66 research outputs found
Architecture of coatomer: Molecular characterization of delta-COP and protein interactions within the complex
- Author
- Publication venue
- 'Rockefeller University Press'
- Publication date
- 01/10/1996
- Field of study
Copyright © 2011 by The Rockefeller University Press.Coatomer is a cytosolic protein complex that forms the coat of COP I-coated transport vesicles. In our attempt to analyze the physical and functional interactions between its seven subunits (coat proteins, [COPs] alpha-zeta), we engaged in a program to clone and characterize the individual coatomer subunits. We have now cloned, sequenced, and overexpressed bovine alpha-COP, the 135-kD subunit of coatomer as well as delta-COP, the 57-kD subunit and have identified a yeast homolog of delta-COP by cDNA sequence comparison and by NH2-terminal peptide sequencing. delta-COP shows homologies to subunits of the clathrin adaptor complexes AP1 and AP2. We show that in Golgi-enriched membrane fractions, the protein is predominantly found in COP I-coated transport vesicles and in the budding regions of the Golgi membranes. A knock-out of the delta-COP gene in yeast is lethal. Immunoprecipitation, as well as analysis exploiting the two-hybrid system in a complete COP screen, showed physical interactions between alpha- and epsilon-COPs and between beta- and delta-COPs. Moreover, the two-hybrid system indicates interactions between gamma- and zeta-COPs as well as between alpha- and beta' COPs. We propose that these interactions reflect in vivo associations of those subunits and thus play a functional role in the assembly of coatomer and/or serve to maintain the molecular architecture of the complex.This work was supported by The Deutsche Forschungsgemeinschaft (SFB 352), the Human Frontier Science Program, and the Swiss National Science Foundation No. 31-43366.95
Increased hallux angle in children and its association with insufficient length of footwear: A community based cross-sectional study
- Author
- A Craigmile Doris
- A Wanievenhaus
- C Schmidt
- CH Mayo
- Christian Klein
- DJ Morton
- E Maier
- E Maier
- Elisabeth Groll-Knapp
- FT Cheng
- G Dhom
- G Eckstein
- G Pisani
- H Kristen
- H Timm
- HB Menz
- HU Debrunner
- IB Shine
- J Jerosch
- K Krohmeyer-Hauschild
- L Sim-Fook
- Michael Kundi
- MJ Coughlin
- MJ Coughlin
- MJ Coughlin
- MJ Coughlin
- MK Glynn
- N Wülker
- NA Barnicot
- O Johnston
- O Stracker
- R Bauer
- R Forst
- R Wheeler Haines
- RA Mann
- RH Hardy
- RI Harris
- T Hellbruegge
- T Kato
- TE Kilmartin
- W Schilling
- W Schneider
- Wieland Kinz
- Publication venue
- BioMed Central
- Publication date
- 17/12/2009
- Field of study
The Compartmentalisation of Phosphorylated Free Oligosaccharides in Cells from a CDG Ig Patient Reveals a Novel ER-to-Cytosol Translocation Process
- Author
- A Chapman
- A Saint-Pol
- A Varki
- AF Hsu
- AG Rosenwald
- B Hoflack
- B Schenk
- BR Ali
- BR Ali
- Brigitte Bader-Meunier
- Christelle Durrant-Arico
- Christophe Delenda
- Cécile Pelatan
- Delphine Peric
- FT Wieland
- GJ Oliver
- Hélène Ogier de Baulny
- I Chantret
- I Chantret
- IS Trowbridge
- Isabelle Chantret
- J Dancourt
- J Helenius
- J Jaeken
- JA Hanover
- JS Rush
- JS Rush
- JS Rush
- K Romisch
- K Romisch
- KR Anumula
- M Aebi
- M Belard
- MJ Spiro
- N Gao
- N Gao
- Olivier Danos
- P Burda
- Pascale De Lonlay
- R Cacan
- R Cacan
- R Cacan
- R Cacan
- R Chapman
- R Kornfeld
- R Oriol
- RG Spiro
- S Bhakdi
- S Hase
- S Sanyal
- S Vuillaumier-Barrot
- SEH Moore
- SEH Moore
- SEH Moore
- SG Miller
- Shuguang Zhang
- Stuart E. H. Moore
- T Suzuki
- Thierry Dupré
- Publication venue
- Public Library of Science
- Publication date
- 20/07/2010
- Field of study
BACKGROUND: Biosynthesis of the dolichol linked oligosaccharide (DLO) required for protein N-glycosylation starts on the cytoplasmic face of the ER to give Man(5)GlcNAc(2)-PP-dolichol, which then flips into the ER for further glycosylation yielding mature DLO (Glc(3)Man(9)GlcNAc(2)-PP-dolichol). After transfer of Glc(3)Man(9)GlcNAc(2) onto protein, dolichol-PP is recycled to dolichol-P and reused for DLO biosynthesis. Because de novo dolichol synthesis is slow, dolichol recycling is rate limiting for protein glycosylation. Immature DLO intermediates may also be recycled by pyrophosphatase-mediated cleavage to yield dolichol-P and phosphorylated oligosaccharides (fOSGN2-P). Here, we examine fOSGN2-P generation in cells from patients with type I Congenital Disorders of Glycosylation (CDG I) in which defects in the dolichol cycle cause accumulation of immature DLO intermediates and protein hypoglycosylation. METHODS AND PRINCIPAL FINDINGS: In EBV-transformed lymphoblastoid cells from CDG I patients and normal subjects a correlation exists between the quantities of metabolically radiolabeled fOSGN2-P and truncated DLO intermediates only when these two classes of compounds possess 7 or less hexose residues. Larger fOSGN2-P were difficult to detect despite an abundance of more fully mannosylated and glucosylated DLO. When CDG Ig cells, which accumulate Man(7)GlcNAc(2)-PP-dolichol, are permeabilised so that vesicular transport and protein synthesis are abolished, the DLO pool required for Man(7)GlcNAc(2)-P generation could be depleted by adding exogenous glycosylation acceptor peptide. Under conditions where a glycotripeptide and neutral free oligosaccharides remain predominantly in the lumen of the ER, Man(7)GlcNAc(2)-P appears in the cytosol without detectable generation of ER luminal Man(7)GlcNAc(2)-P. CONCLUSIONS AND SIGNIFICANCE: The DLO pools required for N-glycosylation and fOSGN2-P generation are functionally linked and this substantiates the hypothesis that pyrophosphatase-mediated cleavage of DLO intermediates yields recyclable dolichol-P. The kinetics of cytosolic fOSGN2-P generation from a luminally-generated DLO intermediate demonstrate the presence of a previously undetected ER-to-cytosol translocation process for either fOSGN2-P or DLO
The Intracellular Transport and Secretion of Calumenin-1/2 in Living Cells
- Author
- AG Hendricks
- B Honore
- B Honore
- B Honore
- Birong Shen
- C Ding
- C Kural
- D Yabe
- D Yabe
- DH Jung
- DH Kim
- DI Meyer
- EV Polishchuk
- F Jaulin
- F Samson
- FT Wieland
- G Kreitzer
- G Lansbergen
- GA Hansen
- H Vorum
- H Vorum
- H Vorum
- H Vorum
- HH Li
- Hui Feng
- I Grigoriev
- I Grigoriev
- JA Cooper
- JA Martinez-Menarguez
- JF Presley
- Jianguo Chen
- JK Burkhardt
- JR Kardon
- Junlin Teng
- K Hirschberg
- K Saito
- LC Kapitein
- Liang Chen
- Lin Liu
- M Ostergaard
- M Setou
- M van der Voet
- MJ Hseu
- MJ Kuehn
- MJ Wozniak
- MJ Wozniak
- N Hirokawa
- N Hirokawa
- N Wajih
- P Malkus
- P Watson
- Pengli Zheng
- Q Wang
- Q Wang
- Q Wang
- Qiao Wang
- Qingsong Hao
- RB Kelly
- RD Burgoyne
- S Mili
- Sara Salinas
- Shunchang Wang
- W Fu
- WJ Belden
- X Wang
- Xiao Liu
- Y Araki
- Y Kanai
- Y Tsukumo
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2012
- Field of study
Calumenin isoforms 1 and 2 (calu-1/2), encoded by the CALU gene, belong to the CREC protein family. Calu-1/2 proteins are secreted into the extracellular space, but the secretory process and regulatory mechanism are largely unknown. Here, using a time-lapse imaging system, we visualized the intracellular transport and secretory process of calu-1/2-EGFP after their translocation into the ER lumen. Interestingly, we observed that an abundance of calu-1/2-EGFP accumulated in cellular processes before being released into the extracellular space, while only part of calu-1/2-EGFP proteins were secreted directly after attaching to the cell periphery. Moreover, we found the secretion of calu-1/2-EGFP required microtubule integrity, and that calu-1/2-EGFP-containing vesicles were transported by the motor proteins Kif5b and cytoplasmic dynein. Finally, we determined the export signal of calu-1/2-EGFP (amino acid positions 20–46) and provided evidence that the asparagine at site 131 was indispensable for calu-1/2-EGFP stabilization. Taken together, we provide a detailed picture of the intracellular transport of calu-1/2-EGFP, which facilitates our understanding of the secretory mechanism of calu-1/2
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A portrait of the Higgs boson by the CMS experiment ten years after the discovery
- Author
- Aarrestad TK
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdelalim AA
- Abdullin S
- Abercrombie D
- Abreu A
- Acharya H
- Acosta D
- Adam W
- Adamidis K
- Adams E
- Adams MR
- Adams T
- Addesa FM
- Adloff C
- Adzic P
- Adán DP
- Afanasiev S
- Agapitos A
- Agarwal G
- Aggleton R
- Agram J-L
- Aguilar-Benitez M
- Agyel D
- Ahmad A
- Ahmad M
- Ahmad WH
- Ahmed A
- Aimè C
- Akchurin N
- Akgun B
- Akpinar A
- Albert A
- Albrecht A
