contributed genome data on GISAID (https://www.gisaid.org/) on which part of this research is based. The opinions expressed in this article are those of the authors and do not reflect the view of the National Institutes of Health, the Department of Health and Human Services, or the United States government. This study is co-funded by Fundação para a Ciência e Tecnologia and Agência de Investigação Clínica e Inovação Biomédica (234_596874175) on behalf of the Research 4 COVID-19 call. Some infrastructural resources used in this study come from the GenomePT project (POCI-01-0145-FEDER-022184), supported by COMPETE 2020 - Operational Programme for Competitiveness and Internationalisation (POCI), Lisboa Portugal Regional Operational Programme (Lisboa2020), Algarve Portugal Regional Operational Programme (CRESC Algarve2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF), and by Fundação para a Ciência e a Tecnologia (FCT).info:eu-repo/semantics/publishedVersio

Pervasive gaps in Amazonian ecological research

Biodiversity loss is one of the main challenges of our time,1,2 and attempts to address it require a clear un derstanding of how ecological communities respond to environmental change across time and space.3,4 While the increasing availability of global databases on ecological communities has advanced our knowledge of biodiversity sensitivity to environmental changes,5–7 vast areas of the tropics remain understudied.8–11 In the American tropics, Amazonia stands out as the world’s most diverse rainforest and the primary source of Neotropical biodiversity,12 but it remains among the least known forests in America and is often underrepre sented in biodiversity databases.13–15 To worsen this situation, human-induced modifications16,17 may elim inate pieces of the Amazon’s biodiversity puzzle before we can use them to understand how ecological com munities are responding. To increase generalization and applicability of biodiversity knowledge,18,19 it is thus crucial to reduce biases in ecological research, particularly in regions projected to face the most pronounced environmental changes. We integrate ecological community metadata of 7,694 sampling sites for multiple or ganism groups in a machine learning model framework to map the research probability across the Brazilian Amazonia, while identifying the region’s vulnerability to environmental change. 15%–18% of the most ne glected areas in ecological research are expected to experience severe climate or land use changes by 2050. This means that unless we take immediate action, we will not be able to establish their current status, much less monitor how it is changing and what is being lostinfo:eu-repo/semantics/publishedVersio

Pervasive gaps in Amazonian ecological research

Biodiversity loss is one of the main challenges of our time,1,2 and attempts to address it require a clear understanding of how ecological communities respond to environmental change across time and space.3,4 While the increasing availability of global databases on ecological communities has advanced our knowledge of biodiversity sensitivity to environmental changes,5,6,7 vast areas of the tropics remain understudied.8,9,10,11 In the American tropics, Amazonia stands out as the world's most diverse rainforest and the primary source of Neotropical biodiversity,12 but it remains among the least known forests in America and is often underrepresented in biodiversity databases.13,14,15 To worsen this situation, human-induced modifications16,17 may eliminate pieces of the Amazon's biodiversity puzzle before we can use them to understand how ecological communities are responding. To increase generalization and applicability of biodiversity knowledge,18,19 it is thus crucial to reduce biases in ecological research, particularly in regions projected to face the most pronounced environmental changes. We integrate ecological community metadata of 7,694 sampling sites for multiple organism groups in a machine learning model framework to map the research probability across the Brazilian Amazonia, while identifying the region's vulnerability to environmental change. 15%–18% of the most neglected areas in ecological research are expected to experience severe climate or land use changes by 2050. This means that unless we take immediate action, we will not be able to establish their current status, much less monitor how it is changing and what is being lost

Pervasive gaps in Amazonian ecological research

Biodiversity loss is one of the main challenges of our time,1,2 and attempts to address it require a clear understanding of how ecological communities respond to environmental change across time and space.3,4 While the increasing availability of global databases on ecological communities has advanced our knowledge of biodiversity sensitivity to environmental changes,5,6,7 vast areas of the tropics remain understudied.8,9,10,11 In the American tropics, Amazonia stands out as the world's most diverse rainforest and the primary source of Neotropical biodiversity,12 but it remains among the least known forests in America and is often underrepresented in biodiversity databases.13,14,15 To worsen this situation, human-induced modifications16,17 may eliminate pieces of the Amazon's biodiversity puzzle before we can use them to understand how ecological communities are responding. To increase generalization and applicability of biodiversity knowledge,18,19 it is thus crucial to reduce biases in ecological research, particularly in regions projected to face the most pronounced environmental changes. We integrate ecological community metadata of 7,694 sampling sites for multiple organism groups in a machine learning model framework to map the research probability across the Brazilian Amazonia, while identifying the region's vulnerability to environmental change. 15%–18% of the most neglected areas in ecological research are expected to experience severe climate or land use changes by 2050. This means that unless we take immediate action, we will not be able to establish their current status, much less monitor how it is changing and what is being lost

ANÁLISE TÉCNICA E ECONÔMICA DO DIMENSIONAMENTO DE RESERVATÓRIOS DE ÁGUAS PLUVIAIS PARA FINS NÃO POTÁVEIS EM CONDOMÍNIO VERTICAL E HORIZONTAL

