O CUIDADO NO DOMICÍLIO: UM DESAFIO EM CONSTRUÇÃO

Revisão bibliográfica sobre o cuidador domiciliar, identificando a tendência atual do cuidado no domicílio como uma estratégia para a desospitalização. Identifica a natureza, as origens e a prática do cuidado, salientando a diversidade de conceituações para a atenção domiciliar. Destaca a importância da concepção abrangente de família e da complexidade do cuidado praticado nesse novo/velho locus - o domicílio - e finaliza ressaltando que a enfermagem pode contribuir significativamente na construção e sistematização do saber e do fazer relacionados ao cuidado no domicílio.Review of bibliography on home care, identifying current tendencies in home care as a strategy for dehospitalization and humanization of care. IT identifies the nature, origins and practice of care, showing the very wide range of concepts of home care. Underline the importance of the concept which covers the family and the complexity of care practice in this new/old site – the home and come to the conclusion that nursing can contribute significantly to build and systematically organize this knowledge and practice

Clinical Aspects of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis With Severe Ocular Complications in Brazil

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are acute and potentially fatal inflammatory vesiculobullous reactions that affect the skin and mucous membranes, and which are most often triggered by particular medications and infections. In Brazil, the drugs most frequently associated with TEN and SJS include cold medicine such as dipyrone and NSAIDs, followed by carbamazepine, phenobarbital, penicillin, and allopurinol. Genetic variations have been found to increase the risk of SJS/TEN in response to triggering factors such as medications. The most closely associated genes found in Brazilian cold-medicine-related SJS/TEN patients with severe ocular complications are HLA-A*66:01 in those of mixed African and European ancestry and HLA-B*44:03 and HLA-C*12:03 in those of solely European ancestry. Our classification system for grading ocular surface complication severity in SJS/TEN patients revealed the most severe complications to be limbal stem cell deficiency and dry eye. Changes to the conjunctival flora have also been observed in SJS/TEN patients. Our group identified bacterial colonization in 95% of the eyes (55.5% of which were gram-positive cocci, 25.5% of which were gram-negative bacilli, and 19% of which were gram-positive bacilli). Several new treatment options in the acute and chronic ocular management of the SJS/TEN patients have been described. This article highlights some Brazilian institutions' contributions to ocular surface care in both the acute phase (including the use of amniotic membrane transplantation) and the chronic phase (such as eyelid margin and fornix reconstruction, minor salivary gland transplantation, amniotic membrane and limbal transplantation, scleral contact lenses, anti-angiogenic eyedrops for corneal neovascularization, ex-vivo cultivated limbal epithelium transplantation, conjunctival-limbal autografting, oral mucosa transplantation, and keratoprosthesis)

Game development as a pedagogical mechanism: a report on an experiment in public schools aimed at sustainability and the protection of the environment .

Educational games have been designed in this study with the aim ofarousing an interest in environmental education among 5th grade student , whichinvolve making sustainable use of the river that flows through the municipality ofInhangapi, located in the North-East of Para State´. The students’ gain inknowledge regarding the subjects covered in class was assessed at the end of thestudents´ game activities that involved the subjects taught. The results showed thatthe use of game construction contributed to the teaching and learning process withregard to the concepts of Computing and environmental education because almost60 % of the students correctly applied what they had been taught about gameconstruction

Potential application for antimicrobial and antileukemic therapy of a flavonoid-rich fraction of Camellia sinensis

The antimicrobial and antileukemic effect of a purified fraction of flavonoids from the leaves of Camellia sinensis was evaluated. An extraction yield of 9.77 mg.g-1 total flavonoids was recovered through a pressurized liquid extraction associated with solid-phase extraction. This fraction was tested against pathogenic microorganisms (Staphylococcus, Salmonella, and Enterococcus), considering the minimum inhibitory concentration. In addition, the human monocyte cell line THP-1, derived from a patient with acute monocytic leukemia, was used for the antitumor assay. The results show that the flavonoid-rich fraction obtained by coupling a Pressurized Liquids Extraction in-line with a Solid Phase Extraction (PLE-SPE) has a high antimicrobial effect and resulted in cell cycle blockage G0 / G1, increased DNA fragmentation, and altered leukemic cell morphology. These results suggest that a flavonoid-rich fraction obtained from Camellia sinensis can be applied as potential adjuvants in chemotherapy treatment to mitigate the side effects caused by chemotherapy or even as a supplement to cancer therapy9 página

Cross-sectional Survey of Hantavirus Infection, Brazil

A cross-sectional serosurvey was conducted to assess the proportion of persons exposed to hantaviruses in a virus-endemic area of the state of Minas Gerais, Brazil. Findings of this study suggested the presence of >1 hantaviruses circulating in this region causing hantavirus pulmonary syndrome, mild disease, or asymptomatic infection