Evidence for a Massive Neutron Star from a Radial-Velocity Study of the Companion to the Black Widow Pulsar PSR B1957+20

The most massive neutron stars constrain the behavior of ultra-dense matter, with larger masses possible only for increasingly stiff equations of state. Here, we present evidence that the black widow pulsar, PSR B1957+20, has a high mass. We took spectra of its strongly irradiated companion and found an observed radial-velocity amplitude of K_obs=324+/-3 km/s. Correcting this for the fact that, due to the irradiation, the center of light lies inward relative to the center of mass, we infer a true radial-velocity amplitude of K_2=353+/-4 km/s and a mass ratio q=M_PSR/M_2=69.2+/-0.8. Combined with the inclination i=65+/-2 deg inferred from models of the lightcurve, our best-fit pulsar mass is M_PSR=2.40+/-0.12 M_sun. We discuss possible systematic uncertainties, in particular in the lightcurve modeling. Taking an upper limit of i<85 deg based on the absence of radio eclipses at high frequency, combined with a conservative lower-limit to the motion of the center of mass, K_2>343 km/s (q>67.3), we infer a lower limit to the pulsar mass of M_PSR>1.66 M_sun.Comment: 7 pages, 3 figures, 1 table, accepted for publication in ApJ; revision includes more detail on the spectral classification and discussion of other recent high neutron-star masse

Young Radio Pulsars in Galactic Globular Clusters

Currently three isolated radio pulsars and one binary radio pulsar with no evidence of any previous recycling are known in 97 surveyed Galactic globular clusters. As pointed out by Lyne et al., the presence of these pulsars cannot be explained by core-collapse supernovae, as is commonly assumed for their counterparts in the Galactic disk. We apply a Bayesian analysis to the results from surveys for radio pulsars in globular clusters and find the number of potentially observable non-recycled radio pulsars present in all clusters to be < 3600. Accounting for beaming and retention considerations, the implied birth rate for any formation scenario for all 97 clusters is < 0.25 pulsars per century assuming a Maxwellian distribution of velocities with a dispersion of 10 km s^{-1}. The implied birth rates for higher velocity dispersions are substantially higher than inferred for such pulsars in the Galactic disk. This suggests that the velocity dispersion of young pulsars in globular clusters is significantly lower than those of disk pulsars. These numbers may be substantial overestimates due to the fact that the currently known sample of young pulsars is observed only in metal-rich clusters. We propose that young pulsars may only be formed in globular clusters with metallicities with log[Fe/H] > -0.6. In this case, the potentially observable population of such young pulsars is 447^{+1420}_{-399} (the error bars give the 95% confidence interval) and their birth rate is 0.012^{+0.037}_{-0.010} pulsars per century. The mostly likely creation scenario to explain these pulsars is the electron capture supernova of a OMgNe white dwarf.Comment: 13 Pages, 6 Figures, 4 Tables, to appear in Ap

The Arecibo 430-MHz Intermediate Galactic Latitude Survey: Discovery of Nine Radio Pulsars

We have used the Arecibo Radio Telescope to search for millisecond pulsars in two intermediate Galactic latitude regions (7 deg < | b | < 20 deg) accessible to this telescope. For these latitudes the useful millisecond pulsar search volume achieved by Arecibo's 430-MHz beam is predicted to be maximal. Searching a total of 130 square degrees, we have discovered nine new pulsars and detected four previously known objects. We compare the results of this survey with those of other 430-MHz surveys carried out at Arecibo and of an intermediate latitude survey made at Parkes that included part of our search area; the latter independently found two of the nine pulsars we have discovered. At least six of our discoveries are isolated pulsars with ages between 5 and 300 Myr; one of these, PSR J1819+1305, exhibits very marked and periodic nulling. We have also found a recycled pulsar, PSR J2016+1948. With a rotational period of 65 ms, this is a member of a binary system with a 635-day orbital period. We discuss some of the the properties of this system in detail, and indicate its potential to provide a test of the Strong Equivalence Principle. This pulsar and PSR J0407+16, a similar system now being timed at Arecibo, are by far the best systems known for such a test.Comment: Accepted for publication in ApJ Referee format: 22 pages, 7 figure

Advanced Nanocellulose-Based Materials: Production, Properties and Applications

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Oral health-related quality of life in portuguese pre-school children: a cross-sectional study