Rainwater harvesting systems are sustainable alternatives that collaborate with the rational use of water in the urban environment. Thus, the objective of this study was to evaluate technically and economically the hydraulic structure's implementation for the use of rainwater in two types of apartment complexes in Lavras - MG, Brazil, one vertical and the other horizontal, comparing the technical differences between them. The precipitation historical series of the municipality was prepared, and with that, itwas possible to estimate the monthly volume of usable rainwater. Then, the pipelinessystem and the water intake and conduction structures were designed, using thestandards NBR 10844 (ABNT, 1989) and NBR 5626 (ABNT, 1998). Still, the demandfor non-potable water was calculated and thus, the volume of the lower and upperreservoirs was determined. Lower reservoir volumes were calculated by the Rippl,Brazilian Practical and Simulation Methods, all presented by NBR 15527 (ABNT,2007). Finally, the budget composition was performed, and the technical and economicanalysis was performed using the Discounted Payback Method. It was identified thatfor the vertical condominium, the Brazilian Practical Method is the most appropriate,while for the horizontal condominium, the most convenient calculation model is theSimulation Method. In addition, it was found that the systems implemented areconsidered long-term investments, however, enable better management of waterresources.Os sistemas de captação e uso de água pluvial são alternativas sustentáveis que colaboram com o uso racional da água no meio urbano, assim, o objetivou-se com este estudo avaliar de forma técnica e econômica a implantação de estruturas hidráulicas para o aproveitamento de águas pluviais em dois tipos de condomínios de múltiplas unidades habitacionais, em Lavras - MG, sendo um dotipo vertical e outro horizontal, comparando assim as diferenças técnicas existentes entre eles. Então, preparou-se a série histórica de precipitações do município, e, com isso, pôde-se estimar o volume mensal de água de chuva aproveitável. Depois, elaborou-se o traçado dos sistemas e dimensionou-se as estruturas de captação e condução de água, utilizando as normas NBR 10844 (ABNT, 1989) e NBR 5626 (ABNT, 1998). Ainda foi calculada a demanda de água não potável e assim, determinou-se o volume dos reservatórios inferiores e superiores. Os volumes dos reservatórios inferiores foram calculados pelos Métodos de Rippl, Prático Brasileiro e Simulações, todos apresentados pela NBR 15527 (ABNT, 2007). Por fim, realizou-se a composição orçamentária e efetuou-se a análise técnica e econômica, por meio do Método de Payback Descontado. Identificou-se que para o condomínio vertical, o Método Prático Brasileiro é o mais adequado, enquanto para o horizontal, o modelo de cálculo mais conveniente é o Método das Simulações. Além disso, constatou-se que os sistemas implantados são considerados investimentos a longo prazo, entretanto, possibilitam uma melhor gestão dos recursos hídricos

MUCORMICOSE PULMONAR EM PACIENTE TRANSPLANTADO RENAL: RELATO DE CASO

A mucormicose é um grupo de infecções causadas por fungos da ordem Mucorales, sendo o Rhizopus oryzae o agente mais comum. Acometem principalmente pacientes imunodeprimidos, como portadores de diabetes mellitus descompensados, transplantados de órgãos sólidos, pacientes em quimioterapia e corticoterapia. A apresentação clínica é variável, onde as infecções rino-órbito-cerebrais e pulmonares são as síndromes mais comuns. A forma rinocerebral está mais associada ao diabetes, enquanto a forma pulmonar é mais presente em indivíduos portadores de neoplasias sob quimioterapia ou submetidos a transplante. O relato de caso abaixo, descreve a evolução de um paciente imunossuprimido após transplante renal com mucormicose pulmonar. Paciente masculino, 34 anos, portador de doença renal crônica dialítica, submetido a transplante renal em 26/05/2022. Apresentou atraso de função do enxerto, e episódios de pielonefrite com tratamento guiado por cultura. Após decretada falência de enxerto, foi internado em 02/09/22 para transplantectomia. Na ocasião, relatava tosse com expectoração escurecida há cerca de duas semanas, além de calafrios, inapetência e náuseas. Em tomografia de tórax, extensa cavitação em lobo superior direito com paredes espessas e nível hidroaéreo, além de nódulo escavado diminuto em lobo superior esquerdo adjacente a brônquio. Crescimento de Rhizopus sp em cultura de lavado broncoalveolar, além de RT-PCR para covid-19 positivo em swab nasofaríngeo. Após um mês de tratamento com anfotericina B, paciente mantinha sintomas e lesão cavitada em imagem de tórax, sendo indicado ressecção cirúrgica via toracotomia. Devido ao acometimento de lobos superior e médio, houve indicação de pneumectomia direita. Em 28/10, apresentou insuficiência respiratória aguda hipoxêmica e enfisema subcutâneo, sendo submetido a intubação orotraqueal, por provável fístula de coto brônquico. No mesmo dia evoluiu com parada cardiorrespiratória, sem resposta às medidas de reanimação. O caso evidencia a importância e gravidade da mucormicose pulmonar como diagnóstico diferencial de infecção oportunista em imunossuprimidos. Ainda há um grande subdiagnóstico da doença visto que o diagnóstico microbiológico e histopatológico é de difícil realização. Quando suspeitada, faz-se necessária intervenção urgente visto que a mortalidade associada a mucormicose mantém-se elevada mesmo com tratamento adequado