339 research outputs found

    A simple E-learning system based on classroom competition

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    The final publication is available at Springer via http://dx.doi.org/10.1007/978-3-642-16020-2_42Proceedings of 5th European Conference on Technology Enhanced Learning, EC-TEL 2010, Barcelona, Spain, September 28 - October 1, 2010.We present an e-learning system based on online forms that allows teachers to easily organise competitions in a classroom. This system is used in a preliminary study to evaluate whether cooperative competition is positive or not in education, and to identify which are the characteristics this kind of activity should have to be no harmful for students, motivating and helping them in their learning process.This work was supported by the Spanish Ministry of Science and Innovation (TIN2008-06566-C04-02), and the Community of Madrid (S2009TIC- 1542)

    Analysis and design of power management scheme for an on-board solar energy storage system

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    This paper investigates the power management issues in a mobile solar energy storage system. A multi-converter based energy storage system is proposed, in which solar power is the primary source while the grid or the diesel generator is selected as the secondary source. The existence of the secondary source facilitates the battery state of charge detection by providing a constant battery charging current. Converter modeling, multi-converter control system design, digital implementation and experimental verification are introduced and discussed in details. The prototype experiment indicates that the converter system can provide a constant charging current during solar converter maximum power tracking operation, especially during large solar power output variation, which proves the feasibility of the proposed design

    Quasicondensate and superfluid fraction in the 2D charged-boson gas at finite temperature

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    The Bogoliubov - de Gennes equations are solved for the Coulomb Bose gas describing a fluid of charged bosons at finite temperature. The approach is applicable in the weak coupling regime and the extent of its quantitative usefulness is tested in the three-dimensional fluid, for which diffusion Monte Carlo data are available on the condensate fraction at zero temperature. The one-body density matrix is then evaluated by the same approach for the two-dimensional fluid with e^2/r interactions, to demonstrate the presence of a quasi-condensate from its power-law decay with increasing distance and to evaluate the superfluid fraction as a function of temperature at weak coupling.Comment: 9 pages, 2 figure

    The superconductivity at 18 K in LiFeAs system

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    A new iron arsenide superconducting system LiFeAs was found that crystallizes into a tetragonal structure with space group P4/nmm. The superconductivity with Tc up to 18 K was observed in the compounds. This simple 111 type layered iron arsenide superconductor can be viewed as an analogue of the infinite layer structure of copper oxides.Comment: 11 pages 3 Figure

    Cosmic histories of star formation and reionization: An analysis with a power-law approximation

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    With a simple power-law approximation of high-redshift (3.5\gtrsim3.5) star formation history, i.e., ρ˙(z)[(1+z)/4.5]α\dot{\rho}_*(z)\propto [(1+z)/4.5]^{-\alpha}, we investigate the reionization of intergalactic medium (IGM) and the consequent Thomson scattering optical depth for cosmic microwave background (CMB) photons. A constraint on the evolution index α\alpha is derived from the CMB optical depth measured by the {\it Wilkinson Microwave Anisotropy Probe} (WMAP) experiment, which reads α2.18lgNγ3.89\alpha\approx2.18\lg{\mathscr{N}_{\gamma}}-3.89, where the free parameter Nγ\mathscr{N}_\gamma is the number of the escaped ionizing ultraviolet photons per baryon. Moreover, the redshift for full reionization, zfz_f, can also be expressed as a function of α\alpha as well as Nγ\mathscr{N}_{\gamma}. By further taking into account the implication of the Gunn-Peterson trough observations to quasars for the full reionization redshift, i.e., 6zf76\lesssim z_f \lesssim7, we obtain 0.3α1.30.3\lesssim\alpha\lesssim1.3 and 80Nγ23080\lesssim\mathscr{N}_{\gamma}\lesssim230. For a typical number of 4000\sim4000 of ionizing photons released per baryon of normal stars, the fraction of these photons escaping from the stars, fescf_{\rm esc}, can be constrained to within the range of (2.05.8)(2.0-5.8)%.Comment: 10 pages, 4 figures, accepted for publication in JCA

    High pressure synthesis of a new superconductor Sr2CuO2+xCl2-y induced by apical oxygen doping

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    Using the apical oxygen doping mechanism, i.e. a partial substitution of divalence O for the monovalence Cl, a p-type oxychloride cuprate superconductor, Sr2CuO2+xCl2-y, was synthesized at high pressure high temperature. The x-ray diffraction refinement suggests the superconductor crystallizes into a 0201 structure with space group I4/mmm and lattice parameters being a=3.92A, c=15.6 A. The magnetic susceptibility as well as resistance measurements indicated that the bulk superconductivity with transition temperature 30K was achieved in the sample.Comment: accepted by physica

    Resonance Fluorescence Spectrum of a Trapped Ion Undergoing Quantum Jumps

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    We experimentally investigate the resonance fluorescence spectrum of single 171Yb and 172Yb ions which are laser cooled to the Lamb-Dicke regime in a radiofrequency trap. While the fluorescence scattering of 172Yb is continuous, the 171Yb fluorescence is interrupted by quantum jumps because a nonvanishing rate of spontaneous transitions leads to electron shelving in the metastable hyperfine sublevel 2D3/2(F=2). The average duration of the resulting dark periods can be varied by changing the intensity of a repumping laser field. Optical heterodyne detection is employed to analyze the fluorescence spectrum near the Rayleigh elastic scattering peak. It is found that the stochastic modulation of the fluorescence emission by quantum jumps gives rise to a Lorentzian component in the fluorescence spectrum, and that the linewidth of this component varies according to the average duration of the dark fluorescence periods. The experimental observations are in quantitative agreement with theoretical predictions.Comment: 14 pages including 4 figures, pdf file, fig.1 replace

    Natural product derivative Gossypolone inhibits Musashi family of RNA-binding proteins

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    Background: The Musashi (MSI) family of RNA-binding proteins is best known for the role in post-transcriptional regulation of target mRNAs. Elevated MSI1 levels in a variety of human cancer are associated with up-regulation of Notch/Wnt signaling. MSI1 binds to and negatively regulates translation of Numb and APC (adenomatous polyposis coli), negative regulators of Notch and Wnt signaling respectively. Methods: Previously, we have shown that the natural product (-)-gossypol as the first known small molecule inhibitor of MSI1 that down-regulates Notch/Wnt signaling and inhibits tumor xenograft growth in vivo. Using a fluorescence polarization (FP) competition assay, we identified gossypolone (Gn) with a > 20-fold increase in Ki value compared to (-)-gossypol. We validated Gn binding to MSI1 using surface plasmon resonance, nuclear magnetic resonance, and cellular thermal shift assay, and tested the effects of Gn on colon cancer cells and colon cancer DLD-1 xenografts in nude mice. Results: In colon cancer cells, Gn reduced Notch/Wnt signaling and induced apoptosis. Compared to (-)-gossypol, the same concentration of Gn is less active in all the cell assays tested. To increase Gn bioavailability, we used PEGylated liposomes in our in vivo studies. Gn-lip via tail vein injection inhibited the growth of human colon cancer DLD-1 xenografts in nude mice, as compared to the untreated control (P < 0.01, n = 10). Conclusion: Our data suggest that PEGylation improved the bioavailability of Gn as well as achieved tumor-targeted delivery and controlled release of Gn, which enhanced its overall biocompatibility and drug efficacy in vivo. This provides proof of concept for the development of Gn-lip as a molecular therapy for colon cancer with MSI1/MSI2 overexpression
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