Supplementation of iron alone and combined with vitamins improves haematological status, erythrocyte membrane fluidity and oxidative stress in anaemic pregnant women

Pregnancy is a condition exhibiting increased susceptibility to oxidative stress, and Fe plays a central role in generating harmful oxygen species. The objective of the present study is to investigate the changes in haematological status, oxidative stress and erythrocyte membrane fluidity in anaemic pregnant women after Fe supplementation with and without combined vitamins. The study was a 2 months double-blind, randomised trial. Pregnant women (n 164) were allocated to four groups: group C was the placebo control group; group I was supplemented daily with 60 mg Fe (ferrous sulphate) daily; group IF was supplemented daily with Fe plus 400 µg folic acid; group IM was supplemented daily with Fe plus 2 mg retinol and 1 mg riboflavin, respectively. After the 2-month trial, Hb significantly increased by 15·8, 17·3 and 21·8 g/l, and ferritin by 2·8, 3·6 and 11·0 µg/l, in the I, IF and IM groups compared with placebo. Polarisation (¿) and microviscosity (¿) decreased significantly in other groups compared with placebo, indicating an increase in membrane fluidity. Significant decreases of ¿ and ¿ values compared with group C were 0·033 and 0·959 for group I, 0·037 and 1·074 for group IF and 0·064 and 1·865 for group IM, respectively. In addition, significant increases of glutathione peroxidase activities and decreases of malondialdehyde were shown in all treated groups, as well as increases of plasma retinol and urine riboflavin in group IM. The findings show that supplementation with Fe and particularly in combination with vitamins could improve the haematological status as well as oxidative stress and erythrocyte membrane fluidit

Random and block copolymers of bioreducible poly(amido amine)s with high- and low-basicity amino groups: study of DNA condensation and buffer capacity on gene transfection

Poly(amido amine) (SS-PAA) random and block copolymers having bioreducible disulfide bonds in the main chain and amino groups with distinctly different basicity in the side chain were designed and synthesized by Michael addition polymerization between N, N′-cystaminebisacrylamide (CBA) and two amine monomers, i.e., histamine (HIS) and 3-(dimethylamino)-1-propylamine (DMPA). Copolymers containing variable HIS/DMPA ratios show higher ability to bind DNA than p(CBA-HIS) homopolymer and condense DNA into the polyplexes with particle sizes (< 150 nm) that are smaller than polyplexes of p(CBA-HIS) (not, vert, similar 220 nm). The buffer capacities of the copolymers increase with increasing HIS/DMPA ratio. These copolymers are able to transfect COS-7 cells in vitro with efficiencies that increase with increasing HIS/DMPA ratio. The random and block copolymers at a HIS/DMPA ratio of 70/30 combines optimal DNA condensation capability and buffer capacity, thereby inducing higher transfection efficiency in the absence and presence of serum as compared to p(CBA-HIS) homopolymer. Moreover, random and block copolymers show a similar transfection capacity, but both have higher capacity than the physical mixtures of p(CBA-HIS) and p(CBA-DMPA) homopolymers. XTT assay reveals that the polyplexes of the SS-PAA copolymers have essentially low cytotoxicity when the highest transfection activity is observed

Numerical simulation of strongly nonlinear and dispersive waves using a Green-Naghdi model

We investigate here the ability of a Green-Naghdi model to reproduce strongly nonlinear and dispersive wave propagation. We test in particular the behavior of the new hybrid finite-volume and finite-difference splitting approach recently developed by the authors and collaborators on the challenging benchmark of waves propagating over a submerged bar. Such a configuration requires a model with very good dispersive properties, because of the high-order harmonics generated by topography-induced nonlinear interactions. We thus depart from the aforementioned work and choose to use a new Green-Naghdi system with improved frequency dispersion characteristics. The absence of dry areas also allows us to improve the treatment of the hyperbolic part of the equations. This leads to very satisfying results for the demanding benchmarks under consideration

