19 research outputs found

    Using Enterprise Architecture Framework

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    Thesis (S.M.)--Massachusetts Institute of Technology, Engineering Systems Division, February 2013."October 2012." Cataloged from PDF version of thesis.Includes bibliographical references (p. 88-92).The demand for Saudi oil is increasing locally and internationally, and being one of the major oil exporters in the world, the government of Saudi Arabia needs to balance between local consumption and international demand. To address this challenge, Saudi Arabia is adopting an aggressive strategy to use solar energy instead of oil to generate electricity. This strategy creates an opportunity to diversify the country's GDP by building solar manufacturing industry. This thesis uses the Enterprise Architecture Framework, developed by Nightingale and Rhodes, to propose the optimal architecture for the Saudi solar manufacturing in terms of organization, policy, strategy, product, services, infrastructure, and R&D. The first stage of the framework identifies the landscape and the major stakeholders in the solar manufacturing, and then studies the current situation of the Saudi solar manufacturing. The second stage analyzes the different proposed architectures. The third stage evaluates the different architectures, and the fourth stage selects and validates the winning architectures. The evaluation criteria for the different proposed architectures are based on three angles: "Attractiveness", which measures the level of compatibility between the architecture and the needs of the Saudi government. The "Effort", measures the human and financial effort required to deploy the architecture. The "Risk", which measures the different risks associated with the architecture. The winning architecture encourages Saudi businessmen to acquire international companies along with building local manufacturing for products in the lower end of the solar manufacturing value chain. The strategy in this architecture is to build fast capabilities in the technology and process side by acquiring international companies and steady capabilities in the production side by gradually moving up in the value chain. Also, the architecture proposes focusing and building the local R&D capabilities to improve the productivity, and profitability of the solar manufacturing companies.by Bassel F. Alsultan.S.M

    Impact of pharmacist intervention in patient counseling at point of hospital discharge in a specialized cardiac center in Saudi Arabia

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    Purpose: To determine the interventions associated with the pharmacist’s patient counseling and review of discharge prescriptions of patients from a specialized cardiac center in Saudi Arabia.Methods: This was a prospective interventional study conducted at Prince Sultan Cardiac Center (PSCC) in Riyadh, Saudi Arabia for a duration of 12 months. The pharmacist responsible for providing patient counseling reviewed the patient records, collected patient demographics and clinical data, as well as medical and medication history, diagnosis and discharge (treatment) plan.Results: The study included 2008 patients who met the inclusion criteria. The counseling pharmacist identified and provided interventions to 358 (18 %) patients for 508 (3.4 %) items. About half of counseling pharmacist interventions concerned involved the addition of a drug to treatment regimen followed by drug discontinuation (28.1 %). The most common reason for adding the drug during patient counseling was the omission of medications (35 %). Angiotensin-converting enzyme inhibitors/angiotensin receptor blockers (ACEI/ARBs), antidiabetics and antihyperlipidemics were the classes of drugs often associated with counseling pharmacist interventions. The cost-saving interventions identified were 200 (39.4 %). Out of these, drug discontinuation (n = 143) was the most frequent suggestion provided by the intervening pharmacist, followed by a dose reduction resulting in cost savings of 66.5 % (US 6,590.10)and8.9 6,590.10) and 8.9 % (US 882.32), respectively.Conclusion: The results indicate that discharge medication discrepancies decrease as a result of pharmacist-facilitated patient counseling at the point of hospital discharge.Keywords: Discharged patients, Cardiac, Counseling, Pharmacist-intervention, Coronary artery diseas

    Preparatory Year Students’ Perception of Pharmacy Profession as a Career Choice: A Cross-Sectional Study

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    The study attempted to assess preparatory year students’ perception towards pharmacists and the pharmacy profession. This cross-sectional survey was conducted between December 2019 and March 2020. The students were invited to complete an anonymous questionnaire via Google Forms®. In total, 244 students, of which 53.7% were female with the mean age of 19.2 ± 0.65, from 12 universities participated in this study. As per our findings, the majority of the respondents (91.8%) regard pharmacy as a well-respected profession, 82.4% thought pharmacists are important decision-makers, 68.4% disagreed that most pharmacists were unkind, and 60.7% did not agree that pharmacy was a low-status occupation. Meanwhile, 95.5% agreed that pharmacists must have a university degree, 88.6% agreed pharmacists must take responsibility for patients, and 82.8% believed pharmacists had to work too hard. Moreover, 62.3% did not think pharmacy was a low-skill occupation, 54.9% did not agree pharmacists must do unpleasant things, and 45.1% disagreed pharmacists only did what physicians requested of them. Lastly, 48.8% had low confidence in choosing pharmacy as a career. The students’ overall perception toward pharmacists and the pharmacy profession was favorable. However, only one-fourth of the students displayed a tendency to choose pharmacy as a future career

