Presentation of the paper "Interaction design principles in WYRED platform" in HCII 2017

This is the presentation of the paper entitled “Interaction design principles in WYRED platform” in the Emerging interactive systems for education session at the HCI International 2017 Conference, held in Vancouver, Canada, 9 - 14 July 2017. This work presents the requirements elicitation phase for the WYRED platform. WYRED (netWorked Youth Research for Empowerment in the Digital society) is a European H2020 Project that aims to provide a framework for research in which children and young people can express and explore their perspectives and interests in relation to digital society, but also a platform from which they can communicate their perspectives to other stakeholders effectively through innovative engagement processes. The requirement elicitation is a basic step to design the interactive mechanism to build up the needed social dialog among the involved stakeholders. In order to set up the right interactive tasks, not only functional requirements are elicited, the non-functional requirements play a key role in this project, specially regarding to ensure the security and privacy of the underage people that will be presented in the development of this project

Combined therapies of antithrombotics and antioxidants delay in silico brain tumor progression

Glioblastoma multiforme, the most frequent type of primary brain tumor, is a rapidly evolving and spatially heterogeneous high-grade astrocytoma that presents areas of necrosis, hypercellularity and microvascular hyperplasia. The aberrant vasculature leads to hypoxic areas and results in an increase of the oxidative stress selecting for more invasive tumor cell phenotypes. In our study we assay in silico different therapeutic approaches which combine antithrombotics, antioxidants and standard radiotherapy. To do so, we have developed a biocomputational model of glioblastoma multiforme that incorporates the spatio-temporal interplay among two glioma cell phenotypes corresponding to oxygenated and hypoxic cells, a necrotic core and the local vasculature whose response evolves with tumor progression. Our numerical simulations predict that suitable combinations of antithrombotics and antioxidants may diminish, in a synergetic way, oxidative stress and the subsequent hypoxic response. This novel therapeutical strategy, with potentially low or no toxicity, might reduce tumor invasion and further sensitize glioblastoma multiforme to conventional radiotherapy or other cytotoxic agents, hopefully increasing median patient overall survival time.Comment: 8 figure

Damages Patterns in Historical Temples of Puebla, Morelos and Oaxaca after September 2017 Mexico Earthquakes

A brief description of the damages observed after the occurrence of the September 2017 earthquakes in some temples located in the states of Oaxaca, Puebla and Morelos is presented. A total of 48 temples were visited where we observed partial or total collapses of structural elements as: towers, roofs, buttresses, walls and arches in the temples. In some cases, the level of the damage was so severe that compromised the stability of the temples

Exploring wind direction and SO2 concentration by circular-linear density estimation

The study of environmental problems usually requires the description of variables with different nature and the assessment of relations between them. In this work, an algorithm for flexible estimation of the joint density for a circular-linear variable is proposed. The method is applied for exploring the relation between wind direction and SO2 concentration in a monitoring station close to a power plant located in Galicia (NW-Spain), in order to compare the effectiveness of precautionary measures for pollutants reduction in two different years.Comment: 17 pages, 7 figures, 2 table

Culture: Not just Burns – what about the poet Robert Fergusson?

No abstract available

Family functioning but not social capital is associated with better mental health in adolescents affected by violence and displacement by armed conflict in Colombia

Background: The effect of the Colombian armed conflict on the mental health of adolescents is still poorly understood. Aims: Given social interventions are most likely to inform policy, we tested whether two potential intervention targets, family functioning and social capital, were associated with mental health in Colombian adolescents, and whether this was moderated by experience of violence and displacement. Methods: We examined the cross-sectional association between family functioning, cognitive social capital, structural social capital and 12-month prevalence of Composite International Diagnostic Interview (CIDI) diagnosed psychiatric disorder, using data on 12 to 17-year-old adolescents (N = 1,754) from the 2015 National Mental Health Survey of Colombia, a nationally representative epidemiological study. We tested whether associations survived cumulative adjustment for demographic confounders, experience of non-specific violence and harm and displacement by armed conflict. Results: Neither structural nor cognitive social capital were associated with better mental health. Better family functioning was associated with reduced risk of poor mental health in an unadjusted analysis (OR 0.90 [0.85–0.96]), and after cumulative adjustments for demographic confounders (OR 0.91 [0.86–0.97]), non-specific violence and harm (OR 0.91 [0.86–0.97]) and social capital variables (OR 0.91 [0.85–0.97]). In the final model, each additional point on the family APGAR scale was associated with a 9% reduced odds of any CIDI diagnosed disorder in the last 12 months. Conclusions: Better family functioning was associated with better mental health outcomes for all adolescents. This effect remained present in those affected by the armed conflict even after accounting for potential confounders

Evolución del crecimiento en salmuera, a bajas temperaturas y diferentes acidulantes, de levaduras aisladas de aceitunas de mesa