Regenerating Nucleus Pulposus of the Intervertebral Disc Using Biodegradable Nanofibrous Polymer Scaffolds

Low back pain is a leading health problem in the United States, which is most often resulted from nucleus pulposus (NP) degeneration. To date, the replacement of degenerated NP relies entirely on mechanical devices. However, a biological NP replacement implant is more desirable. Here, we report the regeneration of NP tissue using a biodegradable nanofibrous (NF) scaffold. Rabbit NP cells were seeded on the NF scaffolds to regenerate NP-like tissue both in vitro and in a subcutaneous implantation model. The NP cells on the NF scaffolds proliferated faster than those on control solid-walled (SW) scaffolds in vitro. Significantly more extracellular matrix (ECM) production (glycosaminoglycan and type II collagen) was found on the NF scaffolds than on the control SW scaffolds. The constructs were then implanted in the caudal spine of athymic rats for up to 12 weeks. The tissue-engineered NP could survive, produce functional ECM, remain in place, and maintain the disc height, which is similar to the native NP tissue.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/98480/1/ten%2Etea%2E2011%2E0747.pd

Electronic structure of fluorides: general trends for ground and excited state properties

The electronic structure of fluorite crystals are studied by means of density functional theory within the local density approximation for the exchange correlation energy. The ground-state electronic properties, which have been calculated for the cubic structures $CaF_{2}$,$SrF_{2}$, $BaF_{2}$, $CdF_{2}$, $HgF_{2}$, $\beta$-$PbF_{2}$, using a plane waves expansion of the wave functions, show good comparison with existing experimental data and previous theoretical results. The electronic density of states at the gap region for all the compounds and their energy-band structure have been calculated and compared with the existing data in the literature. General trends for the ground-state parameters, the electronic energy-bands and transition energies for all the fluorides considered are given and discussed in details. Moreover, for the first time results for $HgF_{2}$ have been presented

Superconducting proximity effect in clean ferromagnetic layers

We investigate superconducting proximity effect in clean ferromagnetic layers with rough boundaries. The subgap density of states is formed by Andreev bound states at energies which depend on trajectory length and the ferromagnetic exchange field. At energies above the gap, the spectrum is governed by resonant scattering states. The resulting density of states, measurable by tunneling spectroscopy, exhibits a rich structure, which allows to connect the theoretical parameters from experiments.Comment: 11 pages, 5 figures (included

Acoustic modelling of exhaust devices with nonconforming finite element meshes and transfer matrices

[EN] Transfer matrices are commonly considered in the numerical modelling of the acoustic behaviour associated with exhaust devices in the breathing system of internal combustion engines, such as catalytic converters, particulate filters, perforated mufflers and charge air coolers. In a multidimensional finite element approach, a transfer matrix provides a relationship between the acoustic fields of the nodes located at both sides of a particular region. This approach can be useful, for example, when one-dimensional propagation takes place within the region substituted by the transfer matrix. As shown in recent investigations, the sound attenuation of catalytic converters can be properly predicted if the monolith is replaced by a plane wave four-pole matrix. The finite element discretization is retained for the inlet/outlet and tapered ducts, where multidimensional acoustic fields can exist. In this case, only plane waves are present within the capillary ducts, and three-dimensional propagation is possible in the rest of the catalyst subcomponents. Also, in the acoustic modelling of perforated mufflers using the finite element method, the central passage can be replaced by a transfer matrix relating the pressure difference between both sides of the perforated surface with the acoustic velocity through the perforations. The approaches in the literature that accommodate transfer matrices and finite element models consider conforming meshes at connecting interfaces, therefore leading to a straightforward evaluation of the coupling integrals. With a view to gaining flexibility during the mesh generation process, it is worth developing a more general procedure. This has to be valid for the connection of acoustic subdomains by transfer matrices when the discretizations are nonconforming at the connecting interfaces. In this work, an integration algorithm similar to those considered in the mortar finite element method, is implemented for nonmatching grids in combination with acoustic transfer matrices. A number of numerical test problems related to some relevant exhaust devices are then presented to assess the accuracy and convergence performance of the proposed procedure.Authors gratefully acknowledge the financial support of Ministerio de Ciencia e Innovacion and the European Regional Development Fund by means of the Projects DPI2007-62635 and DPI2010-15412.Denia, F.; Martínez-Casas, J.; Baeza, L.; Fuenmayor, F. (2012). Acoustic modelling of exhaust devices with nonconforming finite element meshes and transfer matrices. Applied Acoustics. 73(8):713-722. https://doi.org/10.1016/j.apacoust.2012.02.003S71372273

