Parameterized thermal macromodeling for fast and effective design of electronic components and systems

We present a parameterized macromodeling approach to perform fast and effective dynamic thermal simulations of electronic components and systems where key design parameters vary. A decomposition of the frequency-domain data samples of the thermal impedance matrix is proposed to improve the accuracy of the model and reduce the number of the computationally costly thermal simulations needed to build the macromodel. The methodology is successfully applied to analyze the impact of layout variations on the dynamic thermal behavior of a state-of-the-art 8-finger AlGaN/GaN HEMT grown on a SiC substrate

Grape skin phenolics as inhibitors of mammalian α-glucosidase and α-amylase – effect of food matrix and processing on efficacy

Inhibition of mammalian α-amylase and α-glucosidase was studied for white grape skin samples recovered from wineries and found to be higher than that of the drug acarbose

are the source models of the m 7 1 1908 messina straits earthquake reliable insights from a novel inversion and a sensitivity analysis of levelling data

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Modification of the levels of delta-aminolevulinic acid dehydratase in chronic alcoholic patients

Medical and biochemical analysis were performed on 58 patients with chronic alcoholism. In accordance with medical characterisation, patients were divided in three groups: A (patients having only hepatopathy), B (patients with hepatopathy and neuropathy) and C (patients having only alcoholic neuropathy). Simultaneously, several parameters related to heme biosynthesis were examined. Urinary delta-aminolevulic acid (ALA), porphobilinogen (PBG) and porphyrins and fecal porphyrins measurements did not show significant difference among all studied groups. The activities of ALA-dehydratase (ALA-D), uroporphyrinogen-I-synthase (URO-I-S) and uroporphyrinogen-III-synthase (URO-III-S) were monitored in peripheral erythrocytes. From the enzymes measured, only ALA-D levels in groups B and C were significantly depressed (p < 0.002) compared with normal subjects. The decrease in ALA-D correlated with the degree of neuropathy

Seismotectonics of the active thrust front in southwestern Sicily: hints on the Belice and Selinunte seismogenic sources

We present a seismotectonic model of the active thrust front in western Sicily, which includes the area hit by the 1968 Belice earthquake sequence. The ~40 km long South-WEstern Sicilian Thrust (SWEST) is formed by two aligned albeit non-parallel fault arrays, the Granitola-Castelevetrano Thrust System (GCTS) in the west and the Partanna- Poggioreale Thrust System (PPTS) in the east. The ~NE-SW trending, NW-dipping GCTS straddles from the Pelagian coastline to Castelvetrano, is ~18 km long and composed of two segments, with the northern, ~12 km long one showing geodetic and geologic evidence of active deformation (Barreca et al., 2014). The segment is marked by a sharp gradient in Differential SAR interferometry (DinSAR and STAMPs) and GPS velocity fields. Geologic evidence include an up to 60 m high, and up to 15° steep scarp, which is the fore-limb of a broad fold involving Lower Pleistocene shore calcarenites, and cm-scale reverse displacement of an ancient road dated as early Bronze-Hellenistic age. Inversion of fault slip-lineation data from structures displacing the archaeological remains yields a ~N110°E shortening axis, consistent with the geodetic shortening direction estimated from GPS differential velocities. The ~ENE-WSW trending PPTS stretches from Partanna to the macro-seismic area of the 1968 earthquake sequence and is composed of two ~10 km long segments limited by relay ramps. Although geologic and geodetic evidence of deformation are less clear than for the GCTS, we nonetheless observe a gradient in interferometry data for the western segment, and evidence of slow deformation (creep?) in historical to recent (last ~400 yr?) man-made structures. Integration of geologic, geodetic and seismology data suggests the active folds and thrusts are the uppermost expression of steep (45°) crustal ramps (Monaco et al., 1996) which upthrust the Saccense platform at depth. Based on macroseismic and seismological evidence (Monaco et al., 1996), we contend that the PPTS was partly activated during the 1968 sequence, and that rupture stopped at the junction with the GCTS. The current geodetic strain accumulation on the GCTS, on the other hand, suggests that the fault array has been significantly loaded, and that its last important co-seismic event could have been caused the 4th–5th century A.D. destruction of Selinunte (Bottari et al., 2009)

