1,482 research outputs found
Ultra-strong Adhesion of Graphene Membranes
As mechanical structures enter the nanoscale regime, the influence of van der
Waals forces increases. Graphene is attractive for nanomechanical systems
because its Young's modulus and strength are both intrinsically high, but the
mechanical behavior of graphene is also strongly influenced by the van der
Waals force. For example, this force clamps graphene samples to substrates, and
also holds together the individual graphene sheets in multilayer samples. Here
we use a pressurized blister test to directly measure the adhesion energy of
graphene sheets with a silicon oxide substrate. We find an adhesion energy of
0.45 \pm 0.02 J/m2 for monolayer graphene and 0.31 \pm 0.03 J/m2 for samples
containing 2-5 graphene sheets. These values are larger than the adhesion
energies measured in typical micromechanical structures and are comparable to
solid/liquid adhesion energies. We attribute this to the extreme flexibility of
graphene, which allows it to conform to the topography of even the smoothest
substrates, thus making its interaction with the substrate more liquid-like
than solid-like.Comment: to appear in Nature Nanotechnolog
On Geometrically Unified Fields and Universal Constants
We consider the Cartan extension of Riemann geometry as the basis upon which
to build the Sciama--Kibble completion of Einstein gravity, developing the most
general theory in which torsion and metric have two independent coupling
constants: the main problem of the ESK theory was that torsion, having the
Newton constant, was negligible beyond the Planck scale, but in this
theory torsion, with its own coupling constant, may be
relevant much further Planck scales; further consequences of these
torsionally-induced interactions will eventually be discussed.Comment: 10 page
Plasma high sensitivity troponin T levels in adult survivors of childhood leukaemias: determinants and associations with cardiac function
published_or_final_versio
The Classical Harmonic Vibrations of the Atomic Centers of Mass with Micro Amplitudes and Low Frequencies Monitored by the Entanglement between the Two Two-level Atoms in a Single mode Cavity
We study the entanglement dynamics of the two two-level atoms coupling with a
single-mode polarized cavity field after incorporating the atomic centers of
mass classical harmonic vibrations with micro amplitudes and low frequencies.
We propose a quantitative vibrant factor to modify the concurrence of the two
atoms states. When the vibrant frequencies are very low, we obtain that: (i)
the factor depends on the relative vibrant displacements and the initial phases
rather than the absolute amplitudes, and reduces the concurrence to three
orders of magnitude; (ii) the concurrence increases with the increase of the
initial phases; (iii) the frequency of the harmonic vibration can be obtained
by measuring the maximal value of the concurrence during a small time. These
results indicate that even the extremely weak classical harmonic vibrations can
be monitored by the entanglement of quantum states.Comment: 10 pages, 3 figure
Inferring hidden Markov models from noisy time sequences: a method to alleviate degeneracy in molecular dynamics
We present a new method for inferring hidden Markov models from noisy time
sequences without the necessity of assuming a model architecture, thus allowing
for the detection of degenerate states. This is based on the statistical
prediction techniques developed by Crutchfield et al., and generates so called
causal state models, equivalent to hidden Markov models. This method is
applicable to any continuous data which clusters around discrete values and
exhibits multiple transitions between these values such as tethered particle
motion data or Fluorescence Resonance Energy Transfer (FRET) spectra. The
algorithms developed have been shown to perform well on simulated data,
demonstrating the ability to recover the model used to generate the data under
high noise, sparse data conditions and the ability to infer the existence of
degenerate states. They have also been applied to new experimental FRET data of
Holliday Junction dynamics, extracting the expected two state model and
providing values for the transition rates in good agreement with previous
results and with results obtained using existing maximum likelihood based
methods.Comment: 19 pages, 9 figure
Regional Genetic Structure in the Aquatic Macrophyte Ruppia cirrhosa Suggests Dispersal by Waterbirds
The evolutionary history of the genus Ruppia has been shaped by hybridization, polyploidisation and vicariance that have resulted in a problematic taxonomy. Recent studies provided insight into species circumscription, organelle takeover by hybridization, and revealed the importance of verifying species identification to avoid distorting effects of mixing different species, when estimating population connectivity. In the present study, we use microsatellite markers to determine population diversity and connectivity patterns in Ruppia cirrhosa including two spatial scales: (1) from the Atlantic Iberian coastline in Portugal to the Siculo-Tunisian Strait in Sicily and (2) within the Iberian Peninsula comprising the Atlantic-Mediterranean transition. The higher diversity in the Mediterranean Sea suggests that populations have had longer persistence there, suggesting a possible origin and/or refugial area for the species. The high genotypic diversities highlight the importance of sexual reproduction for survival and maintenance of populations. Results revealed a regional population structure matching a continent-island model, with strong genetic isolation and low gene flow between populations. This population structure could be maintained by waterbirds, acting as occasional dispersal vectors. This information elucidates ecological strategies of brackish plant species in coastal lagoons, suggesting mechanisms used by this species to colonize new isolated habitats and dominate brackish aquatic macrophyte systems, yet maintaining strong genetic structure suggestive of very low dispersal.Fundacao para a Cincia e Tecnologia (FCT, Portugal) [PTDC/MAR/119363/2010, BIODIVERSA/0004/2015, UID/Multi/04326/2013]Pew FoundationSENECA FoundationMurcia Government, Spain [11881/PI/09]FCT Investigator Programme-Career Development [IF/00998/2014]Spanish Ministry of Education [AP2008-01209]European Community [00399/2012]info:eu-repo/semantics/publishedVersio
