Multiparametric Analysis of Factors Associated With Eosinophilic Chronic Rhinosinusitis With Nasal Polyps

Introduction: Previous studies have reported a diverse range of threshold values for blood eosinophilia. In addition, a single predictive biomarker for eosinophilic chronic rhinosinusitis (CRS) with nasal polyps (ECRSwNP) has not yet been identified. Objectives: The aim of this study is to compare the clinical characteristics of ECRSwNP and non-ECRSwNP to evaluate the preoperative risk of tissue eosinophilia of chronic rhinosinusitis with nasal polyps (CRSwNP) through a multiparametric statistical analysis. Methods: One hundred ten patients with evidence of chronic polypoid rhinosinusitis were included in this study and clinical records were retrospectively reviewed. Eosinophilic CRSwNP was diagnosed based on the presence of at least 10 eosinophils per high-power field. The demographic and clinical features of ECRSwNP and non-ECRSwNP are described. The values of blood eosinophilia as predictors of tissue eosinophilia have been identified using receiver operating characteristic curves. As the predictive value of the identified cutoff through regression analysis was low, we evaluated whether other risk factors could be statistically associated with ECRSwNP, and from this, a new predictive model was proposed for the identification of eosinophilic nasal polyps before surgery. Results: We found that the best method for predicting ECRSwNP is based on a model having asthma, blood eosinophil percentage, posterior ethmoid value in Lund-Mackay score, and modified Lund-Kennedy score as explanatory variables. Conclusions: This study provides new data for a better understanding of the polypoid CRS endotypes, and the proposed model allows the endotype to be identified preoperatively

Exploring the role of theory of mind in moral judgment: The case of children with autism spectrum disorder

This paper adds to the growing research on moral judgment (MJ) by considering whether theory of mind (ToM) might foster children's autonomous MJ achievement. A group of 30 children with autism spectrum disorder (ASD) was compared in MJ and ToM with 30 typically developing (TD) children. Participants were tested for MJ with a classical Piaget's task and for ToM with a second order False Belief task. In the moral task, children were told two versions of a story: in one version the protagonist acted according to a moral intention but the action resulted in a harmful consequence; in the other version the protagonist acted according to an immoral intention, but the action resulted in a harmless consequence. Children were asked which of the two protagonists was the "naughtier." In line with previous studies, the results indicated that, while the majority of TD participants succeeded in the second order False Belief task, only few individuals with ASD showed intact perspective taking abilities. The analysis of the MJ in relation to ToM showed that children with ASD lacking ToM abilities judged guilty the protagonists of the two versions of the story in the moral task because both of them violated a moral rule or because they considered the consequences of the actions, ignoring any psychological information. These results indicate a heteronomous morality in individuals with ASD, based on the respect of learned moral rules and outcomes rather than others' subjective states

A new management scheme to support reverse logistics processes in the agrifood distribution sector

During the last decades, reverse logistics and reuse of products have received growing attention as profitable and sustainable business strategies. Looking at the agrifood distribution sector, every day thousands of agrifood stores throw away large quantities of food product no longer suitable for sale. This "waste product", in the majority of cases, could still find new uses as animal feed or fertilizer. The return flow of food product is a typical problem of reverse logistics. This study proposes a new bi-modular scheme for managing the process of collection of "food waste" resulting from the agribusiness distribution sector and its subsequent distribution to livestock farms and collection centers located in the area of interest. The proposed management scheme consists of two modules: - module 1: to cluster the observed area into convenient collection sectors by means of clustering algorithms; - module 2: to identify optimal retrieval routes within each cluster by using Vehicle Routing models. The province of Cagliari in Sardinia (Italy) has been identified as test area. An extensive data collection process has been performed in order to collect the information necessary to portray the existing scenario. The following businesses have been recorded: grocery stores and supermarkets with at least 400 sqm of retail area, livestock farms with at least 200 heads of cattle, feed mills. A number of variables concerning location, type, size and demand data have been collected for each recorded unit.The management scheme has been implemented in a software platform and successfully applied in the test area. The outcome provides useful insights to stakeholders and suggests avenues for further research in the area in order to develop a more general and intuitive tool for managing reverse logistics processes in agrifood chains

ISO investigates the nature of extremely-red hard X-ray sources responsible for the X-ray background

We analyse very deep X-ray and mid-IR surveys in common areas of the Lockman Hole and the HDF North to study the sources of the X-ray background (XRB) and to test the standard obscured accretion paradigm. We detect with ISO a rich population of X-ray luminous sources with red optical colours, including a fraction identified with Extremely Red Objects (R-K > 5) and galaxies with SEDs typical of normal massive ellipticals or spirals at z ~ 1. The high 0.5-10 keV X-ray luminosities of these objects (1E43-1E45 erg/s) indicate that the ultimate energy source is gravitational accretion, while the X-ray to IR flux ratios and the X-ray spectral hardness show evidence of photoelectric absorption at low X-ray energies. An important hint on the physics comes from the mid-IR data at 6.7 and 15 um, well reproduced by model spectra of completely obscured quasars under standard assumptions and l.o.s. optical depths tau ~ 30-40. Other predictions of the standard XRB picture, like the distributions of intrinsic bolometric luminosities and the relative fractions of type-I and -II objects (1:3), are also consistent with our results. Obscured gravitational accretion is then confirmed as being responsible for the bulk of the X-ray background, since we detect in the IR the down-graded energy photoelectrically absorbed in X-rays: 63% of the faint 5-10 keV XMM sources are detected in the mid-IR by Fadda et al. (2001). However, although as much as 90% of the X-ray energy production could be converted to IR photons, no more than 20% of the Cosmic IR Background can be attributed to X-ray loud AGNs.Comment: 7 pages, 5 postscript figures, ApJ submitte