- Albrecht S
- Albrow M
- Alcerro LFA
- Aleksandrov A
- Alexander J
- Alhusseini M
- Alimena J
- Alison J
- Allmond B
- Almond J
- Alonso AG
- Alpana A
- Alvarez JDR
- Alverson G
- Alves Gallo Pereira M
- Alves GA
- Aly R
- Alyari M
- Amapane N
- Amarilo KM
- Ambrozas M
- Amendola C
- Amin N
- Amram O
- Amsler C
- An S
- An Y
- Anagnostou G
- Anampa KH
- Andrea J
- Andreev V
- Andreev Y
- Andrejkovic JW
- Andrews MB
- Androsov K
- Anguiano J
- Antchev G
- Antequera JB
- Anthony D
- Antonello M
- Antunovic Z
- Apollinari G
- Apparu D
- Appelt E
- Apresyan A
- Araujo M
- Arcaro D
- Arcidiacono R
- Argiro S
- Arneodo M
- Aruta C
- Asawatangtrakuldee C
- Asenov P
- Asghar MI
- Asilar E
- Askew A
- Asmuss P
- Assiouras P
- Atakisi IO
- Attikis A
- Auffray E
- Aushev T
- Auzinger G
- Avati V
- Avery P
- Avila C
- Awais A
- Awan MIM
- Ayala E
- Ayala G
- Aydilek O
- Azarkin M
- Aziz T
- Azzi P
- Azzurri P
- Baarmand MM
- Babaev A
- Babbar J
- Bacchetta N
- Bachtis M
- Backhaus M
- Baden A
- Baechler J
- Bagliesi G
- Bahinipati S
- Baillon P
- Bainbridge R
- Bakas G
- Bakhshiansohi H
- Bakshi AS
- Ball AH
- Ban Y
- Band R
- Bandyopadhyay H
- Banerjee S
- Banerjee S
- Banos LIE
- Bansal S
- Baradia S
- Barbagli G
- Barberis E
- Bargassa P
- Baringer P
- Barman S
- Barnes VE
- Barney D
- Baron O
- Barrera CB
- Barrera CO
- Barria P
- Barrio Luna M
- Barroso Ferreira Filho M
- Barroso AV
- Bartek R
- Bartosik N
- Bartók M
- Bastos D
- Battilana C
- Baty A
- Bauer G
- Bauerdick LAT
- Baxter S
- Bayatmakou M
- Bean A
- Beauceron S
- Beaudette F
- Bechtel J
- Bedoya CF
- Behera PK
- Behera SC
- Behnke O
- Bein S
- Belforte S
- Bell KW
- Bellan R
- Belloni A
- Bellora A
- Belyaev A
- Belyaev A
- Bemden MV
- Benaglia A
- Benato L
- Bencze G
- Bendavid J
- Benecke A
- Benelli G
- Beni N
- Benitez JF
- Benussi L
- Bergauer T
- Berger P
- Beri SB
- Bernardes CA
- Bernet C
- Berry D
- Berryhill J
- Bertacchi V
- Besancon M
- Bestintzanos I
- Bethani A
- Beyrouthy T
- Bhal E
- Bhardwaj A
- Bharthuar S
- Bhat PC
- Bhatnagar V
- Bhattacharya R
- Bhattacharya S
- Bhattacharya S
- Bhattacharya S
- Bhowmik D
- Bhowmik S
- Bhyun JH
- Bi R
- Bialkowska H
- Bianchini L
- Bianco M
- Bianco S
- Biino C
- Bilei GM
- Bilin B
- Bin Anuar AA
- Bin Norjoharuddeen N
- Bisello D
- Black K
- Blekman F
- Blinov V
- Bloch D
- Bloch P
- Bloom K
- Bluj M
- Blumenfeld B
- Boccali T
- Bocci A
- Bodek A
- Boimska B
- Boldrini G
- Boletti A
- Bols ES
- Bonacorsi D
- Bonanomi M
- Bonham B
- Bonilla J
- Bonomally S
- Boos E
- Boran F
- Borg J
- Borgonovi L
- Bornheim A
- Borras K
- Borshch V
- Bortignon P
- Bose T
- Bossini E
- Botta C
- Botta V
- Boudoul G
- Bouhali O
- Bourgatte G
- Bourilkov D
- Bouza VR
- Bozzo M
- Bragagnolo A
- Braghieri A
- Brainerd C
- Branson JG
- Breedon R
- Breeze S
- Brew C
- Bright-Thonney S
- Brigliadori L
- Brigljevic V
- Brinkerhoff A
- Brivio F
- Brom J-M
- Brommer S
- Brondolin E
- Brooke JJ
- Brown CE
- Brown RM
- Brunner D
- Bruno G
- Bruschini D
- Bryant P
- Bryson M
- Brzhechko D
- Brücken E
- Bubanja I
- Bucci R
- Buccilli A
- Buchmuller O
- Budkouski D
- Bueghly J
- Bundock A
- Bunkowski K
- Buontempo S
- Burkart M
- Burkett K
- Burkle B
- Bury F
- Busson P
- Busza W
- Butalla S
- Butler JN
- Butz E
- Bylsma B
- Bärtschi P
- Caballero IG
- Cabrera A
- Cabrillo IJ
- Cacchio V
- Cadamuro L
- Caillol C
- Cakir A
- Calandri A
- Calderon De La Barca Sanchez M
- Calderon A
- Cali IA
- Calligaris L
- Calzaferri S
- Camaiani B
- Camen C
- Caminada L
- Campagnari C
- Campana M
- Campanini R
- Campbell A
- Campderros JD
- Camporesi T
- Candelise V
- Canelli MF
- Canepa A
- Cankocak K
- Capiluppi P
- Cappati A
- Caputo C
- Caraway B
- Cardini A
- Cardwell B
- Carle A
- Carlin R
- Carnahan T
- Carnevali F
- Carrigan M
- Cartiglia N
- Carvalho Antunes De Oliveira A
- Carvalho W
- Casarsa M
- Caspart R
- Cassese A
- Castaldi R
- Castells S
- Castilla-Valdez H
- Castro A
- Cavallari F
- Cavallo FR
- Cavallo N
- Cavanaugh R
- Ceard L
- Ceccarelli R
- Cepaitis V
- Cepeda M
- Cerati GB
- Cerci DS
- Cerci S
- Cerminara G
- Cerrada M
- Cerri O
- Cetorelli F
- Chabert EC
- Chahal GS
- Chang P
- Chanon N
- Chao Y
- Charlot C
- Chatterjee RM
- Chatterjee S
- Chatzistavrou T
- Chaudhary G
- Chauhan S
- Chauhan S
- Chawla R
- Checchia P
- Chekhovsky V
- Chen C
- Chen GM
- Chen HS
- Chen KF
- Chen M
- Chen PS
- Chen X
- Chen Y
- Chen Y
