Asynchronous variation in the Quaternary East Asian winter monsoon associated with the tropical Pacific ENSO‐like system

Quaternary East Asian winter monsoon (EAWM) evolution has long been attributed to high-latitude Northern Hemisphere climate change. However, it cannot explain the distinct relationships of the EAWM in the northern and southern East Asian marginal sea in paleoclimatic records. Here we present an EAWM record of the northern East China Sea over the past 300 ka and a transient climate simulation with the Kiel Climate Model through the Holocene. Both proxy record and simulation suggest anticorrelated long-term EAWM evolution between the northern East China Sea and the South China Sea. We suggest that this spatial discrepancy of EAWM can be interpreted as El Niño–Southern Oscillation (ENSO)-like controlling, which generates cyclonic/anticyclonic wind anomalies in the northern/southern East Asian marginal sea. This research explains much of the controversy in nonorbital scale variability of Quaternary EAWM records in the East Asian marginal sea and supports a potent role of tropical forcing in East Asian winter climate change

The nature of the intra-night optical variability in blazars

In this paper we present results of a short-term optical monitoring of 13 blazars. The objects were monitored mostly in the R-band for a total of ~ 160 hours between 2006 and 2011. We study the nature of the short-term variations and show that most of them could be described as slow, smooth, and (almost) linear changes of up to ~ 0.1 mag/hour, but many objects show no short-term variations at all. In fact, we found only ~ 2 per cent chance to observe variability of more than 0.1 mag/hour for the sample we observed. Hints for quasi-periodic oscillations at very low amplitude levels are also found for some objects. We briefly discuss some of the possible mechanisms to generate the intra-night variability and the quasi-periodic oscillations.Comment: 10 pages, 13 figures, 1 table, Accepted for Publication in MNRA

EGFR Inhibition in Glioma Cells Modulates Rho Signaling to Inhibit Cell Motility and Invasion and Cooperates with Temozolomide to Reduce Cell Growth

Enforced EGFR activation upon gene amplification and/or mutation is a common hallmark of malignant glioma. Small molecule EGFR tyrosine kinase inhibitors, such as erlotinib (Tarceva), have shown some activity in a subset of glioma patients in recent trials, although the reported data on the cellular basis of glioma cell responsiveness to these compounds have been contradictory. Here we have used a panel of human glioma cell lines, including cells with amplified or mutant EGFR, to further characterize the cellular effects of EGFR inhibition with erlotinib. Dose-response and cellular growth assays indicate that erlotinib reduces cell proliferation in all tested cell lines without inducing cytotoxic effects. Flow cytometric analyses confirm that EGFR inhibition does not induce apoptosis in glioma cells, leading to cell cycle arrest in G1. Interestingly, erlotinib also prevents spontaneous multicellular tumour spheroid growth in U87MG cells and cooperates with sub-optimal doses of temozolomide (TMZ) to reduce multicellular tumour spheroid growth. This cooperation appears to be schedule-dependent, since pre-treatment with erlotinib protects against TMZ-induced cytotoxicity whereas concomitant treatment results in a cooperative effect. Cell cycle arrest in erlotinib-treated cells is associated with an inhibition of ERK and Akt signaling, resulting in cyclin D1 downregulation, an increase in p27kip1 levels and pRB hypophosphorylation. Interestingly, EGFR inhibition also perturbs Rho GTPase signaling and cellular morphology, leading to Rho/ROCK-dependent formation of actin stress fibres and the inhibition of glioma cell motility and invasion

Selective Synthesis of Fe2O3 and Fe3O4 Nanowires Via a Single Precursor: A General Method for Metal Oxide Nanowires

Hematite (α-Fe2O3) and magnetite (Fe3O4) nanowires with the diameter of about 100 nm and the length of tens of micrometers have been selectively synthesized by a microemulsion-based method in combination of the calcinations under different atmosphere. The effects of the precursors, annealing temperature, and atmosphere on the morphology and the structure of the products have been investigated. Moreover, Co3O4 nanowires have been fabricated to confirm the versatility of the method for metal oxide nanowires

A Luminous Peculiar Type Ia Supernova SN 2011hr: More Like SN 1991T or SN 2007if?