Genomic-Bioinformatic Analysis of Transcripts Enriched in the Third-Stage Larva of the Parasitic Nematode Ascaris suum
Differential transcription in Ascaris suum was investigated using a genomic-bioinformatic approach. A cDNA archive enriched for molecules in the infective third-stage larva (L3) of A. suum was constructed by suppressive-subtractive hybridization (SSH), and a subset of cDNAs from 3075 clones subjected to microarray analysis using cDNA probes derived from RNA from different developmental stages of A. suum. The cDNAs (n = 498) shown by microarray analysis to be enriched in the L3 were sequenced and subjected to bioinformatic analyses using a semi-automated pipeline (ESTExplorer). Using gene ontology (GO), 235 of these molecules were assigned to ‘biological process’ (n = 68), ‘cellular component’ (n = 50), or ‘molecular function’ (n = 117). Of the 91 clusters assembled, 56 molecules (61.5%) had homologues/orthologues in the free-living nematodes Caenorhabditis elegans and C. briggsae and/or other organisms, whereas 35 (38.5%) had no significant similarity to any sequences available in current gene databases. Transcripts encoding protein kinases, protein phosphatases (and their precursors), and enolases were abundantly represented in the L3 of A. suum, as were molecules involved in cellular processes, such as ubiquitination and proteasome function, gene transcription, protein–protein interactions, and function. In silico analyses inferred the C. elegans orthologues/homologues (n = 50) to be involved in apoptosis and insulin signaling (2%), ATP synthesis (2%), carbon metabolism (6%), fatty acid biosynthesis (2%), gap junction (2%), glucose metabolism (6%), or porphyrin metabolism (2%), although 34 (68%) of them could not be mapped to a specific metabolic pathway. Small numbers of these 50 molecules were predicted to be secreted (10%), anchored (2%), and/or transmembrane (12%) proteins. Functionally, 17 (34%) of them were predicted to be associated with (non-wild-type) RNAi phenotypes in C. elegans, the majority being embryonic lethality (Emb) (13 types; 58.8%), larval arrest (Lva) (23.5%) and larval lethality (Lvl) (47%). A genetic interaction network was predicted for these 17 C. elegans orthologues, revealing highly significant interactions for nine molecules associated with embryonic and larval development (66.9%), information storage and processing (5.1%), cellular processing and signaling (15.2%), metabolism (6.1%), and unknown function (6.7%). The potential roles of these molecules in development are discussed in relation to the known roles of their homologues/orthologues in C. elegans and some other nematodes. The results of the present study provide a basis for future functional genomic studies to elucidate molecular aspects governing larval developmental processes in A. suum and/or the transition to parasitism
Flavor conversion of cosmic neutrinos from hidden jets
High energy cosmic neutrino fluxes can be produced inside relativistic jets
under the envelopes of collapsing stars. In the energy range E ~ (0.3 - 1e5)
GeV, flavor conversion of these neutrinos is modified by various matter effects
inside the star and the Earth. We present a comprehensive (both analytic and
numerical) description of the flavor conversion of these neutrinos which
includes: (i) oscillations inside jets, (ii) flavor-to-mass state transitions
in an envelope, (iii) loss of coherence on the way to observer, and (iv)
oscillations of the mass states inside the Earth. We show that conversion has
several new features which are not realized in other objects, in particular
interference effects ("L- and H- wiggles") induced by the adiabaticity
violation. The neutrino-neutrino scattering inside jet and inelastic neutrino
interactions in the envelope may produce some additional features at E > 1e4
GeV. We study dependence of the probabilities and flavor ratios in the
matter-affected region on angles theta13 and theta23, on the CP-phase delta, as
well as on the initial flavor content and density profile of the star. We show
that measurements of the energy dependence of the flavor ratios will, in
principle, allow to determine independently the neutrino and astrophysical
parameters.Comment: 56 pages, 19 figures. Minor changes. Accepted by JHEP
Mechano-energetics of the asynchronous and resynchronized heart
Abnormal electrical activation of the ventricles creates major abnormalities in cardiac mechanics. Local contraction patterns, as reflected by measurements of local strain, are not only out of phase, but often also show opposing length changes in early and late activated regions. As a consequence, the efficiency of cardiac pump function (the amount of stroke work generated by a unit of oxygen consumed) is approximately 30% lower in asynchronous than in synchronous hearts. Moreover, the amount of work performed in myocardial segments becomes considerably larger in late than in early activated regions. Cardiac Resynchronization Therapy (CRT) improves mechano-energetics of the previously asynchronous heart in various ways: it alleviates impediment of the abnormal contraction on blood flow, it increases myocardial efficiency, it recruits contraction in the previously early activated septum and it creates a more uniform distribution of myocardial blood flow. These factors act together to increase the range of cardiac work that can be delivered by the patients’ heart, an effect that can explain the increased exercise tolerance and quality of life reported in several CRT trials
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