Elaboration de surfaces nano/micro-structurées pour limiter l’adhésion de micro-organismes

Avec plus d’un million de dispositifs posés par an dans le monde, l’utilisation des chambres implantables s’est maintenant généralisée pour le traitement de certains cancers. Constituées d’un réservoir de quelques dixièmes de microlitres, le plus souvent en titane, relié à un cathéter dont l’extrémité est placée dans une veine à fort débit, ils permettent de délivrer un traitement de chimiothérapie avec un confort augmenté pour le patient. Ces dispositifs permettent aussi le cas échéant d’apporter une nutrition parentérale. Cette dernière utilisation provoque de nombreuses infections, qui conduisent dans la plupart des cas au retrait du dispositif. Afin de réduire le risque de contamination, il est donc nécessaire de mieux comprendre les facteurs favorisant l’adhérence des micro-organismes (bactéries et levures) dans ces dispositifs médicaux invasifs et leur colonisation ultérieure. Dans le cadre du projet régional MAT-INNO, nos travaux de recherche visent à mieux comprendre l’impact des propriétés de surface (en termes de topographie, hydrophobicité et fonctionnalisation) sur l’adhésion de bactéries et de levures. En agissant sur les propriétés physiques et/ou chimiques de surface, nous espérons réduire les capacités d\u27adhérence des micro-organismes et ainsi limiter le risque d\u27infection. Les études actuelles sont réalisées sur des substrats de silicium sur lesquels est déposée une couche mince nanométrique d’oxyde de titane. Nos efforts portent, dans un premier temps, sur la maîtrise de la topographie de surface à l’échelle nanométrique et micrométrique, notamment par la mise au point de procédés de fabrication reproductibles. L’utilisation de la pulvérisation cathodique sur les supports de silicium ultra-lisses permet d’obtenir des surfaces d’oxyde de titane ayant des rugosités inférieures au nanomètre. De plus, l’attaque du silicium par l’hydroxyde de potassium permet de modifier la topographie des surfaces avant le dépôt de films minces d’oxyde de titane. Nous présentons sur le poster les résultats obtenus récemment par microscopie à force atomique et par microscopie électronique à balayage sur les différents types de surface. L’analyse des courbes de réflectivité des rayons X nous a permis de déterminer précisément l’épaisseur des films déposés et de suivre les modifications de la composition chimique suivant les paramètres appliqués

Le point sur certains ravageurs du cèdre de l'Atlas en Afrique du nord, en France et en Europe.

Cette synthèse fait le point sur les connaissances acquises depuis une vingtaine d'années sur certains ravageurs du cèdre de l'Atlas dans son aire naturelle en Afrique du nord (Algérie, Maroc) et dans son aire d'extension en France et en Europe

The CAT Imaging Telescope for Very-High-Energy Gamma-Ray Astronomy

The CAT (Cherenkov Array at Themis) imaging telescope, equipped with a very-high-definition camera (546 fast phototubes with 0.12 degrees spacing surrounded by 54 larger tubes in two guard rings) started operation in Autumn 1996 on the site of the former solar plant Themis (France). Using the atmospheric Cherenkov technique, it detects and identifies very high energy gamma-rays in the range 250 GeV to a few tens of TeV. The instrument, which has detected three sources (Crab nebula, Mrk 421 and Mrk 501), is described in detail.Comment: 24 pages, 15 figures. submitted to Elsevier Preprin

Dielectric response of charge induced correlated state in the quasi-one-dimensional conductor (TMTTF)2PF6

Conductivity and permittivity of the quasi-one-dimensionsional organic transfer salt (TMTTF)2PF6 have been measured at low frequencies (10^3-10^7 Hz) between room temperature down to below the temperature of transition into the spin-Peierls state. We interpret the huge real part of the dielectric permittivity (up to 10^6) in the localized state as the realization in this compound of a charge ordered state of Wigner crystal type due to long range Coulomb interaction.Comment: 11 pages, 3 .eps figure

A new analysis method for very high definition Imaging Atmospheric Cherenkov Telescopes as applied to the CAT telescope

A new method of shower-image analysis is presented which appears very powerful as applied to those Cherenkov Imaging Telescopes with very high definition imaging capability. It provides hadron rejection on the basis of a single cut on the image shape, and simultaneously determines the energy of the electromagnetic shower and the position of the shower axis with respect to the detector. The source location is also reconstructed for each individual gamma-ray shower, even with one single telescope, so for a point source the hadron rejection can be further improved. As an example, this new method is applied to data from the CAT (Cherenkov Array at Themis) imaging telescope, which has been operational since Autumn, 1996.Comment: 22 pages. submitted to Elsevier Preprin

