660 research outputs found
Characterizing top gated bilayer graphene interaction with its environment by Raman spectroscopy
In this work we study the behavior of the optical phonon modes in bilayer
graphene devices by applying top gate voltage, using Raman scattering. We
observe the splitting of the Raman G band as we tune the Fermi level of the
sample, which is explained in terms of mixing of the Raman (Eg) and infrared
(Eu) phonon modes, due to different doping in the two layers. We theoretically
analyze our data in terms of the bilayer graphene phonon self-energy which
includes non-homogeneous charge carrier doping between the graphene layers. We
show that the comparison between the experiment and theoretical model not only
gives information about the total charge concentration in the bilayer graphene
device, but also allows to separately quantify the amount of unintentional
charge coming from the top and the bottom of the system, and therefore to
characterize the interaction of bilayer graphene with its surrounding
environment
Reconstruction of irradiated bone segmental defects with a biomaterial associating MBCP+®, microstructured collagen membrane and total bone marrow grafting: An experimental study in rabbits
The bone tissue engineering models used today are still a long way from any oncologic application as immediate postimplantation irradiation would decrease their osteoinductive potential. The aim of this study was to reconstruct a segmental critical size defect in a weight-bearing bone irradiated after implantation. Six white New Zealand rabbits were immediately implanted with a biomaterial associating resorbable collagen membrane EZ® filled and micro-macroporous biphasic calcium phosphate granules (MBCP+®). After a daily schedule of radiation delivery, and within 4 weeks, a total autologous bone marrow (BM) graft was injected percutaneously into the center of the implant. All the animals were sacrificed at 16 weeks. Successful osseous colonization was found to have bridged the entire length of the defects. Identical distribution of bone ingrowth and residual ceramics at the different levels of the implant suggests that the BM graft plays an osteoinductive role in the center of the defect. Periosteum-like formation was observed at the periphery, with the collagen membrane most likely playing a role. This model succeeded in bridging a large segmental defect in weight-bearing bone with immediate postimplantation fractionated radiation delivery. This has significant implications for the bone tissue engineering approach to patients with cancer-related bone defects
Probing the Electronic Structure of Bilayer Graphene by Raman Scattering
The electronic structure of bilayer graphene is investigated from a resonant
Raman study using different laser excitation energies. The values of the
parameters of the Slonczewski-Weiss-McClure model for graphite are measured
experimentally and some of them differ significantly from those reported
previously for graphite, specially that associated with the difference of the
effective mass of electrons and holes. The splitting of the two TO phonon
branches in bilayer graphene is also obtained from the experimental data. Our
results have implications for bilayer graphene electronic devices.Comment: 4 pages, 4 figure
EVALUATION OF THE NEWLY FORMED BONE IN IRRADIATED AREAS BY ADDITION OF MESENCHYMAL STEM CELLS TO THE ASSOCIATION OF BIPHASIC CALCIUM PHOSPHATE AND TOTAL BONE MARROW
Oral Communication presented at the ";Forum des Jeunes Chercheurs";, Brest (France) 2011
Dynamically coupling system dynamics and SWAT+ models using Tinamït: application of modular tools for coupled human–water system models
Participatory water resource management requires modeling techniques that are accurate and flexible yet stakeholder-friendly. While different modeling frameworks offer advantages and disadvantages, system dynamics (SDs) models have seen sustained use as a stakeholder-friendly approach for participatory water resource modeling. Physically based models (e.g., SWAT+) have seen sustained use to model the hydrological components of water systems. Proposed as a way to combine the relative strengths of both modeling paradigms, model coupling allows researchers to, for example, build participatory SD models with stakeholders, while delegating the hydrological components of the overall model to an external hydrological model. Recently developed to facilitate model coupling, the Tinamït Python package presents an extensible, outward-facing application programming interface (API). It allows for the development of
extensions (wrappers) that expand compatibility with different physically based models. However, no watershed hydrological model has yet been connected to this API. In the present study, a socket and JavaScript Object Notation (JSON)-based communication protocol was developed with the goal of facilitating the coupling of models written in languages such as Fortran. This novel protocol served to develop a Tinamït-compatible wrapper for the hydrological model SWAT+, allowing it to be coupled to human–water SD models. The novel coupling protocol was then applied to a case study of Tanzania's Usa river catchment. This approach provides the modeler with the benefits of both physically based and SD models, thereby allowing the detection of potentially far-reaching effects of policy-makers' decisions.</p
Radiation effects on bone healing and reconstruction: interpretation of the literature
Objective
Reconstructing irradiated mandibles with biomaterials is still a challenge but little investigated. We collected data that could help us understand studies in the field of regeneration with biomaterials and irradiated bone.