- Chen Z
- Chenarani S
- Cheng C
- Cheng H
- Cheng T
- Cherepanov V
- Chernyavskaya N
- Chertok M
- Cheung HWK
- Chhibra SS
- Chiarito B
- Chinellato J
- Chistov R
- Chitroda BK
- Chlebana F
- Cho S
- Choi J
- Choi J
- Choi M
- Choi S
- Chou JP
- Choudhary BC
- Choudhury S
- Chowdhury SR
- Christoforou K
- Chudasama R
- Chwalek T
- Ciangottini D
- Cifuentes JAB
- Ciocci MA
- Cipriani M
- Citron M
- Cittolin S
- Ciulli V
- Civinini C
- Claes DR
- Clare R
- Clement E
- Clerbaux B
- Cockerill DJA
- Coelho E
- Colaleo A
- Coldham K
- Cole JE
- Colino N
- Collard C
- Colling D
- Collura G
- Colombina F
- Connor P
- Contardo D
- Conway J
- Cooke C
- Cooper SI
- Cooperstein S
- Corcodilos L
- Cormier K
- Cortezon EP
- Cosby C
- Cossutti F
- Costa M
- Costa S
- Coubez X
- Couderc F
- Cousins R
- Covarelli R
- Cox B
- Cox PT
- Cranshaw DJ
- Creanza D
- Cremaldi LM
- Cremonesi M
- Cristella L
- Crossman B
- Cruz SS
- Csanád M
- Csorgo T
- Cuevas J
- Cuevas PM
- Cuffiani M
- Cumalat JP
- Cummings G
- Cussans D
- Cutts D
- Czellar S
- Da Costa EM
- Da Rold A
- Da Silva De Araujo FT
- Da Silveira GG
- Dabrowski A
- Dalchenko M
- Dallavalle GM
- Damanakis K
- Damgov J
- Dancu JS
- Darej D
- Darwish MR
- Das A
- Das AK
- Das I
- Das P
- Das S
- Daskalakis G
- Dasu S
- Datta A
- Datta K
- Dauncey P
- David A
- David P
- Davies G
- Davies J
- Davignon O
- Davis J
- de Barbaro P
- De Bruyn I
- de Cassagnac RG
- De Cosa A
- de Fatis TT
- De Filippis N
- De Guio F
- De Iorio A
- De Jesus Damiao D
- De La Cruz B
- De La Cruz-Burelo E
- De Lentdecker G
- De Leo K
- de Monchenault GH
- De Moor A
- De Palma M
- De Roeck A
- De Silva M
- De Souza SF
- de Trocóniz JF
- De Wit A
- Decaro M
- Defranchis MM
- Deile M
- Dejardin M
- Del Burgo R
- Del Re D
- Del Valle AE
- Delaere C
- Delannoy AG
- Delcourt M
- Delgado Peris A
- Delgado A
- Della Negra M
- Della Ricca G
- Dell’Orso R
- Demaria N
- Demina R
- Demiragli Z
- Demiroglu ZS
- Denegri D
- Dengra CP
- Depasse P
- Dermenev A
- Dewanjee RK
- Dezoort G
- Dharmaratna WGD
- Dhingra N
- Di Croce D
- Di Domenico MR
- Di Florio A
- Di Marco E
- Di Mattia A
- Di Petrillo KF
- Diab B
- Diamantopoulou M
- Diaz D
- Dickinson J
- Didukh L
- Diekmann S
- Diemoz M
- Dierlamm A
- Dildick S
- Dilsiz K
- Dimitrov A
- Dimova T
- Dinardo ME
- Dini P
- Diotalevi T
- Dissertori G
- Dittmann J
- Dittmar M
- Dittmer S
- Do Amaral SMS
- Dobson M
- Dobur D
- Dodonova A
- Dogra S
- Dolek F
- Dolen J
- Dominguez A
- Donato S
- Donegà M
- Donertas IS
- Dordevic M
- Dorigo T
- Doroba K
- Dorsett A
- Dozen C
- Dragicevic M
- Dreimanis K
- Dremin I
- Droll A
- Duarte J
- Dube S
- Dubinin M
- Dudko L
- Dugad S
- Dulemba JL
- Dumanoglu I
- Dupont N
- Duric S
- Durkin LS
- Dutta I
- Dutta S
- Dutta V
- Dziwok C
- Dünser M
- D’Alessandro R
- D’Alfonso M
- D’Amante V
- d’Enterria D
- D’Hondt J
- Eble F
- Ebrahimi A
- Eckerlin G
- Ecklund KM
- Eckstein D
- Eerola P
- Ehataht K
- Eich M
- Eich N
- El Faham H
- El Mamouni H
- El Morabit K
- El Nasr-Storey SS
- Eliseev D
- Elkafrawy T
- Elliott-Peisert A
- Ellis KV
- Elmer P
- Elmetenawee W
- Elvira VD
- Emediato L
- Encinas Acosta HA
- Eno SC
- Epshteyn V
- Erbacher R
- Erdmann M
- Erdmann W
- Erice C
- Errico F
- Ershov A
- Escobar JV
- Eskut E
- Espinosa TAG
- Estrada CU
- Etesami SM
- Eusebi R
- Evangelou I
- Evans A
- Evdokimov O
- Everaerts P
- Eysermans J
- Fabbri F
- Fabozzi F
- Faccioli P
- Fackeldey P
- Fallavollita F
- Fallon C
- Falmagne G
- Faltermann N
- Fan J
- Fan X
- Fanfani A
- Fangmeier C
- Fanò L
- Farkas K
- Fasanella D
- Faure JL
- Favart L
- Fay J
- Fayer S
- Fedi G
- Feindt F
- Felcini M
- Feld L
- Feng Y
- Ferbel T
- Ferencek D
- Ferguson T
- Fernandez Perez Tomei TR
- Fernandez M
- Fernández Del Val D
- Fernández Ramos JP
- Fernández JRG
- Ferrero DDR
- Ferri F
- Ferro F
- Field RD
- Figueiredo DM
- Filatov O
- Finco L
- Finger M
- Finger M
- Fiore L
- Fiorendi S
- Fiorina D
- Fischer B
- Flacher H
- Flix J
- Florent A
- Florez C
- Flowers Z
- Flügge G
- Focardi E
- Folgueras S
- Fontana Santos Alves BA
- Fontanesi E
- Ford WT
- Forthomme L
- Foudas C
- Fouz MC
- Fraga J
- Francis B
- Frankenthal A
- Franzoni G
- Freed S
- Freeman J
- Freer C
- Fröhlich A
- Funk W
- Gadallah MMA
- Gadkari D
- Gaile A
- Galanti M
- Gallegos Maríñez LG
- Galli M
- Gallinaro M
- Gallo E
- Galloni C
- Gandrajula RP
- Gandrakota A
- Ganjour S
- Gao X
- Garbers C
