I Capitoli del Peculio delli scudi cento milia (1591) e la politica annonaria della città di Messina tra XVI e XVII secolo

Il saggio analizza il primo regolamento annonario organico della città di Messina, sancito nel 1591, inquadrandolo nella politica annonaria della città in antico regime, e pubblicandone la trascrizion

Familia, honor y género en Sicilia: modelos y nuevas investigaciones

This article shows how the latest research into Sicily’s social and economic history calls into question certain well-established interpretations of the history of the family and its structures, the paradigm of Mediterranean honour, and the theory of familism. This new appraisal also highlights the major significance of the history of women and gender identity. Key words: Italy-Sicily, family history, familism, honour, Mediterranean.El artículo ilustra cómo la reciente historiografía social y económica, sobretodo italiana, sobre Sicilia pone en discusión – en un plano más general – algunas de las interpretaciones consolidadas de la historia de la familia y de sus estructuras, del paradigma del honor mediterráneo, del familismo. Destaca, además, el importante rol que ha jugado, en esta rediscusión, desde la historia de las mujeres y de la identidad de género. Palabras clave: Italia-Sicilia, historia de la familia, familismo, honor, Mediterráneo

Familia, honor y género en Sicilia: modelos y nuevas investigaciones

This article shows how the latest research into Sicily’s social and economic history calls into question certain well-established interpretations of the history of the family and its structures, the paradigm of Mediterranean honour, and the theory of familism. This new appraisal also highlights the major significance of the history of women and gender identity. Key words: Italy-Sicily, family history, familism, honour, Mediterranean.El artículo ilustra cómo la reciente historiografía social y económica, sobretodo italiana, sobre Sicilia pone en discusión – en un plano más general – algunas de las interpretaciones consolidadas de la historia de la familia y de sus estructuras, del paradigma del honor mediterráneo, del familismo. Destaca, además, el importante rol que ha jugado, en esta rediscusión, desde la historia de las mujeres y de la identidad de género. Palabras clave: Italia-Sicilia, historia de la familia, familismo, honor, Mediterráneo

The Evolution of Circumstellar Disks Surrounding Intermediate Mass Stars: IC 1805

We report the results of a study of the intermediate and high mass stars in the young, rich star-forming complex IC 1805, based on a combination of optical, near-infrared, and mid-infrared photometry, and classification spectra. These data provide the basis for characterizing the masses and ages for stars more massive than ~2 Msun and enable a study of the frequency and character of circumstellar disks associated with intermediate- and high-mass stars. Optically thick accretion disks among stars with masses 2 < M/Msun <4 are rare (~2% of members) and absent among more massive stars. A larger fraction (~10%) of stars with masses 2 < M/Msun < 4 appear to be surrounded by disks that have evolved from the initial optically thick accretion phase. We identify four classes of such disks. These classes are based on spectral energy distributions (SEDs) of excess emsission above photospheric levels: disks that are (1) optically thin based on the magnitude of the observed excess emission from 2 to 24 um; (2) optically thin in their inner regions (r< 20 AU) and optically thick in their outer regions; (3) exhibit empty inner regions (r < 10 AU) and optically thin emission in their outer regions; and (4) exhibit empty inner regions and optically thick outer regions. We discuss, and assess the merits and liabilities of, proposed explanations for disks exhibiting these SED types and suggest additional observations that would test these proposals.Comment: Accepted to Ap

Stellar-Mass-Dependent Disk Structure in Coeval Planet-Forming Disks

Previous studies suggest that the planet-forming disks around very-low-mass stars/brown dwarfs may be flatter than those around more massive stars, in contrast to model predictions of larger scale heights for gas-disks around lower-mass stars. We conducted a statistically robust study to determine whether there is evidence for stellar-mass-dependent disk structure in planet-forming disks. We find a statistically significant difference in the Spitzer/IRAC color distributions of disks around very-low-mass and low-mass stars all belonging to the same star-forming region, the Chamaeleon I star-forming region. We show that self consistently calculated disk models cannot fit the median spectral energy distributions (SEDs) of the two groups. These SEDs can be only explained by flatter disk models, consistent with the effect of dust settling in disks. We find that relative to the disk structure predicted for flared disks the required reduction in disk scale height is anti-correlated with the stellar mass, i.e. disks around lower-mass stars are flatter. Our results show that the initial and boundary conditions of planet formation are stellar-mass-dependent, an important finding that must be considered in planet formation models.Comment: Astrophysical Journal, in pres

