Facteurs pharmacologiques impliqués dans l'échec thérapeutique aux inhibiteurs de la protéase du VIH-1

AIX-MARSEILLE2-BU Pharmacie (130552105) / SudocSudocFranceF

Vesicles from peptidic side-chain polymers synthesized by atom transfer radical polymerization

Block copolymers can adopt a wide range of morphologies in dilute aqueous solution. There is a significant amount of interest in the use of block copolymer vesicles for a number of applications. We show that a series of oligo(valine) and oligo(phenylalanine) peptides coupled to a methacrylic group can be prepared by conventional peptide coupling techniques. These can be successfully polymerized by atom transfer radical polymerization (ATPP) in hexafluoroisopropanol (HFIP) giving access to poly(ethylene oxide)-b-poly(side-chain peptides). Many of these polymers self-assemble to form vesicles using an organic to aqueous solvent exchange. One example with a divaline hydrophobic block gives a mixture of toroids and vesicles. Circular dichroism demonstrates that secondary structuring is observed in the hydrophobic region of the vesicle walls for the valine side-chain containing polymers