Infrared Properties of Radio-Selected Submillimeter Galaxies in the Spitzer First Look Survey Verification Field

We report on submillimeter and infrared observations of 28 radio-selected galaxies in the Spitzer First Look Survey Verification field (FLSV). All of the radio-selected galaxies that show evidence for emission at 850um with SCUBA have Spitzer counterparts at 24um, while only half of the radio-selected galaxies without 850um emission have detectable counterparts at 24um. The data show a wide range of infrared colors (S70/S24 < 5--30, S8/S3.6 < 0.3--4), indicative of a mixture of infrared-warm AGN and cooler starburst dominated sources. The galaxies showing 850um emission have Spitzer flux densities and flux density ratios consistent with the range of values expected for high-redshift (z=1--4) ultraluminous infrared galaxies.Comment: Accepted for Spitzer ApJS Special Edition, 12 pages including 4 figures and 1 tabl

A highly obscured and strongly clustered galaxy population discovered with the Spitzer Space Telescope

The ~800 optically unseen (R>25.5) 24mum-selected sources in the complete Spitzer First Look Survey sample (Fadda et al. 2006) with F[24mum]>0.35 mJy are found to be very strongly clustered. If, as indicated by several lines of circumstantial evidence, they are ultraluminous far-IR galaxies at z ~ [1.6-2.7], the amplitude of their spatial correlation function is very high. The associated comoving clustering length is estimated to be r_0=14.0_{-2.4}^{+2.1} Mpc, value which puts these sources amongst the most strongly clustered populations of our known universe. Their 8mum-24mum colours suggest that the AGN contribution dominates above F[24mum] ~ 0.8 mJy, consistent with earlier analyses. The properties of these objects (number counts, redshift distribution, clustering amplitude) are fully consistent with those of proto-spheroidal galaxies in the process of forming most of their stars and of growing their active nucleus, as described by the Granato et al. (2004) model. In particular, the inferred space density of such galaxies at z ~ 2 is much higher than what expected from most semi-analytic models. Matches of the observed projected correlation function w(\theta) with models derived within the so-called Halo Occupation Scenario show that these sources have to be hosted by haloes more massive than ~10^{13.4} M_\odot. This value is significantly higher than that for the typical galactic haloes hosting massive elliptical galaxies, suggesting a duration of the starburst phase of massive high-redshift dusty galaxies of T_B ~ 0.5 Gyr.Comment: 14 pages, 10 figures, minor revisions, to appear on MNRA

Te.M.P.O., an app for using temporal musical mismatch in post-stroke neurorehabilitation: a preliminary randomized controlled study

BACKGROUND: Recently, the potential rehabilitation value of music has been examined and music-based interventions and techniques such as the Negative Mismatch (MMN) have been increasingly investigated in the neurological rehabilitation context. OBJECTIVE: The aim of this study was to investigate the effectiveness of a negative mismatch-based therapy on the disability and quality of life in patients with stroke in sub-acute phase. METHODS: Thirty patients with a stroke diagnosis in sub-acute phase were randomly assigned to one of two groups: Mismatch (Mg) or Control (CTRLg) group. Both groups used an innovative Android application: Temporal Musical Patterns Organisation (Te.M.P.O). The Disability Rating Scale (DRS), the Modified Barthel Index (MBI) and the Stroke Specific Quality of Life scale (SSQoL) were used at the baseline (T0) and after four weeks of training (T1), in order to assess changes over time. RESULTS: Statistical analysis was performed using the data of 24 (Mg = 12, CTRLg = 12) subjects. The results show a major improvement of the Mg with respect to the CTRLg in all clinical scales score. CONCLUSION: The temporal negative mismatch-based therapy performed with the Te.M.P.O. application could be useful in improving the disability and the quality of life in stroke survivors in a sub-acute phase

intra varietal agronomical variability in vitis vinifera l cv cannonau investigated by fluorescence texture and colorimetric analysis

To date, innovative, rapid and non-invasive techniques have been used to assess variations in morphological and technological characteristics between grape cultivars. In order to improve knowledge of the qualitative expression of the genetic traits of cv. Cannonau (syn. Grenache), fluorescence, texture and colorimetric analyses were performed on 85 biotypes attributable to this variety. Eighty-five Cannonau biotypes cultivated in the same vineyard were analysed in order to evaluate their morphological and agronomical characteristics. As regards the morphological traits, of the six descriptors observed, five were able to discriminate the Cannonau population according to different expression levels. Must composition, berry colour (using the Minolta tristimulus colorimeter), texture (assessed using the TaxT2i plus texturimeter) and fluorescence (using the Multiplex III detector) were determined on clusters harvested at the same time. Cluster analysis was able to separate the Cannonau population into five groups, characterised by differences in the following criteria: L*, a* and b*, berry skin thickness, FERARI, TSS, pH and titratable acidity, total polyphenols and total anthocyanins. The FERARI index was highly and positively correlated with total anthocyanins and negatively correlated with grape colour, while berry weight and berry skin thickness were not correlated with any variable assessed. The remarkable intra-variability encountered for the qualitative and quantitative characters in the Cannonau variety suggests that new biotypes could be selected for different oenological purposes, using techniques such as the measure of fluorescence and colorimetry. This is the first study carried out within the cv. Cannonau using innovative and classical techniques suitable to investigate intra-varietal variability