Acoustic monitoring of a prestressed concrete beam reinforced by adhesively bonded composite

ICCRRR 2018, International Conference on Concrete Repair Rehabilitation and Retrofitting, Cape Town, Afrique du Sud, 19-/09/2019 - 21/09/2019The use of adhesively bonded composite reinforcement is relatively widely used for concrete structures. Yet, some questions remain regarding its use in the case of prestressed concrete structures especially in relation with the influence of existing cracking and the verification of the encountered damage phenomena at real scale. French National Organism CEREMA with the help of French motorway bridge owners association ASFA and French National Research Organism IFSTTAR realized several real size experimental investigations of an old prestressed concrete beam coming from a deconstructed bridge to answer these questions (Project CLERVAL). Both flexure and shear tests up to failure were carried out and several measurement methods were used to understand the role of the composite reinforcement on the behavior of the structure and the damage scenario. Acoustic emission was one of these methods and two different systems were investigated. The proposed communication will first describe the two used acoustic systems and their dedication (localized acoustic emission and overall acoustic survey). A specific development will then be presented aiming at optimizing the obtained acoustic phenomena localization taking into account the anisotropy of the prestressed concrete beam. Finally, main results will then be presented for both flexure and shear tests

Capture of radionuclides in porous metal organic frameworks (MOFs)

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ESRF Ramping Injector Power Supply Controlled by Tango

International audienceA new design of ESRF booster power supply system has been developed and installed. A multiple power supplies control through network including real time control is now operational at ESRF. It manages 4 power supplies to generate 3 waveforms defined with 3x1600 values in a setpoint file. The power supplies states are managed by PLCs. The ramping waveforms are managed by a real time program running on a FPGA board. And a high level control on top of them is assumed by a TANGO multiple classes system. This paper presents how these three levels of controls are interlinked and show the results achieve

Capture de radionucléides dans les solides poreux de type Metal-Organique Framework

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Capture of radionuclides in Metal-Organique Framework (MOF)

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Acoustic monitoring of a prestressed concrete beam reinforced by adhesively bonded composite

The use of adhesively bonded composite reinforcement is relatively widely used for concrete structures. Yet, some questions remain regarding its use in the case of prestressed concrete structures especially in relation with the influence of existing cracking and the verification of the encountered damage phenomena at real scale. French National Organism CEREMA with the help of French motorway bridge owners association ASFA and French National Research Organism IFSTTAR realized several real size experimental investigations of an old prestressed concrete beam coming from a deconstructed bridge to answer these questions (Project CLERVAL). Both flexure and shear tests up to failure were carried out and several measurement methods were used to understand the role of the composite reinforcement on the behavior of the structure and the damage scenario. Acoustic emission was one of these methods and two different systems were investigated. The proposed communication will first describe the two used acoustic systems and their dedication (localized acoustic emission and overall acoustic survey). A specific development will then be presented aiming at optimizing the obtained acoustic phenomena localization taking into account the anisotropy of the prestressed concrete beam. Finally, main results will then be presented for both flexure and shear tests

Long-Term Antithrombotic Treatments Prescribed for Cardiovascular Diseases in Patients with Hemophilia: Results from the French Registry

International audienceCardiovascular diseases (CVDs) are a major issue in aging patients with hemophilia (PWHs). Antithrombotic agents are widely used in the general population for CVD treatment, but this recommendation is not fully applicable to PWHs. To improve treatment strategies, a prospective case-control study (COCHE) that analyzed CVD management and follow-up (2 years/patient) in PWHs was performed in France from 2011 to 2018. In total, 68 PWHs (median age: 65 years [39-89]; 48 mild, 10 moderate, and 10 severe hemophilia) were included ( n =50 with acute coronary syndrome, n =17 with atrial fibrillation, n =1 with both). They were matched with 68 control PWHs without antithrombotic treatment. In our series, bleeding was significantly influenced by (1) hemophilia severity, with a mean annualized bleeding ratio significantly higher in COCHE patients than in controls with basal clotting factor level up to 20%, (2) antihemorrhagic regimen (on-demand vs. prophylaxis) in severe (hazard ratio [HR]=16.69 [95% confidence interval, CI: 8.2-47.26]; p3 (odds ratio [OR]=33 [95% CI: 1.43-761.2]; p =0 . 0065). Gastrointestinal bleeding was also significantly higher in COCHE patients than in controls (OR=15 [95% CI: 1.84-268]; p =0 . 0141). The COCHE study confirmed that antithrombotic treatments in PWHs are associated with increased bleeding rates in function of hemophilia-specific factors and also of known factors in the general population