Purpose To study Oral Health related Quality of Life (OHRQoL) of pre-school children and its associated factors. Methods Cross-sectional study with sample data collected through an on-line questionnaire to a non-probabilistic sample. The questionnaire included the Portuguese version of the Early Childhood Oral Health Impact Scale (ECOHIS) and questions about sociodemographic characteristics, oral health behaviours, and reported oral health of the child. Data analyses included descriptive statistics, Mann–Whitney and Kruskal–Wallis tests and Linear regression (α=0.05). Results The sample consisted of 1475 parents of pre-school children (3–5 years-old), residing in Portugal. The mean ECOHIS total score was 1.5 (sd=3.4). In the bivariate analysis the child’s age, starting toothbrushing after one year of age, frequent intake of sugary food and drinks, previous appointment with an oral health professional, all reported of oral health problems, and a negative perception of oral health were negatively associated with OHRQoL (p<0,05). In the regression model the factors that most contributed to a worse quality of life were dental caries and abscess, contributing to an ECOHIS average increase of 2.56 and 3.34, respectively. Conclusions The studied population presented a good OHRQoL, with the item related to pain being the most relevant for the ECOHIS score. Worst OHRQoL was found in older children, whose parents negatively rated the children's oral health and with reported dental caries, trauma, and abscess.info:eu-repo/semantics/publishedVersio

The role of ionic liquids in the pharmaceutical field: an overview of relevant applications

Solubility, bioavailability, permeation, polymorphism, and stability concerns associated to solid-state pharmaceuticals demand for effective solutions. To overcome some of these drawbacks, ionic liquids (ILs) have been investigated as solvents, reagents, and anti-solvents in the synthesis and crystallization of active pharmaceutical ingredients (APIs), as solvents, co-solvents and emulsifiers in drug formulations, as pharmaceuticals (API-ILs) aiming liquid therapeutics, and in the development and/or improvement of drug-delivery-based systems. The present review focuses on the use of ILs in the pharmaceutical field, covering their multiple applications from pharmaceutical synthesis to drug delivery. The most relevant research conducted up to date is presented and discussed, together with a critical analysis of the most significant IL-based strategies in order to improve the performance of therapeutics and drug delivery systems.publishe

Extraction of high value triterpenic acids from eucalyptus globulus biomass using hydrophobic deep eutectic solvents

Triterpenic acids (TTAs), known for their promising biological properties, can be found in different biomass sources and related by-products, such as Eucalyptus globulus bark, and have been extracted using organic volatile solvents such as dichloromethane. Recently, deep eutectic solvents (DES) have been identified as promising alternatives for the extraction of value-added compounds from biomass. In the present work, several hydrophobic DES were tested for the extraction of TTAs from E. globulus bark. Initial solubility studies revealed that DES based on menthol and thymol as the most promising solvents for these compounds given the highest solubilities obtained for ursolic acid (UA) at temperatures ranging from room temperature up to 90 °C. Accordingly, an eutectic mixture of menthol:thymol (1:2) was confirmed as the best candidate for the TTAs extraction from E. globulus outer bark, leading to extraction yields (weight of TTA per weight of biomass) at room temperature of 1.8 wt% for ursolic acid, 0.84 wt% for oleanolic acid and 0.30 wt% for betulinic acid. These values are significantly higher than those obtained with conventional organic solvents under similar conditions. The results obtained using these DES are promising for the recovery of TTAs for nutraceutical and pharmacological applications, while reinforcing the potential of DES as promising solvents to be applied in biorefinery processes.publishe

Proteínas de feijão caupi [Vigna unguiculata (L.) Walp]: caracterização e aplicação nutricional.

Utilização e valor protéico; Proteínas de reserva; Protéinas tóxicas.bitstream/item/35890/1/Doc44.pd

Co‐existing monophasic teratoma and uterine adenocarcinoma in a female dog

Ovarian teratomas are occasionally reported in dogs; the rarest type is the monophasic teratoma,composed of tissues originating from only one germ layer. Canine endometrial adenocarcinomas are also rare in dogs and mainly affect geriatric females. This report describes case of co-existing ovarian teratoma and uterine adenocarcinoma in a 10-year old nulliparous female Boxer presented with lethargy, anorexia and purulent vaginal discharge. Abdominal ultrasonography evidenced pyometra and a mass in the left ovary. This was composed of a uniform whitish tissue with multiple cystic structures. The histology revealed an atrophy of the ovarian parenchyma, compressed by a proliferation of well-differentiated nervous tissue staining positively to vimentin, S100 and neuronal specific enolase (NSE), and negatively to keratin and inhibin. The left uterine horn, whose diameter was markedly increased, showed foci of endometrial cellular atypia, evident nucleoli and mitoses, at light microscopy. To our best knowledge, this is the first report of a coexisting ovarian monophasic teratoma and endometrial adenocarcinoma, two rare reproductive neoplasia in dogs