Eficiência do processo de biodigestão em fossa séptica biodigestora inoculada com esterco de ovino.

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Cartilage and bone regeneration: how close are we to bedside?

The treatment/regeneration of bone and cartilage diseases or defects, whether induced by rheumatism, joint dysplasia, trauma, or surgery presents great challenges that have not been fully solved by the current therapies. In the last few years, tissue engineering and regenerative medicine have been proposing advanced tools and technologies for bone and cartilage tissue regeneration, and some of which have successfully reached the market. Beyond the source of cells, the creation of superior structures for replacing defective bone and cartilage requires strong research in biomechanical signaling and synthesis of advanced biomaterials to mimic human tissues at the most varied levels. Natural and synthetic polymers, bioresorbable inorganic materials, and composites have been investigated for its potential as scaffolding materials with enhanced mechanical and biological properties. Porous scaffolds, hydrogels, and fibers are the most commonly biomimetic structures used for bone and cartilage tissue engineering. Herein, the concepts and current treatment strategies for bone and cartilage repair, as well as biomimetic strategies for bone and cartilage tissue engineering are overviewed. A global review of the ongoing clinical trials and of the scaffolds commercially available for the repair of osteochondral tissue is also presented.(undefined

Determination and comparison of the chemical composition of Calendula L. species growing in Continental Portugal

11th National Meeting of Organic Chemistry and 4th Meeting of Therapeutic Chemistry.The flora of Continental Portugal includes three species of Calendula L. (Calendula officinalis L., C. arvensis L., C. suffruticosa Vahl), one of which comprises three subspecies (C. suffruticosa subsp. algarbiensis (Boiss.) Nyman, C. suffruticosa subsp. lusitanica (Boiss.) Ohle and C. suffruticosa subsp. cinerea (Ohle) P.Silveira & A.C.Gonç.). C. officinalis is recognised for its medical properties and its chemical composition has been widely studied (Muley, B. P., et al. J. Pharm. Res. 2009, 8, 455; Safdar, W., et al. Int. J. Cell Mol. Biol. 2010, 1, 108). Nevertheless, little is known about the chemical composition of C. arvensis and even less regarding the different subspecies of C. suffruticosa. Therefore, the present study aims the elucidation of these plants’ chemical composition and to compare and identify differences and/or similarities among them. […].Instituto da Conservação da Natureza e das Florestas; Universidade de Aveiro; FCT / MEC (FCT UID / QUI / 00062/2013); UEM CESAM (UID / AMB / 50017); FEDER (Acordo de Parceria PT2020).info:eu-repo/semantics/publishedVersio

Neospora caninum: high susceptibility to the parasite in C57BL/10ScCr mice

Neospora caninum: high susceptibility to the parasite in C57BL/10ScCr miceC57BL/10ScCr mice, lack Toll-like receptor 4 and a functional Interleukin-12 receptor. Taking this into account, susceptibility of these mice to Neospora caninum infection was assessed comparatively to that of immunocompetent C57BL/10ScSn mice. C57BL/10ScCr mice inoculated intraperitoneally with 5 x 10(5) N. caninum tachyzoites showed a high Susceptibility to this parasite. All infected C57BL/10ScCr mice were dead by day 8 post-infection whereas all control C57BL/10ScSn mice survived this parasitic challenge. Immunohistochemical analysis of infected C57BL/10ScCr mice showed N. caninum tachyzoites spread in the pancreas, liver, lung, intestine, heart and brain whereas no parasites were detected in similarly infected C57BL/10ScSn controls. The higher susceptibility of C57BL/10ScCr mice to neosporosis correlates with reduced interferon-gamma mRNA expression and increased IL-4 mRNA expression, comparatively to C57BL/10ScSn controls, detected in the spleen after the parasitic challenge. C57BL/10ScCr mice could thus be used as a new experimental model where to study immunobiological mechanisms associated with host Susceptibility to neosporosis.info:eu-repo/semantics/publishedVersio

Separación de Circones: Primer Informe

Fil: López, Faustino A. Servicio Geológico Minero Argentino. Instituto de Tecnología Minera; Argentina.Fil: Romano, Andrea, L. Servicio Geológico Minero Argentino. Instituto de Tecnología Minera; Argentina.Fil: Cozzi, Guillermo. Servicio Geológico Minero Argentino. Instituto de Tecnología Minera; Argentina.En el marco del proyecto del Laboratorio de Geoquímica Isotópica, se realizan los primeros intentos de preparación de muestra. En este trabajo se utilizan exclusivamente las instalaciones del SEGEMAR ubicadas en el parque tecnológico Migueletes, edificios 25 y 14. Se pretende registrar la capacidad real, actual del SEGEMAR para procesar una muestra en bruto y extraer de la misma, una cantidad suficiente de circones para ser analizados por el LA-MCICP-MS adquirido por el organismo, ya sea para datación (U-Pb) o para análisis de elementos traza. Tanto los criterios de selección del material en bruto como los métodos de extracción y transporte adecuados para realizar una separación de circones exitosa, no se analizan en este informe. Tampoco se realizan análisis químicos ni petrográficos. Se comenzó el proceso con una roca previamente molida hasta tamaños de entre 5 a 20 mm y, aunque la capacidad de moler una roca de mayor tamaño se encuentra disponible en SEGEMAR, no se analiza en este informe. Queda pendiente también el armado de la montura, ya sea en pastilla epoxi o en corte delgado, estos aspectos están siendo analizados en conjunto con el proveedor del equipo