- Garcia F
- Garcia JMV
- Garcia-Bellido A
- García CL
- Gardner P
- Garutti E
- Gary JW
- Gascon S
- Gasparini F
- Gasparini U
- Gastler D
- Gavrilov G
- Gavrilov V
- Gecse Z
- Gedia K
- Geiser A
- Gennai S
- Gerber CE
- Gerosa R
- Gershtein Y
- Geurts FJM
- Ghezzi A
- Ghosh S
- Ghosh S
- Giacomelli P
- Giammanco A
- Giani S
- Gianneios P
- Giannini L
- Giassi A
- Giffels M
- Gigi D
- Gilbert A
- Giljanovic D
- Gill K
- Gilmore J
- Giommi L
- Giraldi A
- Glege F
- Glessgen F
- Gleyzer SV
- Glowacki M
- Gninenko S
- Godinovic N
- Goerlach U
- Goh J
- Gola M
- Goldouzian R
- Goldstein J
- Golf F
- Golovtcov V
- Golubev N
- Golutvin I
- Gomber B
- Gomez G
- Gomez JP
- Gomez-Ceballos G
- Goncharov M
- Gonzalez BA
- Gonzalez HB
- Gorbunov I
- Gordon M
- Gosewisch JO
- Gottmann A
- Goulianos K
- Gouskos L
- Gouzevitch M
- Govoni P
- Govorkova E
- Goy Lopez S
- Grab C
- Grandi C
- Gras P
- Gray L
- Greau G
- Green D
- Greenberg B
- Greene S
- Gregores EM
- Grenier G
- Gribushin A
- Grimault C
- Grippo M
- Gritsan AV
- Grohsjean A
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- Özçelik Ö
- Publication venue
- Springer Science and Business Media LLC
- Publication date
- 07/07/2022
- Field of study
A Correction to this paper has been published (18 October 2023) : https://doi.org/10.1038/s41586-023-06164-8.Data availability:
Tabulated results are provided in the HEPData record for this analysis. Release and preservation of data used by the CMS Collaboration as the basis for publications is guided by the CMS data preservation, re-use and open acess policy.Code availability:
The CMS core software is publicly available on GitHub (https://github.com/cms-sw/cmssw).In July 2012, the ATLAS and CMS collaborations at the CERN Large Hadron Collider announced the observation of a Higgs boson at a mass of around 125 gigaelectronvolts. Ten years later, and with the data corresponding to the production of a 30-times larger number of Higgs bosons, we have learnt much more about the properties of the Higgs boson. The CMS experiment has observed the Higgs boson in numerous fermionic and bosonic decay channels, established its spin–parity quantum numbers, determined its mass and measured its production cross-sections in various modes. Here the CMS Collaboration reports the most up-to-date combination of results on the properties of the Higgs boson, including the most stringent limit on the cross-section for the production of a pair of Higgs bosons, on the basis of data from proton–proton collisions at a centre-of-mass energy of 13 teraelectronvolts. Within the uncertainties, all these observations are compatible with the predictions of the standard model of elementary particle physics. Much evidence points to the fact that the standard model is a low-energy approximation of a more comprehensive theory. Several of the standard model issues originate in the sector of Higgs boson physics. An order of magnitude larger number of Higgs bosons, expected to be examined over the next 15 years, will help deepen our understanding of this crucial sector.BMBWF and FWF (Austria); FNRS and FWO (Belgium); CNPq, CAPES, FAPERJ, FAPERGS, and FAPESP (Brazil); MES and BNSF (Bulgaria); CERN; CAS, MoST, and NSFC (China); MINCIENCIAS (Colombia); MSES and CSF (Croatia); RIF (Cyprus); SENESCYT (Ecuador); MoER, ERC PUT and ERDF (Estonia); Academy of Finland, MEC, and HIP (Finland); CEA and CNRS/IN2P3 (France); BMBF, DFG, and HGF (Germany); GSRI (Greece); NKFIH (Hungary); DAE and DST (India); IPM (Iran); SFI (Ireland); INFN (Italy); MSIP and NRF (Republic of Korea); MES (Latvia); LAS (Lithuania); MOE and UM (Malaysia); BUAP, CINVESTAV, CONACYT, LNS, SEP, and UASLP-FAI (Mexico); MOS (Montenegro); MBIE (New Zealand); PAEC (Pakistan); MES and NSC (Poland); FCT (Portugal); MESTD (Serbia); MCIN/AEI and PCTI (Spain); MOSTR (Sri Lanka); Swiss Funding Agencies (Switzerland); MST (Taipei); MHESI and NSTDA (Thailand); TUBITAK and TENMAK (Turkey); NASU (Ukraine); STFC (United Kingdom); DOE and NSF (USA). Individuals have received support from the Marie-Curie programme and the European Research Council and Horizon 2020 Grant, contract Nos. 675440, 724704, 752730, 758316, 765710, 824093, 884104, and COST Action CA16108 (European Union); the Leventis Foundation; the Alfred P. Sloan Foundation; the Alexander von Humboldt Foundation; the Belgian Federal Science Policy Office; the Fonds pour la Formation à la Recherche dans l’Industrie et dans l’Agriculture (FRIA-Belgium); the Agentschap voor Innovatie door Wetenschap en Technologie (IWT-Belgium); the F.R.S.