The evolution of the main yeast species related to table olives ( Pichia anomala, Pichia membranaefaciens, Pichia minuta, Saccharomyces cerevisiae, Candida diddensii, Candida famata , and Debaryomyces hansenii ) at low temperature ( 7 ºC ) and different physico-chemical brine conditions was studied, using the log of the relative growth as response. In general, the NaCl concentration had a reduced effect, which was slightly greater at pH 3.5, although it was never significant. The effects of pH and type of acid were significant: the presence of acetic acid always diminished the yeast population with time; however the population was maintained, or even slightly increased, in the presence of lactic acid. Such effects were higher at pH 3.5 than at pH 4.0. The behaviour of the yeast species was diverse. Sacch. cerevisiae , P. nmembranaefaciens , C. famata y Deb. hansenii diminished with time in 8 % NaCl. The yeast population markedly decreased at pH 3.5, mainly in the case of Sacch. cerevisiae and C. famata. The presence of acetic acid decreased the yeast population in most species and always lead to a progressive diminution of it with time. No differences between species due to lactic acid was observed. These results can be of interest for the development of commercial presentations of table olives to be preserved at low temperature and with a reduced level of sodium.Se ha estudiado la evolución de las principales especies de levaduras relacionadas con las aceitunas de mesa ( Pichia anomala, Pichia membranaefaciens, Pichia minuta, Saccharomyces cerevisiae, Candida diddensii, Candida famata , y Debaryomyces hansenii ) a baja temperara ( 7 ºC ) y en diversas condiciones físico-químicas en las salmueras, utilizando el log del crecimiento relativo como respuesta. En general, la concentración de sal tiene un efecto muy limitado, que se aprecia algo más a pH 4, pero sin llegar a ser significativo. Los efectos del tipo de ácido y pH fueron significativos; la presencia de acético disminuye la población con el tiempo, mientras que con el láctico se mantiene e, incluso, se eleva ligeramente. Estos efectos se acentúan a pH 3,5. El comportamiento de cada levadura frente a las diferentes variables ha sido diverso. La población relativa de las especies Sacch. cerevisiae , P. membranaefaciens , C. famata y Deb. hansenii disminuyó con el tiempo en presencia del 8 % de NaCl. A pH 3,5 disminuye muy sensiblemente la población inicial en todos los casos, siendo tal influencia más destacada en Sacch. cerevisiae y C. famata. La presencia de acético disminuye de forma importante la población inicial inoculada en la mayoría de los casos y provocó siempre un descenso paulatino en las mismas. No se observó diferencias entre las especies debido al ácido láctico. Estos estudios pueden ser de interés para el desarrollo de presentaciones comerciales de aceitunas de mesa refrigeradas y con reducido nivel de sodio

Cómo minimizar los cambios radiológicos laterales en la osteotomía valguizante de adición medial de rodilla

Objetivo: estudiar la relación entre posición del injerto en Osteotomía Valguizante de Adición (OVA) en rodilla, los cambios radiológicos experimentados por la rótula y la pendiente tibial y su correlación clínica. Material y métodos: estudio retrospectivo de 10 pacientes operados de OVA. Medimos el cambio experimentado tras la osteotomía en Índice de Catón y la pendiente tibial y su relación con la ubicación del injerto. Valoración clínica mediante test de Lisholm y WOMAC. Resultados: edad media de 49.5 años, seguimiento medio de 32,2 meses. Se observa un cambio estadísticamente significativo de 1,45º en la pendiente tibial y de 0,15 unidades (Índice Catón) en la altura de la patela, pero sin correlación con la clínica. La ubicación del injerto en el cuadrante posterior se halló en el 80% de los casos. Conclusión : la osteotomía valguizante de adición medial tiene buenos resultados clínicos. Los cambios en la pendiente tibial y en la patela son menores cuanto más posterior es la ubicación del injerto.Objectives: we investigated changes in patellar height and tibial inclination angle after open-wedge high tibial osteotomy, the effect of these changes on patient satisfaction and the correlation with the graft position. Methods: retrospective study of 10 knees who underwent open-wedge proximal tibial osteotomy with allograft and medial plate for medial compartment. Were measured pre- and postoperatively tibial inclination angle, and patellar height (Caton Index), and we study the correlation of these changes with the location of the graft. Clinical evaluations were made using the Lysholm and WOMAC score. Results: the mean age was 49.5 years, the mean follow up was 32,2 months. The mean increase in the tibial inclination angle was 1,45 ° (p<0.05) and the mean of decrease in patellar height was 0.15 Units Caton Index (p<0.05). There weren’t correlation between radiological changes and patients satisfaction. The graft localization was posterior in 80% of patients. Conclusion: the open-wedge tibial osteotomy has good results and high clinical satisfaction. Changes in the tibial slope and the patellar height are lower if the graft position is posterior

Clinical and functional characteristics of individuals with alpha-1 antitrypsin deficiency: EARCO international registry

Background Alpha-1 antitrypsin deficiency (AATD) is a rare disease that is associated with an increased risk of pulmonary emphysema. The European AATD Research Collaboration (EARCO) international registry was founded with the objective of characterising the individuals with AATD and investigating their natural history. Methods The EARCO registry is an international, observational and prospective study of individuals with AATD, defined as AAT serum levels < 11 μM and/or proteinase inhibitor genotypes PI*ZZ, PI*SZ and compound heterozygotes or homozygotes of other rare deficient variants. We describe the characteristics of the individuals included from February 2020 to May 2022. Results A total of 1044 individuals from 15 countries were analysed. The most frequent genotype was PI*ZZ (60.2%), followed by PI*SZ (29.2%). Among PI*ZZ patients, emphysema was the most frequent lung disease (57.2%) followed by COPD (57.2%) and bronchiectasis (22%). Up to 76.4% had concordant values of FEV1(%) and KCO(%). Those with impairment in FEV1(%) alone had more frequently bronchiectasis and asthma and those with impairment in KCO(%) alone had more frequent emphysema and liver disease. Multivariate analysis showed that advanced age, male sex, exacerbations, increased blood platelets and neutrophils, augmentation and lower AAT serum levels were associated with worse FEV1(%). Conclusions EARCO has recruited > 1000 individuals with AATD from 15 countries in its first 2 years. Baseline cross sectional data provide relevant information about the clinical phenotypes of the disease, the patterns of functional impairment and factors associated with poor lung function