1,014 research outputs found
Towards Autopoietic Computing
A key challenge in modern computing is to develop systems that address
complex, dynamic problems in a scalable and efficient way, because the
increasing complexity of software makes designing and maintaining efficient and
flexible systems increasingly difficult. Biological systems are thought to
possess robust, scalable processing paradigms that can automatically manage
complex, dynamic problem spaces, possessing several properties that may be
useful in computer systems. The biological properties of self-organisation,
self-replication, self-management, and scalability are addressed in an
interesting way by autopoiesis, a descriptive theory of the cell founded on the
concept of a system's circular organisation to define its boundary with its
environment. In this paper, therefore, we review the main concepts of
autopoiesis and then discuss how they could be related to fundamental concepts
and theories of computation. The paper is conceptual in nature and the emphasis
is on the review of other people's work in this area as part of a longer-term
strategy to develop a formal theory of autopoietic computing.Comment: 10 Pages, 3 figure
Pain outcomes in patients with bone metastases from advanced cancer: assessment and management with bone-targeting agents
Bone metastases in advanced cancer frequently cause painful complications that impair patient physical activity and negatively affect quality of life. Pain is often underreported and poorly managed in these patients. The most commonly used pain assessment instruments are visual analogue scales, a single-item measure, and the Brief Pain Inventory Questionnaire-Short Form. The World Health Organization analgesic ladder and the Analgesic Quantification Algorithm are used to evaluate analgesic use. Bone-targeting agents, such as denosumab or bisphosphonates, prevent skeletal complications (i.e., radiation to bone, pathologic fractures, surgery to bone, and spinal cord compression) and can also improve pain outcomes in patients with metastatic bone disease. We have reviewed pain outcomes and analgesic use and reported pain data from an integrated analysis of randomized controlled studies of denosumab versus the bisphosphonate zoledronic acid (ZA) in patients with bone metastases from advanced solid tumors. Intravenous bisphosphonates improved pain outcomes in patients with bone metastases from solid tumors. Compared with ZA, denosumab further prevented pain worsening and delayed the need for treatment with strong opioids. In patients with no or mild pain at baseline, denosumab reduced the risk of increasing pain severity and delayed pain worsening along with the time to increased pain interference compared with ZA, suggesting that use of denosumab (with appropriate calcium and vitamin D supplementation) before patients develop bone pain may improve outcomes. These data also support the use of validated pain assessments to optimize treatment and reduce the burden of pain associated with metastatic bone disease
Pulsational Mapping of Calcium Across the Surface of a White Dwarf
We constrain the distribution of calcium across the surface of the white
dwarf star G29-38 by combining time series spectroscopy from Gemini-North with
global time series photometry from the Whole Earth Telescope. G29-38 is
actively accreting metals from a known debris disk. Since the metals sink
significantly faster than they mix across the surface, any inhomogeneity in the
accretion process will appear as an inhomogeneity of the metals on the surface
of the star. We measure the flux amplitudes and the calcium equivalent width
amplitudes for two large pulsations excited on G29-38 in 2008. The ratio of
these amplitudes best fits a model for polar accretion of calcium and rules out
equatorial accretion.Comment: Accepted to the Astrophysical Journal. 16 pages, 10 figures
Pain and analgesic use associated with skeletal-related events in patients with advanced cancer and bone metastases
PURPOSE: Bone metastases secondary to solid tumors increase the risk of skeletal-related events (SREs), including the occurrence of pathological fracture (PF), radiation to bone (RB), surgery to bone (SB), and spinal cord compression (SCC). The aim of this study was to evaluate the impact of SREs on patients' pain, analgesic use, and pain interference with daily functioning.
METHODS: Data were combined from patients with solid tumors and bone metastases who received denosumab or zoledronic acid across three identically designed phase 3 trials (N = 5543). Pain severity (worst pain) and pain interference were assessed using the Brief Pain Inventory at baseline and each monthly visit. Analgesic use was quantified using the Analgesic Quantification Algorithm.
RESULTS: The proportion of patients with moderate/severe pain and strong opioid use generally increased in the 6 months preceding an SRE and remained elevated, while they remained relatively consistent over time in patients without an SRE. Regression analysis indicated that all SRE types were significantly associated with an increased risk of progression to moderate/severe pain and strong opioid use. PF, RB, and SCC were associated with significantly greater risk of pain interference overall. Results were similar for pain interference with emotional well-being. All SRE types were associated with significantly greater risk of pain interference with physical function.
CONCLUSIONS: SREs are associated with increased pain and analgesic use in patients with bone metastases. Treatments that prevent SREs may decrease pain and the need for opioid analgesics and reduce the impact of pain on daily functioning
Pain and analgesic use associated with skeletal-related events in patients with advanced cancer and bone metastases
PURPOSE: Bone metastases secondary to solid tumors increase the risk of skeletal-related events (SREs), including the occurrence of pathological fracture (PF), radiation to bone (RB), surgery to bone (SB), and spinal cord compression (SCC). The aim of this study was to evaluate the impact of SREs on patients' pain, analgesic use, and pain interference with daily functioning.