-FNRS and FWO (Belgium) under the “Excellence of Science – EOS” – be.h project n. 30820817; the Beijing Municipal Science & Technology Commission, No. Z191100007219010; the Ministry of Education, Youth and Sports (MEYS) of the Czech Republic; the Stavros Niarchos Foundation (Greece); the Deutsche Forschungsgemeinschaft (DFG), under Germany’s Excellence Strategy – EXC 2121 “Quantum Universe” – 390833306, and under project number 400140256 - GRK2497; the Hungarian Academy of Sciences, the New National Excellence Program - ÚNKP, the NKFIH research grants K 124845, K 124850, K 128713, K 128786, K 129058, K 131991, K 133046, K 138136, K 143460, K 143477, 2020-2.2.1-ED-2021-00181, and TKP2021-NKTA-64 (Hungary); the Council of Science and Industrial Research, India; the Latvian Council of Science; the Ministry of Education and Science, project no. 2022/WK/14, and the National Science Center, contracts Opus 2021/41/B/ST2/01369 and 2021/43/B/ST2/01552 (Poland); the Fundação para a Ciência e a Tecnologia, grant CEECIND/01334/2018 (Portugal); the National Priorities Research Program by Qatar National Research Fund; MCIN/AEI/10.13039/501100011033, ERDF “a way of making Europe”, and the Programa Estatal de Fomento de la Investigación Científica y Técnica de Excelencia María de Maeztu, grant MDM-2017-0765 and Programa Severo Ochoa del Principado de Asturias (Spain); the Chulalongkorn Academic into Its 2nd Century Project Advancement Project, and the National Science, Research and Innovation Fund via the Program Management Unit for Human Resources & Institutional Development, Research and Innovation, grant B05F650021 (Thailand); the Kavli Foundation; the Nvidia Corporation; the SuperMicro Corporation; the Welch Foundation, contract C-1845; and the Weston Havens Foundation (USA)
Measurement of the Higgs boson width and evidence of its off-shell contributions to ZZ production
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- Zahid S
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- Zalewski P
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- Zeuner WD
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- Zorbilmez C
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- Zuolo D
- Zygala L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
Since the discovery of the Higgs boson in 2012, detailed studies of its properties have been ongoing. Besides its mass, its width—related to its lifetime—is an important parameter. One way to determine this quantity is to measure its off-shell production, where the Higgs boson mass is far away from its nominal value, and relating it to its on-shell production, where the mass is close to the nominal value. Here we report evidence for such off-shell contributions to the production cross-section of two Z bosons with data from the CMS experiment at the CERN Large Hadron Collider. We constrain the total rate of the off-shell Higgs boson contribution beyond the Z boson pair production threshold, relative to its standard model expectation, to the interval [0.0061, 2.0] at the 95% confidence level. The scenario with no off-shell contribution is excluded at a p-value of 0.0003 (3.6 standard deviations). We measure the width of the Higgs boson as ΓH=3.2+2.4−1.7MeV, in agreement with the standard model expectation of 4.1 MeV. In addition, we set constraints on anomalous Higgs boson couplings to W and Z boson pairs
Recommended from our members
Search for light Higgs bosons from supersymmetric cascade decays in pp collisions at √s=13TeV
- Author
- Aarrestad TK
- Abbaneo D
- Abbiendi G
- Abbrescia M
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- Álvarez CR
- Özçelik Ö
- Publication venue
- Springer Science and Business Media LLC
- Publication date
- 06/07/2023
- Field of study
A search is reported for pairs of light Higgs
bosons (H1) produced in supersymmetric cascade decays in
f
inal states with small missing transverse momentum. A data
set of LHC pp collisions collected with the CMS detector
at √s = 13TeV and corresponding to an integrated lumi
nosity of 138fb−1 is used. The search targets events where
both H1 bosons decay into b¯b pairs that are reconstructed
