COVID-19 vaccination and unemployment risk: lessons from the Italian crisis

This paper analyzes the impact of mobility contraction on employee furlough and excess deaths in Italy during the COVID-19 crisis. Our approach exploits rainfall patterns across Italian administrative regions as a source of exogenous variation in human mobility to pinpoint the causal effect of mobility restrictions on excess deaths and furlough workers. Results confirm that the first countrywide lockdown has effectively curtailed the COVID-19 epidemics restricting it mainly to the northern part of the country, with the drawback of a countrywide increase in unemployment risk. Our analysis points out that a mobility contraction of 1% leads to a mortality reduction of 0.6%, but it induces an increase of 10% in Wage Guarantee Funds allowed hours. We discuss return-to-work policies and prioritizing policies for administering COVID-19 vaccines in the most advanced stage of a vaccination campaign when the healthy active population is left to be vaccinated

Relating pain intensity of newborns to onset of nonlinear phenomena in cry recordings

The cries of several full term newborns, recorded during blood sampling, were analyzed. Spectrograms showed the appearance of irregular patterns related to the pain assessed using the method of the DAN scale. In particular, the appearance of Noise concentration Patterns (NP) in spectrograms was related to the increase of the pain suffered by the newborns. In this scenario, pain constitutes a bifurcation parameter for the vocal folds dynamic, inducing a Ruelle-Takens-Newhouse chaotic transition.Comment: 15 pages, 4 figures, 1 table. Accepted for publication in Phys. Lett.

Detailed neutronic study of the power evolution for the European Sodium Fast Reactor during a positive insertion of reactivity

Abstract The new reactor concepts proposed in the Generation IV International Forum require the development and validation of new components and new materials. Inside the Collaborative Project on the European Sodium Fast Reactor, several accidental scenario have been studied. Nevertheless, none of them coped with mechanical safety assessment of the fuel cladding under accidental conditions. Among the accidental conditions considered, there is the unprotected transient of overpower (UTOP), due to the insertion, at the end of the first fuel cycle, of a positive reactivity into the reactor core as a consequence of the unexpected runaway of one control rod. The goal of the study was the search for a detailed distribution of the fission power, in the radial and axial directions, within the power peaked fuel pin under the above accidental conditions. Results show that after the control rod ejection an increase from 658 W/cm 3 to 894 W/cm 3 , i.e. of some 36%, is expected for the power peaked fuel pin. This information will represent the base to investigate, in a future work, the fuel cladding safety margin

A Root in Synapsis and the Other One in the Gut Microbiome-Brain Axis: Are the Two Poles of Ketogenic Diet Enough to Challenge Glioblastoma?

Glioblastoma is the most frequent and aggressive brain cancer in adults. While precision medicine in oncology has produced remarkable progress in several malignancies, treatment of glioblastoma has still limited available options and a dismal prognosis. After first-line treatment with surgery followed by radiochemotherapy based on the 2005 STUPP trial, no significant therapeutic advancements have been registered. While waiting that genomic characterization moves from a prognostic/predictive value into therapeutic applications, practical and easy-to-use approaches are eagerly awaited. Medical reports on the role of the ketogenic diet in adult neurological disorders and in glioblastoma suggest that nutritional interventions may condition outcomes and be associated with standard therapies. The acceptable macronutrient distribution of daily calories in a regular diet are 45–65% of daily calories from carbohydrates, 20–35% from fats, and 10–35% from protein. Basically, the ketogenic diet follows an approach based on low carbohydrates/high fat intake. In carbohydrates starvation, body energy derives from fat storage which is used to produce ketones and act as glucose surrogates. The ketogenic diet has several effects: metabolic interference with glucose and insulin and IGF-1 pathways, influence on neurotransmission, reduction of oxidative stress and inflammation, direct effect on gene expression through epigenetic mechanisms. Apart from these central effects working at the synapsis level, recent evidence also suggests a role for microbiome and gut-brain axis induced by a ketogenic diet. This review focuses on rationales supporting the ketogenic diet and clinical studies will be reported, looking at future possible perspectives

Successful selective arterial embolizations for bone metastases in renal cell carcinoma integrated with systemic therapies: A case report

the initial cytoreductive nephrectomy to 3 successive lines of medical treatment (sunitinib, everolimus, and sorafenib) and multiple locoregional treatments (spinal surgery, radiation therapy, and selective arterial embolization), resulting in a surprisingly long survival of over 75 months. In the era of target therapy, integration strategies, including additional locoregional treatment to medical therapy, are essential to optimize the clinical benefit, to maximize treatment duration overcoming focal progressive disease, and to improve the quality of life. In this context, we would highlight that selective transcatheter embolization of bone metastases from renal cell carcinoma should be considered as an effective and safe option in the palliative setting for patients with bone metastasis, especially for pain relief

MULTI-SCALAR SURVEYS FOR COMPLEX ARCHITECTURES

Abstract. This study is part of a much wider project in which professors and researchers from the University of Naples Federico II and the University of Campania Luigi Vanvitelli are collaborating in different subject areas. The object of study is the ancient Sanctuary of Montevergine characterized by a long history of transformations and stratifications. Driven by the desire to fill a singular gap, linked to the lack of a systematic and comprehensive study of a complex whose first settlement dates back to the early 12th century, various studies have been started relating to the historical, artistic and architectural aspects.Various surveying techniques and methods had to be used due to its architectural, compositional and settlement characteristics. Integrated 3D surveying technologies were used for both the cognitive studies of the entire complex as well as for investigating and detecting the elements at different scales, ranging from the architectural to the detailed ones

Platelet rich plasma from different preparations: effect on chondrocytes and synoviocytes of osteoarthritis patients

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