METHODS: Data were combined from patients with solid tumors and bone metastases who received denosumab or zoledronic acid across three identically designed phase 3 trials (N = 5543). Pain severity (worst pain) and pain interference were assessed using the Brief Pain Inventory at baseline and each monthly visit. Analgesic use was quantified using the Analgesic Quantification Algorithm.
RESULTS: The proportion of patients with moderate/severe pain and strong opioid use generally increased in the 6 months preceding an SRE and remained elevated, while they remained relatively consistent over time in patients without an SRE. Regression analysis indicated that all SRE types were significantly associated with an increased risk of progression to moderate/severe pain and strong opioid use. PF, RB, and SCC were associated with significantly greater risk of pain interference overall. Results were similar for pain interference with emotional well-being. All SRE types were associated with significantly greater risk of pain interference with physical function.
CONCLUSIONS: SREs are associated with increased pain and analgesic use in patients with bone metastases. Treatments that prevent SREs may decrease pain and the need for opioid analgesics and reduce the impact of pain on daily functioning
Expression of interleukin 6 (IL-6) correlates with oestrogen receptor in human breast carcinoma
Multifunctional cytokines play important and only partially defined roles in mammary tumour development and progression. Normal human mammary epithelial cells constitutively produce interleukin 6 (IL-6), IL-8 and a non-secreted form of tumour necrosis factor. Transformation of mammary epithelial cells by different oncogenes is frequently associated with alterations of cytokine/growth factor production and responsiveness. In the present study we analysed the expression of IL-6 in 149 cases of invasive breast carcinoma and the data have been correlated with clinico-pathological variables including tumour size, histological grade, nodal status, and oestrogen and progesterone receptors, Ki67 and p53, protein expression. Though the majority of breast carcinomas expressed at least low levels of immunoreactive IL-6, we found that expression of this cytokine was inversely associated with histological tumour grade (P = 0.0017), but not with tumour size and nodal status. Ki67 positivity was inversely correlated with IL-6 expression (P = 0.027). Among biological parameters analysed, a direct association was found between the percentage of IL-6-positive cells and that of oestrogen (P = 0.00005) and progesterone (P = 0.025) receptor-positive cells. No correlation was observed between IL-6 and p53 protein expression. These data indicate that down regulation of IL-6 is associated with highly malignant mammary carcinomas. It will be of interest to evaluate whether alterations of cytokines that are constitutively produced by mammary cells are also associated with high-grade tumours
"Meaning" as a sociological concept: A review of the modeling, mapping, and simulation of the communication of knowledge and meaning
The development of discursive knowledge presumes the communication of meaning
as analytically different from the communication of information. Knowledge can
then be considered as a meaning which makes a difference. Whereas the
communication of information is studied in the information sciences and
scientometrics, the communication of meaning has been central to Luhmann's
attempts to make the theory of autopoiesis relevant for sociology. Analytical
techniques such as semantic maps and the simulation of anticipatory systems
enable us to operationalize the distinctions which Luhmann proposed as relevant
to the elaboration of Husserl's "horizons of meaning" in empirical research:
interactions among communications, the organization of meaning in
instantiations, and the self-organization of interhuman communication in terms
of symbolically generalized media such as truth, love, and power. Horizons of
meaning, however, remain uncertain orders of expectations, and one should
caution against reification from the meta-biological perspective of systems
theory
Massive gravity from bimetric gravity
We discuss the subtle relationship between massive gravity and bimetric
gravity, focusing particularly on the manner in which massive gravity may be
viewed as a suitable limit of bimetric gravity. The limiting procedure is more
delicate than currently appreciated. Specifically, this limiting procedure
should not unnecessarily constrain the background metric, which must be
externally specified by the theory of massive gravity itself. The fact that in
bimetric theories one always has two sets of metric equations of motion
continues to have an effect even in the massive gravity limit, leading to
additional constraints besides the one set of equations of motion naively
expected. Thus, since solutions of bimetric gravity in the limit of vanishing
kinetic term are also solutions of massive gravity, but the contrary statement
is not necessarily true, there is not complete continuity in the parameter
space of the theory. In particular, we study the massive cosmological solutions
which are continuous in the parameter space, showing that many interesting
cosmologies belong to this class.Comment: v1: 25 pages; v2: 6 references added, discussion streamlined; v3: 24
pages, 20 references added, section 2 summarized, new comments added to
section 3, conclusions improved but unchanged. This version accepted for
publication in Classical and Quantum Gravit
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