as large-radius jets using substructure techniques. No evi
dence is found for an excess of events beyond the back
ground expectations of the standard model (SM). Results
from the search are interpreted in the next-to-minimal super
symmetric extension of the SM, where a “singlino” of small
mass leads to squark and gluino cascade decays that can pre
dominantly end in a highly Lorentz-boosted singlet-like H1
andasinglino-likeneutralinoofsmalltransversemomentum.
Upperlimitsaresetontheproductofthesquarkorgluinopair
production cross section and the square of the b¯b branching
fraction of the H1 in a benchmark model containing almost
mass-degenerategluinosandlight-flavoursquarks.Underthe
assumption of an SM-like H1 → b¯b branching fraction, H1
bosonswithmassesintherange40–120GeVarisingfromthe
decays of squarks or gluinos with a mass of 1200–2500GeV
are excluded at 95% confidence level.SCOA
Recommended from our members
Measurement of the differential tt¯ production cross section as a function of the jet mass and extraction of the top quark mass in hadronic decays of boosted top quarks
- Author
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- Yumiceva F
- Yusuff I
- Yzquierdo AP-C
- Zabi A
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- Zaleski S
- Zalewski P
- Zanetti M
- Zarubin A
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- Zecchinelli AG
- Zeid SA
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- Zghiche A
- Zhang F
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- Zoi I
- Zolkapli Z
- Zorbakir IS
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- Zuo X
- Zuolo D
- Zygala L
- Álvarez CR
- Publication venue
- Springer Nature
- Publication date
- 03/07/2023
- Field of study
Data Availability:
This manuscript has no associated data or the data will not be deposited. [Authors’ comment: Release and preservation of data used by the CMS Collaboration as the basis for publications is guided by the CMS policy as stated in https://cms-docdb.cern.ch/cgibin/PublicDocDB/RetrieveFile?docid=6032 &filename=CMSDataPolicyV1.2.pdf &version=2.]A measurement of the jet mass distribution in hadronic decays of Lorentz-boosted top quarks is presented. The measurement is performed in the lepton + jets channel of top quark pair production (tt¯
) events, where the lepton is an electron or muon. The products of the hadronic top quark decay are reconstructed using a single large-radius jet with transverse momentum greater than 400GeV
. The data were collected with the CMS detector at the LHC in proton-proton collisions and correspond to an integrated luminosity of 138fb−1
. The differential tt¯
production cross section as a function of the jet mass is unfolded to the particle level and is used to extract the top quark mass. The jet mass scale is calibrated using the hadronic W boson decay within the large-radius jet. The uncertainties in the modelling of the final state radiation are reduced by studying angular correlations in the jet substructure. These developments lead to a significant increase in precision, and a top quark mass of 173.06±0.84GeV.SCOAP
Recommended from our members
Portable Acceleration of CMS Computing Workflows with Coprocessors as a Service
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- Publication venue
- Springer Nature
- Publication date
- 04/09/2024
- Field of study
A preprint version of the article is available at: arXiv:2402.15366v2 [physics.ins-det], https://arxiv.org/abs/2402.15366 . Comments: Replaced with the published version. Added the journal reference and the DOI. All the figures and tables can be found at https://cms-results.web.cern.ch/cms-results/public-results/publications/MLG-23-001 (CMS Public Pages). Report numbers: CMS-MLG-23-001, CERN-EP-2023-303.Data Availability: No datasets were generated or analyzed during the current study.Computing demands for large scientific experiments, such as the CMS experiment at the CERN LHC, will increase dramatically in the next decades. To complement the future performance increases of software running on central processing units (CPUs), explorations of coprocessor usage in data processing hold great potential and interest. Coprocessors are a class of computer processors that supplement CPUs, often improving the execution of certain functions due to architectural design choices. We explore the approach of Services for Optimized Network