Helicity Analysis of Semileptonic Hyperon Decays Including Lepton Mass Effects

Using the helicity method we derive complete formulas for the joint angular decay distributions occurring in semileptonic hyperon decays including lepton mass and polarization effects. Compared to the traditional covariant calculation the helicity method allows one to organize the calculation of the angular decay distributions in a very compact and efficient way. In the helicity method the angular analysis is of cascade type, i.e. each decay in the decay chain is analyzed in the respective rest system of that particle. Such an approach is ideally suited as input for a Monte Carlo event generation program. As a specific example we take the decay $\Xi^0 \to \Sigma^+ + l^- + \bar{\nu}_l$ ($l^-=e^-, \mu^-$) followed by the nonleptonic decay $\Sigma^+ \to p + \pi^0$ for which we show a few examples of decay distributions which are generated from a Monte Carlo program based on the formulas presented in this paper. All the results of this paper are also applicable to the semileptonic and nonleptonic decays of ground state charm and bottom baryons, and to the decays of the top quark.Comment: Published version. 40 pages, 11 figures included in the text. Typos corrected, comments added, references added and update

Changes of solar cell parameters during damp-heat exposure

The electrical ageing of photovoltaic modules during extended damp-heat tests at different stress levels is investigated for three types of crystalline silicon photovoltaic modules with different backsheets, encapsulants and cell types. Deploying different stress levels allows determination of an equivalent stress dose function, which is a first step towards a lifetime prediction of devices. The derived humidity dose is used to characterise the degradation of power as well as that of the solar cell's equivalent circuit parameters calculated from measured current–voltage characteristics. An application of this to the samples demonstrates different modes in the degradation and thus enables better understanding of the module's underlying ageing mechanisms. The analysis of changes in the solar cell equivalent circuit parameters identified the primary contributors to the power degradation and distinguished the potential ageing mechanism for each types of module investigated in this paper. © 2016 The Authors. Progress in Photovoltaics: Research and Applications published by John Wiley & Sons Ltd. © 2016 The Authors. Progress in Photovoltaics: Research and Applications published by John Wiley & Sons Ltd.This work was supported in part by the European Commission under FP7 grant N° 262533 SOPHIA (INFRA-2010- 1.1.22_CP-CSA-Infra) and by the Research Councils UK (RCUK) under project ‘Stability and Performance of Photovoltaics (STAPP)’ (contract no: EP/H040331/1)

Leptogenesis with virtual Majorana neutrinos

We present a mechanism of leptogenesis based on the out-of-equilibrium decay of a scalar particle into heavy virtual Majorana neutrinos. This scheme presents many conceptual advantages over the conventional scenario of Fukugita and Yanagida. In particular, the standard techniques of quantum field theory can be used to compute the lepton asymmetry, without resorting to the phenomenological approximations usually made to describe unstable particles. This simplification allows us to address in a well-defined framework some issues raised in the recent literature. We also show, in a toy model, that a successful leptogenesis scenario is possible and requires a rather light scalar particle, $10^6 GeV < m < 10^{13} GeV$. A natural embedding of this scheme in a gauged unified theory encompassing the Majorana fermions seems however difficult.Comment: 23 pages, 9 figures, using Latex and epsfi