Switchable Redox and Thermo‐Responsive Supramolecular Polymers Based on Cyclodextrin‐Polyoxometalate Tandem

International audienceSupramolecular polymers built from stimuli‐responsive host‐guest interactions represent an attractive way of tailoring smart materials. Herein, we exploit the chaotropic effect of polyoxometalates and related host‐guest properties to design unconventional polymer systems with reversible redox and thermo‐responsive sol‐gel transition. These supramolecular networks result from the association of cyclodextrin‐based oligomers and Keggin‐type POMs acting as electro‐active crosslinking agents. The structure and the dynamics of such self‐assembly systems have been investigated using a multiscale approach involving MALDI‐TOF, viscosity measurements, cyclic voltammetry, 1H‐NMR (1D and DOSY), and Small‐Angle X‐ray Scattering. Our results reveal that the chaotropic effect corresponds to a powerful and efficient force that can be used to induce responsiveness in hybrid supramolecular oligomeric systems

Reinvestigation of unidentified causative variants in FXI-deficient patients: Focus on gene segment deletions

International audienceIntroduction: Data on failure to identify the molecular mechanism underlying FXI deficiency by Sanger analysis and the contribution of gene segment deletions are almost inexistent. Aims and methods: Prospective and retrospective analysis was conducted on FXI-deficient patients’ DNA via Next Generation Sequencing (NGS), or Sanger sequencing and Multiplex Probe Ligation-dependent Assay (MLPA) to detect cryptic causative gene variants or gene segment deletions. Results: Sanger analysis or NGS enabled us to identify six severe and one partial (median activity 41 IU/dl) FXI deficient index cases with deletions encompassing exons 11–15, the whole gene, or both. After Sanger sequencing, retrospective evaluation using MLPA detected seven additional deletion cases in apparently homozygous cases in non-consanguineous families, or in previously unsolved FXI-deficiency cases. Among the 504 index cases with a complete genetic investigation (Sanger/MLPA, or NGS), 23 remained unsolved (no abnormality found [n = 14] or rare intronic variants currently under investigation, [n = 9]). In the 481 solved cases (95% efficiency), we identified F11 gene-deleted patients (14 cases; 2.9%). Among these, whole gene deletion accounted for four heterozygous cases, exons 11–15 deletion for five heterozygous and three homozygous ones, while compound heterozygous deletion and isolated exon 12 deletion accounted for one case each. Conclusion: Given the high incidence of deletions in our population (2.9%), MLPA (or NGS with a reliable bioinformatic pipeline) should be systematically performed for unsolved FXI deficiencies or apparently homozygous cases in non-consanguineous families

Prise en charge néphrologique des patients hémophiles A : difficultés diagnostiques et thérapeutiques illustrées par le cas de 2 patients

International audienceHemophilia A is an X-linked genetic hemorrhagic disorder characterized by a factor VIII deficiency. The availability of secured substitution products has led to a dramatic improvement of life expectancy in hemophiliac patients. Nowadays, adult hemophiliac patients may develop Chronic Kidney Disease (CKD) resulting from age-related comorbidities (hypertension, obesity, diabetes). In addition, the high prevalence of viral infections in this population exposes patients to an increased risk of CKD. The risk of hemorrhage in hemophiliac patients is a challenge for their clinical management, both for diagnostic procedures (kidney biopsy in particular) and for renal replacement therapy (dialysis or renal transplantation) when it is needed. This work provides an update of the literature data concerning the management of hemophiliac patients in nephrology, illustrated by the cases of two patients