Inference on Coprocessors (SONIC) and study the deployment of this as-a-service approach in large-scale data processing. In the studies, we take a data processing workflow of the CMS experiment and run the main workflow on CPUs, while offloading several machine learning (ML) inference tasks onto either remote or local coprocessors, specifically graphics processing units (GPUs). With experiments performed at Google Cloud, the Purdue Tier-2 computing center, and combinations of the two, we demonstrate the acceleration of these ML algorithms individually on coprocessors and the corresponding throughput improvement for the entire workflow. This approach can be easily generalized to different types of coprocessors and deployed on local CPUs without decreasing the throughput performance. We emphasize that the SONIC approach enables high coprocessor usage and enables the portability to run workflows on different types of coprocessors.SCOAP3. Open access funding provided by CERN (European Organization for Nuclear Research
Performance of the CMS muon trigger system in proton-proton collisions at root s=13 TeV
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- Vormwald B
- Vorobiev I
- Vorobyev A
- Vourliotis E
- Voutilainen M
- Voytishin N
- Wadud MA
- Wagner SR
- Walczak M
- Wallny R
- Walsh R
- Waltenberger W
- Walter D
- Wamorkar T
- Wang B
- Wang C
- Wang D
- Wang F
- Wang H
- Wang H
- Wang J
- Wang J
- Wang J
- Wang L
- Wang Q
- Wang Q
- Wang S
- Wang TW
- Wang X
- Wang Y
- Wang Z
- Wang Z
- Waqas M
- Wardle N
- Wassmer M
- Watson IJ
- Wayne M
- Webb SN
- Weber HA
- Weber M
- Wen Y
- Wertz S
- West C
- Wetzel J
- Wezenbeek L
- Whitbeck A
- Wichmann K
- Wickramage N
- Wickramarathna DDC
- Wiedenbeck S
- Wieland S
- Wightman A
- Williams J
- Williams T
- Willmott C
- Wilson G
- Wilson J
- Wimpenny S
- Winer BL
- Winterbottom D
- Wisecarver A
- Wissing C
- Wittich P
- Wolf M
- Wolf R
- Wolfe E
- Wong K
- Wong WY
- Wood D
- Wozniak KA
- Wozniewski S
- Wright D
- Wu Z
- Wuchterl S
- Wulz C-E
- Wunsch S
- Wurthwein F
- Wuyckens S
- Wyslouch B
- Xiao J
- Xiao M
- Xiao R
- Xie S
- Xie W
- Yagil A
- Yalvac M
- Yan F
- Yan X
- Yang UK
- Yang YC
- Yao Y
- Yarar H
- Yates BR
- Yazgan E
- Ye Z
- Yetkin EA
- Yi K
- Yigitbasi E
- Yohay R
- Yoo HD
- Yoo J
- Yoon I
- You Z
- Yu D
- Yu GB
- Yu I
- Yu PR
- Yu SS
- Yuan L
- Yuan S
- Yumiceva F
- Yusli MN
- Zabi A
- Zabolotny W
- Zacharopoulou A
- Zahid S
- Zaleski S
- Zalewski P
- Zanetti M
- Zarubin A
- Zarucki M
- Zecchinelli AG
- Zeinali M
- Zenaiev O
- Zeuner WD
- Zghiche A
- Zhang F
- Zhang H
- Zhang J
- Zhang S
- Zhang W
- Zhang Y
- Zhang Z
- Zhao J
- Zhizhin I
- Zhokin A
- Zhu DH
- Zhu RY
- Ziemons T
- Zientek M
- Zlebcik R
- Zoi I
- Zolkapli Z
- Zorbakir IS
- Zorbilmez C
- Zotto P
- Zou D
- Zucchetta A
- Zumerle G
- Zuo X
- Zuolo D
- Zygala L
- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2021
- Field of study
The muon trigger system of the CMS experiment uses a combination of hardware and software to identify events containing a muon. During Run 2 (covering 2015–2018) the LHC achieved instantaneous luminosities as high as 2 × 1034 while delivering proton-proton collisions at √(s) = 13. The challenge for the trigger system of the CMS experiment is to reduce the registered event rate from about 40MHz to about 1kHz. Significant improvements important for the success of the CMS physics program have been made to the muon trigger system via improved muon reconstruction and identification algorithms since the end of Run 1 and throughout the Run 2 data-taking period. The new algorithms maintain the acceptance of the muon triggers at the same or even lower rate throughout the data-taking period despite the increasing number of additional proton-proton interactions in each LHC bunch crossing. In this paper, the algorithms used in 2015 and 2016 and their improvements throughout 2017 and 2018 are described. Measurements of the CMS muon trigger performance for this data-taking period are presented, including efficiencies, transverse momentum resolution, trigger rates, and the purity of the selected muon sample. This paper focuses on the single- and double-muon triggers with the lowest sustainable transverse momentum thresholds used by CMS. The efficiency is measured in a transverse momentum range from 8 to several hundred
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