Probiotics action on gliadin sequences relevant to gluten sensitivity

The Celiac disease in genetically predisposed individuals is mainly induced by specific repetitive sequences in gliadins (PQPYP). This autoimmune disease stems from the interaction between toxic sequences and lamina propria cells, that is relevant also to other forms of gluten sensitivity. Specific endo-esoprolinase were isolated from lactic acid bacteria, suggesting possible practical applications. The ability of some probiotics at removing "toxic" celiac sequences was investigated, at first by assessing the presence and level of endo- and eso-prolinase activity in some of the most popular probiotic bacteria. Significant activities were detected in Lactobacillus and Bifidum species, as well as in the probiotic Escherichia coli Niessle 1917. On the basis of prolinase data, we investigated by mass spectroscopy the removal of "toxic" sequences in gliadin. A complete disappearance of these sequences was observed only with Escherichia coli Niessle 1917. Among the Bifidus and Lactobacillus species, only B. bifidum MIMBb23SG and L. acidophilus LA5 showed a significant decrease in the "toxic" sequences. All together, this study suggests a potential use of lactic bacteria to lower gluten response in sensitive individuals, including celiacs and gluten-sensitive

Geodetic and geological evidence of active tectonics in south-westernSicily (Italy)

Integrated geological, geodetic and marine geophysical data provide evidence of active deformation insouth-western Sicily, in an area spatially coincident with the macroseismic zone of the destructive 1968Belice earthquake sequence. Even though the sequence represents the strongest seismic event recordedin Western Sicily in historical times, focal solutions provided by different authors are inconclusive onpossible faulting mechanism, which ranges from thrusting to transpression, and the seismogenic sourceis still undefined. Interferometric (DInSAR) observations reveal a differential ground motion on a SW–NEalignment between Campobello di Mazara and Castelvetrano (CCA), located just west of the maximummacroseismic sector. In addition, new GPS campaign-mode data acquired across the CCA alignment doc-uments NW–SE contractional strain accumulation. Morphostructural analysis allowed to associate thealignment detected through geodetic measurements with a topographic offset of Pleistocene marine sed-iments. The on-land data were complemented by new high-resolution marine geophysical surveys, whichindicate recent contraction on the offshore extension of the CCA alignment. The discovery of archaeo-logical remains displaced by a thrust fault associated with the alignment provided the first likely surfaceevidence of coseismic and/or aseismic deformation related to a seismogenic source in the area. Resultsof the integrated study supports the contention that oblique thrusting and folding in response to NW–SEoriented contraction is still active. Although we are not able to associate the CCA alignment to the 1968seismic sequence or to the historical earthquakes that destroyed the ancient Greek city of Selinunte,located on the nearby coastline, our result must be incorporated in the seismic hazard evaluation of thisdensely populated area of Sicily

Metabolomics analysis of plasma samples of patients with fibromyalgia and electromagnetic sensitivity using GC–MS technique

Fibromyalgia (FM) is a chronic and systemic condition that causes widespread chronic pain, asthenia, and muscle stiffness, as well as in some cases depression, anxiety, and disorders of the autonomic system. The exact causes that lead to the development of FM are still unknown today. In a percentage of individuals, the symptoms of FM are often triggered and/or exacerbated by proximity to electrical and electromagnetic devices. Plasma metabolomic profile of 54 patients with fibromyalgia and self-reported electromagnetic sensitivity (IEI-EMF) were compared to 23 healthy subjects using gas chromatography-mass spectrometry (GC-MS) coupled with multivariate statistical analysis techniques. Before the GC-MS analysis the plasma samples were extracted with a modified Folch method and then derivatized with methoxamine hydrochloride in pyridine solution and N-trimethylsilyltrifuoroacetamide. The combined analysis allowed to identify a metabolomic profile able of distinguishing IEI-EMF patients and healthy subjects. IEI-EMF patients were therefore characterized by the alteration of 19 metabolites involved in different metabolic pathways such as energy metabolism, muscle, and pathways related to oxidative stress defense and chronic pain. The results obtained in this study complete the metabolomic "picture" previously investigated on the same cohort of IEI-EMF patients with 1H-NMR spectroscopy, placing a further piece for better understanding the pathophysiological mechanisms in patients with IEI-EMF