Ortho-positronium observation in the double chooz experiment

The Double Chooz experiment measures the neutrino mixing angle θ13 by detecting reactor ¯νe via inverse beta decay. The positron-neutron space and time coincidence allows for a sizable background rejection, nonetheless liquid scintillator detectors would profit from a positron/electron discrimination, if feasible in large detector, to suppress the remaining background. Standard particle identification, based on particle dependent time profile of photon emission in liquid scintillator, can not be used given the identical mass of the two particles. However, the positron annihilation is sometimes delayed by the orthopositronium (o-Ps) metastable state formation, which induces a pulse shape distortion that could be used for positron identification. In this paper we report on the first observation of positronium formation in a large liquid scintillator detector based on pulse shape analysis of single events. The o-Ps formation fraction and its lifetime were measured, finding the values of 44 % ± 12 % (sys.) ± 5 % (stat.) and 3.68 ns ± 0.17 ns (sys.) ± 0.15 ns (stat.) respectively, in agreement with the results obtained with a dedicated positron annihilation lifetime spectroscopy setup

Improved measurements of the neutrino mixing angle Ɵ<inf>13</inf> with the double chooz detector

The Double Chooz experiment presents improved measurements of the neutrino mixing angle Ɵ13 using the data collected in 467.90 live days from a detector positioned at an average distance of 1050m from two reactor cores at the Chooz nuclear power plant. Several novel techniques have been developed to achieve significant reductions of the backgrounds and systematic uncertainties with respect to previous publications, whereas the efficiency of the (Formula Presented.) signal has increased. The value of Ɵ13 is measured to be sin22Ɵ13 = 0.090-0.029+0.032 from a fit to the observed energy spectrum. Deviations from the reactor (Formula Presented.) prediction observed above a prompt signal energy of 4MeV and possible explanations are also reported. A consistent value of Ɵ13 is obtained from a fit to the observed rate as a function of the reactor power independently of the spectrum shape and background estimation, demonstrating the robustness of the Ɵ13 measurement despite the observed distortion

Molecular cloning and functional characterization of the pig homologue of integrin-associated protein (IAP/CD47)

We report the cloning of cDNA encoding the pig homologue of human integrin-associated protein (IAP or CD47). A pig CD47-specific probe was generated by polymerase chain reaction (PCR) amplification of pig leucocyte cDNA, using primers based on consensus regions among the known sequences of CD47 from different species. Screening of a pig aorta smooth muscle cDNA library identified seven clones, all containing identical sequences. The clones contained an open reading frame (ORF) that encoded an 18 amino acid putative signal peptide, a 122 amino acid sequence consisting of a single extracellular immunoglobulin variable (IgV)-like domain followed by a 147 amino acid region containing five membrane-spanning domains and a 16 amino acid cytoplasmic tail. The amino acid sequence of the clones was 73% homologous to human IAP and therefore it was termed pig IAP or CD47. Reverse transcription–polymerase chain reaction (RT–PCR) showed that pig CD47 was expressed in a wide range of tissues and detected different alternatively spliced forms. The monoclonal antibody (mAb) BRIC 126, anti-human CD47, was shown, by flow cytometry, to stain pig platelets as well as Chinese hamster ovary (CHO) cells transfected with the cDNA encoding pig CD47. Western blot analysis of pig erythocytes and platelets showed a molecular weight (MW) of 43 000–50 000 and of 55 000–65 000, respectively, under non-reducing conditions. Pig CD47 was stably expressed on CHO cells and shown to bind human thrombospondin (TSP). BRIC126 antibody inhibited the binding of platelets and of CD47-transfected cells to human TSP and to pig fibrinogen, whereas no effect was observed on control CHO cells

Mutism and amnesia following high-voltage electrical injury: psychogenic symptomatology triggered by organic dysfunction

Background: Mutism and dense retrograde amnesia are found both in organic and dissociative contexts. Moreover, dissociative symptoms may be modulated by right prefrontal activity. A single case, M. R., developed left hemiparesis, mutism and retrograde amnesia after a high-voltage electric shock without evidence of lasting brain lesions. M. R. suddenly recovered from his mutism following a mild brain trauma 2 years later. Methods: M.R.'s neuropsychological pattern and anatomoclinical correlations were studied through (i) language and memory assessment to characterize his deficits, (ii) functional neuroimaging during a standard language paradigm, and (iii) assessment of frontal and left insular connectivity through diffusion tractography imaging and transcranial magnetic stimulation. A control evaluation was repeated after recovery. Findings: M. R. recovered from the left hemiparesis within 90 days of the accident, which indicated a transient right brain impairment. One year later, neurobehavioral, language and memory evaluations strongly suggested a dissociative component in the mutism and ret-rograde amnesia. Investigations (including MRI, fMRI, diffusion tensor imaging, EEG and r-TMS) were normal. Twentyseven months after the electrical injury, M. R. had a very mild head injury which was followed by a rapid recovery of speech. However, the retrograde amnesia persisted. Discussion: This case indicates an interaction of both organic and dissociative mechanisms in order to explain the patient's symptoms. The study also illustrates dissociation in the time course of the two different dissociative symptoms in the same patient. Copyright (C) 2011 S. Karger AG, Base