Infrared Signatures of Disrupted Minor Planets at White Dwarfs

Spitzer Space Observatory IRAC and MIPS photometric observations are presented for 20 white dwarfs with T < 20,000 K and metal-contaminated photospheres. A warm circumstellar disk is detected at GD 16 and likely at PG 1457-086, while the remaining targets fail to reveal mid-infrared excess typical of dust disks, including a number of heavily polluted stars. Extending previous studies, over 50% of all single white dwarfs with implied metal accretion rates dM/dt > 3e8 g/s display a warm infrared excess from orbiting dust; the likely result of a tidally-destroyed minor planet. This benchmark accretion rate lies between the dust production rates of 1e6 g/s in the solar system zodiacal cloud and 1e10 g/s often inferred for debris disks at main sequence A-type stars. It is estimated that between 1% and 3% of all single white dwarfs with cooling ages less than around 0.5 Gyr possess circumstellar dust, signifying an underlying population of minor planets.Comment: 47 pages, accepted to Ap

Body mass index and baseline platelet count as predictive factors in Merkel cell carcinoma patients treated with avelumab

BackgroundMerkel cell carcinoma (MCC) is a rare and aggressive skin cancer, associated with a worse prognosis. The Immune Checkpoint Inhibitors (ICIs) avelumab and pembrolizumab have been recently approved as first-line treatment in metastatic MCC (mMCC). The clinical observation of improved outcomes in obese patients following treatment with ICIs, known as the “obesity paradox”, has been studied across many types of tumors. Probably due to the rarity of this tumor, data on mMMC patients are lacking.Patients and methodsThis is an observational, hospital-based, study to investigate the role of Body Mass Index (BMI) as predictive biomarker of ICI response in mMCC patients treated with avelumab as first-line treatment. The study population included the patients treated from February 2019 to October 2022 in an Italian referral center for rare tumors. Clinico-pathological characteristics, BMI, laboratory parameters (NLR and platelet count), and response to avelumab were analyzed from a MCC System database prospectively collected.ResultsThirty-two (32) patients were included. Notably, the presence of pre-treatment BMI ≥ 30 was significantly associated with longer PFS [BMI &lt; 30 Group: median PFS, 4 months (95% CI: 2.5-5.4); BMI ≥ 30 Group: median PFS, not reached; p&lt;0.001)[. Additionally, the median PFS was significantly higher in patients with higher PLT (median PFS: 10 months in the “low PLT” Group (95% CI: 4.9, 16.1) vs 33 months (95% CI: 24.3, 43.2) in the “high PLT” Group (p=0.006). The multivariable Cox regression model confirmed these results.ConclusionTo our knowledge, this is the first study that investigates the predictive role of BMI in MCC patients. Our data were consistent with the clinical observation of improved outcomes in obese patients across other tumor types. Thus, advanced age, a weakened immune system, and the obesity-associated “inflammaging”, are key factors that could impact the cancer immune responses of mMCC patients

How future surgery will benefit from SARS-COV-2-related measures: a SPIGC survey conveying the perspective of Italian surgeons

COVID-19 negatively affected surgical activity, but the potential benefits resulting from adopted measures remain unclear. The aim of this study was to evaluate the change in surgical activity and potential benefit from COVID-19 measures in perspective of Italian surgeons on behalf of SPIGC. A nationwide online survey on surgical practice before, during, and after COVID-19 pandemic was conducted in March-April 2022 (NCT:05323851). Effects of COVID-19 hospital-related measures on surgical patients' management and personal professional development across surgical specialties were explored. Data on demographics, pre-operative/peri-operative/post-operative management, and professional development were collected. Outcomes were matched with the corresponding volume. Four hundred and seventy-three respondents were included in final analysis across 14 surgical specialties. Since SARS-CoV-2 pandemic, application of telematic consultations (4.1% vs. 21.6%; p &lt; 0.0001) and diagnostic evaluations (16.4% vs. 42.2%; p &lt; 0.0001) increased. Elective surgical activities significantly reduced and surgeons opted more frequently for conservative management with a possible indication for elective (26.3% vs. 35.7%; p &lt; 0.0001) or urgent (20.4% vs. 38.5%; p &lt; 0.0001) surgery. All new COVID-related measures are perceived to be maintained in the future. Surgeons' personal education online increased from 12.6% (pre-COVID) to 86.6% (post-COVID; p &lt; 0.0001). Online educational activities are considered a beneficial effect from COVID pandemic (56.4%). COVID-19 had a great impact on surgical specialties, with significant reduction of operation volume. However, some forced changes turned out to be benefits. Isolation measures pushed the use of telemedicine and telemetric devices for outpatient practice and favored communication for educational purposes and surgeon-patient/family communication. From the Italian surgeons' perspective, COVID-related measures will continue to influence future surgical clinical practice