Prototype Tests for the CELESTE Solar Array Gamma--Ray Telescope

The CELESTE experiment will be an Atmospheric Cherenkov detector designed to bridge the gap in energy sensitivity between current satellite and ground-based gamma-ray telescopes, 20 to 300 GeV. We present test results made at the former solar power plant, Themis, in the French Pyrenees. The tests confirm the viability of using a central tower heliostat array for Cherenkov wavefront sampling.Comment: LaTeX2e,30 pages including 14 figures, accepted for publication by Nuclear Instruments & Methods Section

Regulation of 5-HT Receptors and the Hypothalamic-Pituitary-Adrenal Axis

Disturbances in the serotonin (5-HT) system is the neurobiological abnormality most consistently associated with suicide. Hyperactivity of the hypothalmic-pituitary-adrenal (HPA) axis is also described in suicide victims. The HPA axis is the classical neuroendocrine system that responds to stress and whose final product, corticosteroids, targets components of the limbic system, particularly the hippocampus. We will review resulsts from animal studies that point to the possibility that many of the 5-HT receptor changes observed in suicide brains may be a result of, or may be worsened by, the HPA overactivity that may be present in some suicide victims. The results of these studies can be summarized as follows: (1) chronic unpredictable stress produces high corticosteroid levels in rats; (2) chronic stress also results in changes in specific 5-HT receptors (increases in cortical 5-HT2A and decreases in hipocampal 5-HT1A and 5-HT1B); (3) chronic antidepressant administration prevents many of the 5-HT receptor changes observed after stress; and (4) chronic antidepressant administration reverses the overactivity of the HPA axis. If indeed 5-HT receptors have a partial role in controlling affective states, then their modulation by corticosteroids provides a potential mechanism by which these hormones may regulate mood. These data may also provide a biological understanding of how stressful events may increase the risk for suicide in vulnerable individuals and may help us elucidate the neurobiological underpinnings of treatment resistance.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73437/1/j.1749-6632.1997.tb52357.x.pd

Measurement of the W+W-gamma Cross Section and Direct Limits on Anomalous Quartic Gauge Boson Couplings at LEP

The process e+e- -> W+W-gamma is analysed using the data collected with the L3 detector at LEP at a centre-of-mass energy of 188.6GeV, corresponding to an integrated luminosity of 176.8pb^-1. Based on a sample of 42 selected W+W- candidates containing an isolated hard photon, the W+W-gamma cross section, defined within phase-space cuts, is measured to be: sigma_WWgamma = 290 +/- 80 +/- 16 fb, consistent with the Standard Model expectation. Including the process e+e- -> nu nu gamma gamma, limits are derived on anomalous contributions to the Standard Model quartic vertices W+W- gamma gamma and W+W-Z gamma at 95% CL: -0.043 GeV^-2 < a_0/Lambda^2 < 0.043 GeV^-2 0.08 GeV^-2 < a_c/Lambda^2 < 0.13 GeV^-2 0.41 GeV^-2 < a_n/Lambda^2 < 0.37 GeV^-2

Production of Single W Bosons at \sqrt{s}=189 GeV and Measurement of WWgamma Gauge Couplings

Single W boson production in electron-positron collisions is studied with the L3 detector at LEP. The data sample collected at a centre-of-mass energy of \sqrt{s} = 188.7GeV corresponds to an integrated luminosity of 176.4pb^-1. Events with a single energetic lepton or two acoplanar hadronic jets are selected. Within phase-space cuts, the total cross-section is measured to be 0.53 +/- 0.12 +/- 0.03 pb, consistent with the Standard Model expectation. Including our single W boson results obtained at lower \sqrt{s}, the WWgamma gauge couplings kappa_gamma and lambda_gamma are determined to be kappa_gamma = 0.93 +/- 0.16 +/- 0.09 and lambda_gamma = -0.31 +0.68 -0.19 +/- 0.13

Search for Neutral Higgs Bosons of the Minimal Supersymmetric Standard Model in e+e- Interactions at \sqrt{s} = 189 GeV

A search for the lightest neutral scalar and neutral pseudoscalar Higgs bosons in the Minimal Supersymmetric Standard Model is performed using 176.4 pb^-1 of integrated luminosity collected by L3 at a center-of-mass energy of 189 GeV. No signal is observed, and the data are consistent with the expected Standard Model background. Lower limits on the masses of the lightest neutral scalar and pseudoscalar Higgs bosons are given as a function of tan(beta). Lower mass limits for tan(beta)>1 are set at the 95% confidence level to be m_h > 77.1 GeV and m_A > 77.1 GeV