Study design
Systematic review of the literature.
Results
Delay and duration of radiation delivery and total equivalent dose are the most variable parameters in the various studies, resulting in confusion when interpreting the literature. Most reproducible experiments show that radiation reduces osteogenic cell numbers, alters cytokine capacity, and delays and damages bone remodeling. Interindividual variations and how such changes become irreversible lesions are still uncertain. In the case of regeneration using biomaterials, most studies have addressed the question of reconstruction in previously irradiated bone. The results show that osseointegration is often possible, although the failure rate is higher. The sooner the implantation takes place after the end of the radiation, the higher the likelihood of failure. Few studies have focused on primary reconstruction followed by early irradiation, and most of the currently available engineering models would be altered by radiation. Good outcomes have been obtained with bone morphogenetic protein and with total bone marrow transplanation.
Conclusion
This review points out the difficulties in achieving reproducible experiments and interpreting literature in this underinvestigated field
The electronic properties of bilayer graphene
We review the electronic properties of bilayer graphene, beginning with a
description of the tight-binding model of bilayer graphene and the derivation
of the effective Hamiltonian describing massive chiral quasiparticles in two
parabolic bands at low energy. We take into account five tight-binding
parameters of the Slonczewski-Weiss-McClure model of bulk graphite plus intra-
and interlayer asymmetry between atomic sites which induce band gaps in the
low-energy spectrum. The Hartree model of screening and band-gap opening due to
interlayer asymmetry in the presence of external gates is presented. The
tight-binding model is used to describe optical and transport properties
including the integer quantum Hall effect, and we also discuss orbital
magnetism, phonons and the influence of strain on electronic properties. We
conclude with an overview of electronic interaction effects.Comment: review, 31 pages, 15 figure
Observation of Intra- and Inter-band Transitions in the Optical Response of Graphene
The optical conductivity of freely suspended graphene was examined under
non-equilibrium conditions using femtosecond pump-probe spectroscopy. We
observed a conductivity transient that varied strongly with the electronic
temperature, exhibiting a crossover from enhanced to decreased absorbance with
increasing pump fluence. The response arises from a combination of bleaching of
the inter-band transitions by Pauli blocking and induced absorption from the
intra-band transitions of the carriers. The latter dominates at low electronic
temperature, but, despite an increase in Drude scattering rate, is overwhelmed
by the former at high electronic temperature. The time-evolution of the optical
conductivity in all regimes can described in terms of a time-varying electronic
temperature.Comment: 10 pages (4 pages manuscript + Supplemental Info.
Mandibular Segmental Defect Regenerated With Macroporous Biphasic Calcium Phosphate, Collagen Membrane, and Bone Marrow Graft in Dogs
OBJECTIVE:
To reconstruct segmental mandibulectomy using calcium phosphate ceramics and collagen membrane with a delayed bone marrow grafting in experimental animals.
DESIGN:
Defects of segmental mandibulectomy were filled with calcium phosphate granules and wrapped with a collagen membrane in 4 dogs and left empty as a control in 2 dogs. Two months later, a bone marrow graft was injected into the center of the implants. Animals were humanely killed after a 16-week delay.
SUBJECTS:
Six adult beagles were included in this study.
INTERVENTION:
Segmental mandibulectomy.
MAIN OUTCOME MEASURE:
Bone ingrowth and material resorption in the reconstructed segment.
RESULTS:
Successful osseous colonization bridged the whole length of the defects. The good new bone formation at the center and the periosteum-like formation at the periphery suggest the osteoinductive role of the bone marrow graft and the healing scaffold role of the membrane.
CONCLUSIONS:
This model succeeded in regenerating a large segmental defect in the mandible. An investigation with a postimplantation radiation delivery schedule is required with the use of this model, which should be considered as a preclinical study for a bone tissue engineering approach in patients with cancer-related bone defects
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