Photometric and spectroscopic observations of a slowly declining, luminous type Ia supernova (SN Ia) 2011hr in the star-burst galaxy NGC 2691 are presented. SN~2011hr is found to peak at $M_{B}=-19.84 \pm 0.40\,\rm{mag}$, with a post-maximum decline rate $\Delta$m$_{15}$(B) = 0.92 $\pm$ 0.03\,$\rm{mag}$. From the maximum-light bolometric luminosity, $L=(2.30 \pm 0.90) \times 10^{43}\,\rm{erg\,s^{-1}}$, we estimate the mass of synthesized \Nifs\ in SN~2011hr to be M(\rm{^{56}Ni})=1.11 \pm 0.43\,M_{\sun}. SN 2011hr appears more luminous than SN 1991T at around maximum light, and the absorption features from its intermediate-mass elements (IMEs) are noticeably weaker than the latter at similar phases. Spectral modelling suggests that SN 2011hr has the IMEs of $\sim$\,0.07 M_{\sun} in the outer ejecta, which is much lower than the typical value of normal SNe Ia (i.e., 0.3 -- 0.4 M_{\sun}) and is also lower than the value of SN 1991T (i.e., $\sim$\,0.18 M_{\sun}). These results indicate that SN~2011hr may arise from a Chandrasekhar-mass white dwarf progenitor that experienced a more efficient burning process in the explosion. Nevertheless, it is still possible that SN~2011hr may serve as a transitional object connecting the SN 1991T-like SNe Ia with the super-luminous subclass like SN 2007if given that the latter also shows very weak IMEs at all phases

Nuclear dependence of the transverse single-spin asymmetry in the production of charged hadrons at forward rapidity in polarized p+pp+p, p+p+Al, and p+p+Au collisions at sNN=200\sqrt{s_{_{NN}}}=200 GeV

We report on the nuclear dependence of transverse single-spin asymmetries (TSSAs) in the production of positively-charged hadrons in polarized $p^{\uparrow}+p$, $p^{\uparrow}+$Al and $p^{\uparrow}+$Au collisions at $\sqrt{s_{_{NN}}}=200$ GeV. The measurements have been performed at forward rapidity ($1.4<\eta<2.4$) over the range of $1.8<p_{T}<7.0$ GeV$/c$ and $0.1<x_{F}<0.2$. We observed a positive asymmetry $A_{N}$ for positively-charged hadrons in \polpp collisions, and a significantly reduced asymmetry in $p^{\uparrow}$+$A$ collisions. These results reveal a nuclear dependence of charged hadron $A_N$ in a regime where perturbative techniques are relevant. These results provide new opportunities to use \polpA collisions as a tool to investigate the rich phenomena behind TSSAs in hadronic collisions and to use TSSA as a new handle in studying small-system collisions.Comment: 303 authors from 66 institutions, 9 pages, 2 figures, 1 table. v1 is version accepted for publication in Physical Review Letters. Plain text data tables for the points plotted in figures for this and previous PHENIX publications are (or will be) publicly available at http://www.phenix.bnl.gov/papers.htm

Enhanced UV photosensitivity from rapid thermal annealed vertically aligned ZnO nanowires

We report on the major improvement in UV photosensitivity and faster photoresponse from vertically aligned ZnO nanowires (NWs) by means of rapid thermal annealing (RTA). The ZnO NWs were grown by vapor-liquid-solid method and subsequently RTA treated at 700°C and 800°C for 120 s. The UV photosensitivity (photo-to-dark current ratio) is 4.5 × 103 for the as-grown NWs and after RTA treatment it is enhanced by a factor of five. The photocurrent (PC) spectra of the as-grown and RTA-treated NWs show a strong peak in the UV region and two other relatively weak peaks in the visible region. The photoresponse measurement shows a bi-exponential growth and bi-exponential decay of the PC from as-grown as well as RTA-treated ZnO NWs. The growth and decay time constants are reduced after the RTA treatment indicating a faster photoresponse. The dark current-voltage characteristics clearly show the presence of surface defects-related trap centers on the as-grown ZnO NWs and after RTA treatment it is significantly reduced. The RTA processing diminishes the surface defect-related trap centers and modifies the surface of the ZnO NWs, resulting in enhanced PC and faster photoresponse. These results demonstrated the effectiveness of RTA processing for achieving improved photosensitivity of ZnO NWs