32 research outputs found
The U(1)-Higgs Model: Critical Behaviour in the Confinig-Higgs region
We study numerically the critical properties of the U(1)-Higgs lattice model,
with fixed Higgs modulus, in the region of small gauge coupling where the Higgs
and Confining phases merge. We find evidence of a first order transition line
that ends in a second order point. By means of a rotation in parameter space we
introduce thermodynamic magnitudes and critical exponents in close resemblance
with simple models that show analogous critical behaviour. The measured data
allow us to fit the critical exponents finding values in agreement with the
mean field prediction. The location of the critical point and the slope of the
first order line are accurately given.Comment: 21 text pages. 12 postscript figures available on reques
Results, meta-analysis and a first evaluation of UNOxR, the urinary nitrate-to-nitrite molar ratio, as a measure of nitrite reabsorption in experimental and clinical settings
Diabetes mellitus: pathophysiological changes and therap
Inflammatory biomarkers in Alzheimer's disease plasma
Introduction: Plasma biomarkers for Alzheimer's disease (AD) diagnosis/stratification are a \u201cHoly Grail\u201d of AD research and intensively sought; however, there are no well-established plasma markers. Methods: A hypothesis-led plasma biomarker search was conducted in the context of international multicenter studies. The discovery phase measured 53 inflammatory proteins in elderly control (CTL; 259), mild cognitive impairment (MCI; 199), and AD (262) subjects from AddNeuroMed. Results: Ten analytes showed significant intergroup differences. Logistic regression identified five (FB, FH, sCR1, MCP-1, eotaxin-1) that, age/APO\u3b54 adjusted, optimally differentiated AD and CTL (AUC: 0.79), and three (sCR1, MCP-1, eotaxin-1) that optimally differentiated AD and MCI (AUC: 0.74). These models replicated in an independent cohort (EMIF; AUC 0.81 and 0.67). Two analytes (FB, FH) plus age predicted MCI progression to AD (AUC: 0.71). Discussion: Plasma markers of inflammation and complement dysregulation support diagnosis and outcome prediction in AD and MCI. Further replication is needed before clinical translation
Plasma levels of von Willebrand factor, von Willebrand factor propeptide and factor VIII in carriers and patients with nephrogenic diabetes insipidus.
Thrombosis and Hemostasi
Availability of medicines in the European Union: results from the EURO-Medicines project.
Producción CientíficaThere is at present no comprehensive directory of medicines available in European countries. Such a directory would be valuable to policy analysts, clinicians, regulatory agencies, pharmaceutical companies and consumer groups. The aim of this project was to compile such a directory of all medicines marketed in each of the European Union member countries.
METHODS:
Lists of medicines for each country, compiled from several national sources, classified by Anatomical-Chemical-Therapeutic (ATC) code. Census date was late 1998.
RESULTS:
A comprehensive directory was created using data from 14 of the 15 European Union countries. Numbers of trade names and of active ingredients varied widely, from Germany with 18,554 and 1,973, respectively, to Denmark with 1,915 and 1,016, respectively. In individual therapeutic areas, there were variations in the numbers of active ingredients available: the least variation between countries was in antineoplastic medicines (ATC code L, maximum number available in any country 101, minimum 60) and wider variation in alimentary (ATC code A, maximum 256. minimum 103) or cardiovascular (ATC code C, maximum 269, minimum 112). Only 7% of all the active ingredients were available in all the countries studied. The Scandinavian countries had the greatest proportion of active ingredients (60%) available in all other countries. Each country had a number of active ingredients available only in that country Italy had the largest number of these.
CONCLUSIONS:
The directory illustrates the wide variations in the availability of medicines across the European Union. The range of drugs available in each country represents differences in regulatory and market policies, as well as cultural and historic differences. This directory lends itself to many further analyses
Work-leisure relations : leisure orientation and the meaning of work
Etude des relations travail-loisir chez deux groupes d'adultes israéliens (données 1981 et 1993) : l'un orienté vers le loisir, l'autre vers le travail. La compensation du travail par le loisir caractérise la relation entre la satisfaction au travail et l'orientation vers le loisir