    Free-H2 deoxygenation of Jatropha curcas oil into cleaner diesel-grade biofuel over coconut residue-derived activated carbon catalyst

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    Diesel-like hydrocarbons were produced by the catalytic deoxygenation (DO) of Jatropha curcas oil (JCO) over novel Agx/AC and Niy-Agx/AC catalysts under an H2-free atmosphere. The AC was synthesized from coconut fibre residues (CFR), where CFR is the by-product from coconut milk extraction and is particularly rich in soft fibres with high mineral content. The Niy-Agx/AC catalyst afforded higher DO activity via the decarboxylation/decarbonylation (deCOx) route than Agx/AC due to the properties of Ni, synergistic interaction of Ni and Ag species, adequate amount of strong acid sites and large number of weak acid sites, which cause extensive C-O cleavage and lead to rich formation of n-(C15+C17) hydrocarbons. The effect of Ag and Ni content were studied within the 5 to 15 wt% range. An optimum Ni and Ag metal content (5 wt%) for deCOx reaction was observed. Excess Ni is not preferable due to a tendency for cracking and Ag-rich containing catalyst weakly enforced triglycerides breaking. The Ni5-Ag5/AC govern exclusively decarbonylation reaction, which corroborates the presence of Ni²⁺ species and a high amount of strong acid sites. Ultimately, Ni5-Ag5/AC in the present study shows excellent chemical stability with consistent five reusability without drastic reduction of hydrocarbon yield (78–95%) and n-(C15+C17) selectivity (82–83%), which indicate favourable application in JCO DO

    Perception and satisfaction of stakeholders regarding the patient care area pharmacist initiative in a military hospital in Saudi Arabia

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    Purpose: To explore the perceptions and satisfaction of stakeholders (physicians, nurses, and pharmacists) regarding services provided by the patient care area pharmacist (PCAP) initiative. Methods: This was a cross-sectional study conducted at Prince Sultan Military Medical City (PSMMC). The questionnaire was hand-delivered to a random sample of stakeholder groups (including physicians, nurses, and pharmacists) in three different areas of the hospital: the neonatal intensive care unit (NICU), high dependency unit (HDU), and pediatric nephrology. The questionnaire consisted of three sections. The first section collected demographic information of the participants, and the other sections collected anonymous opinions regarding services provided by the PCAP. Results: Ninety-nine participants, comprising physicians (n = 27; 27.27 %), nurses (n = 55; 55.55%), inpatient pharmacists (n = 13; 13.13%), and PCAPs (n = 4; 4.04%), participated in the survey. A majority of the respondents (92.3 %) were satisfied with the PCAP services, and all respondents recommended expansion of the PCAP service to cover all wards. Conclusion: The findings show that all participants have a positive perception of the PCAP service; PCAPs were seen by the participants as drug experts, and their recommendations were perceived as clinically relevant. All stakeholders sought to continue working with the PCAP. Keywords: Patient care, PCAP, Attitude, Satisfaction, Pharmac

    Production of renewable diesel from Jatropha curcas oil via pyrolytic-deoxygenation over various multi-wall carbon nanotube-based catalysts

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    Jatropha curcas is a highly toxic plant that produces seed containing viscous oil with productivity (2 ton/ha), it grows in tropical and sub-tropical regions and offer greater adaptability to a wide range of climatic and soil conditions. Its oils have been noted as an important alternative to produce green diesel via deoxygenation reaction. This study, deoxygenation of jatropha curcas oil (JCO) was carried out over NiO–Fe2O3 and NiO–ZnO catalysts that supported onto multi-walled carbon nanotube (MWCNT). It had found that high Fe and Zn dosages were ineffective in deoxygenation and greatest activity was observed on NiO(20) Fe2O3(5)/MWCNT catalyst. Structure-activity correlations revealed that low metal loading, large density of weak + medium acidic sites and strong basic sites play key role in enhancing the catalytic activities and n-(C15+C17) selectivity. Comparing carbon nanostructures and carbon micron size supported NiO-Fe2O3 revealed that green diesel obtained from NiO–Fe2O3/MWCNT catalysed deoxygenation had the highest heating value and the lowest amounts of oxygen content. Thereby, it confirmed the importance of carbon nanostructure as the catalyst support in improving the diesel quality. Considering the high reusability of NiO-Fe2O3/MWCNT (6 consecutive runs) and superior green diesel properties (flash point, cloud properties and cetane index) demonstrated the NiO–Fe2O3/MWCNT catalyst offers great option in producing excellent properties of green diesel for energy sector

    Production of green diesel from catalytic deoxygenation of chicken fat oil over a series binary metal oxide-supported MWCNTs

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    Deoxygenation processes that exploit milder reaction conditions under H2-free atmospheres appear environmentally and economically effective for the production of green diesel. Herein, green diesel was produced by catalytic deoxygenation of chicken fat oil (CFO) over oxides of binary metal pairs (Ni–Mg, Ni–Mn, Ni–Cu, Ni–Ce) supported on multi-walled carbon nanotubes (MWCNTs). The presence of Mg and Mn with Ni afforded greater deoxygenation activity, with hydrocarbon yields of >75% and n-(C15 + C17) selectivity of >81%, indicating that decarboxylation/decarbonylation (deCOx) of CFO is favoured by the existence of high amount of lower strength strong acidic sites along with noticeable strongly basic sites. Based on a series of studies of different Mg and Mn dosages (5–20 wt%), the oxygen free-rich diesel-range hydrocarbons produced efficiently by Ni10–Mg15/MWCNT and Ni10–Mn5/MWCNT catalysts yielded >84% of hydrocarbons, with n-(C15 + C17) selectivity of >85%. The heating value of the green diesel obtained complied with the ultra-low sulphur diesel standard

    Effectiveness and safety of edoxaban versus warfarin in patients with nonvalvular atrial fibrillation: a systematic review and meta-analysis of observational studies

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    Background: Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia type. Patients with AF are often administered anticoagulants to reduce the risk of ischemic stroke due to an irregular heartbeat. We evaluated the efficacy and safety of edoxaban versus warfarin in patients with nonvalvular AF by conducting an updated meta-analysis of real-world studies.Methods: In this comprehensive meta-analysis, we searched two databases, PubMed and EMBASE, and included retrospective cohort observational studies that compared edoxaban with warfarin in patients with nonvalvular AF from 1 January 2009, to 30 September 2023. The effectiveness and safety outcomes were ischemic stroke and major bleeding, respectively. In the final analysis, six retrospective observational studies involving 87,236 patients treated with warfarin and 40,933 patients treated with edoxaban were included. To analyze the data, we used a random-effects model to calculate the hazard ratio (HR).Results: Patients treated with edoxaban had a significantly lower risk of ischemic stroke [hazard ratio (HR) = 0.66; 95% confidence interval (CI) = 0.61–0.70; p < 0.0001] and major bleeding (HR = 0.58; 95% CI = 0.49–0.69; p < 0.0001) than those treated with warfarin. The sensitivity analysis results for ischemic stroke and major bleeding were as follows: HR = 0.66; 95% CI = 0.61–0.70; p < 0.0001 and HR = 0.58; 95% CI = 0.49–0.69; p < 0.0001, respectively.Conclusion: Our findings revealed that edoxaban performed better than warfarin against major bleeding and ischemic stroke

    The Saudi Critical Care Society practice guidelines on the management of COVID-19 in the ICU: Therapy section

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    BACKGROUND: The rapid increase in coronavirus disease 2019 (COVID-19) cases during the subsequent waves in Saudi Arabia and other countries prompted the Saudi Critical Care Society (SCCS) to put together a panel of experts to issue evidence-based recommendations for the management of COVID-19 in the intensive care unit (ICU). METHODS: The SCCS COVID-19 panel included 51 experts with expertise in critical care, respirology, infectious disease, epidemiology, emergency medicine, clinical pharmacy, nursing, respiratory therapy, methodology, and health policy. All members completed an electronic conflict of interest disclosure form. The panel addressed 9 questions that are related to the therapy of COVID-19 in the ICU. We identified relevant systematic reviews and clinical trials, then used the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach as well as the evidence-to-decision framework (EtD) to assess the quality of evidence and generate recommendations. RESULTS: The SCCS COVID-19 panel issued 12 recommendations on pharmacotherapeutic interventions (immunomodulators, antiviral agents, and anticoagulants) for severe and critical COVID-19, of which 3 were strong recommendations and 9 were weak recommendations. CONCLUSION: The SCCS COVID-19 panel used the GRADE approach to formulate recommendations on therapy for COVID-19 in the ICU. The EtD framework allows adaptation of these recommendations in different contexts. The SCCS guideline committee will update recommendations as new evidence becomes available
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